MCQs: Anti-inflammatory Drugs

Question # 1 (Multiple Answer) Manifestations of rheumatoid arthritis: A) B) C) D) E) inflammatory synovitis cartilage destruction bone erosion changes in joint integrity progressive, relentless polyarthritis with functional impairment

Question # 2 (Multiple Choice) The major role in chronic management of arthr itis: A) glucocorticoids B) nonsteroidal antiinflammatory drugs Question # 3 (Multiple Choice) Mechanism of action: aspirin-platelet effects : A) B) C) D) promotes platelet aggregation activates thromboxane synthesis both neither

Question # 4 (Multiple Answer) Factors accounting for rheumatoid arthritis i ncidence: A) genetics B) climate C) urbanization Question # 5 (Multiple Choice) Mediator most liely to promote pain: A) B) C) D) E) histamine serotonin bradyinin prostaglandins leuotrienes

Question # 6 (True/False) Aspirin: bleeding time A) increases bleeding time B) decreases bleeding time Question # 7 (True/False) Genetic ris factors fully account for the inciden ce of rheumatoid arthritis. A) true B) false Question # 8 (Multiple Choice) At low doses required to inhibition of thymid ylate synthase, an enhanced adenosine release A) B) C) D) chloroquine gold methotrexate cyclophosphamide to

E) etorolac Question # 9 (Multiple Choice) Mediator promoting greatest increase in vascu lar permeability, associated with acute inflammation: A) B) C) D) serotonin prostaglandins bradyinin leuotrienes

Question # 10 (Multiple Choice) Isozyme primarily responsible for prostaglan din production by cells involve an inflammation: A) COX-I B) COX-II Question # 11 (Multiple Answer) Aspirin and antipyresis: A) elevation of body temperature is typically a useful defense mechanism B) aspirin -- best available drug for reducing fever (in the absence of cont raindications to its use recurrent C) aspirin -- more effective in lowering elevated temperature than normal bo dy temperature D) aspirin-induced temperature reduction is caused by vasodilation E) fever associated with infection: caused by actions of prostaglandins and interleuin 1 at the periphery Question # 12 (Multiple Answer) Phases of inflammation: A) acute inflammation B) the immune response C) chronic inflammation Question # 13 (Multiple Answer) Advantages of other NSAIDs compared with asp irin: A) B) C) D) E) generally less expensive less gastric irritation potentially better compliance (e.g. naproxen, sulindac) easier to establish therapeutic range using blood levels absence of acute renal failure/nephrotic syndrome

Question # 14 (Multiple Answer) Aspirin: A) B) C) D) E) inhibits prostaglandin synthase inhibits cyclooxygenase decreases prostaglandin formation decreases thromboxane A2 formation decreases leuotrienes

Question # 15 (Multiple Answer) Mediators of chronic inflammation in rheumat oid arthritis: A) IL-1 B) IL-2

C) IL-3 D) TNF alpha E) interferons Question # 16 (Multiple Choice) Effective in managing acute gouty arthritisa nd anylosing spondylitis; also accelerates closure of patent ductus arteriosus in premature infants: A) B) C) D) E) is: A) B) C) D) E) 1% 5% 7% 10% 15% gold etorolac phenylbutazone methotrexate indomethacin

Question # 17 (Multiple Choice) Approximate prevalence of rheumatoid arthrit

Question # 18 (Multiple Choice) In rheumatoid arthritis: primary effect of t his mediator is on prostaglandin production: A) PDGF (platelet-derived growth factor) B) GM-CSF C) TNF alpha Question # 19 (Multiple Choice) Analgesic effects of aspirin: A) B) C) D) peripheral action (inflammation) subcortical site of action both neither

Question # 20 (True/False) rheumatoid arthritis: genetic predisposition A) yes B) no Question # 21 (Multiple Answer) Correct drug-drug interactions: A) B) C) D) E) aspirin -- acetazolamide: enhanced salicylate intoxication aspirin -- spironolactone: reduced spironolactone activity aspirin -- probenecid: increased uricosuric activity aspirin -- phenytoin: increased free phenytoin serum levels aspirin-alcohol: increased gastrointestinal bleeding

Question # 22 (Multiple Choice) NSAID primarily promoted as an analgesic, no t as an anti-inflammatory agent: A) B) C) D) E) piroxicam ibuprofen naproxen etorolac sulindac

Question # 23 (Multiple Choice) Drug associated with the hepatic/renal toxic

metabolite: N-acetyl-p-benzoquinone A) B) C) D) E) diclofenac meclofenamate indomethacin acetaminophen aspirin

-------------------------------------------------------------------------Correct Answers [HIDE] Question # 1 (Multiple Answer) Manifestations of rheumatoid arthritis: (A) inflammatory synovitis (B) cartilage destruction (C) bone erosion (D) changes in joint integrity (E) progressive, relentless polyarthritis with functional impairment

Question # 2 (Multiple Choice) The major role in chronic management of arthr itis: Answer: (B) nonsteroidal antiinflammatory drugs

Question # 3 (Multiple Choice) Mechanism of action: aspirin-platelet effects : Answer: (D) neither Question # 4 (Multiple Answer) Factors accounting for rheumatoid arthritis i ncidence: (A) genetics (B) climate (C) urbanization Question # 5 (Multiple Choice) Mediator most liely to promote pain:

Answer: (C) bradyinin Question # 6 (True/False) Aspirin: bleeding time Answer: True Question # 7 (True/False) Genetic ris factors fully account for the inciden ce of rheumatoid arthritis. Answer: False

Question # 8 (Multiple Choice) At low doses required to inhibition of thymid ylate synthase, an enhanced adenosine release Answer: (C) methotrexate Question # 9 (Multiple Choice) Mediator promoting greatest increase in vascu lar permeability, associated with acute inflammation: Answer: (D) leuotrienes Question # 10 (Multiple Choice) Isozyme primarily responsible for prostaglan din production by cells involve an inflammation: Answer: (B) COX-II Question # 11 (Multiple Answer) Aspirin and antipyresis: (B) aspirin -- best available drug for reducing fever (in the absence of con traindications to its use recurrent (C) aspirin -- more effective in lowering elevated temperature than normal b ody temperature (D) aspirin-induced temperature reduction is caused by vasodilation

Question # 12 (Multiple Answer) Phases of inflammation: (A) acute inflammation (B) the immune response (C) chronic inflammation

Question # 13 (Multiple Answer) Advantages of other NSAIDs compared with asp

irin: (B) less gastric irritation (C) potentially better compliance (e.g. naproxen, sulindac)

Question # 14 (Multiple Answer) Aspirin: (A) inhibits prostaglandin synthase (B) inhibits cyclooxygenase (C) decreases prostaglandin formation (D) decreases thromboxane A2 formation Question # 15 (Multiple Answer) Mediators of chronic inflammation in rheumat oid arthritis: (A) IL-1 (B) IL-2 (C) IL-3 (D) TNF alpha (E) interferons Question # 16 (Multiple Choice) Effective in managing acute gouty arthritisa nd anylosing spondylitis; also accelerates closure of patent ductus arteriosus in premature infants: Answer: (E) indomethacin Question # 17 (Multiple Choice) Approximate prevalence of rheumatoid arthrit is: Answer: (A) 1% Question # 18 (Multiple Choice) In rheumatoid arthritis: primary effect of t his mediator is on prostaglandin production: Answer: (C) TNF alpha

Question # 19 (Multiple Choice) Analgesic effects of aspirin: Answer: (C) both Question # 20 (True/False) rheumatoid arthritis: genetic predisposition Answer: True Question # 21 (Multiple Answer) Correct drug-drug interactions: (A) aspirin -- acetazolamide: enhanced salicylate intoxication (B) aspirin -- spironolactone: reduced spironolactone activity (D) aspirin -- phenytoin: increased free phenytoin serum levels Question # 22 (Multiple Choice) NSAID primarily promoted as an analgesic, no t as an anti-inflammatory agent: Answer: (D) etorolac Question # 23 (Multiple Choice) Drug associated with the hepatic/renal toxic metabolite: N-acetyl-p-benzoquinone Answer: (D) acetaminophen [/HIDE] . Reply With Quote Reply With Quote 07-02-2009 02:52 PM #2