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Acantholytic acanthoma (Epidermolytic acanthoma)

Deba P Sarma, MD Omaha

M 60, solitary keratotic papule, scrotum


Benign epidermal tumor with characteristic histologic picture of acantholytic hyperkeratosis: Compact hyperkeratosis, acanthosis, papillomatosis. Acantholysis with periperinuclear vacuolization involving all layers of the epidermis except the basal layer

Hypergranulosis with large basophilic keratohyanine granules and intracytoplasmic amorphous eosinophilic bodies.