Metrohm Info 2003-2

Contents
797 VA Computrace – the all-round instrument

for voltammetry .............................................................3
Titropackage provides economical access to
automated titration .......................................................10
MATi – the customer-specific system solution
in titration.....................................................................13
The Titrando system has been successfully audited......14
Wine PAC – know-how package for the titrimetric/
potentiometric analysis of wine and must .....................15
New in our electrode range:
the 6.0150.100 separate pH glass electrode.................17
Alterations in the reagents sector..................................17
The customer application: fully automatic water
analyses at Ondeo Nalco Pte Ltd, Singapore .................19
New Metrohm Application Notes...................................21
New Metrohm publications...........................................23
Book corner .................................................................24
Literature references ....................................................26
The 2nd Conference on Ion Analysis in retrospect ..........28
Metrohm worldwide .....................................................29
Editorial
Metrohm Ltd. Dear Readers,

CH-9101 Herisau Special birthdays are there to give us time to reflect, to pause and think about
Switzerland things, to remember our experiences and, at the same time, to build up the neces-
Phone +41 71 353 85 85 sary momentum to meet new challenges.
Fax +41 71 353 89 01 Metrohm is 60 years old. In 1943 the founder of the company, Bertold Suhner –
E-Mail info@metrohm.com who at an age of more than 70 obtained a doctorate with a scientific thesis – started
Internet www.metrohm.com with the following basic principles:
– Stay totally independent of the banks.
– Keep a hold on the market and do not become a subcontractor to other compa-
nies.
– Use the most modern technology as a means to an end.
– Leave the profits in the company to finance its expansion.
– Employ no more than 50 people.
Well, apart from the number of employees all these principles still apply today, 60
years later. They have secured Metrohm an important position on the world mar-
ket. Metrohm has established itself in the hard-fought analytical instruments sector
and has continually extended its position. We are the market leader in the fields of
titration and voltammetry, in the ion chromatography sector we are a very strong
number two with a high growth rate.
Today Metrohm is active in more than 120 countries throughout the world, with
subsidiaries or joint ventures in the 43 most important of them. We are involved
in the major world markets, either directly or indirectly, in order to provide our cus-
tomers with the greatest benefits.
We have only infringed one of the basic principles: the size of the company. The
success of our products and the demand for new instruments have resulted in the
number of staff at our headquarters increasing to about 350. In the distribution
companies mentioned above, in which Metrohm has a majority or strong minority
participation, a total of more than 700 persons are employed. They are all active in
the interests of the customer.
We have particularly respected one of the basic principles: We are independent,
have no indebtedness to banks, are not listed on the stock exchange and cannot be
«bought». Our resources are primarily concentrated on the continuous expansion
of our product range, the further optimization of our analytical instruments and their
production as well as on increasing our market penetration in order to provide our
customers with the best possible support.
This brings us to the future. We will stick to our basic principles, with the exception
that our growth will continue, particularly on the market. Being large itself means
nothing to us, it is only helpful in enabling us to supply a growing number of cus-
tomers with products and services in an optimal way. This is why we wish to re-
main mobile in our headquarters, set up no bureaucracy and continue to employ
Imprint about 30% of our staff in developing new and powerful analytical instruments that
Metrohm Information is a customer will either strengthen our position as market leader or, where we are not yet the mar-
magazine from Metrohm Ltd. and is ket leader, enable us to reach this goal.
published three times a year in English
and German.
Best regards,
Please contact us if you wish to receive
your own copy regularly. Metrohm Ltd.
Published by: Metrohm Ltd.,

CH-9101 Herisau,
Switzerland
Editor: Claudia Dengler Adrian Déteindre
cd@metrohm.com President & CEO
Printed by: Metrohm Ltd. Delegate of the Board of Directors
ISSN 1424-0904
2 Metrohm Information Issue 2/2003

797 VA Computrace
797 VA Computrace – the all-round instrument for voltammetry
The new 797 VA Computrace.
With the 797 VA Computrace Metrohm presents a completely new voltammetry

instrument that opens up a novel field of application in addition to the classical
voltammetric and polarographic analysis methods used for the determination of
metal traces. The newly implemented Cyclic Voltammetric Stripping technique
(CVS) allows the determination of organic additives in electroplating baths by
means of cyclic voltammetry. In addition, 797 VA Computrace is also eminently
suitable for use in research and teaching, particularly for practice-oriented training
in electrochemistry and for analyses in applied research.
One instrument – three application fields
Stripping voltammetry CVS Exploratory

Voltammetric trace analysis plus specia- Determination of organic additives in elec- The Metrohm concept for electrochemistry
tion of metal ions and other substances troplating baths with Cyclic Voltammetric training
Stripping
Metrohm Information Issue 2/2003 3

797 VA Computrace
The instrument
797 VA Computrace is a modern voltammetric measuring stand that is connected
to the PC via a USB port. The newly designed built-in potentiostat with galvanostat
guarantees the highest degree of sensitivity with reduced noise. As working elec-
trodes the unique Multi-Mode Electrode MME and rotating disk electrodes (RDE)
made of various materials are available.
Measuring cell with Multi-Mode Electrode MME for the determination of metal Measuring cell with rotating platinum disk electrode for the analysis of electro-
traces. plating baths.
The software
The 797 PC software controls the measurement, records the measuring data and
evaluates them. The data can be archived using the Autodatabase software sup-
plied with the instrument. Standard formats are available for printing out the results
but you can also use the report generator to create individually designed analysis
reports. The clear structure of the 797 PC software grants unparalleled ease of
operation.
Validation made easy – with the GLP Wizard

The software automatically checks the validation intervals of the analysis system
and keeps the user informed. Each report shows whether the measurements were
carried out within the validation interval. The GLP Wizard guides the user step by
step through the different tests and automatically checks their validity.
Easy validation with the GLP Wizard.

797 VA Computrace
Application field 1 – Voltammetric trace analysis
VA Computrace system with automatic standard addition for routine analysis.
Analysis of heavy metals: total concentration ... Detection limits

For a fraction of the purchase price of an AAS or ICP instrument it is possible to
Antimony Sb(III)/Sb(V) 200 ppt
carry out metal analyses with the same or even higher sensitivity. The only thing
required apart from small quantities of reagents is a small amount of pure nitrogen. Arsenic As(III)/As(V) 100 ppt
No expensive flammable gases, no specially constructed fume hoods in the labora- Bismuth Bi 500 ppt
tory, no costly metal vapor lamps. Cadmium Cd 50 ppt
... and speciation Chromium Cr(III)/Cr(VI) 25 ppt
Spectroscopic methods can only determine the total concentration of the metals. Cobalt Co 50 ppt
With voltammetry it is additionally possible to differentiate between various oxida- Copper Cu 50 ppt
tion states of metal ions or between free and bound metal ions. This allows state- Iron Fe(II)/Fe(III) 50 ppt
ments to be made about the biological availability and toxicity of heavy metals and
makes voltammetry an essential method in environmental analysis. Lead Pb 50 ppt
Mercury Hg 100 ppt
High ion concentrations? No problem with VA!
Molybdenum Mo(IV)/Mo(VI) 50 ppt
Samples with high ion concentrations are no problem for voltammetry. This means Nickel Ni 50 ppt
that voltammetry is predestined for the analysis of:
Platinum Pt 0.1 ppt
• Water, waste water and sea water
• Salts and pure chemicals Rhodium Rh 0.1 ppt
• Electroplating baths Selenium Se(IV)/Se(VI) 300 ppt
• Foodstuffs Thallium Tl 50 ppt
Tungsten W 200 ppt
Uranium U 25 ppt
Zinc Zn 50 ppt
1 ppt = 1 ng/kg

797 VA Computrace
Specific analysis of organic compounds

Not only heavy metals, but many different organic compounds can also be deter-
mined by voltammetry.
Examples of important applications:
• 4-Carboxybenzaldehyde in terephthalic acid
• Free styrene in polystyrene
• Vitamins in juices and vitamin preparations
Determination of anions
Some special anions can also be determined voltammetrically. Of particular interest
is the analysis of the environmentally relevant species cyanide and sulfide or nitrite
and nitrate.
Application field 2 – CVS for the Cyclic Voltammetric Stripping Analysis (CVS) and Cyclic Pulse Voltammetric Strip-
determination of organic addi- ping Analysis (CPVS) are widespread methods in the electroplating industry for
the determination of organic additives in electroplating baths. For many technical
tives in electroplating baths coatings, particularly in the manufacture of printed circuit boards, these analyses
constitute an essential part of production control. The quantitative determination of
the additive is carried out indirectly via its influence on the deposition of the main
component of the electroplating bath. As the measurement is based on an electrode
reaction that corresponds to the production process, the activity of the additive and
thus its effectiveness in the galvanization process can be measured directly.
The most important applications for the CVS technique are:
• Acidic copper baths
• Tin-lead baths
Quantification of the various types of additives requires special calibration tech-
niques that have been newly integrated into the software of 797 VA Computrace.
The so-called brighteners are determined using the Linear Approximation Technique
(LAT) or Modified Linear Approximation Technique (MLAT). The determination of
the suppressors is carried out by Dilution Titration (DT).
Determination of suppressors in a copper plating bath

using Dilution Titration (DT).
For these analyses a simply constructed, robust and favorably-priced rotating disk
electrode made of platinum is used. The electrochemical conditioning of the elec-
trode, which is necessary before each measurement, is part of the determination
method. It is repeated automatically until the measured value remains constant.

797 VA Computrace
With CVS or CPVS the concentration of the additives can be determined exactly. The
effective concentration of the particular additive in the bath sample is shown and
printed out directly in mL additive per L bath liquid. This means that topping up to
the preset bath concentration can be carried out very accurately, which guarantees
continuous and interference-free operation of the unit. It is mainly the accuracy of
the analytical results that has helped the method to become generally accepted in
the electroplating industry. Other methods, e.g. the classical Hull-cell method, do
not allow the concentration to be determined, but only provide an assessment of
the quality of the deposited metal layer.
To carry out the determination one of the preinstalled methods is loaded. Once a
few parameters have been adapted the analysis can be started. Ready-to-use meth-
ods are supplied for the most important types of baths from the leading manufac-
turers; these have been worked out in our Application Laboratory. Additional appli-
cations with the corresponding methods are available in the Metrohm Application
Bulletins and Application Notes, which can be accessed on our Website.
Application field 3 – 797 VA Com-

putrace as a training tool
Detail of the 797 VA Computrace.
Exploratory is the program part of the 797 VA Computrace specially designed for
training purposes. It is characterized by its crystal-clear layout and intuitive oper-
ation. This means that the instrument is ideal for practice-oriented voltammetry
training in universities, technical colleges, vocational schools and production plant
laboratories.

797 VA Computrace
The following current measuring techniques are available:

Sampled DC Direct Current
DP Differential Pulse
SQW Square Wave (according to Osteryoung)
AC Alternating Current (1st and 2nd harmonic, phase-selective)
CV Cyclic Voltammetry
NP Normal Pulse
PSA Potentiometric Stripping Analysis (stripping chronopotentiometry
with chemical oxidation)
CCPSA Constant Current Potentiometric Stripping Analysis (stripping chro-
nopotentiometry with oxidation/reduction by constant current)
CVS Cyclic Voltammetric Stripping (cyclic voltammetry for the determi-
nation of additives in electroplating baths)
CPVS Cyclic Pulse Voltammetric Stripping (pulse chronoamperometry for
the determination of additives in electroplating baths)
Exploratory is curve-oriented. The voltammograms and their associated param-
eters are shown in two adjacent windows. At the end of the measurement the con-
ditions can be varied and the altered signal recorded. The different voltammograms
can be superimposed on one another for direct comparison.
These possibilities mean that Exploratory is highly useful in developing and opti-
mizing methods for the quantitative determination of substances. The optimized
voltammetric parameters can be transferred directly to the determination method
in the program part Determination. Transfer from Determination to Exploratory is
also possible.
Practical Voltammetry
Metrohm offers the monograph «Practical Voltammetry» for the use of 797 VA
Computrace in teaching and training. This Metrohm Monograph describes 13 easy-
to-perform experiments that can be used directly, as a whole or in parts, in ana-
lytical practice courses. After a detailed description of the task to be carried out,
followed by literature references, examples of curves and solutions are shown. In
this way the necessary basic knowledge is imparted in a clear and concise manner.
Even professionals working in an analytical laboratory will find that the monograph
contains useful information and tips for their daily work.
The Metrohm Monograph «Practical Voltammetry».

797 VA Computrace
797 VA Computrace – manual or automated

Even without additional accessories 797 VA Computrace represents a fully func-
tioning analysis system that satisfies the highest demands regarding accuracy and
sensitivity. An even higher degree of comfort can be achieved with the help of var-
ious accessories.
Automatic addition of standard and auxiliary solutions with 800 Dosinos

In voltammetry the concentrations are determined by means of standard addition
or calibration curve. These procedures can be automated if 800 Dosinos are used.
All other reagents such as supporting electrolyte or complexing agents can, of
course, also be added automatically. Connections are available for a maximum of
three 800 Dosinos.
Fully automatic analyses with sample changer

The Metrohm sample changers allow voltammetric determinations to be carried out
fully automatically and with high precision. The 813 Compact Autosampler is suit-
able for smaller sample series. Its rack accommodates a maximum of 18 samples,
which are transferred by the built-in peristaltic pump to the measuring cell of the
797 VA Computrace and then analyzed. For larger numbers of samples the 766 IC
Sample Processor is available. With this instrument up to 63 samples can be ana-
lyzed in a single run fully automatically.
Completely automated voltammetry system consisting of 797 VA Computrace with PC, 813 Compact Autosampler, two 800 Dosinos and two 772 Pump Units with 731
Relay Box.

Titropackage
Titropackage provides economical access to automated titration
Titrator + sample changer + database

2.785.0020 Titropackage consists of the 785 DMP Titrino, the 760 Sample Changer
and the VESUV 3.0 database software.
The comprehensive accessories supplied facilitate installation. Numerous tried and
tested titration methods, combined with extremely easy operation, allow immedi-
ate use of the system, which requires no demanding configuration, no prolonged
operator training and no tedious optimization of methods. The sample changer au-
tomates the analysis sequences and frees the user from time-consuming routine
operations. The VESUV PC software renders the archiving of results and methods
extremely simple.
Titropackage consisting of 785 DMP Titrino, 760 Sample Changer, VESUV 3.0 PC software and comprehensive accessories.
785 DMP Titrino

This compact routine titrator is universally applicable as it masters all basic meth-
ods that are relevant in titration practice.
No titration without titration curve!

The 785 DMP Titrino’s LCD screen displays the titration curve in real time or shows
the result in large characters. The dialog is easy to follow and available in seven
languages.
Flexibility is everything
A large number of fully worked-out titration methods is supplied with the package on
a memory card. The tedious development of new methods is not necessary. How-
Screen of the 785 DMP Titrino with titration curve and
ever, all titration parameters can be modified if this is required. Calculation formulae
measuring data corresponding to the point marked by can be entered with virtually no restrictions. After the titration, you can re-evaluate the
the cursor. equivalence points with optimized parameters and recalculate the results.

Titropackage
The 785 DMP Titrino is equipped with two high-impedance inputs for pH, redox or
ion-selective electrodes. Titrations in non-aqueous media profit from the built-in
differential amplifier while the polarized electrode input opens up the field of bi-am-
perometric (dead stop) and bi-voltametric indication, e.g. KF titration.
Compatible with GLP and ISO 9000

The 785 DMP Titrino can be programmed to alert the user in good time for service,
calibration and validation work that has to be carried out. To avoid any mishaps there
is the additional possibility of entering limits for the sample size and the result.
760 Sample Changer

The 760 Sample Changer allows the automatic analysis of sample series. The pack-
age includes the titration head with 802 Rod Stirrer as well as the sample rack for
16 x 150 mL beakers. Via the handy keypad you can set the stirrer speed and se-
lect the desired method. Routine operation is easily performed using the keypad’s
HOLD, STOP and START keys.
The most common titration procedures can be carried out using the four standard
programs that are permanently stored in the 760 Sample Changer.
After each titration the electrodes, the stirrer and the additional accessories on the
titration head are washed by dipping them into a rinsing beaker with stirring. At the
end of the sample series the electrode is stored in the rinsing beaker and thus kept
from drying up.
Simple and safe

Despite its straightforward construction, the 760 Sample Changer lacks nothing
in terms of safety. The sample rack is automatically identified by the 760 Sample
Changer, which rules out sample rack mix-ups. A beaker detector integrated into
the sample changer’s tower reacts to missing beakers and avoids any erroneous
dosing of reagents onto the rack. Furthermore, a splash protection on the tower
prevents the spattering of reagents in case of inexpert operation.
The 760 Sample Changer.

Titropackage
VESUV 3.0 – collecting, archiving and record keeping

Automated routine operation produces large amounts of data, which are most con-
veniently archived in a PC. For this purpose, Titropackage contains the VESUV 3.0
PC software, which allows the easy collecting of all titration data and results.
VESUV runs without supervision in the background while the operator works at
the instrument and enters the required parameters.
Flexible database
The analytical results and the raw data supplied by the 785 DMP Titrino are sent
directly to the PC and transferred to the VESUV database, whose organization and
appearance are freely definable. Apart from the actual results, the titration curves
are also shown (see Figure below). Analysis reports can be printed out whenever
required.
VESUV database including the titration curves as well as

the list of variables and calculation formulae associated
with the marked data record.
Evaluation of endpoints and recalculation

Endpoints found by the instrument can be deleted and new endpoints added man-
ually. It is also possible to alter sample parameters after the titration and to have
the result recalculated. All these changes are recorded in compliance with GLP as
a matter of course.
Comfortable export of data

The archived data can be exported to other software packages or long-term ar-
chiving programs in any common format.

MATi Systems
MATi – the customer-specific system solution in titration
After the successful introduction of the Metrohm Robotic Sample Processors we

are now able to present you with the so-called MATi Systems, which are based on
these novel sample changers. MATi stands for Metrohm Automated Titration and is
a synonym for flexible, customer-specific systems that are specifically tailored to
the requirements of the modern titration laboratory. These comprehensive systems
include all the instruments, electrodes and accessories that are required for the
rapid, accurate and economical solution of your titration tasks.
MATi-1 is a completely automated, PC-controlled titration system for water analysis
based on the new 835 Titrando (with PC Control) and the 815 Robotic USB Sample
Processor XL. The latter performs the sample handling operations required. It is
equipped with two 786 Swing Heads on which a titration head or the novel overflow
buret are mounted. Up to 59 water samples of 120 mL each can be analyzed in a
single run. At the first workstation the 712 Conductometer measures the conductiv-
ity and temperature, then the overflow buret transfers exactly 100 mL sample to the
external titration cell in a matter of seconds. Here the 835 Titrando measures first
the pH value of the water sample, then follows the titration of the p and m values
(carbonate hardness, alkalinity). In both cases the time-proven Aquatrode Plus is
used as the indicator electrode. The final step is the complexometric titration of the
calcium and magnesium hardness using the Ca ISE. When the determinations are
finished the Titrando software outputs a comprehensive analysis report. The spent
sample solution is aspirated off completely and the propeller stirrer, electrodes, bu-
ret tips and titration vessel are thoroughly rinsed.
MATi-31 System for fully automatic water analyses, as presented at ACHEMA 2003.
With the aid of the new 6.9958.007 overflow buret, 100
mL sample solution is measured out quickly and accu-
The corresponding analysis system for Titrino users is MATi-31. It is based on the rately and transferred to the titration cell.
799 GPT Titrino and the 789 Robotic Sample Processor XL and also allows the con-
ductivity, temperature, pH value, p and m values as well as the calcium and magne-
sium hardness to be determined fully automatically in 59 water samples. MATi-31
is designed as a stand-alone system, but can also be completely controlled from a
PC via the TiNet software.
With the classical water analysis, MATi-1 and MATi-31 cover one of the most im-
portant applications in titration laboratories. Additional MATi Systems will follow,
for example for the titration of the acid and base numbers in petrochemical prod-
ucts (TAN/TBN) or for the determination of the chemical oxygen demand in water
(COD).

Audited Titrando system
The Titrando system has been successfully audited
The Titrando is the first and, to date, the only titration system that has been certified
by a competent and independent body as fulfilling the requirements of FDA Regula-
tion 21 CFR Part 11 to the full extent.
Metrohm Ltd. commissioned Messrs. Chemgineering GmbH, Stuttgart (Germany),
to subject the new Titrando system to a detailed audit. Chemgineering is one of the
leading providers of services such as technology consultancy, validation of labora-
tory instruments and computers as well as software development in the pharma-
ceutical sector.
The aim of the audit was to check the new Titrando software PC Control 2.0 and
Touch Control for Part-11-compliance. Aspects such as validation, documenta-
tion, audit trail, access protection, data encryption and electronic signature were
investigated.
The result of the audit: The Titrando software fulfills all the requirements of 21
CFR Part 11, as is proved by the corresponding certificate and a detailed assess-
ment report. These documents can be downloaded from the Titrando homepage
www.titrando.com. If you purchase a Titrando you will, of course, receive them
automatically together with the other documentation.
In the titration sector Metrohm customers now have the choice between two
Part-11-compliant software packages: For Titrino systems the Metrodata TiNet
2.5 Compliant software is available; for controlling the new Titrando system you
choose PC Control 2.0.
With these milestones in Part-11-compliant ion analysis Metrohm has once again
demonstrated its pioneering role and extended its leading position in the titration
software sector even further.
This certificate issued by Chemgineering GmbH con-

firms that PC Control 2.0 has successfully completed
the audit and fully meets all the requirements of 21 CFR
Part 11.

Wine PAC
Wine PAC – know-how package for the titrimetric/potentiometric

analysis of wine and must
In our «PAC» documentation series the fourth work is now available. Wine PAC
stands for «Wine Potentiometric Analysis Collection» and contains the electromet-
ric determination methods most often used in wine analysis in an attractive and
practical form. The 25 methods described are based on the official standards of the
following countries or regions:
• Australia and New Zealand
• European Union
• Israel
• Republic of South Africa
• Switzerland
• South America (Chile)
• USA
By using these methods directly as SOPs (Standard Operating Procedures) in your
laboratory, you will save both time and money.
The analysis methods are divided into 15 main groups:
A – pH value
B – Total titratable acidity
C – Free sulfurous acid: orienting Ripper method and official reference method
(distillation method)
D – Total sulfurous acid: orienting Ripper method and official reference method
(distillation method)
E – Volatile acids
F – Fixed acidity
G – Ascorbic acid (vitamin C)
H – Reducing sugars
J – Carbon dioxide
K – Ash and ash alkalinity
L – Calcium and magnesium
M – Chloride (NaCl)
N – Total phosphorus
O – Sulfate
P – Direct potentiometric determinations: ammonium, potassium, sodium, fluo-
ride, alcohol content
The Wine PAC know-how package consisting of an ap-

plication binder with detailed method descriptions, a
method memory card, the Metrodoc CD ROM with the
Wine PAC analysis methods as well as the Metrodata
CD ROM.

Wine PAC
Wine PAC is available in English, French and German (order number 6.6043.003,
6.6043.002 or 6.6043.001). The know-how package consists of:
• An attractive application binder with the 25 methods for the titrimetric/
potentiometric analysis of wine and must. Each method comprises a theoreti-
cal part, information on accessories and reagents required, detailed analysis in-
structions, calculation formulae for the results as well as instrument parameters,
result reports and curve examples.
• A method memory card containing the complete parameter sets of all 25 anal-
ysis methods.
• The Metrodoc CD ROM with
– the electronic version of the Wine PAC ring binder (PDF = Portable Document
Format, Adobe),
– the relevant Metrohm Application Bulletins (PDF),
– Instructions for use of the Metrodata VESUV 3.0 software (PDF),
– VESUV file with the Wine PAC methods as well as
– Adobe Acrobat Reader for reading and printing the PDF files.
• The Metrodata CD ROM with demo versions of the Metrodata programs VESUV
3.0, TiNet 2.5, etc.
Electrometric analysis of wine made easy

The procedure could not be simpler. Depending on the type of Metrohm titrator, you
have three different possibilities:
• 798 MPT Titrino and 799 GPT Titrino (also applies to 751 GPD Titrino with instru-
ment program version 5.751.0020 or higher and 785 DMP Titrino)
Using the method memory card, you load the Wine PAC methods (complete
parameter sets including calculations) into your Titrino. You then equip the Ti-
trino with the corresponding accessories (electrodes, Exchange Unit), load the
desired method into the working memory, prepare the first sample and start the
determination by pressing a key. As soon as the analysis is concluded and the
sample weight entered, the Titrino outputs a complete result report – possibly
with titration curve – on the connected printer.
• 794 Basic Titrino (also applies to 716 DMS Titrino, 736 GP Titrino and 751 GPD
Titrino with instrument program version earlier than 5.751.0020)
Titration curve for the determination of reducing sugars Using a PC and the demo version of Metrodata VESUV 3.0 included in the
in white wine (method 14). package, you load the methods into your Titrino. You then continue using the
Electrode: 6.0431.100 Pt Titrode extremely simple procedure described above.
Titrant: c(Na2S2O3) = 0.1 mol/L • 808, 809, 835 and 836 Titrando
As a Titrando user you will, of course, also profit from the tried and tested Wine
PAC analysis methods. Using the conversion program (method converter)
contained in the PC Control software, you can easily transfer the Titrino param-
eters into your Titrando.
Titration curve for the determination of calcium and mag-

nesium in white wine (method 17).
Electrodes: 6.0504.100 calcium ISE
6.0726.107 Ag/AgCl reference electrode
Titrant: c(Na2EDTA) = 0.1 mol/L

Electrodes and reagents
New in our electrode range:

the 6.0150.100 separate pH glass electrode
With a shaft length of 142 mm the new 6.0150.100 separate pH glass electrode
for non-aqueous acid-base titrations has been specially optimized for use in all
Metrohm sample changer systems.
Technical specifications
Shaft length 142 mm
Shaft diameter 12 mm
Shaft material Glass
Minimum immersion depth 15 mm
Electrode head Metrohm plug-in head G
Membrane glass T glass
Membrane shape Spherical
pH measuring range 0 ... 14
Temperature range 0 ... 80 °C
The new 6.0150.100 separate pH glass electrode.
Alterations in the reagents sector
Electrolyte solution LiClO4 in glacial acetic acid will be dis-

continued
We have decided to discontinue supplying the non-aqueous electrolyte c(LiClO4) =
1 mol/L in glacial acetic acid (6.2309.000) and to replace it by tetraethylammonium
bromide c(TEABr) = 0.4 mol/L in ethylene glycol (6.2320.000). The reasons are:
• LiClO4 is either no longer taken into account in international standards and regu-
lations (DIN, ISO, etc.) or will shortly be removed from them.
• The use of LiClO4 in glacial acetic acid is already prohibited in many countries.
• LiClO4 in glacial acetic acid is a health hazard and is subject to transport regula-
tions.
• LiClO4 in glacial acetic acid must not be filled into the Solvotrode as this would
destroy the electrode.
• c(LiClO4) = 1 mol/L in glacial acetic acid can be replaced by (TEABr) = 0.4 mol/L
in ethylene glycol without any limitations.
New electrolyte for non-aqueous titrations: c(LiCl) = 2 mol/L

in ethanol
In many Metrohm applications we already recommend the dilution of the electro-
lyte LiClsat in ethanol (6.2312.000); as of now the electrolyte solution c(LiCl) = 2
mol/L in ethanol (6.2312.010) is also available directly. The new electrolyte has a
higher electrical conductivity than LiClsat in ethanol, which improves the stability of
the measuring signal. In addition, the Solvotrode is much easier to fill with the less
viscous c(LiCl) = 2 mol/L in ethanol.

Electrodes and reagents
Extremely practical: colored buffer solutions together with

new packaging and labels
In response to numerous customer requests, the ready-to-use buffer solutions pH
= 4.00 (6.2307.100) and pH = 7.00 (6.2307.110) will be colored red and green
respectively; the buffer solution pH = 9.00 (6.2307.120) remains colorless. This
means that buffer mix-ups are now practically impossible.
Moreover, in future all Metrohm buffers, electrolyte solutions and ion standards
will be supplied in boxes in order to prevent transport damage and facilitate bottle
storage. Together with this new packaging we have also redesigned the labels and
included additional GLP-relevant information:
• In order to ensure the safe handling of the electrolyte solutions and ion stand-
ards, the necessary hazard warnings (hazard symbol, toxic class, R and S
phrases) are printed on the packaging and bottles.
• Instead of the date of manufacture and guaranteed shelf life that were previously
given on the label, the expiry date is now printed on the packaging and bottle.
The date of manufacture will in future only be shown on the test certificate.
• The period of use after opening is given on the buffer solution bottles as addi-
tional information.
Important innovation
In future all ion standard solutions supplied by Metrohm will be traceable to
NIST standards. In this way we are providing you with support for observ-
ing the GLP and ISO 9000 regulations.
New: GLP-compliant labeling of all Metrohm reagents,

e.g. electrolyte solution c(LiCl) = 2 mol/L in ethanol.
Well packed: In future all Metrohm buffers, electrolyte solutions and ion standards will be supplied in
boxes.
The label on the buffer solution bottles now additionally

shows the period of use after opening.
New: colored buffer solutions pH = 4.00 (red) and pH = 7.00 (green).

The customer application

Ondeo Nalco Pacific Pte Ltd, Singapore:
Completely automated titration system for rapid, accurate and economical water analyses
Founded in 1928 in Chicago, Illinois, Ondeo Nalco today is one of the world’s
leading companies in the sectors of water treatment, waste water purification and
process optimization. Ondeo Nalco manufactures specialty chemicals and offers
innovative technologies and programs that help to improve the cost-efficiency of
industrial plants as well as to minimize the consumption of resources and envi-
ronmental pollution. Apart from the chemical and pharmaceutical industries, it is,
above all, the food industry, the energy sector and the paper and textile industry that
are Ondeo Nalco’s customers.
Ondeo Nalco’s Pacific Technical Center in Singapore has a laboratory for applied
research and an analytical laboratory. The latter provides services for customers
and field engineers throughout the whole Asian-Pacific region. It offers technical
support for questions and problems in the following application areas: waste water,
cooling water, boiler water, deionized water, ultrapure water and recycling.
Currently about 3000 water samples are analyzed per month in the analytical labo-
ratory, 90% of which are from Singapore. These analyses were previously carried
out manually and required a huge number of time-consuming individual determina-
tions. In order to cope with the ever-increasing number of samples, the Ondeo
Nalco Pacific management decided to search for an automated solution and there-
fore contacted Metrohm Singapore.
The automated titration system in detail

The water analysis system consists of a 736 GP Titrino, a 730 Sample Changer
with 759 Swing Head, a 712 Conductometer, several 700 Dosinos as well as the
Metrodata TiNet 2 software. 32 x 120 mL water samples can be analyzed in a single
run. A single sample aliquot is all that is required for determining four important
water parameters throughout a wide concentration range: conductivity, pH value,
carbonate hardness (alkalinity, p and m values) and chloride content. In order to
supply correct values, the conductivity measurement must take place before the
sample comes into contact with the pH glass electrode, as otherwise the electro-
lyte outflow from the pH electrode would falsify the measurement. For this reason
a special flow-through conductivity cell is used; this is placed upstream from the
titration cell. For the pH measurement and titration of the carbonate hardness a spe-
cially constructed double-junction pH glass electrode is used that guarantees short
response times and stable measuring values even in ion-deficient water samples.
At the end of the determinations the analytical results are automatically exported to
a LIMS by the TiNet software.
Water parameters determined
Parameter Measuring range

Conductivity 10 ... 4000 µS/cm
pH value 5 ... 11
Carbonate hardness
p value 10 ... 300 ppm
m value 10 ... 500 ppm
Chloride 10 ... 1000 ppm Our sincere thanks go to Mrs. Sharyn
Gaspari and her team at Ondeo Nalco
Pacific in Singapore for allowing us
to describe this interesting applica-
tion in Metrohm Information.

Convincing benefits
The automated titration system from
Metrohm has completely fulfilled the expecta-
tions of the laboratory manager, Mrs. Sharyn
Gaspari, and her team. The sample through-
put has been considerably increased, result-
ing in improved efficiency. During an 8-hour
shift more than 70 water samples can be
analyzed. The manual work required has
been reduced to a minimum. The person-
nel is freed from routine work, thus saving
time for other activities. Additional decisive
advantages are the increased reliability and
the improved precision of the results. The
extremely positive experience has led Ondeo
Nalco Pacific to purchase a second Metrohm
titration system in order to be able to keep on
top of the expected increase in the number
of samples. The completely automated water analysis system in Ondeo Nalco Pacific’s analytical laboratory.
Yan Jun is very satisfied with the two automated Metrohm

titration systems, which analyze 3000 water samples per
month rapidly, accurately and economically.
The lab team: from left to right Lum Sock Mun, Aileen
Tan, Yan Jun, Grace Eng, Noor Jahan and Ivy Ng.

Metrohm Application Notes
Metrohm Application Notes – your direct access to the know-how of

our Application Laboratories
Our Application Notes (ANs) present applications in a concise form. They give you rapid and direct access to the know-how of our
Application Laboratories and demonstrate the wide range of applications that are possible with the different analytical methods. The
ANs are written by our Product Managers and are published in English. Practice-oriented and to the point, they inform you about the
most important aspects of the particular determination method in the following sectors: ion chromatography, voltammetry, potentio-
metric and photometric titration, Karl Fischer titration, direct potentiometry (ion-selective electrodes) and stability measurements.
Since the last edition of Metrohm Information a further 20 new Application Notes have been published that deal with the ion chro-
matographic determination of anions, cations, organic acids and carbohydrates in a wide range of matrices. This means that for the
ion chromatography sector there are already more than 330 different ANs. The following table gives an overview of the new titles.
The complete Application Notes can be found in the Internet under
www.metrohm.com.
There the corresponding method files are also provided for downloading, which enables you to carry out the respective ion chro-
matographic determination on your own 761 Compact IC straight away.
Take advantage of this comprehensive application know-how!
Appl. Title
Note
S-168 Bromate in mineral water Anion chromatography with chem-
S-169 Determination of bromate using post-column reaction (o-dianisidine ical suppression – index S
method)
S-170 Oxohalides and bromide in drinking water
S-171 Citrate and polyphosphates in a food additive
S-172 Phosphite in a potato extract
S-173 Nitrite and nitrate in a plant extract
S-174 Iodide in table salt
S-175 Chromate in waste water using conductivity and subsequent UV/Vis de-
tection after post-column reaction (diphenylcarbazide method)
S-176 Four anions in betain
S-177 Five anions in inositol
N-47 Determination of bromate using post-column reaction (triiodide method) Anion chromatography without
N-48 Carbonate in washing powder chemical suppression – index N
C-61 Zinc and manganese besides the standard cations in an extract of a zinc Cation chromatography – index C
compound
C-62 Five cations including iron in monoethylene glycol
C-63 Five cations in lithium bromide using post-column reaction
C-64 Five cations in betain
C-65 Five cations in inositol
O-24 Citrate, ascorbate and acetate in a food additive Ion exclusion and ion pair chroma-
O-25 Sorbate and benzoate in a functional drink tography – index O
P-20 Five carbohydrates in a plant extract Ion chromatography with pulsed

amperometric detection – index P

New Metrohm publications
New Metrohm publications
New instrument brochures

With a new range of brochures Metrohm
once again proves that serious factual in-
formation does not have to be dry and bor-
ing, but can be presented in a very attractive
way. The new concept was launched with the
introduction of the Titrando system; to date
six different instrument brochures have ap-
peared in the new design. These brochures
inform the reader comprehensively about the
particular analytical instrument or analysis
system and impress with their modern and
attractive layout. Convince yourself!
Brochure Size Language Order number

835/836 Titrando 20 pages E 8.835.6003
Sp 8.835.6005
Fr 8.835.6002
G 8.835.6001
780 pH Meter 12 pages E 8.780.6003
781 pH/Ion Meter Sp 8.780.6005
Fr 8.780.6002
G 8.780.6001
778/789/814/815 24 pages E 8.010.6003
Metrohm Sample Processors G 8.010.6001
797 VA Computrace 20 pages E 8.797.6003
G 8.797.6001 The PDF files of these instrument brochures
are provided for downloading on our Website
Our Range of IC Instruments 56 pages E 8.009.6003
www.metrohm.com. You can, of course,
Fr 8.009.6002
also order the documents that interest you
G 8.009.6001
from your local Metrohm distributor.
Articles appear regularly in both national and international technical journals, in Topical Metrohm reprints
which Metrohm employees write about new instrument, electrode or software de-
velopments, special analysis methods or interesting applications. In order to make
this know-how also accessible to our customers, we commission reprints from
some of these publications. The topical reprints listed below can be obtained free of
charge from your local Metrohm distributor. You will also find them on the Internet
under www.metrohm.com.
Title Language
Automatic Karl Fischer Water Determination in Pharmaceuticals E
Automatische Karl-Fischer-Wasserbestimmung in Arzneistoffen G
Matrix Removal Using Inline Procedures in Ion Chromatography E
Antioxidants – Determination and Interpretation of the Temperature E
Correlation of Oxidative Stabilities
Antioxidantien – Bestimmung und Interpretation der Temperatur- G
korrelation von Oxidationsstabilitäten mit dem Rancimat

Book corner
Book corner
Anna Brajter-Toth, James Q. Chambers (Eds.)
Electroanalytical Methods for Biological Materials

Marcel Dekker, Inc., New York, Basel, 2002, 539 pages
ISBN 0-8247-0731-1
This reference details the most recent electroanalytical strategies for the analysis of
biomolecules and electrical phenomena in biological systems – presenting signifi-
cant developments in sequence-specific DNA detection for more efficient and cost-
effective medical diagnoses of genetic and infectious diseases and microbial and
viral pathogens. «Electroanalytical Methods for Biological Materials»
– identifies the latest advances in amperometric biosensing, capillary electropho-
resis, DNA amplification and detection, single-cell neurochemistry, in vivo elec-
trochemistry and electrochemical immunoassay,
– offers current techniques to evaluate the reaction properties of complex elec-
tron-transport enzymes,
– discusses the development of more selective and stable peroxidase-modified
electrodes,
– describes the use of fast-scan cyclic voltammetry (FSCV) to study the mecha-
nisms and kinetics of dopamine neurotransmission,
– illustrates the chemical and electrical requirements for facile communication be-
tween redox centers of enzymes and electrode transducers,
– analyzes separations of biological materials with electrochemical detection.
Written by seasoned experts in the field, this book is an authoritative guide for elec-
trochemists; surface, colloid, analytical, physical, theoretical, industrial and organic
chemists and biochemists; materials and chemical engineers; physicists as well as
upper-level undergraduate and graduate students in these disciplines.
Contents:
Part I: Electrochemistry of DNA
• Charge migration through the DNA double helix
• Electrochemical DNA biosensors
• Amplified and specific electronic transduction of DNA sensing processes in
monolayer and thin-film assemblies
Part II: Protein electrochemistry
• Direct electrochemistry of proteins and enzymes at electrodes
• Voltammetry investigations of iron-sulfur clusters in proteins
It is better • Polyion and surfactant films on electrodes for protein electrochemistry
to be • Electrochemistry of peroxidases
roughly right Part III: In vivo electrochemistry
than to be • Mechanisms and kinetics of neurotransmission measured in brain slices with

cyclic voltammetry
precisely wrong. • Electrochemical monitoring of exocytosis from individual PC12 cells in culture
Part IV: Bioelectroanalysis
• Milestones of electrochemical immunoassay at Cincinnati
John Maynard Keynes
• Electrochemical detection of peptides
• Microfabrication of electrode surfaces for biosensors
• Electrocatalytic determination of biochemical compounds

Book corner
Part V: Biological applications

• Electrodes based on the electrical «wiring» of enzymes
• Capillary electrophoresis/electrochemistry: instrument design and bioanalyti-
cal applications
• Ultrahigh sensitivity analysis of amino acids and peptides by capillary liquid
chromatography with electrochemical detection
Index
Christie G. Enke
The Art and Science of Chemical Analysis

John Wiley & Sons, Inc., New York, Chichester, Weinheim, Brisbane, Singapore,
Toronto, 2001, 500 pages
ISBN 0-471-37369-9
This innovative textbook teaches the reader how to apply the different techniques
of analytical chemistry and how to develop analytical methods in order to solve a
particular problem. The book shows that the differentiating characteristics of the
substances form the basis of all analytical techniques. This novel approach allows
the author to integrate the analytical goals of quantitation, identification, detection
and separation throughout the text.
Numerous study questions and problems with solutions following each section
help the reader to develop a solid understanding of the material covered.
Contents:
• Chemical analysis: what, who and why
• The elements of measurement
• Acidity, activity and pH
• Analysis by acid-base reactivity
• Analysis by absorption of light
• Analysis by photon emission
• Analysis by complexation reactivity
• Analysis by precipitation reactivity
• Analysis by electrode potential
• Analysis by oxidation-reduction reactivity
• Analysis by interphase partition
• Analysis by biochemical reactivity
• Background materials
• Appendices
• Index
NEW: www.metrohm.info
Metrohm Information now has a web address of its own. Under
www.metrohm.info
you will find all issues of our customer magazine published since 1998 in
electronic form. The individual articles are available in English and German
as PDF files. Using the respective tables of contents, just select, download
and print out the articles that are of interest to you.

Literature references
While we are pleased to be able to offer you this literature service, we are not in a position to provide you with photocopies of
the original references simply for copyright reasons. Normally, you can have copies made of any reference that interests you at
your nearest university library and usually at a favorable price. Thank you for your understanding in this matter.
Literature references • Application of an optimization procedure in adsorptive stripping voltammetry

polarography/voltammetry for the determination of chromium with ammonium pyrrolidine dithiocarba-
mate
Olga Domínguez, M. Asunción Alonso, M. Julia Arcos
A procedure for the determination of chromium by differential pulse adsorptive
stripping voltammetry (DPAdSV), using ammonium pyrrolidine dithiocarbamate
(APDC) as complexing agent, has been optimized. The new method allows the
selective determination of Cr(VI) in the presence of Cr(III) at pH values equal to
or below 3. The selection of the experimental conditions was made using ex-
perimental design methodology, and it was under these conditions where the
calibrations were made, using a robust regression method that allows the elimi-
nation of anomalous points. The detection limit obtained was 1.09 x 10–9 mol/L.
The procedure was successfully applied to the determination of Cr(VI) and total
chromium in different water samples.
Electroanalysis 14/15-16 (2002) 1083–1089
• Eighty years of polarography – history and future

Jirí Barek, Jirí Zima
Since 1922, when Professor Jaroslav Heyrovský carried out his pioneering ex-
periment with a dropping mercury electrode, polarography has shown remark-
able ability to adjust to the ever increasing demands regarding sensitivity and
selectivity and up to now mercury electrodes are among the best sensors for
electroanalytical measurements. The aim of this contribution is to both outline
the historical development of these techniques, their present state and possible
future developments as well as to show that even today in certain cases polaro-
graphic and voltammetric techniques at mercury electrodes can successfully
compete with modern separation and spectrometric methods.
Electroanalysis 15/5-6 (2003) 467–472
• Determination of As(III) and As(V) in natural waters by cathodic stripping

voltammetry at a hanging mercury drop electrode
The secret
M. Adelaide Ferreira, Aquiles A. Barros
of getting ahead A simple, fast and quantitative method was developed for the determination of
As(III) and total inorganic arsenic (As (total)) in natural spring and mineral wa-
is getting ters using square wave cathodic stripping voltammetry (SWCSV) at a hanging
mercury drop electrode (HMDE). In the determination of As(III), preconcentra-
started. tion was carried out on the electrode from a solution of 1 mol/L HCl in the pres-
ence of 45 ppm Cu(II) at a potential of –0.39 V versus Ag/AgCl, and the depos-
ited intermetallic compound was reduced at a potential of about –0.82 V versus
Sally Berger Ag/AgCl. In order to determine As(total), the pre-concentration was carried out
in 1 mol/L HCl in the presence of 400 ppm Cu(II) at a potential of –0.40 V versus
Ag/AgCl, and the deposited intermetallic compound was reduced at a potential
of about –0.76 V versus Ag/AgCl. For the determination of As(III), a quantifica-
tion limit of 0.2 ppb was obtained for a deposition time of 40 s, and the rela-
tive standard deviation (RSD) was calculated to be 6% (n = 13) for a solution

containing 8 ppb As(III). For As(total), the quantification limit was 2 ppb for a
deposition time of 3 min, and the RSD was calculated to be 3% (n = 10) for a
solution containing 8 ppb As(V). The method was validated by application of re-
covery and duplicate tests in the measurements of As(III) and As(total) in natural
spring and mineral waters. For As(total), the results of the SWCSV method were
compared with the results obtained by optical emission spectrometry with ICP
coupled to hydride generation (OES-ICP-HG), good correlation being observed.
Anal. Chim. Acta 459 (2002) 151–159
• Speciation analysis of selenium using voltammetric techniques

Maria Ochsenkühn-Petropoulou, Fotis Tsopelas
A simple and accurate method for the separation and determination of Se(IV),
selenocystine and dimethyldiselenide has been developed based on differen-
tial pulse cathodic stripping voltammetry (DPCSV) at a hanging mercury drop
electrode (HMDE) and an extraction procedure for the prior separation of the Se
species. Thus, selenocystine and Se(IV) were determined simultaneously in the
aqueous phase using HCl as electrolyte, while the determination of dimethyl-
diselenide was achieved in the organic phase after extraction of the sample with
dichloromethane using as electrolyte LiClO4 in absolute ethanol acidified with
HCl. No significant effect on the determination of selenocystine by the presence
of sulfur-cystine, even in a 300-fold greater concentration, was observed. For
the optimization of the procedure, several parameters of the voltammetric deter-
mination, such as the deposition time and voltage, the kind of electrolyte and the
acidity of the sample as well as the kind of extractant for the effective separation
of the Se species, were investigated in the aqueous and organic phase. More-
over, the quantitative transformation of the electrochemically inactive Se(VI) to
Se(IV) was achieved by testing different reducing agents. The capability of the
developed procedure was tested on the SRM 1633a (coal fly ash) reference ma-
terial and the whole procedure was applied on a soil sample of Thermopyles Spa
(Greece).
Anal. Chim. Acta 467 (2002) 167–178
• Applications of ion chromatography in cane sugar research and process Literature references
problems ion chromatography
Stephen N. Walford
Ion chromatography (IC) offers the sugar technologist a simple, reliable tech-
nique for the simultaneous separation and determination of inorganic and or-
ganic ions in complex process mixtures. Identification and measurement of ions
present in sugar liquors are important factors in understanding and maximizing
sugar recovery. Choice of IC column packing, eluent composition and pH value
as well as detection mode (suppressed and non-suppressed) are shown to be
useful variables when analyzing sugar factory products, especially the multiva-
lent ions such as phosphate and organic acids (aconitic and oxalic acid). The
IC methods show good agreement with conventional analysis methods (poten-
tiometric titration, atomic emission and absorption). IC also produced excellent
repeatability and recovery from these matrices. Examples of the application of
IC analysis in applied sugar research and processing problems include clarifica-
tion studies, degradation of molasses, sugar solution color removal and factory
process problems.
J. Chromatogr. A 956 (2002) 187–199

The CIA 2003 in retrospect
The 2nd Conference on Ion Analysis in retrospect
From 24 to 26 February 2003 the 2nd Conference on Ion Analysis, CIA 2003, took
place in the Architecture Building of the Technical University Berlin. The conference
was organized jointly by Prof. Dr. Andreas Zemann (Chairman, University of Inns-
bruck), Priv.-Doz. Dr. Wolfgang Frenzel (Technical University Berlin) and Prof. Dr.
Andreas Seubert (Philipps University Marburg).
This conference was the second in a planned series of ion analysis meetings to be
held every two years. This year’s conference location had the major advantage that
all the conference events – i.e. the talks as well as the poster presentations and
company exhibits – could be held under one roof; this contributed greatly to the in-
tensive contact and exchange of information between the participants.
The approximately 150 participants in the 2nd Conference on Ion Analysis presented
34 papers and 30 posters, the majority of which concerned ion chromatography,
but mass spectrometry, flow injection analysis and capillary electrophoresis were
also represented. Very interesting papers were also given on the subjects of food
and environmental analysis as well as on electroanalytical methods.
During the poster sessions the conference participants had sufficient opportuni-
ties for discussing the research results presented on the posters with their authors.
In contrast to the previous CIA 2001, the poster presentations were much better
visited as they were held in the immediate vicinity of the conference rooms. The
numerous booths of well-known instrument manufacturers also met with great in-
terest. Apart from Deutsche Metrohm, Filderstadt, which showed a comprehensive
cross-section of our products, the following companies were represented (among
others): Dionex (Idstein), Fluka (Buchs), J&M (Aalen) and Millipore (Schwalbach).
The Metrohm participants presented five papers and four posters at the CIA 2003.
Dr. Andrea Wille (IC Product Specialist) gave a paper on «High-low detection in ion
chromatography: simultaneous detection of the anions of strong and weak acids»,
René Odermatt (IC development) on a «Dual suppressor system in ion chromatog-
raphy» and Dr. Kai Henning Viehweger (IC Marketing Manager) on a «Dual detec-
tor system for the optimal determination of cations in ion chromatography». On
the subject of titration Dr. Shane O’Neill (Metroglas AG) presented a paper with the
title «An optimized pH electrode for p+m titrations» and Dr. Anja Zimmer (Titration
Product Specialist) reported on «Methods for the potentiometric analysis of phar-
maceutical ingredients, petrochemical products and surfactants». The Metrohm
posters were devoted to the topics «Online IC», «Sugar analysis of dairy products»
and «Inline calibration in ion chromatographic trace analysis» as well as, for the
titration sector, to the subject «Water analysis».
View of the exhibition booth of Deutsche Metrohm at the 2nd Conference on Ion Kathrin Herold and René Odermatt (both ion chromatography development) ready
Analysis. to answer questions about the Metrohm posters.

Metrohm worldwide
During the two-and-a-half days of the conference the social side was not neglected
either. A visit was made to the Wilhelm Foerster Observatory and a «Berlin Evening»
was organized in the university canteen.
It only remains to say that the next Conference on Ion Analysis will take place from
14 to 16 March 2005 and will again be held in Berlin. One of the aims will be to
switch the conference language from German to English.
The Web address of the CIA is:

www.cia-conference.com
Metrohm worldwide
Trade fairs and conferences with the latest Metrohm products
Date Trade fair Location Metrohm distributor

12.10.–17.10.2003 Electrochemical Society Fall Meeting (ECS) Orlando Brinkmann, USA
21.10.–23.10.2003 Gulf Coast Conference Galveston Brinkmann, USA
Metrohm-Peak, USA
21.10.–23.10.2003 Scientific Instruments Show (SIS) Osaka Metrohm-Sibata, Japan
17.11.–20.11.2003 Eastern Analytical Symposium (EAS) Somerset Brinkmann, USA
19.11.–21.11.2003 International Chemistry On-Line Process Instrumentation Clearwater Beach Metrohm-Peak, USA
Seminar
25.11.–28.11.2003 RICH and MAC Milan Metrohm Italiana
28.11.–30.11.2003 Chem 2003 Taipei Hammer Trading, Taiwan
02.12.–05.12.2003 ChemAsia – InstrumentAsia – AnaLabAsia (CIA) Singapore Metrohm Singapore
25.02.–28.02.2004 9th Taipei Instruments Show Taipei Hammer Trading, Taiwan
07.03.–12.03.2004 Pittcon Chicago Brinkmann, USA
Metrohm-Peak, USA
23.03.–26.03.2004 Forum Labo Paris Metrohm France
11.05.–14.05.2004 Analytica Munich Deutsche Metrohm, Germany

Metrohm worldwide
Impressions from ACHEMA 2003
From 19 to 24 May 2003 Frankfurt am Main was once again the scene for
ACHEMA, the largest trade fair in the world for chemical engineering, environ-
mental protection and biotechnology. This was already the 27th time that ACHE-
MA, which takes place every three years, had been held. Despite the difficult
worldwide political and economic situation, the fair was a complete success for
both exhibitors and visitors. More than 3800 companies and institutions from
48 countries presented their products, with foreign participation amounting to
41%. A total of 192’000 visitors was counted during the six exhibition days.
Although, when compared with ACHEMA 2000, this corresponds to a reduc-
tion of about 8%, the exhibitors were still very satisfied with the outcome of the
trade fair. The high degree of specialist knowledge of the visitors was particu-
larly noticeable. Metrohm was, of course, also present with an attractive booth,
on which numerous new instruments were displayed.
View of the Metrohm booth in Hall 6.3, which attracted

large numbers of visitors.
With the Metrohm Sample Processors a completely new

generation of sample changers for titration was present-
ed at ACHEMA 2003.

Metrohm worldwide
Animated discussions between international specialists: from left to right Wolf-

gang Gölz (Titration Product Specialist, sales force of Deutsche Metrohm), Dr.
Markus Läubli (Marketing Support for ion chromatography with Metrohm Ltd.),
Rogério Telles (Application Specialist with Pensalab, Brazil), Jan Volker Geil (Vice
President and Division Manager Sales & Marketing of Metrohm Ltd.), Claudio de
Almeida (Managing Director of Pensalab) and Dr. Ed Neas (President of Chata
Biosystems, USA).
Trade fair and seminar activities of our distributors
Kaohsiung International Instruments Show 2003

This important trade fair for instrumental analysis and process
engineering was held from 23 to 27 March 2003. Kaohsiung
– in the south of Taiwan – is, after Taipei, the second largest
city in the country and the center of the chemical industry. Ham-
mer Trading Company, our local distributor, took also part in
the Kaohsiung International Instruments Show as a matter of
course.
Group portrait with a lady: from left to right Nick Chung (Manager of the Ham-
mer Trading office in Kaohsiung), Joyce Tsai (Application Chemist), Gerhard
Schönstein (Managing Director of Metrohm Singapore und Area Sales Manager
Asia), Sam Wu (President of Hammer Trading) and Allen Yin (Sales Engineer of
the Kaohsiung office).
91st Korean Chemical Society Meeting in Seoul

The two-day Spring Meeting of the Korean Chemical Society
took place in mid-April 2003 in Seoul. The conference was ac-
companied by an instrument exhibition, at which our Korean IC
distributor JL Science was also present with a booth.

Metrohm Info 2003-2

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Contents

797 VA Computrace – the all-round instrument

Metrohm Ltd. Dear Readers,

Published by: Metrohm Ltd.,

2 Metrohm Information Issue 2/2003

797 VA Computrace – the all-round instrument for voltammetry

The new 797 VA Computrace.

With the 797 VA Computrace Metrohm presents a completely new voltammetry

One instrument – three application fields

Stripping voltammetry CVS Exploratory

Metrohm Information Issue 2/2003 3

Validation made easy – with the GLP Wizard

Easy validation with the GLP Wizard.

4 Metrohm Information Issue 2/2003

Application field 1 – Voltammetric trace analysis

VA Computrace system with automatic standard addition for routine analysis.

Analysis of heavy metals: total concentration ... Detection limits

Metrohm Information Issue 2/2003 5

Specific analysis of organic compounds

Determination of suppressors in a copper plating bath

6 Metrohm Information Issue 2/2003

Application field 3 – 797 VA Com-

Detail of the 797 VA Computrace.

Metrohm Information Issue 2/2003 7

The following current measuring techniques are available:

The Metrohm Monograph «Practical Voltammetry».

8 Metrohm Information Issue 2/2003

797 VA Computrace – manual or automated

Automatic addition of standard and auxiliary solutions with 800 Dosinos

Fully automatic analyses with sample changer

Metrohm Information Issue 2/2003 9

Titropackage provides economical access to automated titration

Titrator + sample changer + database

785 DMP Titrino

No titration without titration curve!

10 Metrohm Information Issue 2/2003

Compatible with GLP and ISO 9000

760 Sample Changer

Simple and safe

The 760 Sample Changer.

Metrohm Information Issue 2/2003 11

VESUV 3.0 – collecting, archiving and record keeping

VESUV database including the titration curves as well as

Evaluation of endpoints and recalculation

Comfortable export of data

12 Metrohm Information Issue 2/2003

MATi – the customer-specific system solution in titration

After the successful introduction of the Metrohm Robotic Sample Processors we

Metrohm Information Issue 2/2003 13

The Titrando system has been successfully audited

This certificate issued by Chemgineering GmbH con-

14 Metrohm Information Issue 2/2003

Wine PAC – know-how package for the titrimetric/potentiometric

The Wine PAC know-how package consisting of an ap-

Metrohm Information Issue 2/2003 15

Electrometric analysis of wine made easy

Titration curve for the determination of calcium and mag-

16 Metrohm Information Issue 2/2003

New in our electrode range:

Alterations in the reagents sector

Electrolyte solution LiClO4 in glacial acetic acid will be dis-

New electrolyte for non-aqueous titrations: c(LiCl) = 2 mol/L

Metrohm Information Issue 2/2003 17