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EMCOMPRESS
CaHPO * 2 H O
CaHPO
4 2
4
ANHYDROUS EMCOMPRESS
EMCOMPRESS
EMCOMPRESS
EMCOMPRESS
EMCOMPRESS
EMCOMPRESS
,
EMCOMPRESS
4
EMCOMPRESS
particles
(brittle fracture)
A swelling superdisintegrant requires some resistance in the tab-
let matrix to develop its full disintegrating force. ,
because it is insoluble and non-elastic, provides such resistance.
Soluble materials, such as lactose, do not offer such resistance
and, consequently, disintegrate much slower.
EMCOMPRESS
Fig. 2 : The swelling disintegrant (blue) deforms a plastic particle (brown) but
disintegrates a non-elastic particle (red). EMCOMPRESS
EMCOMPRESS
VIVAPUR
EMCOCEL
is often
blended with or
to create a
synergistic combination. The
combination of brittle fracture
and plastic deformation
properties results in flowabi-
lity and compaction, which is
greater than the individual
components.
How does Improve Tablet Matrices
in a Blend with Microcrystalline Cellulose ?
EMCOMPRESS
EMCOMPRESS
in with a
Swelling Superdisintegrant
Combination
Applications:
Fig. 1 : Tablet matrix after compression
with MCC and . EMCOMPRESS
Flowability
EMCOMPRESS
31
28
Fast Flow Lactose 31
other Lactose 32 - 35
Sugar 31
Ibuprofen 47
CaCO Powder 50
Corn Starch 56
3
as a Tablet binder: 20 - 70 %
as a Diluent: 10 - 80 %
as a Capsule filler: 10 - 50 %
Technical
Newsletter
MCC particles
(plastic)
Table 2
Table 3
Table 4
Table 5
Table 6
Page 2
disintegrant water-soluble
lactose
EMCOMPRESS
(Calcium
Hydrogen
Phosphate
Dihydrate)
swelling
Dissolve remove
Issue I/2006
Info-Hotline: + 49 (0) 79 67 / 1 52-312
Info-Hotline: + 49 (0) 79 67 / 1 52-312
Typical Formulations: EMCOMPRESS
Microcrystalline Cellulose (Binder) 65.0 %
CaHPO * 2 H 0 (Filler) 33.0 %
Sodium Starch Glycolate (Superdisintegrant) 1.5 %
Sodium Stearyl Fumarate (Lubricant) 0.5 %
4 2
By using (Sodium Stearyl Fumarate), instead of Magnesium
Stearate as a lubricant, the resulting matrix is more hydrophyllic. In
a matrix with , water can penetrate faster than into a
lipophyllic matrix. In combination with , a water-
insoluble, non-elastic material, the disintegration time improves
significantly.
This is a
. improves the flow
and (Microcrystalline Cellulose) provides the hardness.
PRUV
PRUV
EMCOMPRESS
EMCOMPRESS
VIVAPUR
4 2
An example of substance in combination with
Microcrystalline Cellulose and : EMCOMPRESS
4 2
Diameter
Weight
Hardness
Friability
0 80
100
80
60
40
20
0
10 20 30 40 50 60 70
Diclofenac
Tablet
d
i
s
s
o
l
v
e
d
(
%
)
time (min)
Technical
Newsletter
Table 7
Table 8
Fig. 3
Table 9
Page 3
Issue I/2006
Literature about EMCOMPRESS :
Fig. 7:
Fig. 6: Compaction force vs. tensile strength.
Formulation: (99 % Calciumhydrogenphosphate + 1 % Magnesium
Stearate).
As can be seen, is slightly more compressible
than
ANHYDROUS EMCOMPRESS
EMCOMPRESS
A
C
B
A
C
B
Tensile Strength as a Function of Compaction force
Particle Size
Binding Properties
0 20.0
2.5
2.0
1.5
1.0
0.5
0
2.5 5.0 7.5 10 12.5 15 17.5
ANHYDROUS EMCOMPRESS
EMCOMPRESS
T
e
n
s
i
l
e
S
t
r
e
n
g
t
h
(
M
P
A
)
Compaction Force (kN)
EMCOMPRESS ANHYDROUS EMCOMPRESS
ANHYDROUS
EMCOMPRESS
is denser, while
possesses a higher specific surface area. As a result,
produces harder compacts at equivalent forces.
Crystal Structure and Application
ANHYDROUS EMCOMPRESS
ANHYDROUS EMCOMPRESS