Endobiogenic Approach (CN)

The Endobiogenic Approach to Health Maintenance and Restoration
as developed by Drs C. Duraffourd and J.-C. Lapraz
The current pathological paradigm: the etiology of the specific:
Germ Enzyme Gene

The organism in its entirety is excluded
Colin Nicholls BA MCPP MNIMH
The evolution of knowledge in medicine

Problem: transition from the pathology of isolated tissues to the physiology of the integrated mechanisms of life: Globality Dynamics Interrelationship
Duraffourd and Laprazs mission is to restore to mainstream medicine an integrative, global approach and to demonstrate that such an approach is:
Consistent with, and supported by, modern

science
More effective than a reductionist approach

(while not excluding modern medicine)
Preventative as well as curative Superior in terms of toxicity
Copyright C Nicholls/SFEM
Fundamental concept
Inherent in the organism there exists an assembly of perpetually dynamic mechanisms intended to maintain the best possible state of equilibrium of terrain for the terrain in question. In sickness or in health, the human being reacts as a systemic unity.
Definition of the terrain

The functional expression of the living whole that constitutes a human being, based on his or her genetic inheritance and its fusion into a certain initial physical state that provides that beings touchstone of physiological equilibrium.
The terrain
regulates and maintains the functioning of
the organism on a second-by-second basis
The endocrine system as manager
guarantees the integrity and reactivity of

the organism in the face of aggression is omnipresent, at every level operates via the endocrine and autonomic nervous systems
Copyright C Nicholls/SFEM Copyright C Nicholls/SFEM
General Adaptation Syndrome

Stimulation of the corticotropic axis in its
adaptative function increase in circulating cortisol Ceases together with the aggression If prolonged, yields adaptability, leading to a change of state, involving A modification of the level of equilibrium (generally downwards this is the price for maintaining balance at a lesser energetic cost)
Therapeutic modality
The multiplicity, ubiquity, and polymorphous nature of the agents that disrupt normal physiological processes is perfectly matched by the plurality and polymorphous nature of the pharmacological activities of medicinal plants. This explains why we chose, very early on, whole plant extractsor extracts that are as near as possible to this idealin our attempt to grapple with the complex task of maintaining or restoring homoeostasis.
Christian Duraffourd
The endobiogenic approach

has implications in terms of:
Parasympathetic system: key features

Anabolic Increases movement and secretions of
digestive tract Increases secretions overall (and sweat) Reduces heart rate More active during childhood, at night, and during and after meals Favours congestion
assessment of the individual patient:

case history taking physical exam knowledge of the endobiogenic mechanisms likely to be active in a particular pathology at a particular time of day/year/life
Vagotonic symptoms and signs

ENT and respiratory problems Mucus congestion Hands and feet warm and moist Slow heart rate Drowsiness/sweating after meals Flat chest and bloated abdomen Enlarged parotids
Parasympatholytic plants
Atropa belladonna Thymus vulgaris Artemisia dracunculus Cypressus sempervirens Hyssopus officinalis Gentiana lutea
Alphasympathetic system: key features

Is response to aggression (inc. cold) Reduces digestive activity Contracts sphincters Causes vasoconstriction of skin, kidneys,
spleen, liver, splanchnic system Dilates pupils Inhibits release of insulin
Alphasympathotonic symptoms and signs

Cold extremities (esp. feet + knees) Hypertension Mydriasis Constipation Haemorrhoids/uterine spasms/varicose
veins
Irritability, anxiety, insomnia

Alphasympatholytic plants
Lavandula officinalis Crataegus oxyacantha Angelica archangelica Origanum majorana Tilia europaea Valeriana officinalis Ballota nigra
Betasympathetic system: key features

Is stimulated by heat Increases motoricity Increases all myocardial activity Vasodilates principal arteries Relaxes intestines, uterus, bladder Dilates bronchi Increases glycaemia and lipolysis
Symptoms and signs of sympathetic insufficiency

Hypotension Small, weak pulse/bradycardia/syncope Susceptibility to allergies Thinness, lack of muscle bulk Recessed sternum Fatigability, lack of concentration Susceptibility to infections, various stresses
Betasympathomimetic plants
Ribes nigrum Menyanthes trifoliata Cinnamomum zeylanicum Satureja montana Salvia officinalis Hyssopus officinalis
Sequencing of the ANS

ParaS
congests
Case study 1
Female, 4, presenting on 23/3/05 with nightly enuresis + accidents during day (mostly trickling). Mother says she leaves it too late because constantly on go too busy. Also doesnt really listen and has lack of concentration, though is very bright and does well academically.
AlphaS
blocks
BetaS
intensifies and releases
Case study 1
(cont)
Case study 1
(cont)
PMH Birth weight 7lb 6oz Born by caesarean (breech) Breastfed only 3 weeks Chest infection at 2 (antibiotics)
Clinical features Is warm and sweaty at night Difficult to get her to sleep takes her up to 2 hours to switch off Sleeps v. heavily doesnt wake up if wets bed
Case study 1
(cont)
Case study 1
Family history
(cont)
Clinical features (cont)
Digestion good, but sometimes complains

of abdominal pain (mother thinks related to stress) V. sensitive, gets easily upset (e.g. moving house) Dark hair on legs and in small of back
Paternal grandmother has to take antinausea tablets every day gets sick at the slightest stress
Case study 1
Prescription 1:
(cont)
Case study 1
2g 10 ml
(cont)
1. EO Lavandula off. 2.
qsp Labrafil 3 gtt in water tds Hypericum perforatum 1:1 Serenoa repens 1:1 aa qsp 100 ml 25 gtt in water tds
Outcome (24/6/05) Some improvement in bladder by day, but no better at night Hyperactive behaviour continues, and still hypersensitive to slights
ANS influence on the bladder
Case study 1
(cont)
Filling the bladder: sympathetic system active
Emptying the bladder: parasympathetic system active
Analysis Very strong parasympathetic response to chronically raised alpha: therefore alpha insufficient at night to control para. Strategy decrease para over course of day reduce alpha at bedtime
Case study 1
(cont)
Case study 1
3.
(cont)
Prescription 2 (15/8/05):
Prescription 2 (cont)
Hypericum perforatum 1:1 Serenoa repens 1:1 Bacopa monniera 1:2 aa qsp 200 ml 60 gtt in water tds
1. EO Thymus vulgaris 2.
2g qsp Labrafil 20 ml 10 gtt in water morning and lunchtime EO Lavandula off. EO Origanum majorana aa 1 g qsp Labrafil 20 ml 20 gtt in water at night
Case study 1
Outcome
(cont)
The endobiogenic approach

has implications in terms of:
10/9/05: 5 dry nights in a row 31/10/05:

Only 2 wet nights a week Improvement in overall behaviour Sleep latency improved 6/2/06: Only 1 wet night per week 20/3/06: Only 2 wet nights per month, with progressive improvement
assessment of the individual patient:

case history taking physical exam knowledge of the endobiogenic mechanisms likely to be active in a particular pathology at a particular time of day/year/life
Seasonal fluctuation in corticoadrenal and thyroid hormones
Hormonal phases in childhood

4 yrs stimulation F: 7 yrs of thyroid 12/18 mo M: 9 yrs
Birth
21 dys
30 dys
F: 9 yrs M: 11 yrs
C/A G
T C/A G
Thyroid phase
Corticoadrenal
Puberty: Genital
Acceleration of structural installation: increase in real needs of organism Thyroid TSH

Adaptation phase: change in level of equilibrium
Example of endobiogenic imbalance: acne
Main modifications of the terrain leading to acne

Emunctory
Functional insufficiency of liver

increase in cutaneous elimination, which aggravates local sebaceous imbalance facilitates risk of infection Liver also plays an important role in maintaining equilibrium of circulating ovarian, glucocorticoid, androgenic and thyroid hormones (key factors in cutaneous imbalance)

Gonadal axis
There is an apparent, relative hyperandrogeny, which is the result of a hypogenital state

Gonadal axis
Note: Androgens are the main stimulus of the
sebaceous glands
In males, a lack of testosterone is compensated

by a rise in adrenal androgens In females, inadequate secretion of progesterone leads to a hyperstimulation of LH with a rise in ovarian androgens
increasing the number of mitoses increasing the size of sebaceous cells increasing the intracellular synthesis of sebum

Gonadal axis
Note: Progesterone has an anti-androgenic action:

Corticoadrenal axis
A key factor is
Competes with testosterone for 5--reductase Inhibits 3--androstenediol Inhibits LH, which
increases fixation of testosterone and DHT to cytosolic receptors increases secretion of androgens by ovarian theca cells stimulates proliferation in its own right
An increase in adrenal androgens, exacerbated

by
An insufficiency in glucocorticoids, which

are anti-inflammatory, and inhibit tissular growth factors, and whose lack stimulates ACTH

Thyroid axis
Plays a role in cystic growth and proliferation TSH Stimulates cellular multiplication Is seen as a key factor in acne by Duraffourd & Lapraz

Thyroid axis
T4
Increases SHBG reduction in free androgens,

BUT
Stimulates secretion of LH, and Increases the hepatic inactivation of cortisol

Somatotropic axis
Hyperfunction of GH and prolactin: Are growth factors in synergy with androgens Encourage growth and proliferation of the sebaceous cyst

Somatotropic axis
There is a reactional hyperinsulinism, linked to:
The need for an increased supply of energy to the skin,

due to cutaneous hypertrophy, +
Disturbances in blood sugar regulation, tied to all the

other endocrine and ANS imbalances: subjects are often
fundamentally vagotonic with an exaggerated reaction of the sympathetic system to the vagotonia, to the lack of
glucocorticoids, and to various stresses to which they are often hypersensitive

This group of mechanisms explains why acne almost always starts at puberty, since, in the run-up to puberty, hyperfunction of the thyroid is followed by that of the adrenals, and then by that of the pituitary
Clinical data
Example: symptoms & signs of raised GH
Hallux valgus, hammer toes Enlargement of foot Thick, rough skin, esp. sole of foot Warts, keloid scars Fungal nail infections Rapid growth Psoriasis (hyper GH)
Plants to modulate endobiogenic imbalances

Antigonadotropic: Lithospermum arvense,
Borrago officinalis Anti-prolactin: Anthriscus cerefolium, Poterium sanguisorba Anti-GH: Poterium sanguisorba, Fragaria vesca
(rad.)
Plants to modulate endobiogenic imbalances

Glucocorticoid stimulant: Ribes nigrum (glycerine
macerate of buds)
Thyroid inhibiting: Brassica oleracea, Fabiana

imbricata
Thyroid stimulant: Avena sativa
Luteotropic: Alchemilla vulgaris, Smilax aspera,

Achillea millefolium
Case study 2
Male, 55, presenting on 29/5/02 with chronic prostatitis. This had begun in January 1973, with infectious episodes accompanied by fever and sometimes inflammation (balanitis), as well as the characteristic symptoms of urgency and burning urination.
Case study 2
(cont)
These episodes at first occurred more or less yearly, but over the years the infections became more and more frequent and recalcitrant, with resistance developing to several of the antibiotics used. At various times different bacteria were identified in the urine: E. coli, Klebsiella pneumoniae
Case study 2
(cont)
Case study 2
(cont)
At the time of presentation the patient had been on antibiotics virtually uninterruptedly for 6 months.
Clinical features General exhaustion Marked pelvic congestion Marked splanchnic congestion, reflecting participation of pancreas, together with Extreme liver sensitivity
Case study 2
(cont)
Case study 2
(cont)
Prescription 1 (29/5/02)
Agrimonia eupatoria MT Carduus marianus MT Hamamelis virginiana MT aa qsp 125 ml 100 gtt bid Evacrine (contains dry extract of Zingiber, Viola tricolor, and acerola) 2 tabs bid
Cessation of all antibiotics Morning and evening, at beginning of meals:

EO Rosmarinus off. EO Eucalyptus globulus EO Juniperus communis aa 1.5 g qsp Sequoia gigantea 1D 125 ml 50 gtt bid
Case study 2
(cont)
Case study 2
(cont)
Vitadil (contains dry extract of Juglans regia and Plantago major, with zinc gluconate and vitamin C) 2 tabs bid Anhydrous magnesium chloride 200 mg 1 caps bid Infusion of Hamamelis leaves 1 cup bid
The patient was also advised to adopt a low-glycaemic-index diet.
Case study 2
(cont)
Case study 2
(cont)
Emergency treatment
(3 times a day for 2 days, then twice a day for 5 days, then once a day for 10 days) An enema containing: EO Thymus vulgaris, Melaleuca cajuputii, Satureja montana, Lavandula off. aa 4 g Oligoelements of Au, Ag, Cu aa 2 vials qsp sweet almond oil 150 ml
Outcome (end of August 2002)

First acute infection since beginning of endobiogenic treatment. After use of the emergency prescription, the attack subsided after a few days, with no further complications.
10
Case study 2
Outcome (3/2/03)
(cont)
The Biology of Functions

was developed by Dr C. Duraffourd as a means of objectively quantifying the functionality of the living organism, in order to guarantee its overall equilibrium and homeostasis. It is expressed as a set of indexes (over 200), calculated by a computer program from the results of a series of blood tests.
No further infections of urinary tract No recurrence of prostatitis Considerable improvement in general health
As of March 2006, this improvement has been maintained, and the patient no longer suffers from prostatitis.
The Biology of Functions: blood tests

Full blood count Erythrocyte sedimentation rate Platelets CPK (or CK) LDH TSH Osteocalcin Total alkaline phosphatase + Alkaline phosphatase iso-enzymes (liver, bone and intestinal fractions [%] must be supplied even if total AP is normal) Ca K Important: All these tests must be taken in a single draw
Case study 2: Biology of Functions
INDEX Inflammation Comparative inflammation
19/6/02 125.60 117.23
30/9/02 3.67 3.00
27/1/03 3.99 3.31
Min 0.30 0.20
Max 2.50 2.50
INDEX Potential histamine
19/6/02 416.44
30/9/02 47.00
27/1/03 35.64
Min 6.00
Max 12.00
INDEX Oxidation-reduction Oxidation Reduction
19/6/02 506815.39 25078.04 0.05
30/9/02 7.13 86.07 12.08
27/1/03 4.25 118.98 28.00
Min 0.70 1.44 0.72
Max 2.00 81.48 116.40
11
INDEX Free radicals Adjusted free radicals Comparative free radicals Free radical nocivity
19/6/02 19826.16 19822.45 19819.64 245363.19
30/9/02 1.43 4.08 3.30 19.34
27/1/03 0.63 3.01 1.74 6.30
Min 0.25 1.80 2.00 1.70
Max 0.60 3.50 4.00 3.50
INDEX Necrosis Adjusted necrosis
19/6/02 161.77 36696.12
30/9/02 3.58 795.99
27/1/03 3.59 723.26
Min 2.50 400.00
Max 6.00 1920.00
INDEX Apoptosis Adjusted apoptosis B
19/6/02 0.03 0.99
30/9/02 0.23 2.75
27/1/03 0.23 2.75
Min 0.30 5.00
Max 0.70 8.00
INDEX Pro-amyloid Amyloid risk Fibrosis
19/6/02 0.00050 0.00001 0.36
30/9/02 1.96 0.04 3.04
27/1/03 2.96 0.04 4.64
Min 0.54 0.07 6.00
Max 145.50 5.56 8.00
INDEX Expansiveness #1 Expansiveness #2 Global expansiveness
19/6/02 10.73 31.59 2.09
30/9/02 1.53 4.38 1.87
27/1/03 1.34 4.43 1.65
Min 0.06 1.00 0.01
Max 2.00 4.00 3.20
INDEX Cancer potential
19/6/02 478105.50
30/9/02 22.01
27/1/03 9.37
Min 6.00
Max 10.00
12
INDEX Thyroid output
19/6/02 7.33
30/9/02 2.21
27/1/03 2.56
Min 1.50
Max 2.50
INDEX Insulin
19/6/02 25.76
30/9/02 5.00
27/1/03 6.72
Min 1.50
Max 5.00
INDEX Serotonin
19/6/02 28.81
30/9/02 10.08
27/1/03 10.79
Min 1.50
Max 7.50
INDEX Passive cellular permeability Active intracellular osmolar gradient
19/6/02 281.66 105.56
30/9/02 13.36 13.93
27/1/03 19.10 16.27
Min 4.00 8.00
Max 9.00 12.00

Conclusion
The bacteria identified were only an

epiphenomenon complicating the illness not its real cause A definitive cure could only be brought about by correction of the endobiogenic imbalances relating to the gonadal, somatotropic and thyroid axes, and of the pelvic congestion.
END
13

Endobiogenic Approach (CN)

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Droits d'auteur :

Endobiogenic Approach (CN)

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Droits d'auteur :

The Endobiogenic Approach to Health Maintenance and Restoration

as developed by Drs C. Duraffourd and J.-C. Lapraz

The current pathological paradigm: the etiology of the specific:

Germ Enzyme Gene

Colin Nicholls BA MCPP MNIMH

The evolution of knowledge in medicine

Consistent with, and supported by, modern

More effective than a reductionist approach

Preventative as well as curative Superior in terms of toxicity

Definition of the terrain

The endocrine system as manager

guarantees the integrity and reactivity of

General Adaptation Syndrome

The endobiogenic approach

Parasympathetic system: key features

assessment of the individual patient:

Vagotonic symptoms and signs

Alphasympathetic system: key features

Alphasympathotonic symptoms and signs

Irritability, anxiety, insomnia

Betasympathetic system: key features

Symptoms and signs of sympathetic insufficiency

Sequencing of the ANS

Clinical features (cont)

Digestion good, but sometimes complains

ANS influence on the bladder

Filling the bladder: sympathetic system active

Emptying the bladder: parasympathetic system active

The endobiogenic approach

10/9/05: 5 dry nights in a row 31/10/05:

assessment of the individual patient:

Seasonal fluctuation in corticoadrenal and thyroid hormones

Hormonal phases in childhood

Acceleration of structural installation: increase in real needs of organism Thyroid TSH

Adaptation phase: change in level of equilibrium

Example of endobiogenic imbalance: acne

Main modifications of the terrain leading to acne

Functional insufficiency of liver

Main modifications of the terrain leading to acne

Main modifications of the terrain leading to acne

In males, a lack of testosterone is compensated

Main modifications of the terrain leading to acne

Main modifications of the terrain leading to acne

An increase in adrenal androgens, exacerbated

An insufficiency in glucocorticoids, which

Main modifications of the terrain leading to acne

Main modifications of the terrain leading to acne

Increases SHBG reduction in free androgens,

Stimulates secretion of LH, and Increases the hepatic inactivation of cortisol

Main modifications of the terrain leading to acne

Main modifications of the terrain leading to acne

The need for an increased supply of energy to the skin,

Disturbances in blood sugar regulation, tied to all the

Main modifications of the terrain leading to acne

Plants to modulate endobiogenic imbalances

Plants to modulate endobiogenic imbalances

Thyroid inhibiting: Brassica oleracea, Fabiana

Thyroid stimulant: Avena sativa

Luteotropic: Alchemilla vulgaris, Smilax aspera,

Cessation of all antibiotics Morning and evening, at beginning of meals:

The patient was also advised to adopt a low-glycaemic-index diet.

Outcome (end of August 2002)

The Biology of Functions

The Biology of Functions: blood tests

Case study 2: Biology of Functions

INDEX Inflammation Comparative inflammation

19/6/02 125.60 117.23