Autoimmune Skin

Disorders

Vesiculopustular diseases

Pemphigus Pemphigus Superficial pustular Mucous membrane Bullous

Disease
foliaceus erythematosus drug reactions pemphigoid pemphigoid

Vesicle location subcorneal superficial superficial subepidermal subepidermal

neutrophils, red blood cells, eosinophils,
Inflammatory cell
eosinophils neutrophisl, empty

dorsal muzzle,
nasal planum, face only, head pinnae, or
gross features
pinnae, periorbital depigmentation generalized
skin, pawpads

autoantibodies
against the bullous
Desmogelin 1 antibasement membrane
pathogenesis pemphigoid
antibodies circulating antibodies
antigen in basal
keratinocytes

if prominent the drug

acantholysis yes related pemphigus is
preferred

superficial
mild inflammation,
interface dermatitis perivascular to
eosinophils,
interstitial mixed, with basal cell interstitial mixed
superficial neutrophils, neutrophils, and
neuts and eos, or damage, inflammation with
dermal inflammation eosinophils, lymphocytes, mixed
lichenoid in facial lymphocytes, neutrophils
and plasma cells. Lichenoid mononuclear cells
predominant forms histiocytes, plasma predominating.
superfically and
cells Eosinophils may be
perivascularly
prominent

Vesiculopustular diseases

epidermolysis bullosa
Paraneoplastic
Disease Pemphigus vulgaris (hereditary or
pemphigus
acquired)
suprabasilar,
Vesicle location suprabasilar intraepidermal, subepidermal
apoptosis

neutrophils and neutrophils,

Inflammatory cell
acantholytic cells eosinophils

oral cavity and

mucocutaneous
mucosa and
junctions, pinnae, junctional and
gross features mucocutaneous
nasal planum, oral dystrophic forms
junctions
cavity, lip margins,
genitalia, anus

basal cell layer

pathogenesis desmoglein 3
problem

acantholysis

secondary
ulceration and
fibrinosuppurative superficial and
inflammation; periadnexal dermis
dermal inflammation
variable lymphocytes, plasma
lymphocytes cells
plasma cells,
neutrophils

Interface dermatitis
 Ischemic
Dermatopathy/ Discoid Lupus Systemic Lupus
erythema multiforme
Canine Erythematosus Erythematosus
dermatomyositis

Scattered basal cell apoptosis,

degeneration of basal cell
variable, basal cell
individual basal degeneration
vacuolation, apoptosis apoptosis, vacuolation of
specific features cells, can look (apoptotic and
of basal cells. Dermal- the BM zone
apoptotic, can show vacuolar), disrupts
epidermal separation
subepidermal dermal epidermal
vesicles junction

Inflammatory cell lymphocytes lymphocytes

face, planum
nasale;
gross features face pleomorphic
depigmentation,
erythema, scaling,
multiple
pathogenesis vasculopathic photo-aggravated
syndromes

interface dermatitis
diffuse mild, interface dermatitis,
extending to superficial hair
lymphocytes, lymphocytes,
follicles, lymphocytes and
dermal inflammation histiocytes, mast macrophages,
macrophages, with some
cells, plasma cells, plasma cells fewer
neutrophilas and plasma
neutrophils neutrophils
cells

Other
Pustular diseases
Impetigo
Superficial
pyoderma
Candidiasis
Dernmatophytosis
Sterile pustular
erythroderma of
miniature
shanauzers