Ralph J.

Knipp
2830 Brookdale Ave Louisville, KY 40220 (614) 920-9239 linkedin.com/pub/ralph-knipp/1b/4ba/69 ralph.knipp@louisville.edu

EDUCATION
Ph.D. University of Louisville, Department of Chemistry, Louisville, KY Organic Chemistry (expected May 2014) Thesis: Triggered Release of Small Molecules from Solid Supports Using Heat or an Applied Magnetic Field Ohio Dominican University, Columbus, OH Chemistry (cumulative GPA: 3.786; degree awarded May 2007) 2009-2014

B.S.

2003-2007

ACADEMIC AND INDUSTRIAL RESEARCH EXPERIENCE

University of Louisville, Department of Chemistry 2009-Present Advisor: Dr. Michael H. Nantz Developed thermally labile linkers for substrate/drug release via intramolecular cyclization. Applied this technology to the chemoselective capture of carbonyls (aldehydes and ketones) utilizing aminooxy clickchemistry from a metabolite stream for FT-ICR-MS detection. Developed a drug delivery mechanism to release an active drug from iron oxide (Fe3O4) nanoparticles on the application of an external alternating magnetic field. Developed and optimized aminooxy probes for the early detection of lung cancer from exhaled human breath using either FT-ICR-MS detection or GC-MS analysis without an extraction procedure. GFS Chemicals, Inc. Columbus, Ohio Organic Chemist: Kilo Lab 2007-2009

Specialized in synthesis of acetylenic, olefinic, silane and Grignard reagent building blocks on a 500 mL to 72 L multi-molar scale for multiple applications. Delivered products meeting customer specifications for custom syntheses, internal and external pilot plant development, as well as maintaining supplies of specific catalog items.

COMMUNICATION SKILLS
Coauthor & Co-inventor of 5 publications and 7 presentations

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PUBLICATIONS
RJ Knipp, and MH Nantz. Heat-Induced Cyclizations of Amino-Carbonyl Linkers for Triggered Release of Immobilized Substrates. Manuscript in preparation (to be submitted to Analytical Chemistry). M Bousamra; M Li; RJ Knipp; MH Nantz and X-A Fu. Detection of Early Lung Cancer Using Exhaled Breath. Ann. Thorac. Surg. 2013, 96, In Press. X-A Fu, M Li, RJ Knipp, MH Nantz and M Bousamra. Noninvasive Detection of Lung Cancer Using Exhaled Breath. Cancer Medicine 2013, 2, In Press. MH Nantz and RJ Knipp. Therapeutic Nanoparticles; US Provisional Patent Application 61/762,832; filed February 8, 2013. S Biswas, RJ Knipp, LE Gordon, SR Nandula, SU Gorr, GJ Clark and MH Nantz. Hydrophobic Oxime Ethers: A Versitile Class of pDNA and siRNA Transfection Lipids. ChemMedChem 2011, 6, 2063-2069.

PRESENTATIONS
RJ Knipp and MH Nantz. AMF-Induced Drug Release via Cyclization of Thermally Labile Amino-Esters and -Carbonates Bound to Iron Oxide Nanoparticles. Oral, IMD3 FallFest, Louisville, KY; November 8, 2013. RJ Knipp and MH Nantz. Thermally Labile Amino-Ester and Amino-Carbonate Linkers for AMF-Induced Drug Release from Iron Oxide Nanoparticles. Oral No. 43, 246th ACS National Meeting and Exposition, Indianapolis, IN; September 8, 2013. RJ Knipp and MH Nantz. AMF-Induced Cyclization of Thermally Labile Amino-Esters and Carbonates Bound to Iron Oxide Nanoparticles. Oral, Kentucky nanoSymposium, Louisville, KY; August, 17 2013. XA Fu, M Li, RJ Knipp, M Bousamra, MH Nantz and RM Higashi. A Microreactor Chip for Analysis of Trace Volatile Organic Compounds. Oral, Kentucky nanoSymposium, Louisville, KY; August, 16 2013. J Bergman, K Gupta, K Afonin, M Viard, RJ Knipp, MH Nantz, A Puri and B Shapiro. Preparation of Oxime-Ether Lipoplexes for siRNA Delivery in Breast Cancer Cells. Poster, Frederick, MD; August 9, 2013. K Nelson, RJ Knipp and MH Nantz. Thermally-Induced Intramolecular Cyclizations for Release of Chemoselectively Bound Carbonyl Metabolites. Poster, Summer Research Opportunities for Undergraduates, University of Louisville, Louisville, KY; July 31, 2013. RJ Knipp, O Uradu and MH Nantz. Magnetic-Field Induced of Amino-Esters and Carbonates Bound to Iron Oxide Nanoparticles. Oral No. 212, Nanotech, Washington, D.C.; May 15, 2013.

TEACHING SKILLS
Teaching Assistant: Organic Spectroscopy and Separations Lab (CHEM 527), Department of Chemistry, University of Louisville; Fall 2012

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FELLOWSHIPS and AWARDS

Travel Award, University of Louisville, Institute for Molecular Diversity and Drug Design to attend Nanotech, Washington, D.C., 2013 Research Fellowship, Bill and Melinda Gates Foundation, 2012-2013 University Graduate Student Fellowship, University of Louisville, School of Interdisciplinary Graduate Studies (SIGS), 2009 Outstanding Senior in Chemistry Award, Ohio Dominican University, Division of Math, Computer and Natural Sciences, 2007 CRC Press Freshman Chemistry Award, Ohio Dominican University, Division of Math, Computer and Natural Sciences, 2004

PROFESSIONAL ACTIVITIES
Member, Kentucky Academy of Science (2013) Presenter, Woodland Elementary School Career Day, Hardin County Schools (2013) Treasurer Elect, Columbus American Chemical Society (2009); Active Member

REFERENCES
Professor Michael H. Nantz Department of Chemistry University of Louisville, KY 40208 (502) 852-8069 michael.nantz@louisville.edu Professor Christopher T. Burns Department of Chemistry University of Louisville, KY 40208 (502) 852-5977 christopher.burns@louisville.edu David Baust General Manager - Organic Chemical Division GFS Chemicals, Inc. Columbus, OH 43222 (614) 224-5013 x310 david@gfschemicals.com Professor Palaniappan Sethu Department of Cardiovascular Disease University of Alabama-Birmingham, AL 35294 (205) 975-4185 psethu@uab.edu Professor Francis Zamborini Department of Chemistry University of Louisville, KY 40208 (502) 852-6550 f.zamborini@louisville.edu