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It is generally more convenient when describing acid strength to use pKa values than Ka values.
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Size, and not electronegativity, determines acidity down a column. The acidity of HA increases both left-to-right across a row and down a column of the periodic table. Although four factors determine the overall acidity of a particular hydrogen atom, element effectsthe identity of Ais the single most important factor in determining the 11 acidity of the HA bond.
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The higher the percent of s-character of the hybrid orbital, the closer the lone pair is held to the nucleus, and the more stable the conjugate base.
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Electrophile
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Nucleophile
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