Dietary Supplement Information for Physicians with Naturokinetics

MCT Oil
Product Code: P2197 Categories: Weight Management, Metabolic Support TECHNICAL SUMMARY Protocol For Life Balance MCT Oil contains 100% pure pharmaceutical-grade MCT oil from glycerin and palm kernel oils. Medium-Chain Triglycerides (MCTs) refer to glycerol esters of fatty acids with the number of carbon atoms between 8 and 12. Caprylic (C8:0) and Capric (C10:0) acids are the predominant fatty acids in MCT Oil. Chemical Name: Structural Formula: Molecular Formula: Molecular Weight: CH3(CH2)6COOH 144.21 CH3(CH2)8COOH 172.26 Caprylic Acid, Octanoic Acid (C8:0) Capric Acid, Decanoic Acid (C10:0)

Allergen Disclosure: Not manufactured with yeast, wheat, gluten, milk, egg, fish or shellfish ingredients. Produced in a GMPcertified facility that processes other ingredients containing these allergens. Dose Form: Liquid ROLE AS A NUTRIENT Essentiality: Medium-chain fatty acids are not considered essential nutrients. Dietary Sources: Medium-chain fatty acids are found in coconut and palm kernel oil. Typical Consumption: Unknown. Structural and Functional Role in the Body: MCTs are metabolized differently than most dietary fats. Unlike longer chain triglycerides, MCTs require little or no enzymatic breakdown and are easily absorbed across the wall of the small intestine and delivered straight to the liver where they can be used directly for energy production (instead of being stored as fat). Metabolically they are processed more like carbohydrates, but without the requirement of insulin and with no effect on blood sugar level.1,2

Page 1 of 3

Dietary Supplement Information for Physicians with Naturokinetics

RECOMMENDED USE Weight Management: In a randomized, controlled, clinical trial with 49 overweight volunteers, consumption of MCT oil (18-24 grams/day for 16 weeks as a part of weight-loss program) resulted in lower body weight compared to olive oil over the same period of time ( -3.7 lb., P = 0.013). Additional endpoint values lowered by MCT oil substitution included trunk fat mass, total fat mass, and intraabdominal adipose tissue (P values < 0.05).3 In a double-blind, controlled, clinical trial with 78 volunteers, MCT oil incorporation into the diet (about 9.2 grams/day for 12 weeks, as a part of calorie-controlled, fat-controlled diet) resulted in significant body weight reduction and subcutaneous fat reduction as compared with the LCT (long-chain triglycerides) group in the individuals whose body mass index (BMI) at the beginning of the study was 23 kg/m2 (Figure 1).4 NATUROKINETICS Liberation: Not applicable. The supplement is in the liquid delivery form. Absorption: MCT can be absorbed with minimal intraluminal concentrations of pancreatic enzymes and bile salts. Due to this, MCTs have a faster transit time through the gastrointestinal tract than both glucose and LCT. During digestion, MCTs are converted to medium-chain fatty acids (MCFAs) and transported directly in the portal venous system, as opposed to being transported in chylomicrons via the lymphatic system like LCTs.5 Distribution: Because MCTs bypass peripheral tissues, such as adipose tissue, they make them less susceptible to the actions of hormonesensitive lipase, as well as to deposition into adipose tissue stores. Additionally, because MCFAs are not repackaged into lipoproteins in the liver, Figure 2: Plasma triglycerides following a single ingestion of MCT oil (71 g) in but rather oxidized rapidly in hepatocytes, 20 healthy male volunteers vs. canola oil. consumption of MCTs does not increase plasma triglycerides. In a single-blind, randomized, crossover study with 20 healthy men, ingestion of a single dose of MCT (71 g) oil resulted in statistically significant 15% reduction in plasma triglycerides above baseline (p < 0.001), while the same amount of canola oil resulted in 47% triglyceride increase (p < 0.001) (Figure 2).6
Page 2 of 3

Dietary Supplement Information for Physicians with Naturokinetics

Metabolism: MCFAs can cross the mitochondrial membrane of liver and muscle cells independently of the acylcarnitine transfer system, making them a much more readily available energy source.5 MCFAs are subject to -oxidation, which results in formation of acetyl-CoA that can be used in a number of different biochemical pathways, including the Krebs cycle, ketogenesis, elongation of fatty acids, and synthesis of fatty acids and cholesterol.6 Elimination: Low molecular weight metabolites of MCFA breakdown may re-enter metabolism or be eliminated, predominantly via urine.5 SAFETY INFORMATION Safety: MCT oil is generally recognized as safe (GRAS). Tolerability: MCT oil can cause gastrointestinal distress when used at high doses; tolerability varies between individuals. Taking MCT oil with food can improve gastrointestinal tolerability.7 Cautions: Due to its ketogenic potential, caution should be exercised in patients with diabetes and liver disease.1 INTERACTIONS Drug Interactions: None known. Supplement Interactions: None known. Interference with Lab Tests: MCT oil can lower blood triglyceride levels and test results.6 Stability & Storage: Stable through the expiration date when stored in a cool place. References 1. 2. Bach AC, Babayan VK. Medium-chain triglycerides: an update. Am J Clin Nutr. Nov 1982; 36 (5): 950-962. Symersky T, Vu MK, Frolich M, Biemond I, Masclee AA. The effect of equicaloric medium-chain and longchain triglycerides on pancreas enzyme secretion. Clinical Physiology and Functional Imaging. Sep 2002; 22 (5): 307-311. St-Onge MP, Bosarge A. Weight-loss diet that includes consumption of medium-chain triacylglycerol oil leads to a greater rate of weight and fat mass loss than does olive oil. Am J Clin Nutr. Mar 2008; 87 (3): 621-626. Tsuji H, Kasai M, Takeuchi H, Nakamura M, Okazaki M, Kondo K. Dietary medium-chain triacylglycerols suppress accumulation of body fat in a double-blind, controlled trial in healthy men and women. J Nutr. Nov 2001; 131 (11): 2853-2859. Clegg ME. Medium-chain triglycerides are advantageous in promoting weight loss although not beneficial to exercise performance. Int J Food Sci Nutr. Nov 2010; 61 (7): 653-679. Calabrese C, Myer S, Munson S, Turet P, Birdsall TC. A cross-over study of the effect of a single oral feeding of medium chain triglyceride oil vs. canola oil on post-ingestion plasma triglyceride levels in healthy men. Altern Med Rev. Feb 1999; 4 (1): 23-28. Sills MA, Forsythe WI, Haidukewych D, MacDonald A, Robinson M. The medium chain triglyceride diet and intractable epilepsy. Archives of Disease in Childhood. Dec 1986; 61 (12): 1168-1172.

3.

4.

5. 6.

7.

Page 3 of 3