DOPAMINE Administration

Mix: 400 mg in 250 ml of NS or 800 mg in 500 ml NS to produce a concentration of 1600

mcg/ml.

Weight (kg)
50
60
70
80
90
100
110

INTRAVENOUS DRIP RATES FOR DOPAMINE

Concentration: 1600 mcg/kg/ml | All doses in mgtts/min
5 (mcg/kg/min)
10 (mcg/kg/min)
15 (mcg/kg/min)
10
20
30
10
25
35
15
25
40
15
30
45
15
35
50
20
35
55
20
40
60

20 (mcg/kg/min)
40
45
50
60
70
75
85

Table 1 Dobutamine Injection USP Infusion Rate (mL/h) for 500 mcg/mL
concentration
Drug Delivery Rate
Patient Body Weight (kg)
(mcg/kg/min)
5
10 20 30 40 50 60 70 80 90
100 110
0.5
0.3 0.6 1.2 1.8 2.4 3
3.6 4.2 4.8 5.4 6
6.6
1
0.6 1.2 2.4 3.6 4.8 6
7.2 8.4 9.6 10.8 12 13.2
2.5
1.5 3 6 9 12 15 18 21 24 27
30 33
5
3
6 12 18 24 30 36 42 48 54
60 66
7.5
4.5 9 18 27 36 45 54 63 72 81
90 99
10
6
12 24 36 48 60 72 84 96 108 120 132
12.5
7.5 15 30 45 60 75 90 105 120 135 150 165
15
9
18 36 54 72 90 108 126 144 162 180 198
17.5
10.5 21 42 63 84 105 126 147 168 189 210 231
20
12
24 48 72 96 120 144 168 192 216 240 264

Dobutamine Injection USP Infusion Rate (mL/h) for 1000 mcg/mL concentration

Drug Delivery Rate

(mcg/kg/min)
0.5
1
2.5
5
7.5
10
12.5
15
17.5
20

5
0.1
0.3
0.7
1.5
2.2
3
3.7
4.5
5.2
6

10
0.3
0.6
1.5
3
4.5
6
7.5
9
10.5
12

20
0.6
1.2
3
6
9
12
15
18
21
24

Patient Body Weight (kg)

30 40 50 60 70 80
0.9 1.2 1.5 1.8 2.1 2.4
1.8 2.4 3
3.6 4.2 4.8
4.5 6 7.5 9 10.5 12
9
12 15 18 21 24
13.5 18 22.5 27 31.5 36
18 24 30 36 42 48
22.5 30 37.5 45 52.5 60
27 36 45 54 63 72
31.5 42 52.5 63 73.5 84
36 48 60 72 84 96

90
2.7
5.4
13.5
27
40.5
54
67.5
81
94.5
108

100
3
6
15
30
45
60
75
90
105
120

110
3.3
6.6
16.5
33
49.5
66
82.5
99
115.5
132

Dobutamine Injection USP Infusion Rate (mL/h) for 2000 mcg/mL concentration
Drug Delivery Rate
Patient Body Weight (kg)
(mcg/kg/min)
5
10 20 30 40 50 60 70 80 90 100 110
0.5
0.07 0.1 0.3 0.4 0.6 0.7 0.9 1
1.2 1.3 1.5 1.6
1
0.1 0.3 0.6 0.9 1.2 1.5 1.8 2.1 2.4 2.7 3
3.3
2.5
0.4 0.7 1.5 2
3 4
4.5 5
6 7
7.5 8
5
0.7 1.5 3
4.5 6 7.5 9
10.5 12 13.5 15 16.5
7.5
1.1 2.2 4.5 7
9 11 13.5 16 18 20 22.5 25
10
1.5 3 6
9
12 15 18 21 24 27 30 33
12.5
1.9 3.7 7
11 15 19 22.5 26 30 34 37.5 41
15
2.2 4.5 9
13.5 18 22.5 27 31.5 36 40.5 45 49.5
17.5
2.6 5.2 10.5 15.7 21 26.2 31.5 36.7 42 47.2 52.5 57.7
20
3
6 12 18 24 30 36 42 48 54 60 66

Nitroprusside
EXP: 1 DAY (RT)
Label: Protect from light.
Onset: immediate.
Duration: 1 to 10 minutes.
Treat hypertensive emergency.
IV infusion rate: 0.5 to 10 mcg/ kg/ min--titrate to BP.
Dosing: Initial: 0.3 to 0.5 mcg/kg/min--increase by 0.5 mcg/kg/min increments. (usual

dose: 3 mcg/kg/min-rarely need > 4 mcg/kg/min).

Note: when > 500 mcg/kg is administered by continuous infusion at > 2 mcg/kg/min-cyanide is produced faster than can be handled by endogenous mechanisms.
Maximum infusion rate: 10 mcg /kg /min.
Dosage rates well within product labeling have resulted in toxicity. Early signs of toxicity
appear to be related to formation of cyanide.
Calculation of drip rate 50 mg/250 ml (ml/hr) = wt (kg) x mcg/min x 0.3.
nfusion Rates (mL/hour) to Achieve Initial (0.3 mcg/kg/min) and
Maximal (10 mcg/kg/min) Dosing of NITROPRESS
Volume

250 mL

500 mL

1000 mL

NITROPRESS

50 mg

50 mg

50 mg

concentration

200 mcg/mL

100 mcg/mL

50 mcg/mL

pt

weight

kg

lbs

init

max

init

max

init

max

10

22

30

60

120

20

44

60

120

240

30

66

90

180

11

360

40

88

120

240

14

480

50

110

150

300

18

600

60

132

180

11

360

22

720

70

154

210

13

420

25

840

80

176

240

14

480

29

960

90

198

270

16

540

32

1080

100

220

300

18

600

36

1200

NITROGLYCERIN DRIP
Dosing: (HTN/ CHF/ angina): initial infusion rate 5 mcg/min. May increase by 5
mcg/min every 3 to 5 minutes until response. If 20 mcg/minute is inadequate, increase by
10 to 20 mcg/min every 3 to 5 minutes.
Calculation of drip rate (50 mg/250 ml) ml/hr = mcg/min x 0.3
(eg 5 mcg/min=@ 2ml/hr ; 20mcg/min = 6 ml/hr etc.)

NITROGLYCERIN INJECTION, USP DILUTION TABLE

Each mL Nitroglycerin Injection = 5 mg Nitroglycerin
Volume of
Volume of
Diluent (mL) Nitroglycerin
Injection

Final Concentration
of Nitroglycerin
(mcg/mL)

500 mL

5 mL (25 mg)

50 mcg/mL

250 mL

5 mL (25 mg)

100 mcg/mL

500 mL

10 mL (50 mg)

100 mcg/mL

250 mL

10 mL (50 mg)

200 mcg/mL

500 mL

20 mL (100 mg) 200 mcg/mL

250 mL

20 mL (100 mg) 400 mcg/mL

500 mL

40 mL (200 mg) 400 mcg/mL

100
Solution
Concentration (mcg/mL)

200

400

Dose

FLOW RATE

(mcg/min)

(microdrops/min = mL/hr)

10

15

20

12

30

18

40

24

12

60

36

18

80

48

24

12

120

72

36

18

160

96

48

24

240

72

36

320

96

48

480

72

640

96