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1. ________ is the simultaneous transmembrane movement of two molecules in opposite directions through a transport protein.
10. ________ is a model of biological membranes in which integral membrane proteins float and diffuse laterally in a fluid lipid layer.
Answer:
Answer:
24. ________ is an amphipathic lipid in which two fatty acyl groups and a polar phosphate derivative are attached to a glycerol backbone.
Question 2
A substance only can be accumulated against its electrochemical gradient by: Your answer: d) active transport. Feedback: To accumulate any substance against its electrochemical gradient requires the expenditure of energy. It therefore requires some form of active transport. Page reference: 36
Question 3
The principal intracellular cation is: Your answer: c) K+ Feedback: The principal intracellular cation is potassium (K+). Sodium (Na+) is the principal extracellular cation. Chloride (Cl-) is an anion. Potassium is accumulated by cells as a consequence of the operation of the sodium pump. Page reference: 36
Question 4
Which of the following is an example of primary active transport? Your answer: d) The Na+, K+ ATPase Feedback: The Na+, K+ ATPase is the sodium pump and exchanges 3 intracellular Na+ for 2 extracellular K+ for each molecule of ATP hydrolyzed. Na+-H+ exchange and Na+-Ca2+ exchange are examples of secondary active transport. Cl--HCO3exchange is passive and is driven by the prevailing electrochemical gradients. Page reference: 36-38
Question 5
The sodium pump: Your answer: b) is important for maintaining a constant cell volume. Feedback: The sodium pump exchanges intracellular Na+ for extracellular K+. Although it is driven by the hydrolysis of ATP it can be directly inhibited by cardiac glycosides, notably ouabain. Page reference: 36
Question 6
The resting membrane potential of a mammalian cell is:
Your answer: b) is mainly determined by the K+ gradient. Feedback: The resting membrane potential of many mammalian cells is around -70 mV close to the equilibrium potential for potassium ions. The chloride distribution is determined largely by the potassium gradient. Page reference: 40
Question 7
Exocytosis: Your answer: b) is used to deliver material into the extracellular space. Feedback: Exocytosis provides a means for cells to deliver material to the extracellular space and to insert new material into the plasma membrane. Lipophilic molecules (e.g. steroids) are secreted directly across the plasma membrane. The retrieval of plasma membrane and the uptake of molecules from the extracellular space both occur by endocytosis. Page reference: 43
Question 1
Hormones: Your answer: d) are secreted into the blood. Feedback: Hormones are blood borne chemical signals secreted by endocrine glands. They act on cells remote from the point of secretion. The secretion of most hormones is regulated by negative feedback. Page reference: 50
Question 2
Prostaglandins: Your answer:
c) re synthesized from membrane lipids. Feedback: Prostaglandins are synthesized as required and act as paracrine signaling agents. As they are highly lipophilic, they cannot be stored in membrane bound vesicles but are secreted by diffusion across the plasma membrane. They act on G protein linked receptors. Page reference: 56-67
Question 3
Hormone receptors: Your answer: a) have a high affinity for their natural ligand. Feedback: Hormone receptors are always proteins but they may be located on the plasma membrane or inside the cell. Many hormone receptors do activate G proteins but others activate membrane bound enzymes or bind to nuclear receptors. Page reference: 53-56
Question 4
G protein activation: Your answer: c) leads to the generation of second messengers. Feedback: G proteins link extracellular signals to the control of intracellular metabolism via the generation of second messengers. Second messengers include cyclic AMP, inositol trisphosphate (IP3) and diacyl glycerol (DAG). Page reference: 55
Question 5
Steroid hormones such as aldosterone: Your answer: a) bind to nuclear receptors to regulate gene expression. Feedback: