What should be careful about using Colistin sulfate Colistin sulfate, guidechem, 1264-72-8 Colistin sulfate is a polymyxin antibiotic

produced by certain strains of Bacillus polymyxa var. Colistin sulfateus. It is a mixture of cyclic polypeptides Colistin sulfate A and B. Colistin sulfate is effective against most Gram-negative bacilli and is used as a polypeptide antibiotic. Colistin sulfate is a decades-old drug that fell out of favor due to its nephrotoxicity. It remains one of the last-resort antibiotics for multidrug-resistant Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter. New Delhi metallo- -lactamase multidrug-resistant Enterobacteriaceae have also shown susceptibility to this medicine. Colistin sulfate(CAS NO.: 1264-72-8) is polycationic and has both hydrophilic and lipophilic moieties. These poly-cationic regions interact with the bacterial outer membrane, by displacing bacterial counter ions in the lipopolysaccharide. Hydrophobic/hydrophillic regions interact with the cytoplasmic membrane just like a detergent, solubilizing the membrane in an aqueous environment. This effect is bactericidal even in an isosmolaric environment. Colistin sulfate is used to treat certain stomach, bowel and digestive tract infections. Here are some information about how to use this medicine in right way. Take Colistin sulfate by mouth as directed. It may be taken with food if stomach upset occurs. Shake well before pouring each dose. For best results, take each dose at evenly spaced intervals around the clock. This will ensure a constant level of medication in your blood. Take this medication for the full time prescribed. Stopping therapy too soon may result in a reinfection. Nausea or loss of appetite may occur especially the first several days as your body adjusts to Colistin sulfate. If these effects continue or become bothersome, inform your doctor. Notify your doctor if you develop: skin rash, dark urine. If you notice other effects not listed above, contact your doctor or pharmacist. Tell your doctor if you have any pre-existing conditions, such as: kidney disease, any allergies. Colistin sulfate should be used only if clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known if this medication appears in breast milk. Consult your doctor before breast-feeding. Tell your doctor of any over-the-counter or prescription medication you may take. Do not start or stop any medicine without doctor or pharmacist approval. Laboratory tests may be done while taking this medication to monitor therapy. If you miss a dose, take it as soon as remembered; do not take it if it is near the time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.

Store Colistin sulfate solution in the refrigerator. Shake well before using. Discard any unused medication after 14 days as noted on the bottle. Want to learn more information about Colistin sulfate, you can access the guidechem.com. Guidechem.com is just a place for you to look for some chemicals. Guidechem provide the most convenient conditions for the international buyers and let these leads benefit all the business people. Guidechem chemical B2B network provides information on china and global chemical market quotation and relative chemical Information.