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Action -Arterial and venous dilation HR (reflex) -Response of Catech. Impaired -Blockade A1 mediated contract nonvascular SM (trigone& int. sphi)
USE Irreversible A1 & A2 Blockade Pheochromocytoma Hypertension Carcinoid Syndrome Raynauds Phenomenon USE Reversible A1 & A2 Blockade Short term Pheochromocytoma HTN USE Treatment of Hypertension Treatment of BPH
Or
Phentolamine
A1/A2 Blocker
Or Re Im
Prazosin
A1 Blocker
Tamsulosin
(Flomax)
A1 Blocker
Propanolol
B1 &B2 Blocker
Sotolol
Beta
B1/B2 Blocker
Labetolol
Timolol
Action -Mainly blockade A1 -inhibit phosphodiesterase (high dose) -slight contractility - No change in HR Action -Mainly blockade A1 -inhibit phosphodiesterase (high dose) -slight contractility - No change in HR Action -HR, conduction, contractility -CO; myocardial perfusion -TPR then normalizes -BP -Bronchoconstriction is minimal but life-threatening in asthma - Aqueous humor production - rennin secretion - VLDL & HDL Action ** pronounced K+ channel blockade Action Marked TPR Minimal HR & CO Action ** profoundly lowers intraocular pressure ** Local anesthetic action
1s Sy Se Le Dr
USE Myocardial Infarction Migraine Hypertension Tachycardia Exertional Angina Thyrotoxicosis (Hyperthyroidism)
Br He Fa Im
USE
Pindolol
USE Hypertension Atrial Fibrillation USE Treatment of Open Angle Glaucoma o AH secretion USE
Beta Antagonist & Sympathomimetic activity
Hy Fa
Sim
Sim
Acebuolol A
B1
Betaxolol B
B1
Esmolol E
Selective B1 blocker
Atenolol A
Selective B1 blocker
Metopolol M
Selective B1 blocker
Metyrosine -Inhibits tyrosine kinase, the rate limiting step in syn. of catecholamines
USE Treatment of Hypertension Exertional Angina Arrhythmias USE Treatment of Hypertension Exertional Angina Arrhythmias USE Treatment of Short Action given IV in surgical situations USE Treatment of Hypertension Exertional Angina Arrhythmias USE Treatment of Hypertension Exertional Angina Arrhythmias USE -Pheochromocytoma pre-op and management of inoperable/metastatic case with A antagonists USE Treatment of Hypertension (RARELY) USE Hypertension (RARELY)
-orth
-Extrapyra
Enters peripheral nerves via NOR reuptake mechanism & blocks release of NOR Blocks the Nerve terminal ability to store NOR by inhibiting NOR Transport from the cytoplasm into Storage Vesicles