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Ozone-Therapy

Applications and Indications


of

Medical Ozone
Ozone Seminar Bad Kreuznach March 26 27, 2004
May 23, 2003 OZONOSAN 1

Medical Ozone
Medical Ozone is a mixture of pure Oxygen and pure Ozone 0,05 % O 3 99,95 % O2 1 g /ml
May 23, 2003

5 % O3 95 % O2 100 g/ml

(Vol.)

O3
2

OZONOSAN

Processing of the Medical Ozonegenerator: OZONOSAN


O2
Ozoneproduction

O2
Catalyst: O3 O2

O3
Photometric

O3

ozone
measurement

O3

Ozone supplyer

O3 O2
Catalyst: O3 O2

O3

Ozone suction pump

O3

Ozone
applications

May 23, 2003

O2

OZONOSAN

OZONOSAN photonik
equiped with UV-Photometer for continous measurement of ozone concentrations
Concentration range: 1- ca 80 g/ ml Suction pump highly effective catalyzer system Option: unit for ozononized water

May 23, 2003

OZONOSAN

OZONOSAN alpha plus


equiped with UV-Photometer for continous measurement of Ozone concentrations

Concentration range: 1- ca130 g/ ml Suction pump highly effective catalyzer system Integrated unit for ozonized water

May 23, 2003

OZONOSAN

Indications of Ozonetherapy
l l l

External Ulcers and Skin Lesions Arterial Circulatory Disorders Immunodeficiency and Immunodysbalance
Additive Therapy in Carcinoma Patients Virus Caused Diseases

l l l

Rheumatic Diseases Inflammatory Conditions Dentistry


OZONOSAN 6

May 23, 2003

Systemic Forms of Application


l Major

Autohemotherapy MAH

as

extracorporeal blood treatment with O3 and reinfusion of activated blood

l Rectal l Minor

Insufflation of O3 -O2 Autohemotherapy


OZONOSAN

mixture

as intramuscular

injection of activated blood


May 23, 2003 7

Major Autohemotherapy

Major Autohaemotherapy as extracorporeal blood treatment avoiding intravascular gas application forms. Indications: - Arterial circulatory disorders - Immunomodulation - Rheumatoid arthritis

May 23, 2003

OZONOSAN

Rectal insufflation for systemic und topical efficacy


Indications:
Proctitis Colitis and the Indications for Major Autohemotherapy
1. 2. 3. 4. 5. 6. May 23, 2003 OZONOSAN Dosing ball (150 ml) Ozone reserve container Lock valve Return valves Connection tube (luer) Catheter 9

Ulcerous Proctocolitis
Florid Stage of Proctocolitis: Pat. female, 45 yrs. Destruction of epithelium, cryptal abscesses, massive leucocytic infiltration, partially under inclusion of the tunica propria (350x) Control biopsy after 4 weeks: Manifest reversal of inflammation. Intact epithelium after rectal ozone insufflation with 20-30 g/ml and 300 to 500 ml in volume.
(Knoch et al. Aktuelle Koloproktologie)

May 23, 2003

OZONOSAN

10

Ulcerous Proctocolitis
Florid Stage of Colitis Pat. male 62 yrs. Cryptitis with cryptal abscesses, chronic inflammation, destruction of the epithelium and massive infiltration of leucocytes (350x). Control biobsy after 4 weeks: regular epithelium, regular glandular tubes. Moderate leucocyte infiltration, manifest reversal of inflammatory changes after 4 weeks of rectal ozone insufflation with 8,527 g/ml and 300 ml dayly, 3x per week.
(Knoch et al. Aktuelle Koloproktologie) May 23, 2003 OZONOSAN 11

Minor Auto Hemo Therapy


Extracorporeal blood treatment: 10 ml ozone with a
concentration of 1020 g/ml + 2-3ml of patients own blood and intramuscular injection

Indications
-

Allergies, Acne, furunculosis, Supportive cancer therapy by non specific activation of the immune system, general stimulation

May 23, 2003

OZONOSAN

12

Topical Forms of Application


l l

Transcutaneous Ozone Gas Application


in gas-tight and ozone-resistent plastic covers

Ozonized Water
in the form of spray or compresses

Rectal O3-O2 Insufflation Intraarticular Injections Ozonized olive oil


May 23, 2003 OZONOSAN 13

Local Ozone-Treatment
in the form of the low pressure system acc. to Werkmeister

Indications
Decubitus ulcer Badly healing wounds Diabetic gangrene Burns

May 23, 2003

OZONOSAN

14

Ozone Treatment in Surgery



OZONOSAN

1915 A. Wolff 1935 E. Payr 1937 P. Aubourg 1977 O. Rokitansky 1981 H. Werkmeister, 1987 H.G. Knoch, 2002 Calderon, N.A. Kauffmann, T
15

Werkmeister 1984

May 23, 2003

The Use of Ozonized Water in the


form of spray or compresses

Held, P

May 23, 2003

OZONOSAN

16

Subcutanous, intracutanous and intramuscular injections


1979 Herget
Gieen

1999 Balkanyi
Zrich

Indications
Myotraumatic syndrome - Myogelosis eg in combination with tonanalgetic treatments
-

May 23, 2003

OZONOSAN

17

Intraarticular Injections in Orthopedics

1981 1989

Z. Fahmy,

Bad Kreuznach, Germany

E. RivaSanseverino,
Bologna, Italy

Indications:

May 23, 2003 OZONOSAN

Knee arthrosis, Gonarthrosis and rheumatoid arthritis as supportive therapy


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Mechanism of Action in Topical Applications


1. Microbicidal Effects , ie bactericidal, fungicidal, virustatic
2. 3.

Wound cleansing effect Wound healing effect Topical immunoactivation


OZONOSAN 19

4.
May 23, 2003

Mechanisms of Action in MAH


Activation of Immunocompetent Cells 2. Activation of Red Blood Cell Metabolism 3. Activation and Induction of Biological Antioxydants and Radical Scavengers
1.
May 23, 2003 OZONOSAN 20

Concentration 100 g/ml

Application topical application

Indication
superinfected wounds colitis

Efficacy
germicidal wound cleansing

90 80 70 60 50 40 30 2o 10
May 23, 2003

topical +system. application, limit for system. treatment

badly healing wounds proctitis


ciculatory disorders, immunodysbalance revitalization,
improvement of wound healing

germicidal, activation of cell metabolism immunomodulation, activation of RBCmetabolism,increase of antioxidants


21

systemic treatment

OZONOSAN

Contra Indications and Applications


Contra Indications
1.

2.
1.
2. 3.

Glucose-6 Phosphat- DehydrogenaseDeficiency (Favism) Hyperthyroidism

Contra Applications
Intravenous Gas Injections Intraarteriel Gas Injections Hyperbaric Reinfusion
OZONOSAN 22

May 23, 2003