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Graduate seminar 1/2013 November 15, 2013


The application of polymer in stabilization of drug solubility in solid dispersions Miss Woralak Leelasornchai Master of Sciences in Pharmaceutical chemistry and natural products /2nd year Asst. Prof. Dr. Soravoot Rujivipat Asst. Prof. Dr. Waree Tiyaboonchai Asst. Prof. Dr. A-nan Ounarun Dr. Nutsawadee Apichartwattana ABSTRACT Low aqueous solubility is a common characteristic in todays biopharmaceutics which


Advisor Co-advisor

is a critical determinant of oral bioavailability [1]. There are many techniques which are used to enhance the aqueous solubility like physical, chemical and others techniques. Solid dispersion technology has been used for improving the dissolution rate and bioavailability of poorly water soluble drugs [24]. Solid dispersions are typically prepared by incorporation of the poorly soluble drug into a water-soluble carrier via melt-extrusion or coprecipitation technique [5, 6], resulting in Such processes result in amorphous drug dispersions [7]. Although the amorphous drug dissolves faster compared to its crystalline alternatives, it is not physically stable and may undergo unpredictable crystallization during the shelf-life [810]. The stabilization of amorphous drug solubility by the incorporation of polymer as inhibitory effect has been introduced. The roles of polymer in stabilization mechanism could be: to increasing glass transition temperature of miscible mixture (anti-platicization by the polymer); specific drug-polymer interaction (e.g., hydrogen bonding, ion-dipole) [1113] and an increase in the activation energy for nucleation or alteration of chemical potential of a drug [14-15]. These results in a decrease in local molecular mobility at regular storage temperatures, then the recrystallization would be decreased.

Keywords; solid dispersion, stabilization mechanism, anti-plasticization, drug-polymer interaction, recrystallization

Graduate seminar 1/2013 November 15, 2013

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