Fibonacci resonances as a major evolutionary breakthrough understanding : Global scale level Chromosome4 DNA sequences Unity, Integrity and

Evolution S ecies !rea"through in #uman, Chim an$e Gorilla and %rangutan Genomes are revealed by &ractal &I!%NACCI Numbers Global 'esonances
(((((((((((((((( a dra)t on the &uture o) my basic research(((((((((((((((( *C +ere$ , -. se tembre -/0- 1 revised -- october -/0- , 2eanclaude ere$-3)ree4)r 2eanclaude ere$-3gmail4com ABSTRACT : 5his dra)t a er sho6s evidence o) 7 eriodic 6aves o) nucleotidic in)ormation7 structuring short, medium and long distance DNA sequences o) 6hole chromosomes4 5his )inding 6ould e8tend the )ractal nature o) human DNA ublished in -//9 : “Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome. !re" Lie#erman-$idenn et al. Science, %ol. &'( )o. *+*,- .cto#er +- ',,+. ; e8tending it 1 this time 1 at the level o) 5CAG DNA nucleotide sequences4 5he 6hole o ulation o) these 7discrete 6aves7 )ires 6ithin global 7resonances7 )or s eci)ic eriods 6hose values are &ibonacci numbers :0< -0 <4 444 == >9 444;4 Already in 0990 : htt ?@@6664emeraldinsight4com@2ournals4htmAarticleidB0..<9/0 ; 6e ublished the )act that the DNA sequences encoding genes 6ere organi$ed around the &ibonacci numbers4 !ut this )inding 6as limited to genes coding DNA sequences4 Chat 6e sho6 here 1 under any other "ind o) resonance 1 thus demonstrate that the &ibonacci numbers also organi$e DNA :including 2un" DNA; at the scale o) 6hole chromosomes4 !y limiting the study to only chromosome4, 6e demonstrate here that the 4 chromosomes4 res ective rights, the human, the chim an$ee, the gorilla and orangutan 6ould di))erentiate itsel) on a global scale by &ibonacci s eci)ic resonances4 PREA B!E : %n the one hand, generali$ing our study ublished in -/0/ http://www.ncbi.nlm.nih.gov/pubmed/20658335 across each o) the -4 human chromosomes, it a ears that the human chromosome4 lay a rivileged role as 6e sho6ed in -/00 http://www.scribd.com/doc/57828784/jcperez eijing0320!! :charts art -;4 5his 6ould be the chromosome4 the most organi$ed in the global and relative ro ortions o) codons corres ond very e8actly to the ro ortion o) the golden ratio :0@+hi;, 6hich is not the case )or the other chromosomes4 5he set o) -4 chromosomes organi$ing structure are di))erencied in a numerical structure ording to numerical order ranging )rom 0@+hi :chromosome 4; 0@+hi D0 @ +i :chromosome 09;4 %n the other hand, 6e sho6 by analy$ing the entire genomic DNA sequence o) the e8istence o) discrete eriodic E 6ave)orms F4 5he sha e o) these 6aves reminds charge @ discharge electronics 7'ela8ation oscillators7 ty e 'C :resistor D ca acitor;4 It became interesting to analy$e the 6aves in the entire sequence o) the human chromosome4 :6hich is one o) the longest in our genome? a ro8imately -// million base airs 5CAG;4 %n the other hand, one may 6onder 6hether the )amous chromosome4 not lay a central role in brain )unction? neurological diseases 444 or erha s intelligenceA Some re)erences brain diseases related chromosome4? #uman chromosome4 and brain diseases? http://www.ncbi.nlm.nih.gov/pubmed/7205435 #untington and +ar"inson neurological
diseases444 htt ?@@6664minddisorders4com@&lu1Inv@Genetic1)actors1and1mental1disorders4htmlGb

Hery quic"ly, it a

ears that 7resonances7 :)ractal scale invariance; emerge )or certain

eriods 6hich are &ibonacci numbers :0< -0 <4 == >9 444;4 5he ma2or resonance o) human chromosome4 is the eriod <4 444 6hich is a &ibonacci number 444 It became interesting to du licate this same analysis on the same chromosome in the s ecies closest to humans? chim an$ees 444 Ce then discover the ma2or resonance chromsome4 chim an$ee is the eriod -0 444 6hich is 1 also 1 a &ibonacci number? 0< -0 <4 == >9 444 Chat ha ens to the same analysis on chromosome4 gorilla http://www.ncbi.nlm.nih.gov/pmc/"rticles/#$%3!!!35/ the second closest to the man a)ter the chim an$ee; 444 A 5hen 6e e8tend this study to t6o other mon"eys "no6n to have very similar genomes also? the gorilla and the orangutan 444 Ce )ind then both resonances o) -0 :orangutan; and == :gorilla;444 6hich are 1 again 1 &ibonacci numbers4 C"#C!$S%"#: Chen analy$ing the chromosomes14 in humans and chim an$ees, 6e )ind that there are highly corelated ? In revious studies : http://jhered.o&'ordjourn"ls.org/content/(2/6/48!.'ull ; including ours :boo" C%DEI !I%GENESIS http://www."m"zon.'r/%ode&) iogenesis)!3) codes)l*+,/dp/2874340448 and https://sites.google.com/site/code&biogenesis/ ; ? these t6o genomes 1 articularly the chromosome4 , are strongly correlated :about 99J;4 !U5? 5he overall study resented here demonstrates that these t6o chromosomes are highly di))erent 6hen 6e consider another GK%!AK analysis scale ? one )iring a 'ES%NANCE over a eriod o) -0 &ibonacci :chim ; and the other )iring a 'ES%NANCE over a eriod o) <4 :human;4 5he same analysis also sho6s resonances == :gorilla; and -0 :orangutan;4 Ce 6ould there)ore be 7)allen7 on a measure o) IN5EG'I5L genomes :GM% considerations;, and these results are intriguing in terms o) the EH%KU5I%N theoryN !ut stranger still, this meta1organi$ation o) these chromosomes4 s eci)ic to )our rimate s ecies emerges )rom the demonstration o) eriodic 6aves embodying the )ractal organi$ation o) DNA sequences )orming these res ective chromosomes4 Question: /oes these 01aves0 1hich 1e demonstrate the 2C$G scale informational realit3 have a realit3 electromagnetic as proposed #3 Luc Montagnier 4 http://iopscience.iop.org/!742)65(6/306/!/0!2007 5 and as leave to suggest the form 0rela6ation oscillators0 1aves that 1e see in the genomic se7uences of /)$8 S$ AR& "F RES$!TS: In the )igures belo6, 6e see 7ma2or resonances7 :eg eriod <4 "ey C#'4 human; and 7minor resonances7 :e8am les -0 and == eriods in the human C#'4;4 %ther secondary harmonic resonances also e8ist? <48- B .>, <48< 444 and also -08-, -0I< etc4 444 In the ma2or resonances case, there is a SCAKE INHA'IANCE? all elementary 6aves 1 6hatever their ty es :lines in the )igures; and 6hatever their eriods 1 enter into 7harmonic resonance7 to the resonance eriod :columns on )igures? )or e8am le <4 human C#'4 case;4 &inally, 6e thin" that three )ields o) a lications are the )ollo6ing ? 1Evolution considerations4 16hole chromosomes and genomes integrity in GM% considerations4 1Cancer and genetic diseases chromosomes translocations4

'$ A# chromosome(: 'Osonance -0 ?

>P////// >.////// >=////// >4////// ><////// >-////// >0////// >/////// P9////// P>////// < P 00 0= 09 -< -P <0 <= <9 4< 4P =0 == =9 .< .P P0 P= P9 0 = 9 0< 0P -0 -= -9 << <P 40 4= 49 =< =P .0 .= .9 P< PP >0 09 -/ -0 --<

Resonance )( *+vidence o, a global ,ractal main RES"#A#CE -ith a .eriod )(/ :

>P////// >.////// >=////// >4////// ><////// >-////// >0////// >/////// P9////// P>////// PP////// < P 00 0= 09 -< -P <0 <= <9 4< 4P =0 == =9 .< .P P0 P= P9 0 = 9 0< 0P -0 -= -9 << <P 40 4= 49 =< =P .0 .= .9 P< PP >0

<-

<<

<4

<=

<.

'Osonance == ?

>=////// >4////// ><////// >-////// >0////// >/////// P9////// P>////// PP////// < P 00 0= 09 -< -P <0 <= <9 4< 4P =0 == =9 .< .P P0 P= P9 0 = 9 0< 0P -0 -= -9 << <P 40 4= 49 =< =P .0 .= .9 P< PP >0 =< =4 == =. =P

Chromosome( C'% PA#0E : 'esonance 0< ?

>P////// >.////// >=////// >4////// ><////// >-////// >0////// >/////// < P 00 0= 09 -< -P <0 <= <9 4< 4P =0 == =9 .< .P P0 P= P9 0 = 9 0< 0P -0 -= -9 << <P 40 4= 49 =< =P .0 .= .9 P< PP >0 00 00< 04 0=

Resonance 12 *+vidence o, a global ,ractal main RES"#A#CE -ith a .eriod 12/ :

>P////// >.////// >=////// >4////// ><////// >-////// >0////// >/////// P9////// P>////// < P 00 0= 09 -< -P <0 <= <9 4< 4P =0 == =9 .< .P P0 P= P9 0 = 9 0< 0P -0 -= -9 << <P 40 4= 49 =< =P .0 .= .9 P< PP >0 09 -/ -0 --<

'Osonance <4 ?

>.////// >=////// >4////// ><////// >-////// >0////// >/////// P9////// P>////// PP////// < P 00 0= 09 -< -P <0 <= <9 4< 4P =0 == =9 .< .P P0 P= P9 0 = 9 0< 0P -0 -= -9 << <P 40 4= 49 =< =P .0 .= .9 P< PP >0 <<< <4 <= <.

Chromosome( 3"R%!!E : 'Osonance <4 ?

90////// 9/////// >9////// >>////// >P////// >.////// >=////// >4////// ><////// >-////// < P 00 0= 09 -< -P <0 <= <9 4< 4P =0 == =9 .< .P P0 P= P9 0 = 9 0< 0P -0 -= -9 << <P 40 4= 49 =< =P .0 .= .9 P< PP >0 <<< <4 <= <.

Resonance 44 *+vidence o, a global ,ractal main RES"#A#CE -ith a .eriod 44/ :

>9////// >>////// >P////// >.////// >=////// >4////// ><////// >-////// >0////// < P 00 0= 09 -< -P <0 <= <9 4< 4P =0 == =9 .< .P P0 P= P9 0 = 9 0< 0P -0 -= -9 << <P 40 4= 49 =< =P .0 .= .9 P< PP >0 =< =4 == =. =P

'Osonance >9 ?

>P////// >.////// >=////// >4////// ><////// >-////// >0////// >/////// < P 00 0= 09 -< -P <0 <= <9 4< 4P =0 == =9 .< .P P0 P= P9 0 = 9 0< 0P -0 -= -9 << <P 40 4= 49 =< =P .0 .= .9 P< PP >0 >P >> >9 9/ 90

Chromosome( "RA#3$TA# : 'Osonance 0< ?

>P////// >.////// >=////// >4////// ><////// >-////// >0////// >/////// 0 4 0/ 0. -- -> <4 4/ 4. =- => .4 P/ P. P 0< 09 -= <0 <P 4< 49 == .0 .P P< P9 00 00< 04 0=

Resonance 12 *+vidence o, a global ,ractal main RES"#A#CE -ith a .eriod 12/ :

>P////// >.////// >=////// >4////// ><////// >-////// >0////// >/////// P9////// P>////// 0 4 0/ 0. -- -> <4 4/ 4. =- => .4 P/ P. P 0< 09 -= <0 <P 4< 49 == .0 .P P< P9

-< --0 -/ 09

'Osonance <4 ?

>.////// >=////// >4////// ><////// >-////// >0////// >/////// P9////// P>////// PP////// < P 000= 09-<-P<0 <=<94<4P=0== =9.<.PP0P=P9 0 = 9 0<0P -0-=-9 <<<P404=49=<=P.0.=.9 P<PP>0

<. <= <4 << <-

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