« FUTURE » FROM J.C. Perez PENDING BASIC RESEARCH...

3-D DNA SCANNER THEORY AND TECHNOLOGY : The Discovery of an Universal Glo!al Resonances " S#ra#e$y in %&' Cancers Chro(oso(al Dele#ions ) Loss of he#ero*y$osi#y +
D R A F T - jean-cla !e "erez # Fe$r ar% &'() re*+,e! N-*e.$er &'() jeancla !e"erez&/0.a+l.c-.

ABSTRACT 1
The large-scale study that follows will analyze - and UNIFY - 120 cases of deletions (L !" #u$lished in dozen #eer re%iew #a#ers& affecting 'ulti#le chro'oso'es& and in%ol%ed in a wide %ariety of cancers( The study will $e $ased on four #rogressi%e generalization layers) first we study %arious cancers affecting chro'oso'e* (+, consensus cases"& then we will analyze 'ulti#le chro'oso'es in%ol%ed in $reast cancer (21 consensus cases"& then we generalize study to any chro'oso'e and any cancer (22 consensus cases"( Finally& we analyze the indi%idual character of these deletions for %arious cancers and chro'oso'es (*0 indi%idual cases"( We run here a numerical analysis method of DNA sequences forming chromosomes. Our theoretical approach is to transform the DNA sequence - which we can demonstrate that it is equivalent to a binary vector (dimension !" # in a digital space dimension $. %his tridimensional space can then be analy&ed using various 'D sections( where the analogy with scanners. %he first type of plans will then highlight waveforms. %he second type of plans will reveal resonances. %he third type of plans will reveal equipotential pea)s( dips and contours. For o%er 20 years& we searched for #ossi$le nu'erical structures of -N.& #roteins and geno'es / !istorical su''aries can $e found in htt#)00fr(scri$d(co'0doc01,222,2*03c#erez4ei3ing0+2011 & in htt#)00fr(scri$d(co'0doc0111*+5*1104 6-Unification-of-Neuroscience-and-7eno'ics8ellionisz-9t-.l-in-:ection-*-:#ringer-the-;ere$ellu'-!and$oo<-2012 and in htt#)00golden-ratio-in-dna($logs#ot(fr020120010last-#u$lications-and-conferences-of-3c(ht'l ( :o& there are 'ore than 20 years& we de'onstrate that the genes coding -N. organized around Fi$onacci nu'$ers and Lucas& so #ro#ortions around the 7olden Nu'$er ( htt#)00www(e'eraldinsight(co'03ournals(ht'=articleid>1??+501 htt#)00fr(scri$d(co'0doc051?,11??01551-3c-#erez-#u$lished-the-FI@:T-#a#er-on-ralations$etween--N.-seAuences-Fractals-and-FI4 N.;;Inu'$ers#eculationsinscienceandtechnology "( 4ut what ha##ened to the non-coding -N. - called B3un< -N.B - for'ing geno'es= 4ecause in 2010 ( htt#)00fr(scri$d(co'0doc01+,*2*1*02010-8erez-;odon-8o#ulations-in:ingle-:tranded-Chole-!u'an-7eno'e--N.-.re-Fractal-and-Fine-Tuned-$y-the7olden-@atio "& we de'onstrated that the entire hu'an geno'e tuned its codons #o#ulations in con3unction with the 7olden ratio& we would then show in 2011 (htt#)00fr(scri$d(co'0doc01,222,2*03c#erez4ei3ing0+2011 " that hu'an chro'oso'e* see's to #lay a s#ecial role a'ong the 2* chro'oso'es in our geno'e( Ce were showing in #articular that see's to fit hu'an chro'oso'e* (at its $alancing #o#ulations of codons" on the %alues of the 7olden Nu'$er 8hi > 1(?120++ / Ce - at first - li'ited this study eDclusi%ely to hu'an chro'oso'e-*( The analysis 'ethod is $ased on 'ultidi'ensional restructuring 'ulti#le di'ensions (in the 'athe'atical sense" of the -N. seAuence of the whole chro'oso'e -N. seAuence( This 'ethod re%eals a Auasi-hologra#hic infor'ation a##ears delocalized -N. and redundant (sa'#ling rates of the seAuence"( 6ind of #aradoD& this redundancy of -N. we add additional le%els of redundancy restructuring so that 'ulti-di'ensional infor'ation( In all cases studied and analyzed hundreds of geno'es ($acteria& archaeas& eucharyotes"& there is still e%idence of syste'atic discrete #eriodic wa%es whose sha#e is %ery si'ilar to those of electronic #heno'ena such as BrelaDation oscillatorsB ( see the 'ethod of highlighting these wa%efor's in the $oo< B; -9E 4I 79N9:I:B #u$lished in 2005&

htt#)00www(a'azon(fr0;odeD-4iogenesis-1+-codes-l.-N0d#022,*+*0**2 "( Interference $etween these 'ultidi'ensional wa%e fields result in dissonances& $ut 'ost of the ti'e so'eti'es - $y resonances( These resonances recognizes a characteristic #ro#erty of fractal uni%erse) the F scale in%ariance G( These #ro#erties ha%e $een o$ser%ed in a co'#rehensi%e 'anner for each of the 2* hu'an chro'oso'es (and also in other geno'es li<e& $y eDa'#le& the radiations resistant $acteria @adiodurans"( !owe%er& in the case of hu'an chro'oso'e-*& these resonances will ta<e re'ar<a$le %alues) they will ad3ust on Fi$onacci integers (9Da'#les 2 1+ 21 +* 11 25"( For eDa'#le& hu'an chro'oso'e-* BresonatesB to the glo$al scale of its -N. seAuence o%er a #eriod of resonance > +*( Ce eD#lore then the chro'oso'e-* following two re'ar<a$le di'ensions) -That of 9H LUTI N) we co'#are the resonances of different chro'oso'es-* hu'an& chi'#anzee& orangutan and gorilla( -That of T@.N:L ;.TI N: (-9L9TI N:" F ;!@ I : I9-* ;!.@.;T9@I:TI;: F ;.N;9@ ;9LL: ('etastases in #articular" and that for +, cases of deletions on %arious ty#es of cancer) $ladder& $reast& lung& head and nec<& colorectal etc( ((( 9ach of these two di'ensions of analysis will then re%eal structures and inno%ati%e results& $ased in all cases on the e'ergence of s#ecific resonances around Fi$onacci nu'$ersJ It was then disco%ered - in ter's of the 9H LUTI N - the chro'oso'es-* of * #ri'ates studied are characterized $y radically different resonances Fi$onacci (21 +* 11"& des#ite their res#ecti%e #o#ulations of codons are correlated with 'ore than 51 K( Ce finally disco%ered - in ter's of chro'oso'es *-;.N;9@ ;9LL: - a high le%el of o%erall organization continues to eDist in all cases& the signature is still @9: N.N;9 glo$al scale in s#ite of large deletions in the -N. seAuence( !owe%er& if a large nu'$er of cases& the resonance +* is retained $ut is 'odulated in so'e cases& the 'utant chro'oso'e Bfor<sB to another Fi$onacci nu'$er (eg 2 1+ 21 11 (((" and in other cases& the 'utant chro'oso'e B$ranchesB into a Lucas nu'$er (*,"( @ecall that the Lucas series 1 + , 11 12 25 *, ((( con%erges too - $ut slower - to the golden 'ean 8hi( T2e 0eneral+za3+-n -4 32+, anal%,+, 3- *ar+- , cancer, 3%"e, an! 3- c2r-.-,-.e, -32er, 32an c2r-.-,-.e5 6c2r ) 7 8 9 (' (( () (8 (: (; &( && ...< re*eal, - +n A== ca,e, ,3 !+e!> (&' ca,e, are +n 3-3al - 32e re,-nance c2r-.-,-.e . 3an3, +, al?a%, a re,-nan3 F+$-nacc+ -r = ca,> ?2+le 32e c-rre,"-n!+n0 re,-nance, -4 2eal32% c2r-.-,-.e, are n-3 nece,arl% al?a%, F+$-nacc+ n .$er, an! = ca, e@" (& &7<A In theory& these results de'onstrate - for the first ti'e - the nature of -N. F@.;T.L scale seAuence T;.7& $ut also - in ter's of a##lications - they o#en #athways re'ar<a$le in%estigations in these two areas 9H LUTI N and ;.N;9@& $ut also a #re%enti%e le%el& in 89@: N.L 79N II;:( !owe%er& the 'ost re'ar<a$le result is the de'onstration that deletions of chro'oso'es associated with cancer cells do not disru#t the resonances Fi$onacci chro'oso'e or 'odulate healthy $ut so'eti'es $ifurcate to other attractors Fi$onacci( ;onseAuently& a chro'oso'e BcancerB would $e 3ust as BorganizedB the healthy chro'oso'e fro' which it originates and degenerated ((( .n o#en Auestion& of course& concern the hy#othetical realization of electro'agnetic wa%es such infor'ation ((( . #ossi$le connection with the current wor< of 8rofessor Luc Iontagnier (L( Iontagnier et al(& -N. wa%es and water& 2011 L( 8hys() ;onf( :er( +0? 012 00, doi) htt# 10(102201,*2?15?0+0?01001200, htt#)00io#science(io#(org01,*2-?15?0+0?01001200, "= 5 ,a."le, +ll ,3ra3+n0 32+, "a"er 1 (B E@a."le -4 ) &D *+e?, 4r-. )D ,"ace +n 32e ca,e -4 = n0 cancer =OH ca,e 1 .n eDa'#le of + 2-- layers sections of the +- s#ace related to whole hu'an chro'oso'e 21& after the L ! deletion) D21S1435;D21S1270 chr21)2,&2*2&2*1+1&,0,&02* +&212&2** $# ( htt#)00ats(ctsnet3ournals(org0cgi0content0full0,1010115,0FI71 "(

This eDa'#le is related the #eer re%iew #a#er F Loss of heterozygosity on the long arm of chromosome 21 in non–small cell lung cancer Eung ae Lee et al reference ! " htt#)00ats(ctsnet3ournals(org0cgi0content0full0,1010115, >>M First case of 2- section layer ) 9%idence of F wa%efor's G (here #eriod > *")
11000000 1*200000 1*?00000 1**00000 1*200000 1*000000 1+200000 1+?00000 1 2 + * 1 ? , 2 5 10 11 12 1+ 1* 11 1? 1, 12 15 20 21 22 2+ 2* 21 2?

>>M :econd case of 2- section layer ) 9%idence of F rNsonances G (here #eriod > 25 > Lucas nu'$er& and +*> Fi$onacci nu'$er" )

1**00000 1*200000 1*000000 1+200000 1+?00000 1+*00000 1+200000 + , 11 11 15 2+ 2, +1 +1 +5 *+ *, 11 11 15 ?+ ?, ,1 ,1 ,5 1 1 5 1+ 1, 21 21 25 ++ +, *1 *1 *5 1+ 1, ?1 ?1 ?5 ,+ ,, 21 25 +0 +1 +2 ++ +*

200000 ,00000 ?00000 100000 *00000 +00000 200000 100000 0 2+ 25 +1 *1 *, 1+ 15 ?1 ,1 ,, 2+ 25 51 20 2? +2 +2 ** 10 1? ?2 ?2 ,* 20 2? 52 52

2 , ? 1 * + 2 1

>>M Third case of 2- section layer ) 9%idence of F #ea<s G (here Lucas nu'$ers * and ," ) &B Re,-nance, !+44erenc+a3+-n, $e3?een H .an 6)5< an! C2+."anzee 6&(< ?2-le 0en-.e, 1

2,000000 2?000000 21000000 2*000000 2+000000 22000000 21000000 20000000 ,5000000 ,2000000 ,,000000 + , 11 11 15 2+ 2, +1 +1 +5 *+ *, 11 11 15 ?+ ?, ,1 ,1 ,5 1 1 5 1+ 1, 21 21 25 ++ +, *1 *1 *5 1+ 1, ?1 ?1 ?5 ,+ ,, 21

2,000000 2?000000 21000000 2*000000 2+000000 22000000 21000000 +* +1 +? 20000000 ,5000000 ,2000000 + , 11 11 15 2+ 2, +1 +1 +5 *+ *, 11 11 15 ?+ ?, ,1 ,1 ,5 1 1 5 1+ 1, 21 21 25 ++ +, *1 *1 *5 1+ 1, ?1 ?1 ?5 ,+ ,, 21 15 20 21 22 2+

+2

++

!u'an co'#lete ;hro'oso'e* ;hi'#anzee co'#lete chro'oso'e* (@esonance>+*& Fi$onacci nu'$er" (@esonance>21& Fi$onacci nu'$er" )B E@a."le, -4 rC,-nance, +n 2 .an cr-.-,-.e5 rela3e! 3- & cancer, 3%"e, 6c-l-rec3al an! $-ne< 1

2*000000 2+000000 22000000 21000000 20000000 ,5000000 ,2000000 ,,000000 ,?000000 + , 11 11 15 2+ 2, +1 +1 +5 *+ *, 11 11 15 ?+ ?, ,1 ,1 ,5 1 1 5 1+ 1, 21 21 25 ++ +, *1 *1 *5 1+ 1, ?1 ?1 ?5 ,+ ,, 21 *1 *? *, *2

22000000 21000000 20000000 ,5000000 ,2000000 ,,000000
*5 ,?000000 ,1000000

,*000000 + , 11 11 15 2+ 2, +1 +1 +5 *+ *, 11 11 15 ?+ ?, ,1 ,1 ,5 1 1 5 1+ 1, 21 21 25 ++ +, *1 *1 *5 1+ 1, ?1 ?1 ?5 ,+ ,, 21

1+

1*

11

1?

1,

!u'an cancer chr* deletion ) 1,1O*+2O1,5P1,?O+,+252 !u'an 4one cancer chr* deletion )+1&200&001-*1&200&000 colorectal cancer resonance>*,& Lucas nu'$er Fi$onacci resonance>11 5B E@a."le, -4 rC,-nance, +n 2 .an c2r-.-,-.e(( rela3e! 3- $rea,3 cancer 1

15000000 12000000 1,000000 1?000000 11000000 1*000000 1+000000 + , 11 11 15 2+ 2, +1 +1 +5 *+ *, 11 11 15 ?+ ?, ,1 ,1 ,5 1 1 5 1+ 1, 21 21 25 ++ +, *1 *1 *5 1+ 1, ?1 ?1 ?5 ,+ ,, 21 2, 22 25 +0 +1

?1000000 ?0000000 15000000 12000000 1,000000 1?000000 11000000 1*000000 + , 11 11 15 2+ 2, +1 +1 +5 *+ *, 11 11 15 ?+ ?, ,1 ,1 ,5 1 1 5 1+ 1, 21 21 25 ++ +, *1 *1 *5 1+ 1, ?1 ?1 ?5 ,+ ,, 21 10 11 12 1+ 1*

4reast cancer chr11 (rNsonance 25>Lucas nu'$er" !u'an regular chr11 (resonance12 co''on nu'$er" (chromosome 11p (region D11S922-D11S988) whole chr11 ) 1+1&00?&11? $#

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