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pi ri mi d in p i razi n
4 3 2
N N
1
N N
8
6 7
OH N H2N N N N
pteridina
pterina
OH
Acidul folic
NaOH H2N
N N
N N
O OH +
aci du l p teri n i c
H2N
C - NH - CH - C O CH2 CH2 C
O OH O OH
H2SO4
H2N
C - OH O
O OH O OH
Acidul
p -amin ob en zoi c
acidul
gl u tami c
O OH
OH N H2N N N N OH H2N N
OH N N N OH OH
xantopterina
leucopterina
OH N H2N N N N
Acidul pteroic
H N N N C CH2 - N C - OH O O
CH2 - NH
C - OH O
OH N H2N
rizopterina
OH N H2N N
C N N H
O OH
Acidul folinic
37 %) O OH
OH N3 H2N
4 5
21 6
C H
+ H2N
C - NH - CH - C O CH2 CH2 C O OH
15%
OH N H2N N
H N N
CH2 - NH
C - NH - CH - C O CH2 CH2 C O OH
O OH I2
O OH
O OH
O OH KMnO4 NaOH ; t0
'dentificarea&
H2N N O R N N N M N N N R O N NH2
OH N3 H2N
4
OH N
5 6
N3
N
5 6
21
21
N H
C - NH - CH - C O CH2 CH2 C O OH
O OH
#
R
Cl
HNO2 +
H2N - S - ONH4 O O
N2
+ NH4HSO4 + H2O
NH - (CH2)2 - NH2 Cl +
NH - (CH2)2 - NH2 N N
#
R
6-formi l fte ri n
acid p teri n i c
/ethotrexat um
NH2 N H2N N N N CH3 CH2 - N C - NH - CH - C O CH2 CH2 C O OH
Metotrexat
O OH
$btinirea&
NH2 N H2N N NH2 + NH2 H2O CH2 - Cl C O + CH - Cl2 CH3 HN C - NH - CH - C O CH2 CH2 C O O O O Ba
# H2SO4 # 2
2,4,1,6-tetra amin op i ri mi di n a
C - NH - CH - C O CH2 CH2 C O OH
O OH
H2N
metot rexat
N N
p i ri mi in
N N N
N N
N N
p teri d i n
b ezop teri d i n a
H N
H N N
10
2 3
N N
O NH
NH
4
i zoal oxazi n
al oxazin
4iboflavinum
OH OH OH H2C - CH - CH - CH - CH2OH H3C H3C N N O N O NH
Riboflavin
5i tami nu m 6 2
OH 2 H2O
$btinerea&
H3C H3C NH2 +
O
H C - (CHOH)3 - CH2OH H2O
H3C H3C
CH - (CHOH)3 - CH2OH
2,4-d i mi til an il i n
D-ri b oza
i mi n
!C6H5 - N
N" #Cl
H3C H3C
N N
!H"
H N
O NH
HO O
O NH
ri b ofl avin a
R N N H
H N
O NH
4-fragmen tu l ri b i til u lu i
H3C H3C H N N O H N
+
N N
h
O NH
h
H3C H3C
H3C H3C
lu mi crom
l u mi fl avin
Dozarea&
OH OH OH H2C - CH - CH - CH - CH2OH H3C H3C N N O O H2C - C H3C + H3C N N O N H O + H-C O + H-C H N O NH + 3 NaIO4
O OH
+ 3 NaIO3 + H2O
NH
O H-C OH
H2O
1 Na' # Na'$2 # 2 92:$4 2 '2 # 2 Na2:$4 # 2 92$ '2 # 2Na2:2$2 2Na' # Na2:4$6
OH OH
O NH
*AD
*AD;2
(forma oxidata )
(forma redu3a )