IGF-1 Des

Published on 17 June, 2013, by Richard Blanchard+

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IGF-1 des refers to the 83 amino acid IGF-1 !his is a highly anabolic hormone that is ty"ically released from the li#er in animals IGF-1 des is one of the more "otent growth factors in the body of animals It can cause muscle cell hy"erlasisa as well as insulin-like reactions in the natural setting when stimulated $tudies are currently ongoing to better determine the effects of this chemical on different tissues !his is hel"ing researchers determine "otential dosing that could someday be used to treat diseases that are associated with a lack of IGF1 des in animal

Effects on Brain In uries in !dult Rats

It is known that insulin growth factors IGF binding "roteins are e%"ressed in certain regions of the brains of rats after they ha#e e%"erienced neuronal loss It was found that three days after the hy"o%ic-ishemic brain in&uries the IGF-' le#els would change later while central administration of the rh-IGF-1 were noticeably altered after the in&ury caused by neuronal loss in #i#o

 !he le#els of IGF-1 and IGF-' were monitored two hours after the chemical was administered in the lateral cerebral #entricle following the in&ury (nilateral in&uries that were induced in adult rat sub&ects in the right carotid artery ligation was followed by a 1) minute e%"osure to o%ygen !he neuronal loss was determined in the striatum* dentate gyrus* hi""ocam"us and thalamus + days after the in&ury ,dministration of ') micrograms of IGF-1 after the in&ury caused a reduction in neuronal loss !he trends in lowering neuronal loss remained constant until administrations of 1+) micrograms of the chemical were reached ,t this "oint there was an increase of neuronal loss in the dentate gyrus and hi""ocam"us

Bo"ine #a$$ar% &ell 'roliferation

!he mammary e"ithelial cells were isolated in "regnant but non-lactating heifers to determine the effects of IGF-1 on these cells !he truncated forms of IGF-1 and IGF-' in these cells stimulated a significant "roliferation of cells , media serum along with IGF-1 the mammary cells would also secret and "roduce an additional four s"ecies of IGF-1 binding "roteins that would range from '1--8. !hose that were e%"osed to cells that were grown in a serum only saw detectable /uantities of two of these ma&or forms of the chemical at 3---8. Immunoblot analysis was used to identify these "roteins It was found that they were inducible if IGF was added to the serum-free media 0I, analysis was used on the bo#ine mammary cells to control the cultures of these secretions Cells that were e%"osed to des-3 IGF-1 were 1) "ercent less to "roduce IGF231 while insulin and IGF-' failed to stimulate this "roduction 4ngoing studies are being a""lied to understand how IGF-1 des reacts in insects or am"hibians as o""osed to sub&ects like rats which fall into

mammalian categories !hese differences will hel" scientists better understand the nature of this chemical so it can be better a""lied for thera"eutic uses in the future
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