IV Cephalosporins

Organism 1st 2nd Gen Gen 3rd/4th Generation

Oral Cephalosporins
1st Gen 2nd Gen 3rd Gen

Cefpodox/Cefdinir/Cefditoren

Cefaclor/Loracarbef

Cefuroxime axetil

Ceftizoxime

Ceftazidime

Cefuroxime

Ceftriaxone

Cefotaxime

Cephalexin

Ceftibuten

Cefadroxil

Cefotetan

Cefepime

Cefazolin

Cefoxitin

Cefixime

Cefprzil

Gram Positive Strep, Group A,B,C,G Step. Pneumoniae Virdans strep E. faecalis Staph. Aureus (MSSA) Staph. Aureus (MRSA) Staph. Epidermidis C. jeikeium L. monocytogenes Gram Negative N. gonorrhoeae N. meningitidis M. catarrhalis H. influenzae E. coli Klebsiella sp. Enterobacter sp. Serratia sp. Salmonella sp. Shigella sp. Proteus mirabilis Proteus vulgaris Provedencia sp. Morganella sp. C. freundii C. diversus Citrobacter sp. Aeromonas sp. Acinetobacter sp. Ps. Aeruginosa B. (Ps.) cepacia S. (X.) maltophilia Y. enterocolitica Legionella sp. P. multocida H. ducreyi ANAEROBES: Actinomyces Bacteroides fragilis P. melaninogenica Clostridium difficile Clostridium (NOT difficile) Peptostreptococcus sp.

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+ + + + + + + + + + + + + + = effective or > 60% susceptibility, - = clinical trials lacking or 30-60% susceptible, 0 = not effective or < 30% susceptibility, blank = data in not available 1 Ceftaz is 8-16 times less active than cefotax/ceftriax. Effective only vs Pen-sens. Strains. Oral cefuroxime, cefprozil, cefpodoxime most active in vitro vs S. pneumo. 2 Cefotetan is less active against B. ovatus, B. distanosis, B. thetaiotamicron.