Design of Experiments Using Statgraphics Centurion

Neil W. Polhemus, CTO, StatPoint Technologies, Inc.

Copyright 2011 by StatPoint Technologies, Inc. Web site: www.statgraphics.com

Design of Experiments Wizard

Phase 1: Creating an experiment Phase 2: Analyzing the results Phase 3: Further experimentation

Phase 1: Creating an experiment

Phase 1: Creating an experiment
Step 1: Define responses Step 2: Define experimental factors Step 3: Select design Step 4: Specify model Step 5: Select runs Step 6: Evaluate design Step 7: Save design

Phase 2: Analyzing the results Phase 3: Further experimentation

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Phase 2: Analyzing the results

Phase 1: Creating an experiment Phase 2: Analyzing the results
Step 8: Analyze data Step 9: Optimize responses Step 10: Save results

Phase 3: Further experimentation

Phase 3: Further experimentation

Phase 1: Creating an experiment Phase 2: Analyzing the results Phase 3: Further experimentation
Step 11: Augment design
Step 12: Extrapolate

Example from Response Surface Methodology by Myers and Montgomery

Find the settings of time, temperature and catalyst that maximize the conversion percentage of a chemical process while keeping the thermal activity as close as possible to 57.5.

DOE Wizard Main Window

Step 1: Define responses

Step 2: Define experimental factors

Step 3: Select design

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Step 3: Select design (cont.)

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Step 3: Select design (cont.)

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Step 3: Select design (cont.)

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Datasheet

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Step 4: Select model

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Step 5: Select runs (D-optimal design only)

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Step 6: Evaluate design

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Plot of design space

RSM Example

3.4 3.1

catalyst

2.8 2.5 2.2 1.9 1.6

8.3

10.3

12.3 time

14.3

16.3

210 200 190 180 170 temperature 18.3 160

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Prediction variance plot

Prediction Variance Plot catalyst=2.5

Stnd. error

0.8 0.6 0.4 0.2 0

230 210 190 10.1 12.1 time 14.1 170 temperature 16.1 18.1 150

8.1

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Power curve
Power Curve for A:time alpha = 5.0%, sigma estimated from total error with 10 d.f. 1

Probability of detection

0.8 0.6 0.4 0.2 0 -4 -2 0 True effect/sigma 2 4

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Do the experiment! Then enter the results:

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Step 8: Analyze data

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Step 8: Analyze data (cont.)

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ANOVA table

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Pareto chart
Standardized Pareto Chart for conversion AC C:catalyst CC B:temperature BB BC AA AB A:time 0 2 4 Standardized effect 6 8

+ -

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Exclude effects

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Final models
Standardized Pareto Chart for conversion
Standardized Pareto Chart for thermal activity

AC C:catalyst CC B:temperature BB BC A:time 0 2 4 6 8

+ -

A:time

+ -

C:catalyst

AA

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Standardized effect

Standardized effect

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Step 9: Optimize responses

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Step 9: Optimize responses (cont.)

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Step 9: Optimize responses (cont.)

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3-D contour plot

Desirability Plot catalyst=2.31889 Desirability 0.0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1.0 230 210 10.1 12.1 time 14.1 16.1 18.1 190 170 tem perature 150

3.4 3.1

catalyst

2.8 2.5 2.2 1.9 1.6

8.1

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Overlaid contour plots

Overlay Plot catalyst=2.34412 230 57.0 123.0 59.0 61.0 63.0 65.0 67.0 69.0 115.0 71.0 107.0 99.0 91.0 83.0 190 75.0

conversion therm al activity

210
temperature

170

150 8.1 10.1 12.1 tim e 14.1 16.1 18.1

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Step 10: Save results

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Step 11: Augment design

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Step 12: Extrapolate

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Step 12: Extrapolate (cont.)

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More (next webinar)

Creating and using RPDs (Robust Parameter Designs)

Analyzing designs with both process and mixture

components
Using D-optimal designs to fix a botched experiment

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More Information
Go to www.statgraphics.com Or send e-mail to info@statgraphics.com

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