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Volume 2, Issue: 10 (October December 2013) | Page: 66 - 88 Editor-in-Chief Dr. Saurav Arora Editorial Advisory Board Dr. Jos Eizayaga (Argentina) Dr. Silvia Waisse (Brazil) Dr. Leoni Bonamin (Brazil) Dr. Shivang Swaminarayan (India)

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Important Announcement
Dear reader, wish you a very happy prosperous new year 2014! The latest issue of Research Updates-Homeopathy is now live. I hope you liked the new graphic user interface, responsive design and growing contents at IPRH website after the last upgrade. In future too, IPRH shall strive hard towards betterment, incorporating more of research oriented sections, better interaction and intuitive ideas. I would like to bring to your kind notice the updated email policy of IPRH. Now onwards homeopathic research updates may be opted via: RSS Feed : http://feeds.feedburner.com/iprhblogs You may subscribe the feed via any feed reader and also Google Feedburner at feedburner.google.com/fb/a/mailverify?uri=iprhblogs. The email subscribed via this method will be delivered to your inbox as soon any new post is published online.

Mailchimp : http://eepurl.com/j_vZj. The email subscription via this mode will be delivered quarterly in your inbox.

The above mentioned subscription is totally free. You may also opt out at any point of time by clicking the Unsubscribe Link or sending a reply email with subject Unsubscribe. Last but not the least, Research Updates-Homeopathy will now be published quarterly. This frequency of publication aims at publishing a better issue with latest contents, wider approach and less of email load in your inbox. Dr. Saurav Arora

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Table of Contents
Important Announcement ........................................................................................................................67 Promotion of Homeopathic Research by Community Initiated and Supported Studies (PHORECISS ) ................................................................................................................................................70 What is PHORECISS* ................................................................................................................................. 70 WHAT PHORECISS AIMS at..................................................................................................................... 70 THE MODUS OPERANDI ........................................................................................................................... 71 WORKING GROUPS .................................................................................................................................... 71 WHAT I CAN CONTRIBUTE ..................................................................................................................... 71 WHAT BENEFIT I WILL GET OUT OF PHORECISS ......................................................................... 71 HONORARIUM.............................................................................................................................................. 71 GRANTS/FUNDS .......................................................................................................................................... 72 BE A PART OF PHORECISS ...................................................................................................................... 72 SPREAD THE WORD .................................................................................................................................. 72 NEED TO SAY ANYTHING ........................................................................................................................ 72 WHAT NEXT.................................................................................................................................................. 72 Web-updates at IPRH .................................................................................................................................73 Database of Scientific Publications in Homeopathy Update of studies included till date ............................................................................................................................................................................ 73 Hydroalcoholic solution of Eugenia jambolana pretreatment is cardioprotective: An update from in-vivo study ....................................................................................................................... 73 Homeopathy in Public Health System: An update from a recently published study ........ 74 Calcarea carbonica is capable of knocking out cancer cells Updates from a recently published study* ......................................................................................................................................... 75 Streptococcinum: A homeopathic proving conducted by the School of Homeopathy, Verona ............................................................................................................................................................. 75 Case Record Format for Thyroid Disorders DRAFTT PDF Format ................................... 76 Survey: Quantity of dose in routine homeopathic practice Studies appeared online during third quarter .................................................................................................................................. 76 Homeopathic Management of Subclinical Hypothyroidism....................................................... 76 IPRH New Links update ........................................................................................................................ 76 New Studies Update ....................................................................................................................................77 Fundamental Research........................................................................................................................................ 77 Condurango-glycoside-A fraction of Gonolobus condurango induces DNA damage associated senescence and apoptosis via ROS-dependent p53 signalling pathway in HeLa cells ....................................................................................................................................................................... 77 Read Online at www.audesapere.in/ejournal #researchinhomeopathy 68

Homeopathic Rhus toxicodendron treatment increased the expression of cyclooxygenase2 in primary cultured mouse chondrocytes .......................................................................................... 77 Dielectric dispersion studies of some potentised homeopathic medicines reveal structured vehicle .................................................................................................................................................................. 78 Anti-proliferative effects of homeopathic medicines on human kidney, colon and breast cancer cells ......................................................................................................................................................... 78 Clinical Research .................................................................................................................................................... 79 Additional benefits of homeopathy in the treatment of chronic periodontitis: A randomized clinical trial ............................................................................................................................... 79 Homeopathic prescribing for chronic and acute periodontal conditions in 3 dental practices in the UK. ......................................................................................................................................... 80 Effect of a homeopathic-complex medicine on state and trait anxiety and sleep disorders: a retrospective observational study......................................................................................................... 80 Plant-based ointments versus usual care in the management of chronic skin diseases: a comparative analysis on outcome and safety. ...................................................................................... 81 Aquaculture ............................................................................................................................................................... 82 Morpho-functional response of Nile tilapia (Oreochromis niloticus) to a homeopathic complex ............................................................................................................................................................... 82 Physiological responses of pacu (Piaractus mesopotamicus) treated with homeopathic product and submitted to transport stress. .......................................................................................... 83 Review .......................................................................................................................................................................... 83 Homeopathy for treatment of irritable bowel syndrome ................................................................ 83 The importance of case histories for accepting and improving homeopathy. ........................ 84 A dynamic network model of the similia principle. ........................................................................... 85 Rebound effect of modern drugs: Serious adverse event unknown by health professionals. ................................................................................................................................................................................ 85 Homeopathy: meta-analyses of pooled clinical data ......................................................................... 86 News ................................................................................................................................................................87 Expression of Interest for Collaborative & Fundamental Research in Homeopathy ....... 87 Wikipedia co-founder wants to stop homeopathy ........................................................................ 87 Abstract Submission deadline For LMHI Congress 2014 05 January 2014...................... 87 New regulations for homeopathy in Spain ....................................................................................... 87 Events..............................................................................................................................................................88

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Promotion of Homeopathic Research by Community# Initiated and Supported Studies (PHORECISS ) Time and again we come across difficulties in conducting/undertaking homeopathic research, due to reasons like insufficient funds/grants, scarce resources, limited exposure, inadequate manpower, lack of expertise, or just lack of time.

What is PHORECISS1

To promote interdisciplinary and community supported homeopathic research, IPRH presents you a unique, intuitive, not-for-profit, voluntary initiative called PHORECISS which is Promotion of Homeopathic Research by Community2 Initiated and Supported Studies. PHORECISS is introduced on the philosophy that we as physician and researchers have the capabilities to contribute to homeopathic research, and PHORECISS abridges this gap between desire of research and undertaking research by community motivation and support. For any research to be viable we need few basics like: Research question Hypothesis Literature review Suitable design Population/Sample Instrumentation Data collection Data processing Analysis and Evaluation Publication support Funds/Grants Etc. And this is also true that every individual has his/her own insights, experiences, USPs and expertise. All these qualities may be worth of sharing to significantly strengthen the impact, and improving standards of homeopathic research. PHORECISS recognizes how homeopathic clinicians, researchers and organizations are connected and have the capabilities to contribute for the promotion of research in homeopathy. At PHORECISS a contributor shares his/her USPs and expertise for the homeopathy.

WHAT PHORECISS AIMS at

Providing research sensitization and orientation training to strengthen members within organizational and community settings. Motivating organizations and homeopathic communities to design and undertake quality homeopathic research.

1
2

Copyright Dr. Saurav Arora under IPRH Homeopathic Community

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Research evaluation of studies undertaken under PHORECISS and other studies also. Formulation of Working Groups. Promotion of Delphi processes to make PHORECISS transparent and practical.

THE MODUS OPERANDI

Collaboration with individual clinicians, researchers/scientists, homeopathic organizations/associations. Identification of core areas for undertaking research in homeopathy by discussions, exchange of ideas. Identifying research questions and generation of hypothesis. Formulations of proposals and protocols. Obtaining approval of protocols as per standards of research. Data collection at single or multiple sites using approved protocols. Evaluation and analysis of results. Publication of results.

WORKING GROUPS

To function better PHORECISS believes in formulating Working Groups of physicians, researchers, organizations and homeopathic communities and request them to give their inputs/data from time to time. Working groups are formed according to expertise and area of interest. PHORECISS aims to work closely with working group member, self-help groups, to build the capacity of individuals, so that key areas of homeopathic research can be addressed at local, regional, and state-wide level. See also Working Group Enrolment Form.

WHAT I CAN CONTRIBUTE

PHORECISS runs on support, and each one of us can contribute our expertise, cases, data, laboratory support, etc. To contribute please leave your details via Working Group Enrolment Form.

WHAT BENEFIT I WILL GET OUT OF PHORECISS

PHORECISS believes in supporting homeopathy. As a contributor, your name will be acknowledged in project you will be associated with. And above all, let Homeopathy be benefited at the end.

HONORARIUM

The biggest honorarium is the benefit of science itself. PHORECISS is a community supported voluntary, not-for-profit, initiative, and therefore, doesnt pay to contributors. After all it should be our passion to support homeopathy unconditionally.

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GRANTS/FUNDS

Contributors at PHORECISS have the option to contribute data and not grants as such. For example, if a clinical trial involves certain investigations, a contributing physician may get them done on their own. Such endeavors are highly appreciated. However, in situations where such things are not feasible, PHORECISS will use the grants received from individuals/charitable societies to support homeopathic research projects. The grants received under PHORECISS are project based and subjected to local audits and utilization proofs. To make a donation please visit the Support IPRH section here. New projects under PHORECISS will be notified on the website from time to time.

BE A PART OF PHORECISS

To be a part of PHORECISS you dont need any membership, but yes you must fill the Working Group Enrolment Form so that you may be contacted for your services and expertise. You may also consider making Donations to IPRH.

SPREAD THE WORD

If you like this concept take it further to your friends, circle, colleagues etc. #phoreciss Share this link: http://audesapere.in/phoreciss/

NEED TO SAY ANYTHING

At IPRH you have every right to criticize, promote or support it. Leave your comments at info@audesapere.in or use Contact Form.

WHAT NEXT
PHORECISS is soon initiating research projects, which will be notified via web-update and email. You may subscribe to RSS Feed of IPRH at http://feeds.feedburner.com/iprhblogs to receive every notifications via email.

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Web-updates at IPRH
Database of Scientific Publications in Homeopathy Update of studies included till date Database of Scientific Publications in Homeopathy compiles peer reviewed scientific publications at one place, according to type of research. The various subsections of DSPH are: Fundamental Research Clinical Research Drug Proving Drug Standardization Veterinary Agro Literary Research Primary Health Care Editorials Surveys Till date a total of 485 studies have been included in the database. The database may be accessed freely at http://audesapere.in/database-of-scientific-publications-in-homeopathy Hydroalcoholic solution of Eugenia jambolana pretreatment is cardioprotective: An update from in-vivo study A recent study by Santosh Kumar Shukla et al has been published in Journal of Medical Food titled, Eugenia jambolana Pretreatment Prevents Isoproterenol-Induced Myocardial Damage in Rats: Evidence from Biochemical, Molecular, and Histopathological Studies. The authors used hydroalcoholic extracts of fruit pulp of Eugenia jambolana (HEEJ) and gave it to rats with induced myocardial damage, pre-treated with HEEJ daily for 30 days. Myocardial damage was induced on the 28th and 29th days at an interval of 24h. There was a control group. In group treated with HEEJ, cardioprotective activity was seen as observed by decreasing levels of studied bio-markers and increased levels of superoxide dismutase and reduced glutathione. The present study reports that pre-treatment with HEEJ attenuates oxidative stress, apoptosis and improves cardiac architecture in ISP-induced rats and, hence, is cardioprotective. Few other studies done on similar lines are: A molecular connection of Pterocarpus marsupium, Eugenia jambolana and Gymnema sylvestre with dipeptidyl peptidase-4 in the treatment of diabetes. Corrective role of Eugenia jambolana on testicular impairment in streptozotocin-induced diabetic male albino rat: An approach through genomic and proteomic study. Cytoprotective effects of fruit pulp of Eugenia jambolana on H2O2-induced oxidative stress and apoptosis in rat Leydig cells in vitro. Effect of homeopathic preparations of Syzygium jambolanum and Cephalandra indica on gastrocnemius muscle of high fat and high fructose-induced type-2 diabetic rats.

The hydroalcoholic solution of many substances used in homeopathy are termed as mother tinctures, which is the precursor of future potencies. Mother tinctures are preferred by homeopathic physicians in their routine practice as similimum and specifics, but their use is

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largely based upon traditional knowledge and clinical experiences, and to some extent research study findings. Although not directly related to Homeopathy, these studies add in depth knowledge to a physicians database. We must take further steps to translate such work for clinical use. Remedies like Eugenia jambolana are standardized pharmacopoeial preparations, therefore, further experiments like drug proving and clinical verification may be undertaken to add substantial knowledge for their homeopathic use. Homeopathy in Public Health System: An update from a recently published study Public Healthcare System (PHS) caters health needs of majority of population, and truly represents the interaction of population and health services. Homeopathy is now the second largest practicing alternative system of medicine worldwide. It is practiced in some 80 countries; is legally recognized as an individual system of medicine in 42 countries; and is recognized as a part of complementary and alternative medicine in 28 countries (Homoeopathy Science of Gentle Healing by Deptt. of AYUSH, GoI). To have more insight of its legislative position the need of hour is to report real time data regarding position of homeopathy in PHS. In same context a study has been published recently titled, Homeopathy in the Public Health System: Outcome Data from the Homeopathic Clinic of the Campo di Marte Hospital, Lucca (1998-2010) by Rossi Elioa et al. The study summarizes the 12 years observations at Homeopathic Clinic of Lucca Public Hospital (Italy) with particular attention to sociodemographic features of the patients, distribution of the different diagnoses, follow-up and clinical outcome. The authors report that a sample of 1129 patients (out of total 2592 who attended) were analyzed using Glasgow Homeopathic Hospital Outcome Score. The main findings were: Females use homoeopathy more than males. Persons who already use conventional medicine are not hesitant to use homeopathy. People consult homeopathy for respiratory ailments (29.4%), digestive tract (17%) and dermatological (14.7%) diseases. The improvement rate is nearly 47%. Homeopathy has good outcome in younger age and for longer periods.

The authors conclude that homeopathy may be associated with symptom improvement for a range of chronic and recurring diseases. They also suggest that we need more thorough, randomized and controlled studies, and the integration of homeopathy in a Public Health System can ensure mostly safety and the equity in access for the patient. The time has come when we must work together to make homeopathy as an integral part of PHS of every countries. To begin with we must report descriptive studies regarding legislative position of Homeopathy in hospital, clinics etc. Once we are fully aware of USP and acceptance of Homeopathy, further strategies may be made for propagation and due recognition of homeopathy as part of PHS worldwide. The article is not open access and may www.sciencedirect.com/science/article/pii/S1876382013001893 be accessed at

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For more articles on Homeopathy visit Database of Scientific Publication in Homeopathy by IPRH at http://audesapere.in/database-of-scientific-publications-in-homeopathy/primaryhealth-care-research/ Calcarea carbonica is capable of knocking out cancer cells Updates from a recently published study* Shilpi Saha et al from Bose Institute recently published a paper in BMC Complement Altern Med titled Calcarea carbonica induces apoptosis in cancer cells in p53-dependent manner via an immuno-modulatory circuit. This papers aimed at exploring the underlying mechanism of anti-cancer effect of homeopathic medicine Calcarea carb by studying the molecular mechanism. The team investigated the role of calcarea carbonica on tumour regression and apoptosis (cancer cell death) in mice having Ehrlichs ascites carcinoma (EAC) and Sarcoma-180 (S-180). Modern techniques like Trypan blue dye-exclusion test, flow cytometric, Western blot and reverse transcriptase-PCR techniques were used to study this effect. Also the team studied the role of p53 pathway in calcarea carbonica-induced apoptosis in cancer cells. The team observed that calcarea carbonica administration resulted in 30-35% tumor cell apoptosis. It has been put forward that a two-step mechanism is involved for Calcarea carbonica to induce apoptosis in cancer cells and that is (1) activation of the immune system of the host; and (2) induction of cancer cell apoptosis via immuno-modulatory circuit in p53dependent manner. The study serves an important study since it proposes the long awaited answers for many question in homeopathic cure for e.g. mode of action. The significant observation of involvement of immuno-modulatory circuit in Calcarea carb action may open new vistas for future research in cancer. The paper is freely available at link: http://www.ncbi.nlm.nih.gov/pubmed/24053127 Streptococcinum: A homeopathic proving conducted by the School of Homeopathy, Verona The School of Homeopathy, Verona has recently concluded and reported details of the homeopathic proving of Streptococcinum undertaken at the Institute. The proving, as stated, is a triple blind proving done on 16 healthy volunteers from the Institute. The Institute has put forth a methodically written document. Such proving needs to be undertaken and results should be shared for discussion, criticism and improvement of drug proving designs. I am sure the work will add substantial knowledge to homeopathic database of authentic symptomatology. The proving may be seen at School of Homeopathy, Verana website www.omeopatiaroma.it/pdf/1379839080Streptococcinum_proving_eng.pdf

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Case Record Format for Thyroid Disorders DRAFTT PDF Format A while ago, the Data Record & Assessment Form for Treated Thyroid Disorders (DRAFTT) Beta Version was publish online. The aim of this Record and Assessment form is to data collect analysis of cases of thyroid disorders treated homeopathically. The data provided by contributors will be periodically assessed to reach to a common consensus, which may further strengthen the role of homeopathy in various thyroid disorders. In continuation, the PDF version of the same has been published online at http://audesapere.in/blogs/draftt-pdf/. The form is an open access publication. You may also report suggestions, errors and feedback at www.audesapere.in/contact Survey: Quantity of dose in routine homeopathic practice Studies appeared online during third quarter In homeopathic clinical practice we often come across lack of standardization at some or the other place. One such small yet important issue is the quantification of dose e.g. number of pills to be 4 or 6. This is a prospective area for further exploration and standardization, keeping in view the real time clinical setting and experience. The aim of this survey is to collect your opinion regarding quantity of dose in routine homeopathic clinical practice, with special emphasis to globules, mother tincture and bio-chemic salts. Your opinion will help IPRH to report a common consensus, so that a uniformity in dosage may be communicated to homeopathic physicians across the globe. NO personal information, style of prescription, repetition of medicine etc. will be asked. Take the Survey here. Homeopathic Management of Subclinical Hypothyroidism Homeopathic Management of Subclinical Hypothyroidism: Excerpt of the presentation given at monthly CME of Noida Homoeopathic Medical Association, Noida on 09.11.2013. Read full PPT here.

IPRH New Links update The following new links under Links have been incorporated at website of Initiative to Promote Research in Homeopathy (IPRH): Web Links: Links to important homeopathic websites. Video Links: Links to interesting homeopathic videos. Article Links: Links to research articles (popular and scientific)

If you have any web, video or article link to be included, please share it via Contact Form.

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New Studies Update

Studies published during October December 2013 in addition to updates given above

Fundamental Research
Condurango-glycoside-A fraction of Gonolobus condurango induces DNA damage associated senescence and apoptosis via ROS-dependent p53 signalling pathway in HeLa cells Mol Cell Biochem. 2013 Oct;382(1-2):173-83. Bishayee K, Paul A, Ghosh S, Sikdar S, Mukherjee A, Biswas R, Boujedaini N, Khuda-Bukhsh AR. Cytogenetics and Molecular Biology Laboratory, Department of Zoology, University of Kalyani, Kalyani, 741235, India. Gonolobus condurango plant extract is used as an anticancer drug in some traditional systems of medicine including homeopathy, but it apparently lacks any scientific validation. Further, no detailed study is available to suggest whether condurango-glycoside-A (CGA), a major ingredient of condurango serves as a potent anticancer compound. Therefore, we investigated apoptosisinducing ability of CGA against cervix carcinoma cells (HeLa). -galactosidase-activity and DNA damage were critically studied at different time points; while induced DNA-damage was observed at 9-12th hours, senescence of cells appeared at a later stage (18th hour after CGA treatment), implicating thereby a possible role of DNA damage in inducing pre-mature cell senescence. Concurrently, the number of cells undergoing apoptosis increased along with increase in reactive oxygen species (ROS) generation. Expression of p53 was also up-regulated, indicating that apoptosis could have been mediated through p53 pathway. DCHFDA (4',6Diamidino-2-phenylindole dihydrochloride) assay, acridine orange/ethidium bromide staining and annexin V/PI assay results collectively confirmed that apoptosis was induced by increased ROS generation. Reduction in proliferation of cells was further evidenced by the cell cycle arrest at G0/G1 stage. Expression profiles of certain relevant genes and proteins like p53, Akt, Bcl-2, Bax, cytochrome c and caspase 3 also provided evidence of ROS mediated p53 up-regulation and further boost in Bax expression and followed by cytochrome c release and activation of caspase 3. Overall results suggest that CGA initiates ROS generation, promoting up-regulation of p53 expression, thus resulting in apoptosis and pre-mature senescence associated with DNA damage. Homeopathic Rhus toxicodendron treatment increased the expression of cyclooxygenase2 in primary cultured mouse chondrocytes Yun Hyun Huh, Meong Ju Kim, Myeong Gu Yeo. Homeopathy, Volume 102, Issue 4, October 2013, Pages 248-253 Abstract Background: Rhus toxicodendron (Rhus tox) is a homeopathic remedy with anti-inflammatory activities used for arthritis pain. Methods: We studied the effects of 4, 30, 30c and 200c homeopathic dilutions of Rhus tox in primary cultured mouse chondrocytes. We examined the expression of collagen type II, a marker protein of chondrocytes, and cyclooxygenase-2 (COX-2), which is responsible for the biosynthesis of prostaglandin E2 (PGE2) and the regulation of the inflammatory response. We assessed the expression of collagen type II and COX-2 using biochemical and immunological methods, such as reverse transcription polymerase chain reaction (RT-PCR), quantitative (or real-time) RT-PCR (qRT-PCR) and immunoblot assays.

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Results: Stimulation with different concentrations of Rhus tox increased the mRNA expression of COX-2, and stimulation with 30 Rhus tox showed the most prominent mRNA expression in both RT-PCR and qRT-PCR analyses. We also observed that homeopathic dilutions of 4, 30 and 30c Rhus tox inhibited collagen type II expression, suggesting that Rhus tox induced the dedifferentiation of chondrocytes. In addition, treatment with 30 Rhus tox significantly increased PGE2 release compared with other homeopathic dilutions of Rhus tox. Conclusions: Taken together, these results suggest that homeopathic treatment with Rhus tox induced chondrocyte dedifferentiation and inflammatory responses, such as COX-2 expression and PGE2 production, in primary cultured chondrocytes. Dielectric dispersion studies of some potentised homeopathic medicines reveal structured vehicle C.R. Mahata Homeopathy, Volume 102, Issue 4, October 2013, Pages 262-267 Abstract Background: Avogadro's Number gives 12c as the limit beyond which no original substance can be present in a highly diluted and succcussed (potentised) homeopathic medicine, implying that chemically such dilutions consist of nothing but the vehicle. But there is evidence that living systems react to homeopathic medicines diluted even above 12c. To explain how such medicines differ from another I hypothesise that altered structure may cause the difference, such as that between diamond and amorphous carbon. Some scientists have argued that dilution followed by succussion may lead to altered structural arrangement of water molecules. This concept may be termed Induced Molecular Structure. Methods: Dielectric dispersion studies were conducted in a broad range with potencies below and above the Avogadro limit by taking 6c and 30c potencies of Graphites and Cuprum Metallicum in liquid form. Measurements were made with an Anomalous Dielectric Dispersion Detector (A3D), an instrument developed by the author. Results: Experiments were carried out in a frequency range of 100 kHz to 50 MHz. Shifting of resonance frequencies as a function of medicine and potency, with potencies below and above the Avogadro limit, was observed. Conclusion: The range of resonance frequencies suggest that the phenomenon might originate from oscillation of dipoles caused by electric field in variously structured and polarised water. Also, there is reasonable evidence that frequencies change with materials and potency. Anti-proliferative effects of homeopathic medicines on human kidney, colon and breast cancer cells Shagun Arora, Ayushi Aggarwal, Priyanka Singla, Saras Jyoti, Simran Tandon, Homeopathy, Volume 102, Issue 4, October 2013, Pages 274-282 Abstract Objective: Homeopathy is controversial, due to the claims made for very high dilutions. Although several theories are proposed to understand the mechanisms of action, none are scientifically verified. This study aimed to investigate the efficacy of the selected homeopathic medicines in specific in vitro cancer models.

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Methods: We assessed the cytotoxic activity of selected homeopathic medicines in mother tincture (MT), and ultramolecular dilution (30C, 200C, 1M and 10M) against cell lines deriving from tumors of particular organs, Sarsaparilla (Sars) on ACHN cells (human renal adenocarcinoma), Ruta graveolens (Ruta) on COLO-205 (human colorectal carcinoma), and Phytolacca decandra (Phyto) on MCF-7 (human breast carcinoma). Sars was also tested against MadinDarby canine kidney (MDCK) cells (a non-malignant cell line). Cytotoxicity was measured using the 3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) method, antiproliferative activity by trypan blue exclusion assay, apoptosis determined by dual staining the cells with ethidium bromide (EB) and acridine orange (AO) dyes. Results: MTs and ultra-diluted preparations of the three homeopathic medicines had highly significant effects in the respective cancer cell lines, producing cytotoxicity and a decrease in cell proliferation. The effects were greatest with the MTs, but in all cases and persisted, although to a lesser degree in the ultra-diluted molecular preparations. Sars showed no effect on MDCK cells. In the homeopathic medicine treated cultures, hallmarks of apoptosis were evident including, cell shrinkage, chromatin condensation and DNA fragmentation. Conclusion: This study provides preliminary laboratory evidence indicating the ability of homeopathic medicines as anticancer agents. Further studies of the action of these homeopathic remedies are warranted.

Clinical Research
Additional benefits of homeopathy in the treatment of chronic periodontitis: A randomized clinical trial Complement Ther Clin Pract. 2013 Nov;19(4):246-50. Mouro LC, Moutinho H, Canabarro A. Source: Department of Periodontology, School of Dentistry, Veiga de Almeida University (UVA), Rio de Janeiro, Brazil; Hahnemanniano Institute of Brazil (IHB), Rio de Janeiro, Brazil. Electronic address: leilamourao@hotmail.com. Background and Objective: Homeopathic medicine (HM) in the treatment of Chronic Periodontitis (CP) aims to restore the vital energy balance of the patient allowing the body to heal itself. Thus, the aim of this study was to evaluate the additional benefits of HM as an adjunctive to conventional periodontal treatment (CPT). Materials and Methods: After sample size calculation, sixty individuals of both genders, and ages varying between 35 and 70 years old, 40 with chronic periodontitis (CP group - CPG) and 20 without CP (Healthy Group - HG) participated in this "Single-Blind Randomized Controlled Clinical Trial". The CP patients were divided into two groups: one was submitted only to CPT (CP Control Group - CPT-C) and the other group was submitted to CPT and HM, according to the similia principle (CP Test Group - CPTT). Assessments were made at baseline and after 90 days of treatments. The local and systemic responses to the treatments were evaluated by clinical and laboratory parameters, respectively. Data were analyzed by parametric and nonparametric tests. The level of significance was 5%. Results: At baseline, CP patients presented higher values of LDL cholesterol and blood glucose than HG individuals. After the treatment, all the systemic parameters evaluated decreased in CP patients, except LDL and HDL Cholesterol in CPT-C, and HDL Cholesterol in CPT-T. There was a

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statistical gain in clinical attachment level only in CPT-T (+0.51 mm) after 90 days; however, there was a reduction in probing depth, in the level of visible plaque and in the bleeding on probing, in both CP groups (CPT-C and CPT-T) after 90 days. Conclusion: The findings of this 3-month follow-up study concluded that H M, as an adjunctive to CPT, can provide additional benefits in the treatment of CP. Homeopathic prescribing for chronic and acute periodontal conditions in 3 dental practices in the UK. S. Farrer, E.S. Baitson, L. Gedah, C. Norman, P. Darby, R.T. Mathie, Homeopathy, Volume 102, Issue 4, October 2013, Pages 242-247 Abstract Introduction: This investigation extends our previous dental data collection pilot study with the following main aims: to gain insight into the periodontal complaints that dentists in the UK treat using individualised homeopathic prescription; to record patient-assessed change in severity of treated complaint (acute or chronic); to determine periodontal pocket depth (PPD). Materials and methods: Three dentists recorded data systematically at 249 homeopathic appointments in 51 patients over a period of 18 months. A spreadsheet enabled the data collection of the following records: date of appointment; anonymised patient identity; main periodontal problem treated; whether the condition was acute or chronic; patient-assessed clinical outcome on a 7-point Likert scale, ranging from 3 to +3, to compare the first and any subsequent appointments; whether any interventional dental surgery (IDS) had been carried out; clinician-assessed PPD measurements. Results: At least one follow-up (FU) appointment was reported for each of 46 patients (22 chronic [6 with IDS, 16 without IDS]; 24 acute [10 with IDS, 14 without IDS]). In chronic cases, strongly positive outcomes (score of +2 or +3) were reported by 2 (33.3%) of 6 IDS patients and by 1 (6.3%) of 16 non-IDS patients. In acute cases, strongly positive outcomes were reported by 7 (70%) of 10 IDS patients and by 8 (57.2%) of 14 non-IDS patients (no statistically significant difference between sub-groups). The FU conditions most frequently treated with homeopathy were chronic periodontitis (19 patients) and acute periodontal abscess (11 patients). Analysis of PPD data was not feasible due to the small numbers of patients involved. Conclusion: Limited insight has been gained into the periodontal complaints treated by homeopathy in the UK. Due to small sample size and equivocal results, the interpretation of the patient-reported outcomes data is unclear. Positive findings obtained in the acute treatment setting suggest that this may be a promising area for research in periodontal homeopathy. Effect of a homeopathic-complex medicine on state and trait anxiety and sleep disorders: a retrospective observational study Luigi Coppola, Fabio Montanaro Homeopathy, Volume 102, Issue 4, October 2013, Pages 254-261 Abstract Purpose: The primary objective of this open-label, retrospective, observational study was to examine change in indicators of anxiety changed after treatment period of at least 1 month with the homeopathic-complex medicine Datif-PC. A secondary objective was to describe the quantitative changes in the sleep pattern of the subjects included in the study.

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Methods: The study population consisted of 71 subjects suffering from mild to moderate anxiety, who were treated with a homeopathic-complex medicine. The subjects had attended at least 2 consultations during the year 2010, with the second visit taking place at least 30 days after the first baseline visit. At both visits, subjects were administered the State-Trait Anxiety Inventory (STAI)-Y questionnaire (consisting of trait and state subscales) to assess their level of anxiety. Sleep quality was assessed based on the subjects' self-reported number of hours slept and number of night-time awakenings, before and after treatment. Results: Compared to baseline, the average (STAI)-state score at visit 2 decreased by more than 6 points, while the STAI-trait score decreased by more than 3 points. This was statistically significant (p < 0.0001) for both subscales. These findings were stable in subgroup analyses (gender, age and anxiety level). The average number of hours slept per night increased significantly at visit 2 compared to baseline (from 5.1 1.1 to 5.56 0.9 h, p < 0.0001). A marked decrease in the average number of night-time awakenings was also observed at the second visit (42%, p < 0.0001). Conclusions: This retrospective observational study suggests that treatment of anxiety and sleep disorders with Datif-PC can produce notable improvements even in a short period of time. Furthermore, the observed effects were not affected by sex, age or baseline anxiety. Further controlled, randomized studies are justified. Plant-based ointments versus usual care in the management of chronic skin diseases: a comparative analysis on outcome and safety. Complement Ther Med. 2013 Oct;21(5):453-9. Jong MC, Ermuth U, Augustin M. Louis Bolk Institute, Department of Nutrition & Health, Driebergen, The Netherlands; MidSweden University, Department of Health Sciences, Sundsvall, Sweden; NIKIM, Amsterdam, The Netherlands. Electronic address: m.jong@louisbolk.nl. OBJECTIVES: To assess the outcome and safety of plant-based ointments versus usual care in the management of chronic skin diseases. METHODS: Prospective mono-centric comparative analysis. Patients were recruited at an outpatient dermatology clinic and treated with plant-based ointments or care as usual. Main outcome criterion was the response rate, defined as the proportion of patients experiencing 'complete recovery' or 'major improvement' at 6, 12 and 24 months. Secondary outcome criteria were quality of life (SF-12 and EQ-5D), patient satisfaction and safety of treatment. RESULTS: A total of 112 patients with chronic skin diseases were evaluated of which 44 were treated with plant-based ointments (PO) and 68 received usual care (UC). The majority of patients suffered from psoriasis (PO: 50%; UC: 56%) or eczema (PO: 41%; UC: 32%) and were treated with homoeopathic topical ointments containing mahonia or cardiospermum or usual care creams containing calcipotriene and corticosteroids. The only significant difference in baseline status between the two groups was in disease severity score (PO: 1.80.7 versus UC: 2.40.8, p=0.0004). After two years, the main outcome of responders to treatment was 52.3% (95%-CI: 36.1-64.9) in the ointment and 41.2% (95%-CI: 20.4-42.2) in the UC group. Change in SF-12 (2 years compared to baseline), adjusted for baseline disease severity, was not significantly different between both groups; PO: 5.4 (95%-CI: 3.4-7.3) versus UC: 3.2 (95%-CI: 1.5-4.9). The adjusted EQ-5D was found to be significantly different between the two groups after two years, in favour of the ointment group; PO: 0.113 (95%-CI: 0.052-0.174) and UC: -0.008

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(95%-CI: -0.055-0.038). Other secondary outcome parameters such as patient satisfaction and number of adverse drug reactions were comparable. CONCLUSIONS: The outcome of this study suggests at least therapeutic equivalence between plant-based ointments and usual care management of chronic skin diseases. As this nonrandomized study was open to selection and other bias, further rigorous studies are needed to demonstrate the effectiveness of these topical products.

Aquaculture
Morpho-functional response of Nile tilapia (Oreochromis niloticus) to a homeopathic complex Graciela Lucca Braccini, Maria Raquel Maral Natali, Ricardo Pereira Ribeiro, Ricardo Hideo Mori, Rafael Riggo, Carlos A.L. Oliveira, Joo Fbio Hildebrandt, Lauro Vargas Homeopathy, Volume 102, Issue 4, October 2013, Pages 233-241 Abstract Background: This study evaluated the performance, prevalence of ectoparasites and morphofunctional response of the liver and the branchiae of Nile tilapia (Oreochromis niloticus) raised on fish meal with added of the homeopathic complex Homeopatila 100 at different concentrations. Methods: Post-reversed juvenile Nile tilapia (O. niloticus) of the GIFT (Genetic Improvement of Farmed Tilapia) strain were used in this study. The performance, ectoparasite prevalence and parasite load in the branchiae and skin as well as the liver and branchial histology. Fish were randomly assigned to receive one of four treatments: control, 20 mL hydroalcoholic solution (alcohol 30 GL); 20 mL Homeopatila 100 per kg of meal; 40 mL Homeopatila 100 per kg of meal; or 60 mL of Homeopatila 100 per kg of meal, compared to control with out the addition of the complex. There were four replications per treatment type (16 experimental units total) at a density of 40 fish per m3 over a period of 57 days. The KruskalWallis H test (p < 0.05) was employed to analyse the physical and chemical parameters of water as well as for parasite prevalence; whereas analysis of variance was used for liver performance. If the values were significant (p < 0.05), they were compared by Tukey's test. Multiple comparisons of averages were performed using Student's t test (p < 0.05). Results: There were no significant between the physical and chemical parameters of the water between the different groups at the end of the experiment. Significant differences (p < 0.05) in the mixed parasite conditions were found within the different Homeopatila 100 treatments. The hepatosomatic ratio of fish treated with Homeopatila 100 was significantly lower than that of fish from the control group. The best results in the liver and branchiae occurred in fish receiving Homeopatila 100 at 40 mL/kg in terms of the number of hepatocytes/mm2, the intercellular glycogenic behaviour, the rates of histological changes (hyperplasia, lamella fusion and telangiectasia) and the percentage of neutral and acidic mucin-producing cells. Conclusion: The addition of Homeopatila 100 at a concentration 40 mL per kg/meal to the diet of juvenile Nile tilapias resulted in improved hepatocytes and intracellular glycogen levels as well as the lowest mean rate of branchial histological changes with an increase in acidic mucin-producing cells compared to neutral mucin-producing cells, compared to control. Keywords: Homeopathy; Population homeopathy; Aquaculture; Tilapia farming; Performance; Histopathology

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Physiological responses of pacu (Piaractus mesopotamicus) treated with homeopathic product and submitted to transport stress. Knia Cristine de Oliveira Feitosa, Jayme Aparecido Povh, Janessa Sampaio de Abreu, Homeopathy, Volume 102, Issue 4, October 2013, Pages 268-273 Abstract Background: Pacu (Piaractus mesopotamicus) is a species with great potential for Brazilian fish farming and losses through mortality are common after transport as a direct or indirect result of stress. The use of homeopathic complex is a further option to minimize the various stress factors that can interfere negatively in production. Methods: After feeding for 10 consecutive days with commercial diet; or diet supplemented with sucrose; or commercial diet supplemented with homeopathic complex, juvenile pacu were placed in a polyethylene bags and transported for four hours with the following treatments: commercial diet (control); commercial diet and homeopathic complex dissolved in the transport water (W + HP); commercial diet supplemented with sucrose (D + SU) and commercial diet supplemented with homeopathic complex (D + HP). Blood was collected before transport (basal), after transport (arrival), 24 and 72 h after transport. The physiological indicators of the stress were blood glucose, cortisol and chloride levels, hematocrit, hemoglobin and total protein. Condition factor and mortality were also determined. Results: Blood glucose increased significantly on arrival, returning to the basal values 24 h after, similarly in all treatments. Plasma cortisol levels were elevated on arrival but not significantly compared to the basal values for fish from W + HP and D + SU groups. Increase in hematocrit and hemoglobin and low plasma chloride levels were observed after transport in all treatments. Conclusion: Transport resulted in stress responses in juvenile pacu and the homeopathic complex, administered in the water or diet, did not minimize these responses. Sucrose supplementation altered the cortisol and blood glucose levels, suggesting a moderating effect on these stress indicators.

Review
Homeopathy for treatment of irritable bowel syndrome Peckham EJ, Nelson EA, Greenhalgh J, Cooper K, Roberts ER, Agrawal A. Cochrane Database Syst Rev. 2013 Nov 13;11:CD009710. [Epub ahead of print] Background: Irritable bowel syndrome (IBS) is a common, chronic disorder that leads to decreased health-related quality of life and work productivity. Evidence-based treatment guidelines have not been able to give guidance on the effects of homeopathic treatment for IBS because no systematic reviews have been carried out to assess the effectiveness of homeopathic treatment for IBS. Two types of homeopathic treatment were evaluated in this systematic review. In clinical homeopathy a specific remedy is prescribed for a specific condition. This differs from individualized homeopathic treatment, where a homeopathic remedy based on a person's individual symptoms is prescribed after a detailed consultation. Objectives: To assess the effectiveness and safety of homeopathic treatment for treating IBS. Search Methods: We searched MEDLINE, the Cochrane Central Register of Controlled Trials, EMBASE, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), the Allied and Complementary Medicine Database (AMED), Cochrane IBD/FBD Group Specialized Register,

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Cochrane Complementary Medicine Field Specialised Register and the database of the Homeopathic Library (Hom-inform) from inception to February 2013. Selection Criteria: Randomised controlled trials (RCTs), cohort and case-control studies that compared homeopathic treatment with placebo, other control treatments, or usual care, in adults with IBS were considered for inclusion. Data Collection and Analysis: Two authors independently assessed the risk of bias and extracted data. The primary outcome was global improvement in IBS. The overall quality of the evidence supporting this outcome was assessed using the GRADE criteria. We calculated the mean difference (MD) and 95% confidence interval (CI) for continuous outcomes and the risk ratio (RR) and 95% CI for dichotomous outcomes. Main Results: Three RCTs (213 participants) were included. No cohort or case-control studies were identified. Two studies published in 1976 and 1979 compared clinical homeopathy (homeopathic remedy) to placebo for constipation-predominant IBS. One study published in 1990 compared individualised homeopathic treatment (consultation plus remedy) to usual care (defined as high doses of dicyclomine hydrochloride, faecal bulking agents and diet sheets asking the patient to take a high fibre diet) for the treatment of IBS in female patients. Due to the low quality of reporting in the included studies the risk of bias in all three studies was unclear on most criteria and high for some criteria. A meta-analysis of two small studies (129 participants with constipation-predominant IBS) found a statistically significant difference in global improvement between the homeopathic remedy asafoetida and placebo at a short-term followup of two weeks. Seventy-three per cent of patients in the homeopathy group improved compared to 45% of placebo patients (RR 1.61, 95% CI 1.18 to 2.18). There was no statistically significant difference in global improvement between the homeopathic remedies asafoetida plus nux vomica and placebo. Sixty-eight per cent of patients in the homeopathy group improved compared to 52% of placebo patients (1 study, N = 42, RR 1.31, 95% CI 0.80 to 2.15). GRADE analyses rated the overall quality of the evidence for the outcome global improvement as very low due to high or unknown risk of bias, short-term follow-up and sparse data. There was no statistically significant difference found between individualised homeopathic treatment and usual care (1 RCT, N = 20) for the outcome "feeling unwell", where the participant scored how "unwell" they felt before, and after treatment (MD 0.03; 95% CI -3.16 to 3.22). None of the included studies reported on adverse events. Authors' Conclusions: A pooled analysis of two small studies suggests a possible benefit for clinical homeopathy, using the remedy asafoetida, over placebo for people with constipationpredominant IBS. These results should be interpreted with caution due to the low quality of reporting in these trials, high or unknown risk of bias, short-term follow-up, and sparse data. One small study found no statistically difference between individualized homeopathy and usual care (defined as high doses of dicyclomine hydrochloride, faecal bulking agents and diet sheets advising a high fibre diet). No conclusions can be drawn from this study due to the low number of participants and the high risk of bias in this trial. In addition, it is likely that usual care has changed since this trial was conducted. Further high quality, adequately powered RCTs are required to assess the efficacy and safety of clinical and individualised homeopathy compared to placebo or usual care. The importance of case histories for accepting and improving homeopathy. Complement Ther Med. 2013 Dec;21(6):565-70. Rutten LA. Abstract

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Case histories are necessary besides other types of evidence to convince doctors of a specific type action of homeopathic medicines. Prognosis of treatment does not merely depend on efficacy. Some considerations based on consensus meetings about best cases and prospective research into the relationship between symptoms and result. Many data in homeopathic literature are unreliable because of wrong interpretation, insufficient numbers and confirmation bias. Causal relationship between medicine and 'cure' could be documented better. Extraordinary cases are not helpful to increase reproducibility. Conclusion: For acceptance and improvement of homeopathy cases should be reproducible. 'Normal' cases reflecting daily practice contribute more to this goal than extraordinary cases. Accuracy can be increased by larger samples of comparable cases. Causal relationship between medicine and improvement should be further explored. A dynamic network model of the similia principle. Bellavite P, Olioso D, Marzotto M, Moratti E, Conforti A. Complement Ther Med. 2013 Dec;21(6):750-61. Abstract The use of drugs in high dilutions and the principle of similarity (or "similia") are two basic tenets of homeopathy. However, the plausibility of both is a subject of debate. Although several models have been proposed to explain the similia principle, it can be best understood and appreciated in the framework of complexity science and dynamic systems theory. This work applies a five-node Boolean network to show how self-organization and adaptation are relevant to rationalizing this traditional medical principle. Simulating the trajectories and attractors of the network system in the energy state-space provides a rudimentary and qualitative illustration of how targeted external perturbations can have pathological effects, leading to permanent, selfsustaining alterations. Similarly, changes that conversely enable the system to find its way back to the original state can induce therapeutic effects, by causing specific shifts in attractors when suitable conditions are satisfied. Extrapolating these mechanisms to homeopathy, we can envisage how major changes in the evolution of homeodynamic systems (and, eventually, healing of the entire body) can be achieved through carefully selected remedies that reproduce the whole symptom pattern of the ill state. Rebound effect of modern drugs: Serious adverse event unknown by health professionals. Teixeira MZ. Disciplina Fundamentos da Homeopatia, Faculdade de Medicina, Universidade de So Paulo, So Paulo, SP, Brasil. Rev Assoc Med Bras. 2013 Nov 7. pii: S0104-4230(13)00175-9. [Article in English, Portuguese] Objective: Supported in the Hippocratic aphorism primum non nocere, the bioethical principle of non-maleficence pray that the medical act cause the least damage or injury to the health of the patient, leaving it to the doctor to assess the risks of a particular therapy through knowledge of possible adverse events of drugs. Among these, the rebound effect represents a common side effect to numerous classes of modern drugs, may cause serious and fatal disorders in patients. This review aims to clarify the health professionals on clinical and epidemiological aspects of rebound phenomenon. Methods: A qualitative, exploratory and bibliographic review was held in the PubMed database using the keywords 'rebound', 'withdrawal', 'paradoxical', 'acetylsalicylic acid', 'anti-

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inflammatory', 'bronchodilator', 'antidepressant', 'statin', 'proton pump inhibitor' and 'bisphosphonate'. Results: The rebound effect occurs after discontinuation of numerous classes of drugs that act contrary to the disease disorders, exacerbating them at levels above those prior to treatment. Regardless of the disease, the drug and duration of treatment, the phenomenon manifests itself in a small proportion of susceptible individuals. However, it may cause serious and fatal adverse events should be considered a public health problem in view of the enormous consumption of drugs by population. Conclusion: Bringing together a growing and unquestionable body of evidence, the physician needs to have knowledge of the consequences of the rebound effect and how to minimize it, increasing safety in the management of modern drugs. On the other hand, this rebound can be used in a curative way, broadening the spectrum of the modern therapeutics. Keywords: Adverse effects, Efeito rebote, Efeitos adversos, Efeitos fisiolgicos de drogas, Farmacologia, Homeopathy, Homeopatia, Law of Similars, Lei dos semelhantes, Pharmacology, Physiological effects of drugs, Rebound effect Homeopathy: meta-analyses of pooled clinical data Hahn RG. Forsch Komplementmed. 2013;20(5):376-81. Research Unit, Sdertlje Hospital, Sdertlje, Sweden. In the first decade of the evidence-based era, which began in the mid-1990s, meta-analyses were used to scrutinize homeopathy for evidence of beneficial effects in medical conditions. In this review, meta-analyses including pooled data from placebo-controlled clinical trials of homeopathy and the aftermath in the form of debate articles were analyzed. In 1997 Klaus Linde and co-workers identified 89 clinical trials that showed an overall odds ratio of 2.45 in favor of homeopathy over placebo. There was a trend toward smaller benefit from studies of the highest quality, but the 10 trials with the highest Jadad score still showed homeopathy had a statistically significant effect. These results challenged academics to perform alternative analyses that, to demonstrate the lack of effect, relied on extensive exclusion of studies, often to the degree that conclusions were based on only 5-10% of the material, or on virtual data. The ultimate argument against homeopathy is the 'funnel plot' published by Aijing Shang's research group in 2005. However, the funnel plot is flawed when applied to a mixture of diseases, because studies with expected strong treatments effects are, for ethical reasons, powered lower than studies with expected weak or unclear treatment effects. To conclude that homeopathy lacks clinical effect, more than 90% of the available clinical trials had to be disregarded. Alternatively, flawed statistical methods had to be applied. Future meta-analyses should focus on the use of homeopathy in specific diseases or groups of diseases instead of pooling data from all clinical trials. 2013 S. Karger GmbH, Freiburg.

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News
Expression of Interest for Collaborative & Fundamental Research in Homeopathy There is a good news for researchers/scientists and Institutes, who are interested to undertake scientific, organized research in Homeopathy. The Central Council for Research in Homeopathy, an autonomous organization under Department of AYUSH, Govt. of India has advertised for calling Expression of Interest to undertake collaborative and fundamental research in pre-identified areas in Homeopathy. Read the full post here. Wikipedia co-founder wants to stop homeopathy After a pharmacy recommended a potentised remedy for his sore throat, Jimmy Wales, cofounder of Wikipedia, vented his thoughts on homeopathy on Quora and his desire to stop it. In a surprisingly ill-informed and slanderous manner, Jimmy said: ..homeopathy is a proven fraud. makes me ill. Homeopathic remedies of no value whatsoever are legally marketed See more at: http://homeopathyplus.com.au/wikipedia-co-founder-wants-to-stophomeopathy/#sthash.jkJd8Y03.dpuf

Abstract Submission deadline For LMHI Congress 2014 05 January 2014 The 69th annual international congress of Liga Medicorum Homeopathica Internationalis is lined up from 16 19 July 2014 in Paris, France. This year the congress will focus on various aspects of clinical practice. Congress organizers invite abstracts which must be submitted as a MS Word document (.doc or .docx) via the Online Submission System. The deadline for submitting abstracts is 05 January 2014 and authors will receive a notification e-mail by 15 March 2014. Quick Links:

Official web address of LMHI2014 Congress: http://www.lmhi2014.org Abstract Submission Link: http://abstracts.flexmax.eu/lmhi2014 Liga Medicorum Homeopathica Internationalis: http://liga.iwmh.net Technical assistance at: els@medicongress.com

New regulations for homeopathy in Spain Homeopathic products will soon get the definitive green light from the Health Ministry. A ministerial order is being readied to give the seal of approval for thousands of products that are already being sold in pharmacies thanks to a temporary permit that has, in fact, been in place nearly two decades. Read more at http://elpais.com/elpais/2013/12/06/inenglish/1386341386 _709371.html

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Events
Logon to www.audesapere.in/events for more details of following upcoming events

14 January 2014: 18 19 January 2014: 21 January 2014: 24 January 2014: 25 January 2014: 31 January 01 February 2014: February 2014: 08 March 2014: 18 March 2014: 28 March 2014:

Masterclass 6 Chronic Fatigue Syndrome Leap to the Similimum by Dr. Divya Chhabra Clinical meeting: Overview and Focus A Look at Two Cases of Bird Remedies GEMS study day 3 Master class: Womens Health Gynaecological and Sexual Health in Homeopathy National Homoeopathic Conference of Asian Homoeopathic Medical League. Northern Ireland Homeopathic Group The Role of Homeopathy in Podiatry Masterclass: Sensational Sarcodes and Nosodes The Inner Experience of Healthy or Diseased Tissue Clinical meeting for current LFHom/MFHom course students GEMS Study day 4

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