‘Successful treatment of enigmatic cases of acute inflammation ‘Ann Walker PhD MCPP MNIMH. Senior Lecierin Hunan Notion Hugh Sinclar Uni of Homan Nutrition School of Food Biosclences ms The University of Reading Diseases associated with inflammation + Infectious disease and conditions with “satis atthe end of the word + Atopic: eczema, asthma = Autoimmune + rheumatoid arts, SLE, inflammatory ‘howl disease, multiple sclerosis ete + Atherosclerosis, cancer, migraine Minor health problems related to enhanced inflammatory response = Catarth 1» Headaches * Wheezing «= Period pains 1 Dry skin 1 Breast pain Eczema 1 Fatigue ‘= Plantar fasciitis * Fluid retention = Hayfever = Allergies Urano stn | uv ——— ‘Common immune dysequilibrium Total Ipmphooyte count Normal Antibody production Increased Gutbarierfinction Decreased Tel release Decreased W-2release ‘Nonmal T6relene Increased NF Tnoreased ey 09 Ped 330382 ‘Some effects of excess TNF. Inflammation 4 Loss of lean body mass ‘% Loss of bone mass 4% Associated with atherosclerosis 4 Associated with dementia + Insulin resistance 4% Poor outcome from injury, surgery & trauma== Healthy balance of essential fatty acids ‘Two major pathways for eicosanoid production aes) Pragati trembesn Ycemcecnm) — Prenphaansirentee mr) uae ima Bioeng Dietary unsaturated fatty acids and inflammation cme tity 4| i 5 — i ne orn iy wi ye Fish oil and sheumatoid arthritis > 13 double-blind, placebo-controlled trials of fish oil supplementation for RA:- 116-67 patients each ‘Duration from 12-52 weeks “Used 1 to 6p/4 EPA + DHA (average 3.3 2/4) “All show benefit in at east two clinical scores “Some show >4 clinical benefits (e-, increased vip strength, deerease in swollen/tendes joints) ‘Thee studies monitored of NSAIDs use a8 an ‘outcome and reported significant reduction Other inflammatory conditions showing response ‘to omega-3 supplementation in clinical trials + Good evidence: «= Hyperctivity 1 Proriasis = Dyslaxie ‘Mental pin «Preliminary evidence~ 1 Bipolar inorder = Ostooporori,sronis Host disease fiiguenyneome, ‘Raynand’s aera . slp, + Colitis and Cr’ ephropay 1 Bipolar deprasion = LapurFree radical attack =DNA «Proteins @ ~e «= Fats (EFAs) Cell membranes 1 Transport systems [Diseases with free-radical involvement «= Heart and artery disease = Cancer «= Inflammatory conditions: rheumatoid arthritis, colitis + Liver damage by toxins «= Cataract and retinal damage += Tobacco-related lung conditions Nutrient antioxidants = Viumins = # ACE = Non-essential» Phytochemicals including nutrients carotenoids (e.g. beta cearotene), flavonoids ete ‘= Minerals Selenium, zine, copper, ‘manganese Some documented actions of flavonoids «Antioxidant += Oestrogenic = Diuretic «« Antiallergenic ‘= Muscle relaxant» Hypotensive = Antiinflammatory — » Membrane + Artvcancer stabilisation 1 Hearireulatory —* Antiseptic: stimulant Zutphen study: effets of food flavonoids ‘onrisk of coronary heart disease a assessed ‘by prospective epidemiology over 5 years Foods Subjects ‘Outcome Tea, onions 805 ‘Give rennton apples elderly mortality (high versus low intake) Heap eal 1988 Effects ofa dally supplement of 320 mg grape seed flavonsids (for 4 months on premenstrual symptoms in 30 women with heavy leg’ syndrome ? a nae