Mission

to prevent and cure diabetes and to improve the lives of all people affected by diabetes.

Embargoed until: Sunday, June 12 2:20 #$ %DT

Contact:

Diane Tuncer, 703-299-5510 Rachel Mor an, 703-5!9-1500, e"t 2290 NEWS ROOM June 10-14, 2005: Roo$ 17, San Die o Con&ention Center, San Die o, C' (oice )*19+ 525-*392, -a": )*19+ 525-*!00

NEW TWO-IN-ONE DRUG FOR TYPE 2 DIABETES AND LIPIDS Muraglitazar L !"r# Bl $ Glu% #" a&$ '"l(# D)#li(i$"*ia S""& i& Dia+"t"#

San Diego, CA (June 12, 2005) . ' no&el co$#ound #ro&ide/ lon -ter$ lo0erin o1 2lood luco/e le&el/ and i$#ro&e/ #la/$a li#id/ )1at/+ that are o1ten a #ro2le$ in #eo#le 0ith ty#e 2 dia2ete/ . all in a oncedaily #ill, accordin to a re#ort #re/ented here today at the '$erican Dia2ete/ '//ociation3/ *5th 'nnual Scienti1ic Se//ion/4 5Mura lita6ar #ro&ided e11ecti&e and dura2le 2lood luco/e lo0erin o&er t0o year/, and al/o

/i ni1icantly lo0er/ tri lyceride/, non-7D8-C, and a#oli#o#rotein 9, a/ 0ell a/ rai/in 7D8-C, all o1 0hich $ay reduce the ri/: o1 cardio&a/cular di/ea/e in #eo#le 0ith ty#e 2 dia2ete/,; /aid Da&id <endall, MD, Chie1 o1 Clinical Ser&ice/ and Medical Director o1 the =nternational Dia2ete/ Center and '//ociate %ro1e//or o1 Medicine at the >ni&er/ity o1 Minne/ota Medical School, in a recent inter&ie04 5-urther, $ura lita6ar achie&ed the/e oal/ 0ith only one #ill a day, 0hich $a:e/ it ea/ier 1or #eo#le 0ith ty#e 2 dia2ete/ to $ana e $ulti#le health #ro2le$/ and $ay enhance #atient co$#liance,; he e"#lained4 Mura lita6ar tar et/ the #ero"i/o$e #roli1erator-acti&ated rece#tor/ )%%'R/+4 'cti&ator dru / /uch a/ $ura lita6ar are 5:ey/; that 1it into rece#tor 5loc:/,; chan in cell 1unction4 'cti&ator dru / that tar et %%'Ra$$a )the lita6one/+, 0hich i/ a//ociated 0ith i$#ro&e$ent/ in in/ulin /en/iti&ity and lyce$ic control, ha&e lon 2een /ucce//1ully u/ed to treat ty#e 2 dia2ete/4 Mura lita6ar tar et/ %%'R- a$$a a/ 0ell a/ %%'R-al#ha, 0hich i/ a//ociated 0ith re ulation o1 li#id/ )2lood 1at/+4 '/ a dual %%'R acti&ator, $ura lita6ar 2eco$e/ the 1ir/t o1 a no&el 5 lita6ar; cla//4 - $ore -

National Office 1701 North Beauregard Street Ale andria! "A ##$11 %el& '70$( )*+,1)00
-or .iabetes /nformation 0all 1,100,./AB2%2S diabetes.org The Association gratefully accepts gift through your will.

Mission
to prevent and cure diabetes and to improve the lives of all people affected by diabetes.

Muraglitazar Page 2

More than 1? $illion '$erican/ ha&e dia2ete/, a rou# o1 /eriou/ di/ea/e/ characteri6ed 2y hi h 2lood luco/e le&el/ that re/ult 1ro$ de1ect/ in the 2ody3/ a2ility to #roduce and@or u/e in/ulin4 Dia2ete/ can lead to /e&erely de2ilitatin or 1atal co$#lication/, /uch a/ heart di/ea/e, 2lindne//, :idney di/ea/e, and a$#utation/4 =t i/ the 1i1th leadin cau/e o1 death 2y di/ea/e in the >4S4 Ty#e 2 dia2ete/ in&ol&e/ in/ulin re/i/tance . the 2odyA/ ina2ility to #ro#erly u/e it/ o0n in/ulin4 =t u/ually occur/ in tho/e 0ho are o&er !5 and o&er0ei ht, 2ut it ha/ increa/in ly 2een /een in o2e/e children and teen/ in recent year/4 Dr4 <endall re#orted on /e&eral /tudie/ 0ith $ura lita6ar4 =nitially, a dou2le-2lind do/in trial 0a/ done4 =t in&ol&ed 9?5 #atient/ i&en, 2y rando$ /election, one o1 1i&e di11erent once-daily do/e/ o1 $ura lita6ar )045 - 20 $ 4+ or #io lita6one 15 $ 4 'll #artici#ant/ 0ere in their $id-50/, enerally o2e/e, and had dia2ete/ 1or 1i&e to /i" year/4 The rou# 0a/ rou hly 2alanced 2et0een $en and 0o$en4 't the initiation o1 the /tudy, all had inadeBuate 2lood luco/e control on diet and e"erci/e4 9a/ed on thi/ /tudy, the 5 $ 4 do/e 0a/ /elected 1or 1urther /tudy4 Thi/ /hort-ter$, 2!-0ee: do/in trial al/o 0a/ the 2a/e 1ro$ 0hich the /u2Cect/ 1or the ne"t trial 0ere e"tracted4

D--DCT=(DEDSS 'ED D>R'9=8=TF G- H8FCDM=C CGETRG8 ' #re-#lanned o#en /tudy o1 the dura2ility o1 $ura lita6ar dre0 on 157 #eo#le 0ho had 2een in the do/in trial and had #re&iou/ly 2een in the 5 $ 4 ar$4 G1 the/e 157, /u2/eBuently 3* 0ithdre0 1ro$ the /tudy, and 33 0ere una2le to achie&e adeBuate control o1 luco/e at 5 $ 4 The re$ainin ?? #artici#ant/ 0ho continued on 5 $ 4 1or the entire t0o-year trial achie&ed &ery ti ht control o1 2lood luco/e le&el/4

- $ore -

National Office 1701 North Beauregard Street Ale andria! "A ##$11 %el& '70$( )*+,1)00
-or .iabetes /nformation 0all 1,100,./AB2%2S diabetes.org The Association gratefully accepts gift through your will.

Mission
to prevent and cure diabetes and to improve the lives of all people affected by diabetes.

Muraglitazar Page 3

5The #atient/ on $ura lita6ar 0ent 1ro$ #oor control . an a&era e '1C o1 ?40 #ercent . to an e"cellent le&el o1 control . an a&era e o1 *45 #ercent 2y the 20th 0ee: . and then $aintained that le&el o1 control o&er t0o year/,; re#orted Dr4 <endall4 The '$erican Dia2ete/ '//ociationA/ reco$$ended '1C tar et in ty#e 2 dia2ete/ i/ under 740 #ercent4 5=t i/ 0ell :no0n that ty#e 2 dia2ete/ i/ a #ro re//i&e di/ea/e and deterioration in control i/ co$$only o2/er&ed in #eo#le 0ho are treated 0ith con&entional luco/e-lo0erin thera#ie/, /uch a/ the /ul1onylurea/ and $et1or$in,; noted Dr4 <endall4 57o0e&er, $edication/ that tar et in/ulin re/i/tance, /uch a/ the %%'R- a$$a acti&ator/, $ay i$#ro&e the a2ility o1 the 2eta cell/ in the #ancrea/ to /ecrete in/ulin 0hich hel#/ #atient/ to achie&e their luco/e control oal/ and /u/tain the$ o&er ti$e4;

CGETRG8 G- 8=%=DS ' ty#e o1 dy/li#ide$ia co$$only /een in #eo#le 0ith ty#e 2 dia2ete/ i/ a clu/ter o1 a2nor$alitie/ includin : ele&ated tri lyceride/, reduced le&el/ o1 7D8 chole/terol, and a /hi1t to0ard /$aller and den/er 8D8chole/terol #article/, althou h total and 8D8 chole/terol le&el/ $ay 2e nor$al or ele&ated4 ' nu$2er o1 the/e #ro2le$/ /ee$ed to 2e i$#ro&ed 2y $ura lita6ar4 =n the ne"t /tudy re#orted 2y Dr4 <endall, the dru 0a/ e&aluated in 1,159 #atient/ 0ith ty#e 2 dia2ete/, all o1 0ho$ 0ere ta:in the anti-dia2ete/ dru $et1or$in4 'll continued to ta:e $et1or$in 2ut 0ere al/o rando$i6ed in dou2le-2lind, rando$i6ed 1a/hion to recei&e either 5 $ 4 $ura lita6ar or 30 $ 4 #io lita6one )0hich acti&ate/ only %%'R a$$a+ once daily4 '1ter 2! 0ee:/, the $ura lita6ar rou# lo0ered 2lood luco/e 2y 141! #ercent &/4 04?5 #ercent 1or the #io lita6one rou#4

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National Office 1701 North Beauregard Street Ale andria! "A ##$11 %el& '70$( )*+,1)00
-or .iabetes /nformation 0all 1,100,./AB2%2S diabetes.org The Association gratefully accepts gift through your will.

Mission
to prevent and cure diabetes and to improve the lives of all people affected by diabetes.

Muraglitazar Page 4

-urther, the di11erence/ in li#id/ 0ere al/o reater 1or $ura lita6ar &/4 #io lita6one, re/#ecti&ely: . . . tri lyceride/: -2?4! #ercent &/4 -134! #ercent, 7D8-C )the 5 ood; chole/terol+: I1942 #ercent &/4 I134* #ercent, non-7D8-C )8D8, the 52ad; chole/terol, #lu/ the chole/terol contained in tri lyceride-rich li#id #article/+: -549 #ercent &/4 -142 #ercent, . a#oli#o#rotein 9 )a #rotein 1ound in i$#ortant li#id #article/+: -114? #ercent &/4 -*40 #ercent4

5Mura lita6ar treat$ent re/ulted in reater i$#ro&e$ent in 2oth luco/e control and li#id/ 0hen added to $et1or$in 0hen co$#ared to #io lita6one #lu/ $et1or$in,; e$#ha/i6ed Dr4 <endall4 9oth luco/e control and dy/li#ide$ia are 2elie&ed to #lay an i$#ortant role in the reater ri/: o1 heart attac:/ and /tro:e/ /een in #eo#le 0ith dia2ete/4

S=DD D--DCTS The $o/t co$$on /ide e11ect/ /een in the trial/ 0ere ede$a that occurred in 5 #ercent to ? #ercent o1 the dura2ility /tudy #artici#ant/, a/ 0ell a/ 0ei ht ain o1 2 l2/4 to 10 l2/4 Dr4 <endall e"#lained that 0ei ht ain i/ ty#ical 0ith co$$only u/ed dia2ete/ treat$ent/ 2ecau/e a/ 2lood luco/e le&el/ i$#ro&e, the calorie/ circulatin a/ luco/e are a&aila2le to 2e /tored in cell/ 1or later u/e, unle// they are #ro$#tly 2urned 1or ener y4 The '$erican Dia2ete/ '//ociation i/ the nation3/ leadin &oluntary health or ani6ation /u##ortin dia2ete/ re/earch, in1or$ation and ad&ocacy4 -ounded in 19!0, the '//ociation ha/ o11ice/ in e&ery re ion o1 the country, #ro&idin /er&ice/ to hundred/ o1 co$$unitie/4 -or $ore in1or$ation, #lea/e call the '$erican Dia2ete/ '//ociation at 1-?00-D='9DTDS )1-?00-3!2-23?3+ or &i/it 0004dia2ete/4or 4 =n1or$ation 1ro$ 2oth the/e /ource/ i/ a&aila2le in Dn li/h and S#ani/h4 JJJ 8ate-9rea:in Clinical Trial/ Sy$#o/iu$
National Office 1701 North Beauregard Street Ale andria! "A ##$11 %el& '70$( )*+,1)00
-or .iabetes /nformation 0all 1,100,./AB2%2S diabetes.org The Association gratefully accepts gift through your will.