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  • Reaction Mechanism VCMP

    Transféré par

    LoveSahilSharma
    111 vues3 pages
    This document provides an overview of common organic reaction mechanisms including SN1, SN2, E1, E2, and Hoffman elimination reactions. It describes the key features of each reaction such as whether they proceed in one or two steps, if they involve carbocation intermediates, and if they result in rearrangement, inversion, or retention of configuration. Rate laws and selectivity are discussed for different substrate structures. The document also lists common reaction conditions and reagents that promote each type of mechanism.

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    Resonance reaxn mechanism-VCMP

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    This document provides an overview of common organic reaction mechanisms including SN1, SN2, E1, E2, and Hoffman elimination reactions. It describes the key features of each reaction such as whether they proceed in one or two steps, if they involve carbocation intermediates, and if they result in rearrangement, inversion, or retention of configuration. Rate laws and selectivity are discussed for different substrate structures. The document also lists common reaction conditions and reagents that promote each type of mechanism.

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    Attribution Non-Commercial (BY-NC)
    Téléchargez comme PDF, TXT ou lisez en ligne sur Scribd
    Signaler comme contenu inapproprié
    111 vues3 pages

    Reaction Mechanism VCMP

    Transféré par

    LoveSahilSharma
    This document provides an overview of common organic reaction mechanisms including SN1, SN2, E1, E2, and Hoffman elimination reactions. It describes the key features of each reaction such as whether they proceed in one or two steps, if they involve carbocation intermediates, and if they result in rearrangement, inversion, or retention of configuration. Rate laws and selectivity are discussed for different substrate structures. The document also lists common reaction conditions and reagents that promote each type of mechanism.

    Droits d'auteur :

    Attribution Non-Commercial (BY-NC)
    Téléchargez comme PDF, TXT ou lisez en ligne sur Scribd
    Signaler comme contenu inapproprié
    sur 3

    ASSIGNMENT CHEMISTRY

    (ENGLISH) COURSE : SANKALP (VCMP)

    REACTION MECHANISM
    Reaction Mechanism :
    Substrate (Alkyl Halides) CH3 X 1 R X Reagent Dominating Mechanism SN2 SN2 Major

    Any nucleophile Any nucleophile (except hindered base) *Hindered base give E-2 reaction.

    2 R X

    Strong nucleophile ( SH , RS I , Br , Cl , CN ,NH3, OAc )

    ! !

    SN2 Major > E-2 minor

    2 R X 2 R X 3 R X

    Strong base ( NH2 , Alc.KOH,MeO, EtO, tBuO, Et3N) Weak nucleophile + Polar Protic solvent (H2O, ROH, RCOOH) Strong nucleophile ( SH , RS I , Br , Cl , OAc )

    ! ! !

    E2 Major > SN2 minor SN1 > E-1 No reaction

    3 R X 3 R X Substrate (Alcohol) ROH (3 2 &1 with " -branch) ROH (1 without "-branch) ROH (1>2>3) ROH (1>2>3) ROH (3>2>1) ROH ROH

    Strong base ( NH2 , alc. KOH, MeO, EtO, t-BuO, Et3N,OH) Weak nucleophile or weak base (H2O, ROH, RCOOH) Reagent

    E-2 Only SN1 > E-1 Dominating Mechanism SN1

    HI, HBr, HCl / ZnCl2 HI, HBr, HCl

    SN2

    PX3, PX5, P4+ X2, SOCl2/Base SOCl2 without base Conc.H2SO4,H3PO4,HClO4, KHSO4/# Al2O3/#, P2O5/# (Saytzeff elimination without rearrangement) dehydration reaction ThO2/#, WO3/# (Hoffmann elimination without rearrangement) dehydration reaction

    SN2 SNi [Retention] E-1 (Saytzeff)

    RESONANCE

    PAGE - 1

    Important feature of reaction mechanism SN1 SN2 Two steps process/Intermediate C+/Rearrangement/Weak Nu./PPS/Racemisation/ Rate : 3 > 2 > 1 or (Stability of C+),Ag+ $ One step process/No intermediate/No rearrangement/Strong Nu/PAS/Inversion at %-carbon/ Rate : CH3 X > 1RX > 2 R X/Stereospecific reaction. E1 Two step process/Intermediate C+/Rearrangement/Weak base/#/Regioselective reaction saytzeff alkene (more branched) major. Rate : 3 > 2 > 1 or (Stability of C+) E2 One step process/No rearr./Strong base, #/Regioselective, Regiospecific, stereoselective, stereospecific, antielimination reaction. ! Kinetic primary isotopic effect is observed. ! Rate of E-2 : 3 > 2 > 1 ! Smaller base & Saytzeff alkene ! Big base & Hofmann alkene. E1 cB Two step/Intermediate C!/Hofmann elimination product. ! Regioselective, stereospecific, anti elimination reaction. ! Dexchange at "-carbon.
    ' '

    ! Condition : More acidic " -H or e.g. (F, NR 3 , SR 2 ) or EWG at " position. Condition for Hofmann elimination : (1) Hindered strong base (2) Poor leaving group.
    ' '

    (3) When Strong I groups behave as leaving group. (F, NR 3 SR 2 ) (4) When()-carbon is quaternary.

    RESONANCE

    PAGE - 2

    RESONANCE

    PAGE - 3

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