Code No: RR322303 Set No.

1
III B.Tech II Semester Supplimentary Examinations, Aug/Sep 2007
BIO-INFORMATICS
(Bio-Technology)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
⋆⋆⋆⋆⋆

1. What is Bioinformatics? Describe its scope in modern biology? [16]

2. Write short notes on:

(a) Gapped BLAST

(b) PSI-BLAST
(c) BLAST (2) [16]

3. What is multiple sequence alignment? Describe the applications of multiple se-

quence alignments? [16]

4. Describe the following:

(a) Structural classifications of proteins

(b) The CATH (Class, Architecture, Topology, Homology) databases [16]

5. Explain Database searching with Smith-waterman Dynamic programming method?

[16]

6. Describe about Phylogenetic tree construction by using UPGMA method? [16]

7. Define Genome? Outline the structure and composition of prokaryotic and Eukary-
otic genomes? [16]

8. Write short notes on:

(a) GRAIL II
(b) ORF [16]

⋆⋆⋆⋆⋆

1 of 1
Code No: RR322303 Set No. 2
III B.Tech II Semester Supplimentary Examinations, Aug/Sep 2007
BIO-INFORMATICS
(Bio-Technology)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
⋆⋆⋆⋆⋆

1. Describe the following:

(a) Uniform Resource Locator (URL)

(b) Role of Internet in Bioinformatics [16]

2. Write a note on Parametric sequence alignment? [16]

3. How to multiply Aligned sequences and assessing quality of alignment? [16]

4. Define Secondary databases? Give an overview of secondary databases? [16]

5. What is Block Substitution Matrices (BLOSUM)? Describe them in detail? [16]

6. Write short notes on:

(a) Star decomposition

(b) PHYLIP programs [16]

7. Define Genome? Outline the structure and composition of prokaryotic and Eukary-
otic genomes? [16]

8. Write an essay on gene Prediction in Eukaryotes? [16]

⋆⋆⋆⋆⋆

1 of 1
Code No: RR322303 Set No. 3
III B.Tech II Semester Supplimentary Examinations, Aug/Sep 2007
BIO-INFORMATICS
(Bio-Technology)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
⋆⋆⋆⋆⋆

1. What are the basic Computer skills required for Bioinformatician? Write elemen-
tary commands in Linux operating system? [16]

2. Explain about different BLAST programs in detail with a neat flow charts and how
are they useful? [16]

3. How to multiply Aligned sequences and assessing quality of alignment? [16]

4. Write short notes on:

(a) Tr-EMBL
(b) P-fam [16]

5. Name the Database search algorithm employed in alignment of sequences and ex-
plain in detail about any one of it? [16]

6. Discuss in detail about Character based methods in phylogenetic Analysis? [16]

7. Describe briefly about different types of Gene mapping? [16]

8. Write short notes on:

(a) GRAIL II
(b) ORF [16]

⋆⋆⋆⋆⋆

1 of 1
Code No: RR322303 Set No. 4
III B.Tech II Semester Supplimentary Examinations, Aug/Sep 2007
BIO-INFORMATICS
(Bio-Technology)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
⋆⋆⋆⋆⋆

1. Write short notes on the following:

(a) Domain and Domain name

(b) Modem
(c) Routers
(d) FQDN [16]

2. Describe the following:

(a) Importance of GAPs and GAP penalties in sequence alignment

(b) Edit distance of two strings
(c) Dot matrix Analysis [16]

3. What is a multiple alignment and why we do it? [16]

4. Write short notes on:

(a) PDB
(b) SCOP [16]

5. What is Block Substitution Matrices (BLOSUM)? Describe them in detail? [16]

6. Describe about Phylogenetic tree construction by using UPGMA method? [16]

7. Write short notes on:

(a) Computer tools for sequencing

(b) DNA fingerprinting [16]

8. Write short notes on:

(a) GRAIL II
(b) ORF [16]

⋆⋆⋆⋆⋆

1 of 1