<p class="nojs"> <strong>Warning:</strong> The NCBI web site requires JavaScript to function. <a href="http://www.ncbi.nlm.nih.gov/corehtml/query/static/unsupported-browser.

html#enablejs" title="Learn how to enable JavaScript" target="_blank">more...</a> </p>

NCBI kip to main content kip to navigation Resources All Resources Chemicals & Bioassays BioSystems PubChem BioAssay PubChem Compound PubChem Structure Search PubChem Substance All Chemicals & Bioassays Resources... DNA & RNA

BLAST (Basic Local Alignment Search Tool) BLAST (Stand-alone) E-Utilities GenBank GenBank: BankIt GenBank: Sequin GenBank: tbl2asn Genome Workbench Influenza Virus Nucleotide Database PopSet Primer-BLAST ProSplign Reference Sequence (RefSeq) RefSeqGene

Sequence Read Archive (SRA) Splign Trace Archive UniGene UniSTS All DNA & RNA Resources... Data & Software BLAST (Basic Local Alignment Search Tool) BLAST (Stand-alone) Cn3D Conserved Domain Search Service (CD Search) E-Utilities GenBank: BankIt GenBank: Sequin

GenBank: tbl2asn Genome ProtMap Genome Workbench Primer-BLAST ProSplign PubChem Structure Search SNP Submission Tool Splign Vector Alignment Search Tool (VAST) All Data & Software Resources... Domains & Structures BioSystems Cn3D Conserved Domain Database (CDD)

Conserved Domain Search Service (CD Search) Structure (Molecular Modeling Database) Vector Alignment Search Tool (VAST) All Domains & Structures Resources... Genes & Expression BioSystems Database of Genotypes and Phenotypes (dbGaP) E-Utilities Gene Gene Expression Omnibus (GEO) Database

Gene Expression Omnibus (GEO) Datasets Gene Expression Omnibus (GEO) Profiles Genome Workbench HomoloGene Map Viewer Online Mendelian Inheritance in Man (OMIM) RefSeqGene UniGene All Genes & Expression Resources... Genetics & Medicine Bookshelf

Database of Genotypes and Phenotypes (dbGaP) Genetic Testing Registry Influenza Virus Map Viewer Online Mendelian Inheritance in Man (OMIM) PubMed PubMed Central (PMC) PubMed Clinical Queries RefSeqGene All Genetics & Medicine Resources... Genomes & Maps Database of Genomic Structural Variation (dbVar)

GenBank: tbl2asn Genome Genome Project Genome ProtMap Genome Workbench Influenza Virus Map Viewer Nucleotide Database PopSet ProSplign Sequence Read Archive (SRA) Splign Trace Archive UniSTS All Genomes & Maps Resources... Homology

BLAST (Basic Local Alignment Search Tool) BLAST (Stand-alone) BLAST Link (BLink) Conserved Domain Database (CDD) Conserved Domain Search Service (CD Search) Genome ProtMap HomoloGene Protein Clusters All Homology Resources... Literature Bookshelf E-Utilities Journals in NCBI Databases

MeSH Database NCBI Handbook NCBI Help Manual NCBI News PubMed PubMed Central (PMC) PubMed Clinical Queries PubMed Health All Literature Resources... Proteins BioSystems BLAST (Basic Local Alignment Search Tool) BLAST (Stand-alone) BLAST Link (BLink)

Conserved Domain Database (CDD) Conserved Domain Search Service (CD Search) E-Utilities ProSplign Protein Clusters Protein Database Reference Sequence (RefSeq) All Proteins Resources... Sequence Analysis BLAST (Basic Local Alignment Search Tool) BLAST (Stand-alone) BLAST Link (BLink)

Conserved Domain Search Service (CD Search) Genome ProtMap Genome Workbench Influenza Virus Primer-BLAST ProSplign Splign All Sequence Analysis Resources... Taxonomy Taxonomy Taxonomy Browser Taxonomy Common Tree All Taxonomy Resources... Training & Tutorials

NCBI Education Page NCBI Handbook NCBI Help Manual NCBI News Science Primer All Training & Tutorials Resources... Variation Database of Genomic Structural Variation (dbVar) Database of Genotypes and Phenotypes (dbGaP) Database of Single Nucleotide Polymorphisms (dbSNP) SNP Submission Tool All Variation Resources...

How To All How To Chemicals & Bioassays DNA & RNA Data & Software Domains & Structures Genes & Expression Genetics & Medicine Genomes & Maps Homology Literature Proteins Sequence Analysis Taxonomy Training & Tutorials Variation

bout NCBI Accesskeys Sign in to NCBI

PubMed
US National Library of MedicineNational Institutes of Health

Search database Search term Search

PubMed

results

Advanced Help

esult Filters
Display Settings: Abstract Send to:
abstract abstract abstract 20 20

1
1

false

Adv Biochem Eng Biotechnol. 2008;111:187-228. doi: 10.1007/10_2008_103.

Production of secondary metabolites using plant cell cultures.

Smetanska I.

Source
Department of Methods in Food Biotechnology, Berlin University of Technology, 14195, Berlin, Germany. iryna.m.smetanska@tu-berlin.de

Abstract
Plant cell cultures represent a potential source of valuable secondary metabolites which can be used as food additives, nutraceuticals, and pharmaceuticals. The synthesis of phytochemicals by the cell cultures in contrast to these in plants is independent of environmental conditions and quality fluctuations. In many cases, the chemical synthesis of metabolites is not possible or economically feasible. Moreover, the

natural food additives are better accepted by consumers in contrast to those which are artificially produced. In this chapter, the process for obtaining the secondary metabolites from plant cell cultures is represented as a multi-stage strategy, and each link should be described according to specifications of cell cultures or products. For the establishing of high-producing and fast-growing cell lines, the parent plants should be selected. The expression of synthetic pathways can be influenced by environmental conditions, the supply of precursors, and the application of elicitors, and it can be altered by special treatments such as biotransformation and immobilization. The efficiency of bioprocessing can be increased by the simplification of methods for product recovery, based on the principle of continuous product release into the cultivation media. This can be induced through influencing membrane permeability by chemical or physical factors, e.g., high electric field pulses. The combined research in the fields of establishment of in vitro cultures, targeting of metabolite synthesis, and development of technologies for product recovery can exploit the potential of plant cells as sources of secondary metabolites. PMID: 18594786 [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types Review

MeSH Terms Biotechnology/methods* Cell Culture Techniques/methods* Plant Proteins/isolation & purification* Plant Proteins/metabolism* Plants/metabolism*

Substances Plant Proteins

LinkOut - more resources

Full Text Sources Springer

Other Literature Sources COS Scholar Universe Labome Researcher Resource - ExactAntigen/Labome
2008/7/3

18594786

upplemental Content

Save items
Add to FavoritesView more options loading Create collection... Manage collections...

Related citations in PubMed

Review Exudation: an expanding technique for continuous production and release of secondary metabolites from plant cell suspension and hairy root cultures.[Plant Cell Rep. 2012] Review Bioprocessing of plant cell cultures for mass production of targeted compounds.[Appl Microbiol Biotechnol. 2009] Review Hairy root culture for mass-production of high-value secondary metabolites.[Crit Rev Biotechnol. 2007] Review Adventitious roots and secondary metabolism.[Sheng Wu Gong Cheng Xue Bao. 2...] Review Use of plant cell cultures in biotechnology.[Biotechnol Annu Rev. 1998]

See reviews...See all...

Cited by 5 PubMed Central articles

Metabolomics Analysis and Biosynthesis of Rosmarinic Acid in Agastache rugosa Kuntze Treated with Methyl Jasmonate.[PLoS One. 2013] Deep Sequencing Reveals Transcriptome Re-Programming of Taxus media Cells to the Elicitation with Methyl Jasmonate.[PLoS One. 2013] Current approaches toward production of secondary plant metabolites.[J Pharm Bioallied Sci. 2012]

See all...

Related information
Related Citations Cited in PMC

Recent activity

Clear Turn Off Turn On Production of secondary metabolites using plant cell cultures.

PubMed PRODUCTION OF SECONDARY METABOLITE (1161)

PubMed SECONDARY METABOLITE (4212)

PubMed SECONDARY METABOLITE (28592)

PMC Current approaches toward production of secondary plant metabolites

PMC Your browsing activity is empty. Activity recording is turned off. Turn recording back on
See more...

You are here: NCBI > Literature > PubMed

Write to the Help Desk<img alt="" src="/stat?jsdisabled=true&ncbi_app=ent rez&ncbi_db=pubmed&ncbi_pdid=abstra ct&ncbi_phid=396F16101B12E5A100000 000005D6703" />

imple NCBI Directory

GETTING STARTED
NCBI Education NCBI Help Manual NCBI Handbook Training & Tutorials

RESOURCES
Chemicals & Bioassays Data & Software DNA & RNA Domains & Structures Genes & Expression Genetics & Medicine Genomes & Maps Homology Literature

Proteins Sequence Analysis Taxonomy Training & Tutorials Variation

POPULAR
PubMed Nucleotide BLAST PubMed Central Gene Bookshelf Protein OMIM Genome SNP Structure

FEATURED
Genetic Testing Registry PubMed Health GenBank Reference Sequences

Map Viewer Human Genome Mouse Genome Influenza Virus Primer-BLAST Sequence Read Archive

NCBI INFORMATION
About NCBI Research at NCBI NCBI Newsletter NCBI FTP Site NCBI on Facebook NCBI on Twitter NCBI on YouTube NLM NIH DHHS USA.gov Copyright | Disclaimer | Privacy | Browsers | Accessibility | Contact National Center for Biotechnology Information, U.S. National Library of

Medicine8600 Rockville Pike, BethesdaMD, 20894USA

pubmed pubmed 5

EntrezSystem2

pubmed

396B39211B12C2 /projects/entrez/p