D-Mannose & Bladder Infection

The Natural Alternative to Antibiotics

Jonathan V. Wright, M.D. And Lane Lenard, Ph.D. Published by Dragon Art 366 6 3!nd Avenue "outheast Auburn# $ashington %&''( )a* +!,3-&- -!6-(c)2001 Jonathan V. Wright, M.D. All Rights Reserved IS ! !o. 0"#$1%&00"0"&

D-Mannose. The Natural Alternative to Antibiotics for /rinary Tract Infections

In this 'oo(let, )e descri'e a co*+letel, nat-ral a++roach to treating ./I that involves the -se o0 the si*+le s-gar D-0annose, a close co-sin o0 D"gl-cose. When ta(en ', *o-th, relativel, large 1-antities o0 D"*annose can c-re *ore than #02 o0 all ./Is )ithin one to t)o da,s. 3ven *ore re*ar(a'l,, D-0annose acco*+lishes this 0eat )itho-t (illing a single 'acteri-*4 5es, ,o- read that correctl,. D-0annose cures /TIs# but it doesn1t 2ill bacteria3 6o) D"*annose acco*+lishes this s-'stantial 0eat )ill 'e e7+lained later. S-00ice it to sa, that, 'eca-se it gets rid o0 ./I"ca-sing 'acteria )itho-t co**itting 8'acteria"cide,9 +eo+le )ho -se it s-00er none o0 the -n)anted side e00ects o0 anti'iotics: no ;I side e00ects, no ,east in0ections, no resistance. In 0act, D"*annose has no adverse side e00ects o0 an, (ind. And as a 'on-s, it act-all, tastes good. Where a 8s+oon0-l o0 s-gar9 hel+ed the *edicine go do)n in Mar, <o++ins= da,, )ith D"*annose 0or ./Is, a s+oon0-l o0 s-gar is the *edicine. eca-se it is so e00ective and so 'enign, )o*en (even +regnant )o*en) )ho are s-sce+ti'le to rec-rrent ./Is can sa0el, ta(e D"*annose as a +reventative *eas-re to head o00 0-t-re attac(s. D"*annose is also ideall, s-ited 0or children )ith ./I. eca-se it tastes so good (it is a s-gar, a0ter all4), children act-all, en>o, ta(ing it. Altho-gh D"*annose is virt-all, -n(no)n to +ractitioners o0 conventional *edicine, *an, research re+orts have de*onstrated its *ode o0 action and e00ectiveness against E. coli,? the *icroorganis* that ca-ses *ost ./Is. Moreover, nearl, 1@ ,ears o0 clinical e7+erience have sho)n that it is >-st a'o-t as e00ective at c-ring ./Is as anti'iotic dr-gs. At 0irst glance D"*annose *a, so-nd too good to 'e tr-e: a 8*edicine9 that=s highl, e00ective, +er0ectl, sa0e, +leasant to -se, ine7+ensive, and availa'le )itho-t a doctor=s

+rescri+tion. 5es, it is tr-e4 .nli(e virt-all, an, conventional *edication, and *an, nat-ral or 8alternative9 treat*ents as )ell, D"*annose has no (no)n dra)'ac(s. I0 ,o- or so*eone ,o- love has a ./I or is +rone to rec-rrent ./Is, )e -rge ,o- to read this 'oo(let and then tr, D"*annose. Adds are ,o-=ll soon 0ind that ./Is B and anti'iotics B are a thing o0 the +ast.

The "tory of A0y

A*, )as not ,et 0ive ,ears old )hen her *other 'ro-ght her to the /aho*a Clinic in the late 1#D0s. A*,=s *other also 'ro-ght )ith her a ver, detailed set o0 note'oo(s in )hich she=d recorded descri+tions o0 her da-ghter=s n-*ero-s hos+italisations and e7tensive tests 0or nearl, contin-o-s -rinar, tract in0ections (./Is). , act-al co-nt, A*, had 'een seen ', $2 di00erent +h,sicians, and had 'een on anti'iotics 0or *ost o0 her short li0e. 37tensive tests sho)ed 8nor*al (idne,s, -reters, and 'ladder9 )ith no a++arent reason 0or all the in0ection. !evertheless, these doctors had told A*,=s *other and 0ather that the, )ere 8r-nning o-t o0 e00ective anti'iotics,9 and that she )o-ld li(el, need a (idne, trans+lant d-ring the ne7t 0e) ,ears, 'eca-se her (idne,s )ere 'eginning to 0ail 0ro* the chronic in0ection. Eort-natel,, Mo* also had records o0 A*,=s *an, -rine 'acterial c-lt-res, all o0 )hich sho)ed the sa*e 'acteria: E. coli. At the end o0 o-r cons-ltation, I advised her *other to give A*, F to 1 teas+oon (a++ro7i*atel, F to 1 gra*) o0 D"*annose +o)der stirred into a glass o0 )ater ever, t)o to three ho-rs, e7ce+t )hen she )as slee+ing.
A note about ter0inology. In this 'oo(let, )e -se the general ter* 8./I9 (-rinar, tract in0ection) to re0er to an, in0ection o0 the 'ladder, -reters, or (idne,s. /he *a>orit, o0 -s are *ore 0a*iliar )ith the ter* bladder infection , )hich re0ers to the *ost co**on 0or* o0 ./I. Still, all these in0ections have a si*ilar origin and are t,+icall, treated the sa*e )a,.

Des+ite 'eing a 'it d-'io-s that a si*+le s-gar +rescri'ed ', a 8nat-ral *edicine9 doctor (re*e*'er, this )as the 1#D0s) )o-ld do an,thing, she tried it. Within GD ho-rs, A*,=s in0ection vanished. She re*ained in0ection 0ree 0or over t)o ,ears, rela+sing onl, )hen her 0a*il, 0orgot to ta(e the D"*annose )ith the* on vacation. When she res-*ed ta(ing it, the in0ection i**ediatel, cleared. Aver the ne7t ten ,ears or so, A*, has had no 0-rther ./Is and, o0 co-rse, has (e+t her (idne,s. Altho-gh A*,=s case is e7tre*e, ./I re*ains a co**on and distressing disease that a00ects -+ to @02 o0 all )o*en and girls (and a *-ch s*aller n-*'er o0 *en and 'o,s) over the co-rse o0 a li0eti*e. 3ach ,ear, ./Is are res+onsi'le 0or 10 *illion doctor visits. So*e +eo+le see* to 'e *ore s-sce+ti'le than othersH )o*en )ho have s-00ered one ./I are ver, li(el, to e7+erience a rec-rrence 0ro* ti*e to ti*e. 1"G So*e ./Is are *erel, +ain0-l (so*eti*es ver, +ain0-l) and anno,ing. 6o)ever, as A*,=s case ill-strates, other ./Is B es+eciall, i0 the,=re chronic, rec-rrent, or not treated +ro*+tl, and +ro+erl, B can 'e 1-ite dangero-s. .nder these conditions, 'acteria *a, ascent to the (idne,s, )here in0ection can lead to serio-s da*age and even (idne, 0ail-re.

Conventional *edical treat*ent o0 ./Is involves the -se o0 anti'iotics. While these dr-gs are -s-all, B '-t not al)a,s B e00ective, c-ring *ost in0ections in a 0e) da,s, the, also have so*e i*+ortant dra)'ac(s: Anti'iotics are e1-al"o++ort-nit, *icro'e (illers. Altho-gh the, -s-all, *a(e 1-ic( )or( o0 the ./I"ca-sing '-gs, the, don=t >-st sto+ there. /he, also (ill *illions o0 other 80riendl,9 'acteria that 'elong in the 'od, )here the, serve n-*ero-s i*+ortant 0-nctions. eca-se the, (ill o00 8friendly 9 'acteria living in the gastrointestinal (;I) tract, anti'iotics can ca-se -n)anted side e00ects, s-ch as diarrhoea, consti+ation, na-sea and occasionall,, vo*iting. I0 eno-gh 0riendl, 'acteria are (illed, 8not"so"0riendl,9 ,easts, *o-lds, and 'acteria B all o0 )hich can +rod-ce -n)anted to7ins B are enco-raged to ta(e their +laces. Since 0riendl, 'acteria nor*all, +rod-ce signi0icant a*o-nts o0 several vita*ins B 0olic acid and vita*in I are the 'est (no)n e7a*+les B anti'iotic -se can contri'-te to long"ter* hidden vita*in de0icienc,. In addition, *an, )o*en )ho ta(e anti'iotics (to treat ./I or an, other in0ection) soon co*e to expect that the, )ill develo+ a vaginal ,east in0ection re1-iring the* to ta(e ,et another dr-g B this ti*e an anti0-ngal B to (ill the ,east. /he reason is that 0riendl, 'acteria that nor*all, inha'it the vagina (ee+ the ,east (-s-all, Candida albicans ) +o+-lation -nder control. Ance these 0riendl, 'acteria are ta(en o-t o0 the +ict-re ', the anti'iotic, the ,east organis*s are 0ree to gro) -nchec(ed. Altho-gh *ost o0 -s can tolerate anti'iotics )itho-t i**ediate side e00ects, ever, ,ear a 0e) +eo+le are r-shed to the hos+ital 'eca-se o0 allergic reactions to these dr-gs. Jastl,, the -se o0 anti'iotics +ro*otes the develo+*ent o0 'acterial s+ecies that are a'le to resist these dr-gs. acteria are ver, clever in their a'ilit, to *-tate genes, *a(ing the*selves 8i**-ne9 to the e00ects o0 anti'iotics. /hose 'acteria that have 'eco*e i**-ne then +ass this a'ilit, on to their o00s+ring or other 'acteria. /he li(elihood that resistant 'acteria )ill develo+ is enhanced ', the *is-se and over-se o0 anti'iotics. /he develo+*ent o0 anti'iotic" resistant 'acteria is a *a>or +ro'le* in *edicine toda, that has *an, e7+erts 0earing the inevita'le arrival o0 a 8s-+er'-g9 that is resistant to all (no)n anti'iotic dr-gs.

$hat is /TI4
A ./I is a 'acterial in0ection (ca-sed ', the 'acteria E. coli over #02 o0 the ti*e) that a00ects the inside lining tiss-e o0 the -rinar, s,ste* (or tract). /his s,ste* incl-des t)o idneys, )hich 0or* -rine 0ro* li1-id )aste in the 'lood: t)o narro) !reters , t-'es that carr, -rine 0ro* the (idne,s to the *-sc-lar bladder, )hich stores itH and a single urethra, the 0inal co**on +ath 0ro* the 'ladder to the o-tside )orld. /he -rinar, tract reacts to a 'acterial in0ection in *-ch the sa*e )a, that the -++er res+irator, s,ste* reacts to a cold vir-s. /he tiss-es 'eco*e in0la*ed, irritated and s)ollen. J-st as itKs hard to 'reathe thro-gh s)ollen and in0la*ed nasal +assages, s)ollen and in0la*ed -rinar, d-cts can +artiall, o'str-ct nor*al 0lo), *a(ing it +ain0-l and di00ic-lt to +ass -rine. Ardinaril,, the -rinar, s,ste* is hostile territor, 0or 'acteria, vir-ses or an, other *icroorganis*s. -gs that do *a(e their )a, into a health, -rinar, tract are li(el, to 0ind an

inhos+ita'le acidic environ*ent (+6 L@.@). /he, are also s-'>ect to attac( ', the 'od,=s i**-ne de0enses. (Ad-lt *en have the added +rotection o0 a s+eci0ic 'acterial gro)th inhi'itor s1-irted directl, into the -rinar, s,ste* ', their +rostate gland.) 3ven i0 *icro organis*s *anage to overco*e these considera'le o'stacles, the, )o-ld t,+icall, 'e 0l-shed o-t )ith the nor*al 0lo) o0 -rine. So e00ective are these nat-ral anti'acterial de0enses that in a st-d, in )hich 'acteria )ere instilled into the 'ladders o0 g-inea +igs, si*+le -rination e7+elled ##.#2 o0 the '-gs. @ Des+ite all these '-ilt"in sa0eg-ards, each ,ear *illions o0 +eo+le, over)hel*ingl, )o*en, still develo+ ./Is. Most ./Is 'egin )hen 'acteria originating in the 'o)els travel to and gro) in the -rethra. In0ections li*ited to the -rethra are (no)n as 8-rethritis.9 When 'acteria travel -+strea* to the 'ladder, the in0ection is called 8 the (idne,s are (no)n as 8ne+hritis9 or 8+,elone+hritis.9

cystitis.9 In0ections that reach

/he E. coli that ca-se *ost ./Is are a*ong the *ost co**on 80riendl,9 'acteria in the ;I tract, )here the, aid digestion, +rod-ce a 0e) vita*ins, and in general, 'ehave the*selves )itho-t 'othering -s. I0, ho)ever, )hen E. coli and other '-gs e7it the lo)er ;I tract, the, *anage to gain entr, to the -rinar, tract via the -rethra, then the, attach to the internal lining o0 the 'ladder, *-lti+l, and s+read. Altho-gh -+ to #02 o0 ./Is are ca-sed ', E. coli, the re*aining 102 are ca-sed ', 'acteria (no)n as Chla"ydia, Mycoplas"a, #eisseria gonorrhoeae, and others. .nli(e E. coli, these '-gs tend to 'e trans*itted via se7-al contact and rarel, ca-se the *ore serio-s 'ladder and (idne, in0ections. Chla"ydia, Mycoplas"a and #. gonorrhoeae in0ections do not res+ond to D-0annose treat*ent and )ill +ro'a'l, re1-ire anti'iotic treat*ent. In addition, a 0e) ./Is are ca-sed ', other 'acteria, s-ch as Prote!s or $taphylococc!s (8$taph9). Still, all o0 these non"E. coli in0ections co*'ined a*o-nt to no *ore than 102 o0 all ./Is.

$ho 5ets /TI4

Anato0y is /TI destiny. Wo*en are 0ar *ore li(el, to develo+ ./I than *en. /he reason lies in a di00erence in anato*, 'et)een the t)o se7es. !or*al 0e*ale anato*,, in )hich the -rethral o+ening, vagina, and an-s are all in close +ro7i*it,, in tailor"*ade 0or ./I, 'eca-se it *a(es it relativel, eas, 0or 'acteria 0ro* the 'o)el to gain a 80oothold9 in the vagina or the -rethra or 'oth. 3ven s*all di00erences in the location o0 these o+enings can *a(e a 'ig di00erence. In one st-d, o0 )o*en )ho tended to get ./Is over and over again, the -rethral o+ening )as >-st 0.2 c* closer to the an-s than )o*en )ho never got ./I. & In *ales, o0 co-rse, the -rethra e7its the 'od, via the +enis, *a(ing it too 0ar a distance 0or *ost E. coli to travel. /he 0e*ale -rethra is also 0ar shorter than the *ale=s. /his *eans that the distance 'acteria have to travel to reach the 0e*ale 'ladder is *-ch shorter, increasing the chances that a -rethral in0ection )ill 1-ic(l, 'eco*e a 'ladder in0ection, or cystitis. Poor hygiene. Eail-re to re*ove 'acteria 0ro* the region s-rro-nding the -rethra is an i*+ortant ca-se o0 ./I. eca-se the -rethra is in 0ront o0 the an-s, *others teach their s*all da-ghters to 8al)a,s )i+e 0ro* 0ront to 'ac(9 to avoid introd-cing 'acteria 0ro* the an-s

into the -rethra. In -ncirc-*cised *ales, the 0ores(in, i0 not cleansed +ro+erl,, can serve as an e7cellent 'reeding gro-nd 0or 'acteria, )hich co-ld then easil, gain access to the -rethra. Bloc2ing the flo6 of urine3 !or*all,, the 0lo) o0 -rine 0ro* (idne,s to 'ladder to the -rethra )ashes o-t *ost 'acteria. 6o)ever, an,thing that inhi'its the 0lo) o0 -rine can increase the ris( o0 ./I. /h-s, +eo+le )ith certain anato*ic ano*alies, as )ell as 'lood clots, stones, t-*o-rs or strict-res (narro)ings) are *ore li(el, to have rec-rrent ./Is. In *en, enlarge*ent o0 the +rostate gland can i*+ede the 0lo) o0 -rine. ladder )ea(ness d-e to dia'etes, stro(e, or other ne-rologic disorder can so*eti*es lead to the 8+ooling9 o0 -rine in the 'ladder a0ter -rination. In ti*e, this stagnant, resid-al -rine can serve as a gro)th *edi-* 0or 'acteria. ./I is also 1-ite co**on in +eo+le )ho are severel, de'ilitated and re1-ire a -rinar, catheter (a t-'e inserted into the -rethra to drain the 'ladder), )hich can easil, 'eco*e conta*inated. Altho-gh 'loc(ages can +ro*ote in0ection in 'oth se7es, the, are the +ri*ar, ca-se o0 ./I in *ales. Ta2ing the 7oy out of se*3 Eor *an, )o*en, the 'est )a, to get ./I is to have se7-al interco-rse. 88oney0oon cystitis9 res-lts )hen 'acteria *ove 0ro* the vagina and the +erianal area to the -rethra d-ring interco-rse. (In a si*ilar *anner, it is +ossi'le to 8inoc-late9 the -rethra d-ring *ast-r'ation and sa*e"se7 se7-al activit,). So*e contrace+tive *ethods also increase the chances o0 ./I. Research has sho)n that )o*en )ho -se a dia+hrag* )ith a s+er*icidal >ell, or 0oa*, or >-st the s+er*icide itsel0, are *-ch *ore li(el, to develo+ a ./I the ne7t da,. /he sa*e thing is tr-e 0or condo*s )ith s+er*icide. $ !ot onl, do s+er*icides +ro*ote the gro)th o0 E. coli, the, also allo) ,easts and other 'acteria to thrive in the vagina. D It see*s that nono7,nol"#, the *ost co**onl, -sed s+er*icide, (ills a lot *ore than >-st s+er*. It also (ills the 0riendl, 'acteria, (no)n as Lactobacilli that inhi'it the vagina. Ane o0 Lactobacilli%s *ain 0-nctions is to +rod-ce lactic acid, )hich lo)ers the +6 o0 the vagina. /he relativel, acidic nor*al environ*ent hel+s (ee+ the +o+-lation o0 ,easts and -n0riendl, 'acteria, li(e E. coli, -nder control. With Lactobacilli o-t o0 the )a,, the +6 rises (less acid), allo)ing +athogenic organis*s to gro) -nchec(ed. !ono7,nol"# *a, also +ro*ote in0ection ', *a(ing it easier 0or E. coli to stic( to the e+ithelial cells that line the vagina, -rethra, and 'ladder. # Antibiotics9 5es, it=s tr-e that anti'iotics are )idel, -sed to treat ./I, '-t it=s also tr-e that anti'iotics given 0or ./I or an, other in0ection can act-all, increase the ris( o0 ./I. 6o) can that 'eM Ji(e s+er*icide, *an, anti'iotics (ill vaginal Lactobacilli. Ance the anti'iotic treat*ent ceases, the a'sence o0 Lactobacilli leaves the vagina v-lnera'le to E. coli (and ,east) in0ection. 10 Ance in the vagina, E. coli can *ore easil, reach the -rethra and 'ladder and 'egin the in0ection c,cle all over again. 5etting older3 /he incidence o0 ./I increases a0ter )o*en reach *eno+a-se. /he lac( o0 ,o-th0-l levels o0 oestrogen leads to a loss o0 Lactobacilli )ith a s-'se1-ent rise in vaginal +6 leading to E. coli (and ,east) colonisation. 11 In ver, old (and ver, ,o-ng) +eo+le, -rinar, and 0aecal incontinence can also +ave the )a, to ./I. In the genes3 So*e +eo+le have a genetic +redis+osition to ./I. In other )ords, i0 ,o-r *other had rec-rrent ./I, ,o- have a good chance o0 having it too. /he reasons are not entirel, clear, '-t one +ossi'ilit, is that so*e ./I"+rone )o*en have a +rotein that *a(es it

easier 0or E. coli to 8stic(9 to their -rinar, tract tiss-e. Ather )o*en see* to lac( certain antigens that nor*all, inhi'it 'acterial adhesion (8stic(iness9). Still other )o*en have ele*ents in their -rine, s-ch as lo) +6, that activel, disco-rage 'acterial gro)th, *a(ing the* *ore resistant to in0ections. In so*e 0ort-nate instances, -rine *a, 'e nat-rall, 0atal to *an, 'acteria. 12 I00une i0:air0ent3 An, condition that i*+airs nor*al i**-ne 0-nction can *a(e the -rinar, tract a *ore hos+ita'le +lace 0or 'acteria. /h-s, +eo+le )ith diseases, s-ch as dia'etes or AIDS or +eo+le ta(ing i**-nos-++ressive dr-gs (e.g., corticosteroids), sho-ld 'e e7tra care0-l.

$hat Are the "y0:to0s of /TI4

So*e +eo+le )ith ./I have no s,*+to*s and are co*+letel, -na)are o0 their in0ection. 6o)ever, it is 0ar *ore co**on to have at least so*e s,*+to*s. /he *ost co**on s,*+to*s o0 ./I incl-de:

A 0re1-ent -rge to -rinate /ric(ling o0 -rine, des+ite a strong -rge to -rinate A +ain0-l, '-rning 0eeling in the area o0 the 'ladder or -rethra d-ring -rination or even )hen not -rinating An -nco*0orta'le +ress-re a'ove the +-'ic 'one (in )o*en) or a 0-llness in the rect-* (in *en) Clo-d,, *il(, or reddish -rine

When these s,*+to*s are co*'ined )ith a 0ever, one or 'oth (idne,s *a, 'e in0ected. Ather s,*+to*s o0 (idne, in0ections are na-sea, vo*iting and 'ac( or side +ain 'elo) the ri's. In children, the s,*+to*s o0 ./I are not al)a,s o'vio-s. /his is es+eciall, tr-e in ver, ,o-ng children, )ho *a, not 'e a'le to descri'e ho) the, 0eel. <arents sho-ld 'e on the loo(o-t 0or ./I i0 their (ids are irrita'le, have no a++etite, have no lo)"grade 0ever )ith na-sea and vo*iting, andNor i0 their -rine s*ells 80-nn,9. I0 children are sic( 0or *ore than a da, )ith a high te*+erat-re '-t have no 8cold9 s,*+to*s, the, *a, have ./I.

;onventional Antibiotic Treat0ent

Conventional *edical treat*ent o0 ./I involves the -se o0 anti'iotic dr-gs, )hich t,+icall, c-re *ost in0ections )ithin one or t)o da,s. 3ven tho-gh the in0ection *a, a++ear to 'e gone in a co-+le o0 da,s, doctors o0ten reco**end ta(ing anti'iotics 0or 10 to 1G da,s >-st to *a(e s-re no relativel, resistant 'acteria s-rvive. Jonger treat*ent is es+eciall, indicated in cases )here s,*+to*s have lasted *ore than a )ee(, )hen the in0ection is rec-rrent, or )hen the individ-al has dia'etes (or other diseases in )hich the i**-ne s,ste* *a, 'e i*+aired). When )o*en are s-'>ect to rec-rrent ./I, *an, doctors +rescri'e dail, lo) dose anti'iotics 0or as long as t&o or three years4 Ane +ro'le* )ith s-ch long"ter* treat*ent is that it is g-aranteed to serio-sl, disr-+t the 'od,=s nor*al ecological 'alance ', eradicating 0riendl, 'acteria, incl-ding E. coli in the ;I tract and Lactobacilli in the vagina. /he anti'iotic dr-gs *ost o0ten +rescri'ed 0or ./I incl-de:

/ri*etho+ri* (/ri*+e7) /ri*etho+ri*Ns-l0a*etho7aOole ( actri*, Se+tra, Cotri*) A*o7icillin (A*o7il, /ri*o7, W,*o7) !itro0-rantoin (Macrodantin, E-radantinH technicall, ter*ed 8-rinar, tract antis+etics9) El-oro1-inolones (Elo7in, !oro7in, Ci+ro, /rovan) A*+icillin (Man, 'rands)

Treating /TI Naturally 6ith D-Mannose

When 0aced )ith a +otentiall, +athogenic ger* li(e E. coli, conventional, +har*ace-ticall, 'ased *edicine t,+icall, con0ronts the +ro'le* ', thro)ing the *ost +otent +oisons it can 0ind at the '-gs. While there=s nothing essentiall, )rong )ith (illing disease"ca-sing 'acteria, this a++roach does have so*e ver, serio-s dra)'ac(s, as )e have noted earlier. 6a++il,, 8'acteria"cide9 is not the onl, +ossi'l, aven-e o0 attac(. Another, *ore nat-ral )a, to eli*inate E. coli in0ections 0ro* the -rinar, tract is to 'eat the* at their o)n ga*e. I0 the,=re going to ca-se tro-'le, 'acteria -s-all, have to 0ind a )a, to adhere (stic() to the 'od, tiss-e the,=re in0ecting. In ./I, E. coli attach to cells lining the 'ladder and -rinar, tract -sing 0il*, hair"li(e +ro>ections called fi"bria on their cell )alls. 1% At the ti+ o0 each 0i*'ri-* is a gl,co+rotein (a co*'ination car'oh,drate and +rotein) called a lectin that is +rogra**ed to 'ind to the 0irst *olec-le o0 the s-gar 0annose that it enco-nters. 1G It t-rns o-t that *olec-les o0 *annose (+rod-ced inside -rinar, tract lining cells) nat-rall, dot the s-r0aces o0 these cells. 6ere the, act as 8rece+tors9, inviting the 0i*'ria o0 E. coli to attach, and allo)ing the* to 'ind to the tiss-e in a right, Velcro"li(e gri+. 1G I0 not 0or this attach*ent to the cells=s *annose, an, E. coli that had s-ccess0-ll, vent-red -+ the -rethral river )o-ld 'e -na'le to stic( to the sli++er, s-r0ace and )o-ld 'e )ashed right 'ac( o-t on the ne7t tide o0 -rination.? What happens when we take D-mannose to treat a UTI? !o) i*agine )hat )o-ld ha++en to E. coli in the -rinar, tract i0 those s)eet little *annose *olec-les the, crave )ere +resent not >-st on the s-r0ace o0 the e+ithelial cells '-t s-rro-nding the* in the -rine as )ell. /he E. coli co-ldn=t t-rn aro-nd )itho-t '-*+ing into D"*annose 8>-st 0loating aro-nd9 in the -rine. .na'le to resist the tast, 'ait the, s-ddenl, 0ind the*selves s)i**ing in, the, )o-ld latch on to the nearest *annose *olec-les, and ha++il, sail o00 into the +orcelain s-nset. /hose 0e) E. coli le0t clinging to *annose *olec-les on cells then 'eco*e eas, +re, 0or )hite 'lood cells and other agents o0 the i**-ne s,ste*. 1@"1$ How taking D-mannose can treat or prevent UTI. In addition to its nat-ral occ-rrence in the cells lining the e+ithelial tract, the s-gar D" *annose is also 0o-nd in relativel, large 1-antities in 0r-it s-ch as +eaches, a++les, oranges and certain 'erries, li(e cran'erries and 'l-e'erries. 37tracted in the 0or* o0 D-0annose,? a )hite cr,stal s-gar si*ilar to gl-cose, it can 'e easil, dissolved in a li1-id and s)allo)ed. (Mannose can also 'e s,nthesiOed 0ro* other si*+le s-gars.)

When so*eone )ith ./I cons-*es a dose o0 D-0annose, the s-gar is a'sor'ed in the -++er ;I tract, '-t at a *-ch slo)er rate than *ost other s-gars. (Eor e7a*+le, gl-cose is a'sor'ed *ore than eight ti*es 0aster.) Moreover, -nli(e other s-gars, D"*annose is not readil, converted to gl,cogen (and stored) in the liver, '-t instead +asses directl, into the 'loodstrea* largel, -nchanged. 1D,1# As the D"*annose"laden 'lood +asses thro-gh the (idne,s, a considera'le +ro+ortion o0 the s-gar is e7tracted and added to the -rine. /he D"*annose"s)eetened -rine 0lo)s 0ro* the (idne,s thro-gh the -reters to the 'ladder and on to the -rethra, literall, s-gar"coating an, 0ree"0loating E. coli it *ight enco-nter, so the, can=s stic( to cells an, *ore. It also -nstic(s *ost o0 the E. coli alread, 8Velcro"ed9 to the inner s-r0ace o0 the 'ladder and -rinar, tract, -lti*atel, 0l-shing the* all do)n the drain. (? !ot all varieties o0 E. coli 0ind the *annose *olec-le s-ch a treat. /hose that do are said to 'e 8*annose"s+eci0ic,9 and the, are the ones that can +otentiall, ca-se ./I.1G P Man, *olec-les have D" (de7tro") and an J" (levo") (literall,, right and le0t) 0or*s. It is not -nco**on 0or the D" and J" 0or*s o0 a *olec-le to have ver, di00erent activit, +ro0iles. In the case o0 *annose, onl, the D" 0or* is -se0-l 0or dislodging E. coli.)

D-Mannose. 5uidelines for /se

<ngoing infections ;hildren: F to 1 teas+oon0-l Dissolved in a glass o0 )ater or >-ice ever, 2 or % ho-se. Adults: 1 teas+oons0-l dissolved In )ater or >-ice ever, 2 or % ho-rs. Preventing infections Start )ith 1-antities noted a'ove, Ad>-st a*o-nts do)n)ard i0 <ossi'le Preventing =honey0oon cystitis> 1 teas+oon0-l one ho-r +rior to i**ediatel, a0ter)ards. $hat is the :roof that D-0annose really 6or2s4 Eirst, the 8*olec-lar *echanis*9 o0 the action o0 D"*annose on E. coli is scienti0icall, +roven. /here=s no arg-*ent at all a'o-t this a*ong researchers )ho=ve st-died it. Second, literall, tens o0 tho-sands o0 )o*en )or(ing )ith nat-ral *edicine doctors have s-ccess0-ll, a++lied this science to their )on ./Is.

Considera'le circ-*stantial evidence, co*'ined )ith co**on sense and over 1@ ,ears o0 clinical e7+erience, *a(es a co*+elling case 0or the thera+e-tic val-e o0 D"*annose. In one la'orator, st-d,, 0or e7a*+le, rats= -rinar, tracts )ere inoc-lated )ith E. coli. Within one da,, those rats also given D"*annose )ere 0o-nd to have signi0icantl, lo)er levels o0 'acteria in their -rine. 20 In another st-d,, ad*inistering a *annose"li(e s-'stance (*eth,l a"D" *anno+,ranoside) to E. coli"in0ected *ice led to a #02 red-ction in 'acterial attach*ent to the -rinar, tract. Research in h-*ans sho)s that ingesting D"*annose signi0icantl, elevates 'lood *annose levels, a +rere1-isite i0 -rinar, levels are to rise. 21 <erha+s the 'est availa'le evidence, tho-gh, co*es 0ro* the e7+erience o0 +eo+le )ho have -sed it. At the /aho*a Clinic, )e have 'een reco**ending D"*annose to +eo+le )ith ./I since the *id"1#D0s )ith great s-ccess. While it )o-ld certainl, 'e nice to have the res-lts o0 a do-'le"'lind, +lace'o"controlled st-d, to +rove this, it=s hard to do-'t the val-e o0 D" *annose )hen )e see case a0ter case li(e that o0 A*,, descri'ed at the 'eginning o0 this 'oo(let, or o0 0o-r",ear"old Anne Marie, )ho had a ver, serio-s genetic disease called galactose*ia:

A*ong her other +ro'le*s, Anne Marie had 'een s-00ering 0ro* an E. coli "'ased -rinar, tract in0ection 0or al*ost t)o ,ears. !earl, constant anti'iotic treat*ent had 'een ine00ective in clearing her in0ection. As +art o0 Anne Marie=s overall treat*ent +lan, I advised her +arents to ta(e her o00 the anti'iotics and 'egin giving her D" *annose (Fto 1 teas+oon (a++ro7i*atel, F to 1 gra*)) stirred into so*e )ater or >-ice ever, three to 0o-r ho-rs. 6er ./I vanished )ithin t)o )ee(s and never ret-rned. When Anne Marie=s +arents too( her 'ac( to her -rologist 0or )hat had +revio-sl, 'een *onthl, or 'i*onthl, visits, the, )ere told to chec( 'ac( again in another t)o ,ears4 D"*annose can also 'e ver, e00ective in cases o0 8honey0oon cystitis .9 Caroline )as a *arried )o*an, )ho )as avoiding se7 'eca-se she )o-ld get a 'ladder in0ection 8ever, ti*e9 she and her h-s'and had interco-rse. !ot s-r+risingl,, this )as ca-sing so*e discord in her *arriage. Since a c-lt-re o0 her -rine sho)ed the +resence o0 E. coli , she started ta(ing D"*annose, 1 teas+oon one +rior to interco-rse and again shortl, a0ter)ards. /he res-ltM !o 0-rther in0ections. We have 0o-nd that )o*en +rone to ver, 0re1-ent rec-rrent ./Is not necessaril, related to se7-al interco-rse can also o0ten 'ene0it 0ro* ta(ing D"*annose +reventivel, at the sa*e dose. /o save e7+ense, so*e )o*en have 'een a'le to 8ta+er do)n9 their dosage and dose 0re1-enc,. , 0ar the *ost 0re1-ent -se o0 D"*annose has 'een ', tho-sands o0 )o*en )ho have s-00ered single (nonrec-rrent) e+isodes o0 'ladder in0ection. In over #02 o0 s-ch cases, 1 teas+oon o0 D"*annose ever, t)o to three ho-rs clears the in0ection in one to three da,s.

It is not >-st /aho*a Clinic +atients )ho are achieving these re*ar(a'le res-lts )ith D" *annose. We o0ten hear 0ro* other *edical +ractitioners )ho give it to their +atients. /he 0ollo)ing is t,+ical: 'D!ring "y () years of practice, * ha+e tried e+erything i"aginable for idney and bladder proble"s &ith "ixed res!lts or at least not reprod!cible res!lts. To this day we have not had a single patient that did not improve with D-mannose. E+en so"e of the ones that &ere of

chronic nat!re ha+e i"pro+ed to the point that a single &ee ly dose of D,"annose is eeping the" proble",free.-

Preventing /TI
In addition to ta(ing D"*annose, +eo+le can do *an, things to avoid getting 'ladder in0ections and other ./Is. So*e are h,gienic, )hile others involve diet. !one o0 the* re1-ires ta(ing an, dr-gs:

Drin2 a lot of 6ater or other fluids# & to 6 ounces daily# if :ossible3 El-ids (ee+ the -rine 0lo)ing, so invading 'acteria are li(el, to 'e )ashed o-t. Drin2 cranberry 7uice. Eor *an, ,ears, ./I"+rone )o*en, )ho )anted to avoid anti'iotics, have tried drin(ing cran'err, >-ice. It t-rns o-t that cran'err, >-ice )or(s, in +art, 'eca-se it contains so*e D"*annose, as )ell as a s-'stance called proanthocyanidin that )or(s in a slightl, di00erent )a, to *a(e it di00ic-lt 0or E. coli to 8stic( aro-nd,9 22,2%. 6o)ever, the a*o-nt o0 D"*annose (even )ith +roanthoc,anidin) in a glass o0 cran'err, >-ice is 0ar less than the thera+e-tic dose )e reco**end in this 'oo(let. <l-s, *ost cran'err, >-ice +rod-cts are loaded )ith added s-gars, the (ind o0 s-gars that are (no)n to s-++ress the activit, o0 the )hite 'lood cells that destro, -n0riendl, 'acteria (see 'elo)). Altho-gh drin(ing large vol-*es o0 cran'err, >-ice )o-ld +ro'a'l, not, ', itsel0, 'e s-00icient to c-re an esta'lished in0ection, drin(ing !ns&eetened cran'err, >-ice *a, hel+ +revent 0-t-re in0ections. Ta2e vita0in ; su::le0ents3 .se the ascorbic acid 0or* o0 vita*in C, )hich can hel+ acidi0, the -rine and th-s, disco-rage 'acterial gro)th. 8ygiene: Eor )o*en: 80ront to ac(9 )i+ing. (As g-,s, )e a+ologise 0or re+eating )hat ever, )o*an learned 0ro* her *other, '-t )e=d 'e o+en to 8scienti0ic criticis*9 i0 )e didn=t.) Men )ho=ve 'een l-c(, eno-gh to esca+e circ-*cision sho-ld (ee+ their 0ores(in area clean. In -ncirc-*cised in0ants, 0ores(in in0ections are -+ to 20 ti*es *ore co**on co*+ared )ith circ-*cised in0ants. 1 Eor 'oth: Cleanse the genital and anal areas 'e0ore se7-al interco-rse. Don1t =hold it in3> It=s al)a,s 'est to -rinate )hen )e 0eel the need, i0 +ossi'le. Resisting the -rge to -rinate too o0ten or 0or too long can da*age the delicate tiss-e that lines the -rinar, tract and +er*it 'acteria to thrive. )or 7ust a fe6 of us. ta2e sho6ers# not baths. ath )ater contains *illions o0 'acteria that get )ashed o00 o-r 'odies. It is 1-ite +ossi'le that E. coli 0ro* the an-s co-ld 0loat over to the vagina or -rethra. I0 ,o-=ve had 0re1-ent ./Is, '-t can=t resist a long, hot soa( in the t-', ta(e a cleansing sho)er 0irst. Avoid using fe0inine hygiene s:rays and scented douches. /hese +rod-cts *a, irritate the -rethra, )hich co-ld lead to in0ection.

The $orld According to the )DA

In an ideal )orld, the scienti0ic and clinical evidence disc-ssed here sho-ld 'e s-00icient at least to +i1-e the interest o0 *edical +ractitioners. .n0ort-natel,, in the earl, 1#&0s, Congress gave the Eood and Dr-g Ad*inistration (EDA) the e7cl-sive legal +o)er to decide )hich re*edies )ere 8+roven9 or )hich )ere not. As discovered ', Eederal >-dges in recent co-rt cases (e.g. Pearson +. $halala), /he EDA ad*itted that it has no ob.ecti+e standard 0or s-ch +roo0. Jac(ing s-ch a standard, the EDA has 'een a'le to 8disa++rove9 nearl, all re*edies

that are not s+onsored ', a *a>or +har*ace-tical co*+an,, e7ce+t )hen the, have 'een ordered to do so ', a co-rt. 1 Sadl,, the EDA has convinced nearl, all +racticing +h,sicians, as )ell as the *edia, that )itho-t 8EDA a++roval,9 a re*ed, is 8-n+roven,9 even )hen real" )orld +roo0 is a'-ndant. /he -se o0 +atented, EDA"a++roved anti'iotic dr-gs 0or treating ./I is s-++orted ', large, e7+ensive, do-'le"'lind +lace'o"controlled la'orator, and clinical trails that are +aid 0or ', the +har*ace-tical (+atent *edicine) ind-str,. 2 eca-se nat-ral s-'stances li(e D"*annose cannot 'e +atented, the, do not o00er the astrono*ical +ro0its that +atenta'le dr-gs do. In the a'sence o0 a 0inancial incentive to do the sa*e (inds o0 trials on D"*annose, there are ver, 0e) +ieces o0 +-'lished evidence one can +oint to to 8+rove9 de0initivel, (according to the EDA=s -nde0ined standards) that it is as e00ective and sa0e as )e sa, it is. /he EDA has never o00iciall, denied the state*ent *ade ', Dr Richard J. Cro-t, Director, EDA=s (then) -rea- o0 Dr-gs: 8I never have and never )ill a++rove a ne) dr-g to an individ-al, '-t onl, to a large +har*ace-tical 0ir* )ith -nli*ited 0inances.9 (Q-oted in the S+otlight 0or Jan-ar, 1D, 1#D2.)
1

, la) +assed in 1##2, +har*ace-tical co*+anies are +er*itted to +a, the EDA h-ndreds o0 *illions o0 dollars to hel+ e7+edite ne) dr-g 8a++rovals.9 !ot s-r+risingl,, this +ractice, (no)n as <rescri+tion Dr-g .ser Eees, leads to scandalo-s con0licts o0 interest that have recentl, 'een decried in an editorial the ritish *edical >o-rnal, /he Jancet, 2001H%@$:1@GG" 1@G@.
2

/TI# "ugar and )ood Allergies

In nat-ral *edicine, it=s a7io*atic that refined s-gar and hidden 0ood allergies are 8'ehind9 *ost rec-rrent in0ections, 'eca-se re0ined s-gar inter0eres )ith the a'ilit, o0 )hite 'lood cells to eng-l0 and destro, *icroorganis*s. 2G Eood allergies a++ear to irritate and in0la*e Rtarget" organ9 tiss-es, *a(ing in0ection easier and *a, also inter0ere )ith the 0-nction o0 the i**-ne s,ste*. As long ago as 1#$&, res-lts )ere re+orted 0ro* a st-d, o0 @0 children (aged G to 1D ,ears) )ho had chronic rec-rrent ./I des+ite -rologic e7a*inations that )ere other)ise co*+letel, nor*al. All the children had an allergic 8'ac(gro-nd,9 incl-ding ha, 0ever, +ersistent co-ghing, nasal o'str-ction or other 'reathing di00ic-lt, (e.g. asth*a, ecOe*a, hives, or rec-rrent s(in rashes). All )ere as(ed to 0ollo) eli*ination diets, ta(e 8anti"allergic9 *edication, and to receive s+eci0ic allerg, desensitisation. A0 the @0 children, G2 (DG2) 8de0initel, 'ene0ited,9 )hile nine had a 8ra+id and s+ectac-lar c-re,9 1# had c-res a0ter si7 to nine *onths, and 1G )ere 8noticea'l, i*+roved.9 Anl, eight o0 the 0i0t, children sho)ed no i*+rove*ent. 2@,2& Doctors )or(ing )ith the 8nat-ral9 a++roach to health care 0ind that eli*inating s-gar and 0ood allergies is 0re1-entl, s-00icient to signi0icantl, red-ce the incidence o0 an, rec-rrent in0ection, incl-ding ./I, in 'oth children and ad-lts.

/TI and Meno:ause

Wo*en generall, 0ind that their chances o0 develo+ing a ./I increase as the, reach their *eno+a-sal ,ears. When oestrogen is +lenti0-l, 80riendl,9 'acteria (no)n as Lactobacilli thrive in the vagina, ha++il, s+e)ing lactic acid into their s-rro-ndings. /his nat-rall, created, nor*all, lo) +6 (relativel, high acidit,) o0 the vagina disco-rages the gro)th o0 E. coli and other 'acteria. As oestrogen levels 0all d-ring and a0ter *eno+a-se, tho-gh, the Lactobacill!s +o+-lation 'egins to d)indle, )hich allo)s the +6 to rise ('eco*e less acidic), *a(ing the area *ore hos+ita'le to E. coli (and ,easts). Re+lacing *issing oestrogen can hel+ restore this nat-ral de0ense. In a rando*ised, do-'le"'lind, +lace'o controlled st-d, +-'lished in the !e) 3ngland Jo-rnal o0 Medicine, #% +ost*eno+a-sal )o*en )ith a histor, o0 rec-rrent ./I a++lied a crea* containing the nat!ral oestrogen oestriol or a +lace'o to their vaginas. A0ter eight *onths, the )o*en in the oestriol gro-+ had had *ore than @02 0e)er ./Is than the )o*en in the +lace'o gro-+ (%12 vs. &$2 res+ectivel,.) 2$.2D In addition to +reventing ./I, there are *an, other good reasons 0or *eno+a-sal )o*en to re+lace their oestrogens and +rogesterone as their ovarian 0-nction )anes. 6o)ever, +lease avoid B at all costs B conventional +har*ace-tical 6R/ (8hor*one9 re+lace*ent thera+,) that e*+lo,s s-ch !nnat!ral or s,nthetic hor*one"li(e dr-gs as <re*arin, <rovera, 3strace (the 8oestrogen +atch9) and other +atented +rod-cts. While the, *a, red-ce the chances o0 getting a ./I, the, can 'e ver, dangero-s and *a, ca-se *an, -n+leasant side e00ects. I0 a )o*an decides to -se hor*one re+lace*ent, it=s essential 0or her to o+t 0or the -se o0 nat!ral, identical,to,h!"an oestrogens, incl-ding oestrone, oestradiol and es+eciall, oestriol in the +ro+ortions in )hich the, occ-r nat-rall, in health, ,o-ng )o*en. /he -se o0 nat-ral h-*an estrogens ', *eno+a-sal )o*en is a vitall, i*+ortant s-'>ect that is 'e,ond the sco+e o0 this 'oo(let. /o learn *ore, +lease read !atural Hormone "eplacement #or Women $ver %& ', Jonathan V. Wright, M.D., and John Morgenthaler, S*art <-'lications, <etal-*a, CA, 1##$.

Is D-0annose "afe for Peo:le $ith Diabetes4

<eo+le )ith dia'etes -s-all, need to li*it their inta(e o0 s-gar. 6o) does this a00ect their -se o0 D"*annoseM Eort-natel,, ver, little. /here are anecdotal re+orts that so*e +eo+le )ith dia'etes e7+erience a transient increase in 'lood s-gar levels, '-t the e00ect is not great and never +er*anent, lasting onl, 0or the length o0 ti*e *annose is -sed.

Try D-Mannose )irst9

We strongl, -rge +eo+le )ith ./I to try D-mannose be#ore resorting to antibiotic drugs. !inet, +ercent o0 the ti*e, ./I is ca-sed ', 3. coli and )ill res+ond to D"*annose treat*ent )ith signi0icant s,*+to* red-ction )ithin 2G ho-rs. (3ven tho-gh s,*+to*s are i*+roved )ithin 2G ho-rs, D"*annose sho-ld 'e contin-ed 0or t)o to three da,s a0ter the last s,*+to* is gone, >-st to 8*a(e s-re.9 .nli(e )ith conventional anti'iotics, there=s no har* in doing this.) Still, *an, +h,sicians thin( it=s a good idea to collect a -rine s+eci*en 0or 'acterial c-lt-re, i0 +ossi'le >-st 'e0ore starting D"*annose. In the one chance in ten that the in0ection is not ca-sed ', E. coli and D"*annose doesn=t )or(, this allo)s the* to identi0, the in0ecting 'acteria and select an a++ro+riate conventional anti'iotic as 1-ic(l, as +ossi'le.

"u00ary
D"*annose is a si*+le s-gar that can 'e -sed to treat or +revent the #02 or *ore o0 ./Is that are ca-sed ', the 'acteria E.coli. Altho-gh D"*annose can eli*inate ./Is as 1-ic(l, as conventional anti'iotic dr-gs, it is 0ar sa0er 'eca-se it does not (ill 3. coli or an, 80riendl,9 'acteria. Instead, it *a(es it i*+ossi'le 0or 3. coli 'acteria to stic( to the lining o0 the -rinar, tract, )hich allo)s the nor*al 0lo) or -rine to )ash the '-gs do)n the drain. , -sing this re*ar(a'l, sa0e, e00ective, ine7+ensive, nat-ral treat*ent, )o*en can -s-all, treat their o)n ./Is )itho-t the need 0or e7+ensive doctor visits, +rescri+tion dr-gs, and ins-rance co*+an, rei*'-rse*ents. A $<?D <) ;A/TI<N If a /TI treated 6ith D-0annose does not sho6 significant i0:rove0ent 6ithin ! hours @about ('A of casesB# it is li2ely that the causative organis0 if not C3 coli# and a visit to the doctor for a conventional antibiotic drug is therefore necessary3

D-Mannose vs3 Antibiotics for Bladder Infections

Eliminates UTI within 1-2 days Kills friendly bacteria Can safely sto treatment in a few days Can ca!se "I ! set Can romote yeast infections Can ca!se aller#ic reactions $ell-s!ited for re#nant women $ell-s!ited for infants and Yo!n# children $ell-s!ited for lon#-term% &re'entati'e !se (e)!ires a doctor*s rescri tion Antibiotic Drugs Yes Yes No Yes Yes Yes No No No Yes D-mannose Yes No Yes No No No Yes Yes Yes No

Re0erences
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