CBE 9250B ADVANCED BIOMATERIALS ENGINEERING COURSE OUTLINE 2013-2014

Description This course will provide an introduction of materials science & engineering topics. 1). The four materials classes (metals, ceramics, polymers, composites) will be addressed with emphasis upon the material types and material properties pertinent to their use in implanted medical devices. 2) The structure and properties of biologic tissues and biocompatibility. 3) Specific implant applications will be addressed. Prerequisites Engineering Science 1021 A/B and CBE 4421A. Unless you have either the requisites for this course or written special permission from your Dean to enroll in it, you may be removed from this course and it will be deleted from your record. This decision may not be appealed. You will receive no adjustment to your fees in the event that you are dropped from a course for failing to have the necessary prerequisites. Antirequisites BME 9525. Contact Hours 3 lecture hours, 1 tutorial hour, 0.5 course. Instructors A. S. Rizkalla (TEB 435) Telephone: 519-661-2111 ext: 82212 email: arizkall@uwo.ca W.K. Wan (TEB 433) Telephone: 519-661-2111 ext 88440; Email: wkwan@eng.uwo.ca Graduate Assistant Ashley Jokhu (TEB 477) Telephone: 519-661-2111 ext: 88352 email: cbegrad@uwo.ca Required Texts Joon B. Park and Roderic S. Lakes. Biomaterials, An Introduction. Third Edition. Springer, New York 2007. Reference Texts Biomaterials Science, An Introduction to Materials in Medicine Edited by Buddy DS. Ratner, Allan S. Hoffman, Frederick J. Schoen and Jack E. Lemons, 3rd Edition 2013, Academic Press is an imprint of Elsevier . Course Notes As available from the instructors.

CBE 9250B Course Outline

Laboratory Notes None. Laboratory None. Units SI and other engineering units will be used in this course. General Learning Objectives Knowledge Base Problem Analysis Investigation Design Engineering Tools Learning Objectives 1. To introduce undergraduate students to the common types of materials and implant device currently utilized in the surgical practice of medicine. 2. To present and discuss the areas of materials science and engineering, which are particularly important to achieve desired implant properties and performance. 3. To address the important aspects of biocompatibility that determine how the body responds to implanted materials and devices. 4. To introduce regulatory and ethical concerns dealing with the implementation and commercialization of biomaterials and medical devices. Topics 1. Introduction to Biomaterials (Chapter 1) - Historical background and performance of biomaterials X X Individual Work Team Work Communication Professionalism Impact on Society X Ethics and Equity Economics and Project Management Life-Long Learning X

2. The structure of solids (Chapter 2, 7) - Atomic bonding and crystal structure of metals and ceramics - Long chain polymers and types of polymerization - Composite materials 3. Characterization of Materials (Chapters 3, 4) - Basics on physical, chemical and mechanical properties of materials 4. Biological Materials and Their Properties (Chapter 9) - The extracellular matrix and composition of hard and soft tissues: proteins (collagen & elastin), polysaccharides, and minerals (hydroxyapatite)

CBE 9250B Course Outline

- Structure and properties of mineralized tissue (bone and teeth), cartilage, tendons, ligaments and cardiovascular tissues 5. Metallic Implant Materials (Chapter 5) - Stainless steels, Co-based alloys, Ti & Ti alloys and dental metals - Corrosion of metallic implants 6. Ceramic Implant Materials (Chapter 6) - Aluminum oxides, calcium phosphates, glass-ceramics and carbons - Static and dynamic fatigues of ceramics 7. Polymeric Implant Materials (Chapter 7) - Effect of structure and temperature on properties - Deterioration of polymers 8. Composite Implant Materials (Chapter 8) - Structure and mechanics of composites - Application of composite biomaterials: dental filling composites, porous implants, fibrous and particulate composites in orthopaedic implants 9. Tissue Response to Implants (Chapter 10) - Normal wound healing process - Inflammation - Biocompatibility and hemocompatibility - Body response to implants - Carcinogenecity 9. Application of Biomaterials for Soft and Hard Tissue Replacement (Chapters 12, 14) - Vascular and heart valve implants - Artificial organs: artificial hearts, cardiac pacemakers and artificial kidney dialysis membrane - Joint replacements: dental implants and interface problems in orthopaedic implants 10. Commercialization of Implants - Regulations and regulatory testing - The ethics of biomaterials and implants Evaluation The final course mark will be determined as follows: Tests, project and assignments 50% Final exam 50% All tests and final examination will be open book. Notes 1) Students must pass the final examination to pass this course. Students who fail the final examination will be assigned 48% if the aggregate mark is higher than 50%, or the aggregate mark.

CBE 9250B Course Outline

Repeating All Components of the Course In accordance with Senate and Faculty Policy, students who have failed an Engineering course (i.e. <50%) must repeat all components of the course. No special permissions will be granted enabling a student to retain laboratory, assignment or test marks from previous years. Previously completed assignments and laboratories cannot be resubmitted for grading by the student in subsequent years. Use of English In accordance with Senate and Faculty Policy, students may be penalized up to 10% of the marks on all assignments, tests, and examinations for the improper use of English. Additionally, poorly written work with the exception of the final examination may be returned without grading. If resubmission of the work is permitted, it may be graded with marks deducted for poor English and/or late submission. Attendance Any student who, in the opinion of the instructor, is absent too frequently from class or laboratory periods in any course, will be reported to the Associate Dean (Graduate) (after due warning has been given). On the recommendation of the Department concerned, and with the permission of the Associate Dean (Graduate), the student will be debarred from taking the regular examination in the course. Cheating University policy states that cheating is a scholastic offence. The commission of a scholastic offence is attended by academic penalties, which might include expulsion from the program. If you are caught cheating, there will be no second warning (see Scholastic Offence Policy in the Western Academic Calendar). Plagiarism Students must write their essays and assignments in their own words. Whenever students take an idea or a passage from another author, they must acknowledge their debt both by using quotation marks where appropriate and by proper referencing such as footnotes or citations. Plagiarism is a major academic offence (see Scholastic Offence Policy in the Western Academic Calendar). The University of Western Ontario has software for plagiarism checking. Students may be required to submit their work in electronic form for plagiarism checking. Conduct Students are expected to arrive at lectures on time, and to conduct themselves during class in a professional and respectful manner that is not disruptive to others. Sickness and Other Problems Students should immediately consult with the instructor or Associate Chair (Graduate) if they have problems that could affect their performance in the course. The student should seek advice from the Instructor or Associate Chair (Graduate) regarding how best to deal with the problem. Failure to notify the Instructor or the Associate Chair (Graduate) immediately (or as soon as possible thereafter) will have a negative effect on any appeal. Please contact the course instructor if you require material in an alternate format or if any other arrangements can make this course more accessible to you. You may also wish to contact Services

CBE 9250B Course Outline

for Students with Disabilities (SSD) at 661-2111 x 82147 for any specific question regarding an accommodation. Notices Students are responsible for regularly checking their Western email and notices posted on Instructors' doors. Course cancellations will also be sent out via Twitter. Consultation Students are encouraged to discuss problems with their teaching assistant and/or instructor in tutorial sessions. Office hours will be arranged for the students to see the instructor. Other individual consultation can be arranged by appointment with the instructor. Accreditation (AU) Breakdown Engineering Design = 28% Engineering Science = 72% Total AUs = 44.0

January 5, 2014