Académique Documents
Professionnel Documents
Culture Documents
Table of Contents: Sources and Composition Structure Neurology and the Brain Kinetics and Distribution Neuroprotection Neuropathy Glutaminergic Signalling Cholinergic Signalling Memory Fatigue Addiction and Withdrawal nteractions with Glucose Metabolism nteractions with !rgan Systems "yes nteractions with Se#uality
wee,s in rats noted that despite these similar doses that sulbutiamine was able to increase total circulating thiamin( $hiamine diphosphate( and $hiamine Monophosphate le4els 2+8& times higher than that o- $hiamin itsel-+/90 n other measured organs %hippocampus( medulla( cerebellum( corte#( and ,idney' le4els o- $hiamin $riphophate were only increased with sulbutiamine( and sulbutiamine increased total thiamine compounds higher than $hiamine in all organs e#cept the hippocampus+/90 2.2. Neuroprotection Sulbutiamine may protect neuronal cells %in the hippocampus' -rom o#ygen6glucose depri4ation according to one study+/80 $his study used a staining protocol to identi-y dead cells -rom glucose6o#ygen depri4ation( and the *+&3-old increase seen in control was attenuated to a 8+&3-old increase when Sulbutiamine was incubated at 7:uM+ $he disruption o- synaptic transmission that occurs under these conditions o- nutrient depri4ation/70 was preser4ed with sulbutiamine to a degree( measuring preser4ation at 27+&;632+2&<( 8=+9;639+&&< and **+9;63&&+:< -or the concentrations o- &( &:( and 7:uM when control was standardi1ed to &::< and the group without Sulbutiamine recorded &2+>;63?+><+/80 2.". Neuropathy A * wee, trial in humans with type diabetes and diabetic neuropathy using Sulbutiamine at 8::mg daily noted that on the signs and symptoms scores %constricting sensation( paraesthesia( pain and wea,ness -or symptoms. etc+' there was an impro4ement when compared against baseline but no impro4ement against placebo %and thus it was deemed no o4erall impro4ement'+/*0 mpro4ement was noted in electrophysical measures( including ner4e conduction 4elocity and compound motor action potential+/*0 2.#. $lutaminergic Signalling )ositi4e glutaminergic and dopaminergic transmission has been noted in anterior corticol regions( speci-ically the pre-rontal and cingular cortices which organi1e decisions and strategies+/&0 Daily in5ections o- &2+7mg6,g sulbutiamine -or 2 wee,s prior to sacri-ice noted decreases in ,ainate receptors in tested areas as well as decreased dopamine le4els( despite no changes in dopamine receptor content+/&0 No 4ariations in dopaminergic or glutaminergic receptors were noted in the nuclear accumbens(/&0 and in a model o- glucose6o#ygen depri4ation( Sulbutiamine at &( 7( and 7:uM -ailed to modi-y e#citability o- neurons in the hippocampus+/80 2.%. Cholinergic Signalling n an animal model where Sulbutiamine was -ed at 9::mg6,g -or &: days( the rate osodium3dependent choline upta,e into the hippocampus appeared to be increased appro#imately &:+&< when compared to gum acacia control+/=0 2.&. 'emory n a model o- BA@B6c mice &83&* wee,s o- age( &: days o- 9::mg6,g sulbutiamine by oral ga4age with 7< gum acacia appeared to impro4e memory %assessed by operant tas,'. this study noted that there were no di--erences between groups in acAuisition but there were signi-icant di--erences in retention which resulted in increased per-ormance+/=0 n5ections o- &2+7 and 27mg6,g Sulbutiamine daily -or ? wee,s -ailed to modi-y
per-ormance in a DNM$S tas, %operant conditioning ma1e' and at times &2+7mg sulbutiamine was associated with a greater amount o- encoding errors+/>0 When di1ocilpine %NMDA antagonist that induces amnesia' was administered during the DNM$S tas,( sulbutiamine was able to negate the amnesiac e--ects o- it on the mice and preser4e per-ormance+/>0 Sulbutiamine has been implicated in increasing ob5ect3recognition memory in mice at both &2+7 and 27mg6,g in5ections o4er ? wee,s+/>0 2.(. )atigue !ne study has been conducted on chronic postin-ectious -atigue %C) F' with sulbutiamine at either 8:: or *::mg daily -or 2> days noted that both groups had signi-icantly less -atigue than placebo( but that -or the most part there was no signi-icant di--erence between groups with the *::mg group inconsistently per-orming better at times+/?0 A similar study using a large %uncontrolled( unblinded' sample o- persons seeing their doctors about in-ection who reported at least one symptom o- -atigue gi4en 8::mg Sulbutiamine at brea,-ast daily -or &7 days alongside their anti3in-ecti4e treatment noted complete resolution o- sel-3reported asthenic symptoms in 7&+=< o- the study population+
/&:0
mpro4ement has also been noted regarding -atigue in ?&+9=< o- persons tested %nB*:' with Multiple Sclerosis( with =8+&9< o- the sample reporting the impro4ement as CsubstantialC %analysis was done 4ia sub5ecti4e impro4ement' with no reported e#acerbation in -atigue state+/&&0 2.*. +ddiction and ,ithdra-al A case study currently e#ists where a patient with bipolar disorder became addicted to sulbutiamine+/&20 $he sub5ect was using high dose antipsychotics %olan1apine and haloperidol at 2:mg( the ben1odia1epines dia1epam and tema1epam at 8:mg and &:mg( &:mg biperiden( unspeci-ied doses o- lithium and carbama1epine' and reported that his large doses %abo4e *::mg but otherwise unspeci-ied' made him -eel stronger and warmer+
/&20
!ne study in primeapes using a large dose o- sulbutiamine %9::mg6,g daily -or &: days' noted that while Sulbutiamine was able to in-luence the circadian rhythm %increasing wa,e-ulness and reducing phase 2 sleep while increasing phase & and not a--ecting D"M' that &: days o- usage was associated with 237 days o- withdrawal+/&90
&:uM Sulbutiamine was as e--ecti4e as &:uM $rolo# %anti3o#idant standard' while attenuation was seen signi-icantly at &uM. these protecti4e e--ects were associated with a seAuestering the increase in supero#ide and pero#ide radicals( with no in-luence on hydro#yl radicals( and a relati4e increase in glutathione+/&*0
chronic treatment with sulbutiamin %Arcalion' in Macaca mulatta+ Rev !lectroencephalogr Neurophysiol "lin+ %&?>2' &83Asregadoo "D+ Blood le4els o- thiamine and ascorbic acid in chronic open3angle glaucoma+ Ann #phthalmol+ %&?=?' &73Sedel F( et al+ $hiamine responsi4e pyru4ate dehydrogenase de-iciency in an adult with peripheral neuropathy and optic neuropathy+ J Neurol Neurosurg Psychiatry+ %2::>' &*3Kang KD( et al+ Sulbutiamine counteracts trophic -actor depri4ation induced apoptotic cell death in trans-ormed retinal ganglion cells+ Neurochem Res+ %2:&:' &=3Dmitrie4 DG( Gamido4 S ( )ermia,o4a !H+ Clinical e--icacy o- the drug enerion in the treatment o- patients with psychogenic %-unctional' erectile dys-unction+ $rologiia+ %2::7' %Common phrases used by users -or this page include sulbutiamine ta,e it daily( sulbutaiamine dosage( salbutamine( composition o- sulbutiamin( arcalion bodybuilding( Sulbutamine beni-its' %Isers who contributed to this page include KurtisFran,'