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Provera general information What is Provera used for? Provera 2.

5mg tablets are used to treat several menstrual and uterine problems to re-establish a regular menstrual cycle. These conditions are: secondary amenorrhoea (menstrual periods that have stopped are absent or irregular! abnormal uterine bleeding during the menstrual cycle instead of at the end endometriosis (gro"th of endometrial tissue outside the uterus! causing pain and bleeding. Provera 2.5mg tablets are also used to counteract the stimulating effect of oestrogen on the endometrium therefore reducing the ris# of endometrial cancer "hich can develop in response to oestrogen in "omen ta#ing hormone replacement therapy ($%T! for menopausal symptoms. &dding a progestin "ith an oestrogen is thought to help the feminisation process for male to female transse'uals and Provera 2.5mg tablets are used as a component of transgender hormone therapy to help stimulate breast development and reduce the production of testosterone. $o" does Provera "or#? Provera 2.5mg tablets contain medro'yprogesterone a synthetic derivative of the female se' hormone progesterone "hich means that its chemical structure closely resembles that of naturally produced progesterone and it therefore "or#s in a similar "ay. (ndogenous (naturally produced! progesterone is produced by the ovaries during the second phase of the menstrual cycle. )t acts on the endometrium (lining of the uterus! converting the proliferating phase to the secretory phase. This causes the endometrium "hich has thic#ened in response to oestrogen during the first half of the cycle to stop gro"ing and start secreting hormones and other proteins needed to maintain a pregnancy if conception occurs* if not levels of oestrogen and progesterone fall and the endometrium is shed (menstruation!. This action helps re-establish a regular menstrual cycle in the treatment of secondary amenorrhoea and abnormal uterine bleeding during the menstrual cycle. Provera 2.5mg tablets act on the endometrium in all its locations to stop it gro"ing "hich alleviates symptoms of endometriosis including pain and bleeding. What does Provera contain? Provera 2.5mg tablets contain medro'yprogesterone a synthetic derivative of the female se' hormone progesterone used for treating several menstrual and uterine problems. Provera 2.5mg tablets also contain lactose sucrose mai+e-starch li,uid paraffin purified talc calcium stearate purified "ater and the colouring agents sunset yello" -.- .)/5015. Treating endometriosis "ith Provera Provera 2.5mg tablets contain medro'yprogesterone a synthetic derivative of the female se' hormone progesterone "hich means that its chemical structure closely resembles that of naturally produced progesterone and it therefore "or#s in a similar "ay. 2uring a normal menstrual cycle progesterone (produced by the ovaries! acts on the endometrium and causes it to stop gro"ing and start secreting hormones and other proteins needed to maintain a pregnancy if conception occurs. )f not levels of oestrogen and progesterone fall and the endometrium is shed (menstruation!. (ndometriosis is the gro"th of endometrial tissue outside the uterus "hich behaves in the same "ay as uterine endometrium. Provera 2.5mg tablets act on the endometrium in all its locations to stop it gro"ing "hich alleviates symptoms of endometriosis including pain and bleeding. Treating menstrual problems "ith Provera Provera 2.5mg tablets contain medro'yprogesterone a synthetic derivative of the female se' hormone progesterone "hich means that its chemical structure closely resembles that of naturally produced progesterone and it therefore "or#s in a similar "ay. & normal menstrual cycle is dependent on the interaction of several hormones including oestrogen and progesterone produced by the ovaries as "ell other regulating hormones produced by the pituitary gland. )f any of these hormones are not produced in the correct amounts this can disrupt the cycle and cause problems li#e amenorrhoea (menstrual periods that have stopped are absent or irregular! and abnormal uterine bleeding during the menstrual cycle instead of at the end. Provera 2.5mg tablets

can re-establish a regular menstrual cycle by helping to restore natural hormone levels. Provera for hormone replacement therapy Provera 2.5mg tablets contain medro'yprogesterone a synthetic derivative of the female se' hormone progesterone "hich means that its chemical structure closely resembles that of naturally produced progesterone and it therefore "or#s in a similar "ay. Ta#ing oestrogen for hormone replacement therapy ($%T! helps reduce symptoms of menopause caused by oestrogen deficiency including hot flushes night s"eats sleeplessness vaginal dryness headaches mood s"ings lac# of concentration and loss of energy. 3estrogen also has several other beneficial actions in various metabolic processes including bone turnover and lipid (fat! metabolism but its effect of thic#ening the endometrium (uterine lining! can lead to endometrial (uterine! cancer in some menopausal "omen ta#ing oestrogen only $%T. Provera 2.5mg tablets counteract the stimulating effect of oestrogen on the endometrium reducing the ris# of endometrial cancer "hich can develop in response to an oestrogen in "omen ta#ing $%T for menopausal symptoms. What is the difference bet"een a synthetic progesterone li#e Provera (medro'yprogesterone! and natural progesterone? Provera 2.5mg tablets contain medro'yprogesterone a synthetic derivative of the female se' hormone progesterone "hich means that its chemical structure closely resembles that of naturally produced progesterone and it therefore "or#s in a similar "ay. $o"ever unli#e natural progesterone it is easily absorbed and can be ta#en in tablet form at relatively lo" concentrations "hereas natural progesterone is not "ell absorbed by the gastrointestinal system and until recently could only be administered by in4ection. & ne" form of microni+ed progesterone (reduced to tiny particles so that it is better absorbed! is no" available. Provera 2.5mg tablets are used as part of a hormone replacement therapy ($%T! regime to counteract the effect of oestrogen and reduce the ris# of endometrial cancer ho"ever unli#e microni+ed natural progesterone Provera can interfere "ith the beneficial effects of oestrogen such as preventing bone loss and regulating cholesterol. Provera for transgender treatment Provera 2.5mg tablets contain medro'yprogesterone a synthetic derivative of the female se' hormone progesterone "hich means that its chemical structure closely resembles that of naturally produced progesterone and it therefore "or#s in a similar "ay. &dding a progestin "ith an oestrogen is thought to help the feminisation process for male to female transse'uals and Provera 2.5mg tablets are used as a component of transgender hormone therapy to help stimulate the development of female se'ual characteristics such as breast development and reduce the production of testosterone. Provera for feminising hormone therapy Provera 2.5mg tablets are used as a progestin component of transgender hormone therapy along "ith the feminising hormone oestrogen to help stimulate the development of female se'ual characteristics such as breast development and reduce the production of testosterone. What are the side effects of Provera? The most fre,uently reported side effects "hen ta#ing Provera 2.5mg tablets include acne menstrual changes (brea#through bleeding spotting or missed periods! di++iness dro"siness fever headache nausea nervousness s#in rash and itch sleeplessness stomach pain "eight gain or loss. 5ore severe side effects include 4aundice. What are the health ris#s of using Provera? 6ong-term $%T "ith Provera 2.5mg tablets does have associated health ris#s particularly increased ris# of breast and ovarian cancer compared "ith oestrogen alone $%T but it does reduce ris# of endometrial cancer. .ombined $%T "ith oestrogen and progestin therapy has been associated "ith an increased ris# of cardiovascular events such as myocardial infarction and stro#e as "ell as venous thrombosis and pulmonary embolism. )f you are pre-menopausal and particularly if you have a family history of brittle bones (osteoporosis! you may be at ris# of losing bone mineral density and developing brittle bones. When should Provera not be used? 7ou should not use Provera if you: are allergic to medro'yprogesterone or any other ingredient in Provera 2.5mg tablets

have a past or family history of carcinoma of the breast endometrial carcinoma or liver disease a history of thrombosis (blood clots! or stro#e porphyria (a metabolic disease resulting in abnormal pigment in the urine and s#in! abnormal genital bleeding of un#no"n cause are pregnant or planning to become pregnant are ta#ing aminoglutethimide used to treat breast cancer as this may reduce the effectiveness of provera $o" should Provera be ta#en? 7ou should ta#e Provera 2.5mg tablets "ith "ater "ith or "ithout food at the same time each day. The dose of Provera you ta#e ho" often your ta#e it and for ho" long "ill depend on the condition for "hich you are being treated and should be as recommended by your doctor. $o" long should you ta#e Provera? 7ou should ta#e Provera 2.5mg tablets for as long as your doctor recommends "hich may be for /8 days /8 days a month for several months or continuously for several months. 5issed dose of Provera )f you miss a dose of Provera ta#e it as soon as you remember unless it is time to ta#e the ne't dose then s#ip the missed dose. 2o not ta#e a double dose. $o" should product name be stored? 9eep your Provera 2.5mg tablets in the blister pac# until use. :tore in a cool dry place belo" ;8<..