Why Spray?

| A-Z Guide For Healthy Life

Page 1 of 3

Sublingual & Buccal route

Nutrients in a Super Health spray can be absorbed in both sublingual (placed under the tongue) and buccal (placed inside the cheek) areas where they go through the thin mucous membrane directly into the bloodstream.

Higher Absorption
The process of Absorption with Super Health Sprays occurs when nutrients or other molecules are taken up into the capillaries and veins that line the mouth. To do this, the nutrient molecules must cross the buccal membrane, which lines the inside of the mouth. Once across this membrane the nutrient enters the blood vessels, which drain into the jugular vein and from there they enter the systemic circulation, which distributes blood, and the nutrients it is carrying, throughout the body. This is a rapid process, taking place in the space of a few seconds. Oral transmucosal delivery (especially buccal and sublingual absorption) is an interesting and simple concept with massive repercussions throughout the health industry. Drug delivery is a highly active research field and in the next few years we can expect more and more drugs to be developed for delivery by buccal absorption. The main key factor is that transmucosal delivery allows the bypass of significant barriers imposed for the peroral administration of drugs, such as hepatic first pass metabolism and drug degradation within the gastrointestinal (GI) tract. As the spray delivers the dose in fine particulates or droplets, the lag time for the drug to be available for the site of the absorption is reduced.

Some Facts about Buccal Mucosa

Mucosa of the buccal cavity was found to be the most convenient and easily accessible site for the delivery of therapeutic agents for both local and systemic delivery. The mucosa has a rich blood supply and it is relatively permeable. Blood vessels drain directly into the jugular vein; due to its particular features, it has been of increasing interest to researchers as an alternative site of drug administration. Direct access to the systemic circulation through the internal jugular vein bypasses drugs from the hepatic first pass metabolism leading to high bioavailability. The oral cavity is an attractive site for drug delivery due to ease of administration and avoidance of possible drug degradation in gastrointestinal tract and first-pass metabolism.

Case Study: Insulin

Pharmacokinetic studies of buccal insulin spray in patients with Type I diabetes revealed that insulin, delivered through a novel insulin buccal spray, easily passed through the buccal mucosa. It proved that administration of insulin in spray form can be an effective therapeutic alternative to current medication systems for treating diabetes (references 1- 2).

Case Study: Nitroglycerin

Nitroglycerin is perhaps the best-known example. In fact, the only way that nitroglycerin is administered is by oral absorption. (The first recognition of the ability of a substance to cross the oral mucosa was reported by Braunton in his Gaulstonian Lectures delivered at the Royal College of Physicians in 1877.) In addition to nitroglycerin, there are numerous other drugs and vitamins that have been shown to absorb

http://superhealthsprays.com/why-spray/

3/18/2014

Why Spray? | A-Z Guide For Healthy Life

Page 2 of 3

across the buccal membrane. There are literally thousands of published research papers on oral absorption (both buccal and sublingual) of vitamins, minerals and drugs.

Studies by Dr Squier and co-workers revealed that the permeability of water through the buccal mucosa was approximately 10 times higher, whilst in floor of the mouth the permeability was approximately 20 times higher than skin.

Effective Formulation
We have taken great care to create excellence in our Super Health Sprays - there are no artificial flavours or colours added to their solutions. The products are totally safe and contain no sugar, starch, wheat, soy, gluten, eggs, salt, or dairy. We use Xylitol (which is known for cavity protection and it is diabeticsafe) The flavors are natural mints or fruits. All products are suitable for vegetarians

C.A. Lesch, C.A. Squier, A. Cruchley, D.M. Williams, P. Speight, The permeability of human oral mucosa and skin to water, J. Dent. Res. 68 (1989) 1345-1349. Campisi G, Paderni C, Saccone R, Di Fede O, Wolff A, Giannola LI., Human buccal mucosa as an innovative site of drug delivery. Shojaei AH., Buccal mucosa as a route for systemic drug delivery: a review. Hao J, Heng PW., Buccal delivery systems.

Precision of Dosage
Each Super Health Spray gives a precise, metered dose of nutrients with every pump. This ensures that a user receives the correct dose each time.

Absorption and Bioavailability of Tablets

Absorption and bioavailability (how quickly and how much of a drug reaches its target of action) of tablets can be affected by many factors: the way a drug product is manufactured, its physical and chemical properties and the physiologic characteristics of the person taking the drug. However, the following properties of pills hinder absoption the most: Tablets/capsules consist of the drug (active ingredient) and additives (inactive ingredients): dilutents, stabilizers, disintegrants, lubricants and a gelatin shell. The latter affects how quickly the tablet disintegrates and how quickly the drug is absorbed. If the tablet does not release the drug quickly enough, much of the drug may be eliminated in the feces without being absorbed, and blood levels may be too low. Tablets and capsules can be coated with a substance intended to prevent it

Bioavailability
As analysed by Dr Srinivasan (reference 3) in study referring to tablets, Good quality is associated with the ability to disintegrate and dissolve. In the case of our spray vitamins the active components are already in solution or suspension; in other words, the nutrient is already dissolved and just waiting to be absorbed into your system. For example,Vitamin D3 is an oil-soluble vitamin therefore it can be a challenge for any producer to develop a truly beneficial formulation. We invested significant time and resources to research a right solution for this problem. As a result, while being a fine mist spray, our products are also an emulsion, meaning that the vitamin is fully mixed with the water base this again helps the absorption and bioavailability within the body. The metal container we use protects the liquid from oxidation ( light and air), keeping the ingredients potent and providing a much longer shelf life.

Safety
Our sprays contain no fillers, like tablets do. This reduces the chance of an allergic or nauseous reaction to nearly zero.

Convenience
No need to look for a glass of water to take your tablets with. No more trouble with counting the number of spoonfuls of liquid/powder per cup of

http://superhealthsprays.com/why-spray/

3/18/2014

Why Spray? | A-Z Guide For Healthy Life

Page 3 of 3

water or counting the number of drops under the tongue. Our sprays produced in light metal tubes which easily fit in your pocket, purse or briefcase and deliver a precise dosage of nutrients per spray.

from dissolving until it reaches the small intestine. For the coatings to dissolve, they must come in contact with the less acidic environment of the small intestine or with the digestive enzymes there. However, the coatings do not always dissolve as intended therefore tablets or capsules may be passed intact in the feces, especially in older people. Food, other drugs, and digestive disorders can affect drug absorption and bioavailability. For example, calcium supplements and high-fiber foods may bind with a drug that affects absorption of such drug. Other factors reducing drug absorption are laxatives and diarrhea, which speed up the passage of substances through the digestive tract. Surgical removal of parts of the digestive tract (such as the stomach or colon) may also affect drug absorption. The drug in some pills deteriorates and becomes ineffective or harmful if stored improperly or kept too long. To preserve them safe for consumption, some pills must be stored in a dry, cool or dark place. So, you should always check and strictly follow directions and expiration dates for pills at all times.

Reference: Medical Papers

P. Pozzilli, S. Manfrini, F. Costanza, G. Coppolino, M.G. Cavallo, E. Fioriti, P. Modi, Biokinetics of buccal spray insulin in patients with type 1 diabetes, Metabol. Clin. Exp. 54 (2005) 930-934. H. Xu, K. Huang, Y. Zhu, Q. Gao, Q. Wu, W. Tian, X. Sheng, Z. Chen, Z. Gao, Hypoglycaemic effect of a novel insulin buccal formulation on rabbits, Pharmacol. Res. 46 (2002) 459-467. Srinivasan, V.S. 2001. Bioavailability of Nutrients: A Practical Approach to In Vitro Demonstration of the Availability of Nutrients in MultivitaminMineral Combination Products. J. Nutr. 131:1349S-1350S. Hoag, S.W., Ramachandruni, H. and Shargraw, R.F. 1997. Failure of Prescription Prenatal Vitamin Products to Meet USP Standards for Folic Acid Dissolution. J. Am. Pharm Assoc. 37:397-400. Stamatakis, M.K. and Meyer-Stout, P.J. 1999. Disintegration Performance of Renal Multivitamin Supplements. J.Renal Nutr. 9:78-83.

Copyright by SuperHealthSprays

This page is copy protected

http://superhealthsprays.com/why-spray/

3/18/2014