APPENDIX

CD Molecules
STEPHAN VON GUNTEN | VIVIANE GHANIM | PETER VALENT | BRUCE S. BOCHNER

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Neutrophil Eosinophil Basophil

Mast Cell

Monocyte

Dendritic Cell T Cell

B Cell

NK Cell Platelet

Erythrocyte

Thymocytes

Stem Cell/Precursor Endothelial Cell Epithelial Cell Known or Proposed Function Non-peptide antigen presentation Non-peptide antigen presentation Non-peptide antigen presentation c Non-peptide antigen presentation Non-peptide antigen presentation

CD Molecule (Common Name) a a a s +

Molecular Weight (kD, Unreduced), Family

Binding Partner(s) Glycolipids, lipopeptides; associates with 2-microglobulin Glycolipids, lipopeptides; associates with 2-microglobulin Glycolipids, lipopeptides; associates with 2-microglobulin Glycolipids, lipopeptides; associates with 2-microglobulin Glycolipids, lipopeptides; associates with 2-microglobulin

CD1a

49, Ig

Appendix A CD Molecules

CD1b

45, Ig

a a a s

CD1c (BDCA-1)

43, Ig

a s a s s

CD1d

49, Ig

s a s

CD1e

28, Ig

CD2 (LFA-2)

50, Ig

s s

Costimulation, adhesion, regulation of apoptosis, immunoregulation s Recognition of peptide antigen presented by MHC molecules, T cell activation

CD58, CD48, CD59, CD15; associates with CD45

CD3 (d,e,g)

d,e-20kD, g-25-28kD, Ig

MHC classes I and II, CD38; associated in TCR complex; associates with CD45 s MHC class II antigenrestricted T-cell activation, thymic differentiation, receptor for HIV-1 MHC class II, IL-16, HIV-1 gp120; associates with CD45, CD82

CD4

55, Ig

w s s s

CD5

58, SR

Modulates signaling through TCR and BCR; regulates T-B lymphcyte interaction + s + w/s Adhesion, costimulation, regulation of apoptosis

CD72; associates with TCR or BCR, CD2

CD6

100-120 [reduced], SR

CD166

CD7

38, Ig

+ s

+ s

Costimulation, immunoregulation MHC class I restricted T-cell activation

Galectin-1, SECTM1 (K12) MHC class I; forms dimers with CD8a, CD8b

CD8a

32-34 [reduced], Ig

cursor

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Neutrophil Eosinophil Basophil

Mast Cell

Monocyte

Dendritic Ce T Cell

B Cell

NK Cell Platelet

Erythrocyte

Thymocytes

Stem Cell/Pr Endothelial

CD Molecule (Common Name) Binding Partner(s) s + a s s Adhesion, activation + + + + Associates with CD63, CD81, CD82, CD171, CD315, CD316 Unknown CD54, CD102, CD50; possibly CD242, CD321, ICAM-5 CD54, extracellular matrix proteins, C3bi, LPS/LBP complex, microbial proteins iC3b, brinogen, CD23, CD87, LPS/LBP complex CD50, CD106 Unknown Small peptides, encephalins, MIP-1, Coronavirus, CMV Activation s + + + Adhesion Adhesion Adhesion Phagocytosis and antibodydependent cytotoxicity s + Phagocytosis and antibodydependent cytotoxicity + + + + + + Homotypic adhesion, phagocytosis, intracellular trafcking, granule exocytosis w + + s + + + + s s Adhesion B cell maturation, proliferation and activation; germinal center formation LPS/LBP complex, LTA, phosphatidyl inositol CD62E, CD62P CD62E, CD62P CD62L Aggregated IgG s s MHC class I restricted T-cell activation MHC class I; forms dimers with CD8a, CD8b w + w + +

Molecular Weight (kD, Unreduced), Family Known or Proposed Function

Epithelial Ce

CD8b

30-32 [reduced], Ig

CD9

24 [reduced], TM4

CD10 (Neutral endopeptidase) + s s s Adhesion, migration + + + + + + +

100, metalloproteinase

+ s s s s s Enzymatic activity, differentiation

CD11a (LFA-1 )

170, integrin

CD11b (Mac-1, CR3) s s s s Adhesion, migration

165, integrin

CD11c (p150,95) s s

145, integrin

Adhesion, migration

CD11d + + s s s s + + + + + + + + +

125, integrin

+ w w w w w

Adhesion Unknown Enzymatic activity

CDw12

120, unknown

CD13 (Aminopeptidase N) w + w + a a s + + s s + + + + + + + + w + + + + + w s w w w +

150, metalloproteinase

CD14 (LPS receptor)

53, leucine-rich repeat

CD15 (Lewis x, Lex)

Branched trisaccharide

CD15s (Sialyl-Lewis X, sLex)

Terminal tetrasaccharide

CD15su (6-sulfo sLex, L-selectin ligand)

Sulfated CD15

CD16a (FcRIIIa)

50-65, Ig

CD16b (FcRIIIb) a s s s

48, Ig

Aggregated IgG

CD17 (Lactosylceramide)

150-160, ceramide

GM3 gangliosides, bacteria

CD18 (2 integrin subunit)

120, integrin

See CD11a,b,c,d CD77; associates with CD21, CD81

Appendix A CD Molecules

CD19

90, Ig

1665
Continued

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Neutrophil Eosinophil Basophil

Mast Cell

Monocyte

Dendritic Cell T Cell

B Cell

NK Cell Platelet

Erythrocyte

Thymocytes

Stem Cell/Precursor Endothelial Cell Epithelial Cell Known or Proposed Function B cell activation and proliferation B cell activation and proliferation; on interaction with CD23 regulates synthesis of IgE B cell adhesion, immunoregulation, signal transduction Low-afnity IgE receptor; mediates cytotoxicity and phagocytosis; soluble form has multiple functions, including B cell differentiation s s Regulation of B cell proliferation and differentiation, reactive oxygen species production in neutrophils, eosinophils C3d, C3dg, iC3b, CD35, Epstein-Barr virus; associates with CD19, CD23 and CD81 Sialylated glycans, CD45RO, CD75 IgE

CD Molecule (Common Name) s/w s + + s + +

Molecular Weight (kD, Unreduced), Family

Binding Partner(s)

CD20

33/35/37, TM4

Appendix A CD Molecules

CD21 (CR2)

130-145, RCA

CD22 (Siglec-2)

140, Ig

s s

CD23 (FcRII)

45, lectin

/w

CD24

35-45, selectin

CD171

CD25 (IL-2R chain) a + + + + a a/s a +

55, CCP-like

w/s s

Activation/ costimulation Activation/ costimulation, adhesion; enzymatic activity

IL-2; associates with CD122, CD132 Adenosine deaminase, collagen, broblast activation protein, Tat protein of HIV

CD26 (dipeptidyl peptidase IV)

110, peptidase

CD27

110-120, TNFR

Activation/ costimulation, cell differentiation + Activation/ costimulation, signal transduction

CD70, TRAF2, TRAF5

CD28

90, Ig

CD80, CD86

CD29 (1 integrin subunit) + + +

110, integrin

+ +

+ + +

+ a s

+ a s

+ a +

+ +

+ s +

Adhesion, migration Cell death, immunoregulation Adhesion, migration

Associates with CD49a-f CD153 CD31 (homophilic binding), CD38

CD30

120, TNFR

CD31 (PECAM-1)

130-140, Ig

cursor

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Neutrophil Eosinophil Basophil

Mast Cell

Monocyte

Dendritic Ce T Cell

B Cell

NK Cell Platelet

Erythrocyte

Thymocytes

Stem Cell/Pr Endothelial

CD Molecule (Common Name) Binding Partner(s) + s s + a + s + Adhesion Phagocytosis, regulation of complement Adhesion, pathogen recognition + + Adhesion, regulation of cell growth s s + + Activation, ADCC + + + + + + + + + + + s Immunoregulation + Aggregated IgG or complexes with antigen Aggregated IgG or complexes with antigen Sialylated glycans CD62L, CD62E C3b, iC3b, C3dg, C4b, iC3, iC4 Collagen, thrombospondin, oxidized LDL, bacterial diacyl glycerides Associates with CD53, CD81, CD82, MHC class II CD31, hyaluronic acid s Activation, phagocytosis Aggregated IgG or complexes with antigen + + + + + + +

Molecular Weight (kD, Unreduced), Family Known or Proposed Function

Epithelial Ce

CD32a (FcRIIA)

40, Ig

CD32b (FcRIIB)

40, Ig

CD32c (FcRIIC)

40, Ig

CD33 (Siglec-3)

150, Ig

CD34

105-120, sialomucin

CD35 (CR1)

165-255, RCA

CD36

88-113, SR

CD37

40-52, TM4

Immunoregulation

CD38

45, ectoenzyme

s/a s/a s

Adhesion, activation/ costimulation, enzymatic activity + Platelet aggregation, enzymatic activity

CD39 s a + + + + + s +

78, ectoapyrase

+ a s a

ADP, ATP w/s Activation/ costimulation, differentiation, isotype switching of B-cells CD154

CD40

85 (dimers), TNFR

CD41 (GPIIb)

120/23, integrin

Adhesion

Fibrinogen, von Willebrand factor, bronectin, vitronectin, thrombospondin; associates with CD61 + s Adhesion, CD42 a-d complex serves as von Willebrand factor receptor Von Willebrand factor, thrombin

CD42a (GPIX)

22, leucine-rich repeat

CD42b (GPIb)

160, leucine-rich repeat

Actual binding site for von Willebrand factor and thrombin lies on CD42b + + s s See CD42a See CD42a

See CD42a

CD42c (GPIb) + + +

160, leucine-rich repeat

See CD42a See CD42a + + + a + + + + Adhesion, signal transduction CD54, CD169, MHC class I, CD62P, hyaluronic acid Continued

CD42d (GPV)

82, leucine-rich repeat

Appendix A CD Molecules

CD43

95-135, sialomucin

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Neutrophil Eosinophil Basophil

Mast Cell

Monocyte

Dendritic Cell T Cell

B Cell

NK Cell Platelet

Erythrocyte

Thymocytes

Stem Cell/Precursor Endothelial Cell Epithelial Cell Known or Proposed Function Adhesion, activation/ costimulation See CD44 Activation/ costimulation, differentiation, apoptosis Activation/ costimulation, differentiation, apoptosis Activation/ costimulation, differentiation, apoptosis

CD Molecule (Common Name) + s + + + + + + + + + +

Molecular Weight (kD, Unreduced), Family

Binding Partner(s) Hyaluronan, MIP-1b, osteopontin, ankyrin, bronectin See CD44 Galectin-1, CD206; associates with CD2, CD3, CD4, LPAP See CD45

Appendix A CD Molecules

CD44

85, core/link proteoglycan a + w/s + + + + + + + + + + + s

CD44R

85-200, core/link proteoglycan

CD45

180-240, RPTP

CD45RA

205-220, RPTP

CD45RB

190-220, RPTP

+ s

See CD45

CD45RC

220, RPTP

+ s

Activation/ costimulation, differentiation, apoptosis + + w/s Activation/ costimulation, differentiation, apoptosis

See CD45

CD45RO

180, RPTP

+ s

See CD45; CD22

CD46

52-58, RCA

Regulation of complement, pathogen recognition

C3b, C4b, many pathogens including measles virus, Herpes virus, Streptococcus pyogenes, and pathogenic Neisseria sp. + + + + + + + + Adhesion, activation/ costimulation, cell death, hemostasis Thrombospondin-1, CD172a, CD172g; associates with integrins; part of the Rhesus antigen complex (see CD240CE)

CD47

45-60, Ig

CD47R (Formerly CDw149)

120, Ig

See CD47

See CD47

cursor l

ell

ll

Neutrophil Eosinophil Basophil

Mast Cell

Monocyte

Dendritic Ce T Cell

B Cell

NK Cell Platelet

Erythrocyte

Thymocytes

Stem Cell/Pr Endothelial

CD Molecule (Common Name) Binding Partner(s) s Activation/ costimulation, immunoregulation, pathogen recognition Adhesion, costimulation + Adhesion, costimulation Laminin, collagen type IV; associates with CD29 Laminin, collagen type I, VLA-3, E-cadherin, echovirus; associates with CD29 Laminin, collagen, bronectin, entactin, CD151; associates with CD29, CD63 CD53, CD160, bronectin, MAdCAM1; associates with CD29 Fibronectin, CD171; associates with CD29 Adhesion Laminin, invasin, merosin, CD151; associates with CD29, CD63 Adhesion, costimulation + + + s + Adhesion Costimulation Activation/ costimulation, signal transduction w s +/a +/a Adhesion VLA-4 (CD49d/CD29), HLA-DR LFA-1 (CD11a/CD18), Mac-1 (CD11b/CD18), brinogen, hyaluronan, CD227, rhinovirus, Plasmodium falciparuminfected erythrocytes + + + + + + + + Complement regulation, activation C3b/C3bBb convertase, C4b/C4b2a convertase, CD97, coxsackie virus, echovirus, enterovirus, E.coli s + Adhesion, differentiation/ development CD56 (homotypic binding), CD155, CD171, heparin sulfate, chondroitin sulfate, proteglycans + + + + + + s + + s + + + + s + Adhesion Adhesion, activation/ costimulation Laminin CD2 Continued LFA-1 (CD11a/CD18), d2 (CD11d/CD18), CD209 ECM proteins CD2, CD244, FimH + + + + + + + +

Molecular Weight (kD, Unreduced), Family Known or Proposed Function

Epithelial C

CD48 (SLAMF2)

45, Ig

CD49a (VLA-1) a a + s + + + a s + +

200, integrin

CD49b (VLA-2)

160, integrin

CD49c (VLA-3) Adhesion

150, integrin

CD49d (VLA-4) a s Adhesion

150/180, integrin

CD49e (VLA-5) a/s + w s + + + + a/s s + + + +

155, integrin

Adhesion

CD49f (VLA-6)

140, integrin

CD50 (ICAM-3)

110-170, Ig

+ s s

CD51 (Vitronectin-Ra) + s + + + + + + + + + + + + +

150, integrin

a s

CD52

25-29, CD24/HSA/ CD52

CD53

32-42, TM4

CD54 (ICAM-1)

80-114, Ig

+ a w a a

CD55 (decay accelerating factor)

50/70, RCA

Appendix A CD Molecules

CD56 (NCAM)

130/140/180, Ig

CD57

110, carbohydrate

CD58 (LFA-3)

40-70, Ig

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Neutrophil Eosinophil Basophil

Mast Cell

Monocyte

Dendritic Cell T Cell

B Cell

NK Cell Platelet

Erythrocyte

Thymocytes

Stem Cell/Precursor Endothelial Cell Epithelial Cell Known or Proposed Function Complement regulation, activation, cell survival Apoptosis, costimulation s Costimulation s + Adhesion + Costimulation Vitronectin, brinogen, von Willebrand factor, CD9; associates with CD41 and CD51 Rolling and adhesion CD15, CD62L, CD65, CD66a, CD162, CD163, CD227, ESL-1, myeloglycans s Rolling and adhesion CD15su, CD34, CD62E, CD227, MAdCAM-1, GlyCAM-1

CD Molecule (Common Name) + s s + + + + + + + + +

Molecular Weight (kD, Unreduced), Family

Binding Partner(s) Complement components C8a and C9

Appendix A CD Molecules

CD59

18-25, Ly-6

CD60a (GD3) + s + s s + + a +

Glycolipid

+ s

Siglec-7

CD60b (9-O-acetyl-GD3)

Glycolipid

CD60c (7-O-acetyl-GD3)

Glycolipid

CD61 (b3 integrin subunit)

90, integrin

CD62E (E-selectin)

107-115, lectin

s a/s

CD62L (L-selectin)

65, lectin

CD62P (P-selectin) + s a + + + + + + +

120, lectin

a a

Rolling and adhesion Adhesion

CD15s, CD24, CD162, CD227 Associates with VLA-3 (CD49c/CD29), VLA-6 (CD49f/CD29), CD9, CD81

CD63

40-60, TM4

CD64 (FcRI) a s

72, Ig

ADCC, phagocytosis of immune complexes + s Adhesion

Monomeric IgG

CD65 (Ceramidedodecasaccharide) + + + + + +

Carbohydrate

+ a

CD62E + + Adhesion Multifunctional, adhesion, signal transduction, inhibition, tumor suppression Possibly CD62E or CD62P CD62E, CD66a,c,e, microbial proteins

CD65s (sialylated-CD65)

Carbohydrate

CD66a (CEA-related cell adhesion molecule 1, CEACAM1)

140-180, Ig

CD66b

95-100, Ig

Adhesion, signal transduction, activation + + Adhesion, signal transduction, activation

CD66c

CD66c

90 [reduced], Ig

CD66a,b,c,e, microbial proteins

cursor l

ell

ll

Neutrophil Eosinophil Basophil

Mast Cell

Monocyte

Dendritic Ce T Cell

B Cell

NK Cell Platelet

Erythrocyte

Thymocytes

Stem Cell/Pr Endothelial

CD Molecule (Common Name) Binding Partner(s) + Adhesion, signal transduction, activation + Adhesion, possibly tumor metastasis Essential for successful pregnancy, may protect fetus from maternal immune system Atherosclerosis (foam cell formation) Signal transduction, activation + Activation/ costimulation Metabolism, cell growth Differentiation, immunoregulation + a a Enzymatic activity Antigen presentation, activation, differentiation s + + s + + Adhesion Adhesion Apoptosis Part of the BCR, activation, differentiation s s Part of the BCR, activation, differentiation a a Activation/ costimulation, immunoregulation + + + + w s + + Associates with CD19 and CD21 for signalling complex, B cell activation, regulation of cell growth + + + + + + + s + + Activation/ costimulation Unknown CD66a,c,e, microbial proteins Microbial proteins + +

Molecular Weight (kD, Unreduced), Family Known or Proposed Function

Epithelial C

CD66d

35, Ig

CD66e (Carcinoembryonic antigen, CEA) +

180-200 [reduced], Ig

CD66f

54-72, Ig

CD68 a a + s w w + s a + s + + + + + + a a w w s + w + + + a a a a a a a + a

110, sialomucin

Oxidatively modied LDL Unknown CD27 Transferrin, IgA CD5, CD100 Unknown HLA-DR heterodimers, MIF, CD44 CD22 CD22 CD19, Shiga toxin, verotoxin 1 Associates with membrane Ig (mIgM), CD179b, CD5, CD19, CD22 Associates with membrane Ig (mIgM), CD179a, CD5, CD19, CD23

CD69

60, lectin

CD70

170 [trimeric], TNF

CD71 (transferrin receptor)

190

CD72

43, lectin

CD73

69-72

CD74 (Invariant chain)

33-41

CD75 + s a/s + + + +

Carbohydrate

CD75s

2,6 sialylated CD75

CD77

Carbohydrate

CD79a (Iga)

33, Ig

CD79b (Igb)

31, Ig

CD80 (B7-1)

60, Ig

CD28, CD152

Appendix A CD Molecules

CD81 (TAPA-1)

26, TM4

Hepatitis C virus; associates with CD9, CD19, CD21, CD63, CD82, CD315, CD316

CD82

45-90, TM4

1671

Associates with MHC molecules, integrins, CD4, CD8, CD20, CD37, CD53, CD81 Continued

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Neutrophil Eosinophil Basophil

Mast Cell

Monocyte

Dendritic Cell T Cell

B Cell

NK Cell Platelet

Erythrocyte

Thymocytes

Stem Cell/Precursor Endothelial Cell Epithelial Cell Known or Proposed Function Possibly activation, differentiation Immunoregulation Immunoregulation Immunoregulation, differentiation Immunoregulation Unknown CD84 [homotypic adhesion] HLA class I molecules HLA class I molecules HLA class I molecules, CMV Unknown CD28, CD152

CD Molecule (Common Name) + s + s + + w a + a a/s + + + + + + s w + + a + + + + + + s + + + + + + + + + + +

Molecular Weight (kD, Unreduced), Family

Binding Partner(s)

CD83

43 [reduced], Ig

Appendix A CD Molecules

CD84 (SLAMF5)

68-80, Ig

CD85a

110, Ig

CD85d

110, Ig

CD85j

110, Ig

CD85k

60, Ig

Immunoregulation, differentiation Activation/ costimulation, immunoregulation Adhesion, migration, tumor metastasis

CD86 (B7-2)

80 [reduced], Ig

CD87 (uPAR, urokinase plasminogen activator receptor) + s + + + w + + + +

35-68, Ly-6

+ a

uPA, Vitronectin, integrins, kininogen + + Activation Activation, signal transduction C5a, anaphylatoxin Serum and secretory IgA1 and IgA2; associates with common Fc receptor -chain, Mac-1 (CD11b/CD18)

CD88 (C5a receptor)

43, TM7

CD89 (IgA receptor)

45-100, Ig

CD90 (Thy-1)

25-35, Ig

Activation/ costimulation, adhesion, differentiation + + Antigen presentation, phagocytosis, metabolism

Mac-1 (CD11b/CD18)

CD91 (LDL receptor)

600, LDLR

Plasminogen activator, lipoproteins, lipoprotein lipase, -amyloid precursor protein, heat shock proteins, various toxins and drugs + + s w w w + + w + w Metabolism, possibly immunoregulation Possibly phagocytosis s + Immunoregulation Choline C1q

CD92 + + + + +

70, choline transporter-like

+ w

CD93

110, lectin

CD94

30 [reduced], lectin

Heterodimer formation with CD159a, CD159c + + + + + + + + + + w/a + Apoptosis, immunoregulation Adhesion CD178 CD155

CD95 (Fas)

45, TNFR

CD96

160, 180, 240, Ig

cursor l

ell

ll

Neutrophil Eosinophil Basophil

Mast Cell

Monocyte

Dendritic Ce T Cell

B Cell

NK Cell Platelet

Erythrocyte

Thymocytes

Stem Cell/Pr Endothelial

CD Molecule (Common Name) Binding Partner(s) + a + Adhesion, metabolism Adhesion, apoptosis, activation/ costimulation Activation/ costimulation Activation/ costimulation, immunoregulation Adhesion, costimulatin Adhesion, lymphocyte homing to epithelia + Adhesion, activation Angiogenesis, signal transduction Adhesion, costimulation, differentiation s a + s + + + + + + w + + s Possibly adhesion, metabolism Possibly adhesion, metabolism Activation Possibly differentiation Differentiation Adhesion CD99 [homophilic adhesion] CD45, CD72, plexin B Unknown + + + + + + + + + + + + + + + Integrins, associates with actin, CD147 a a Adhesion, migration, tumor metastasis CD55, chondroitin sulphate + + + + + + + + + + + + +

Molecular Weight (kD, Unreduced), Family Known or Proposed Function

Epithelial C

CD97

28, 74-89,TM7

CD98

125

CD99

32

CD100 + a w + + +

300, Ig

CD101

240, Ig

CD102 (ICAM-2) a s s a + s s + + + a

55-65kD, Ig

LFA-1 (CD11a/CD18), CR3 (CD18/CD11b) CD324 Laminins, keratin laments TGF-1, TGF-3 isoforms VLA-4 (CD49d/CD29), 47 integrin Galectins, CD62L,E,P Galectins, CD62L,E,P CD232 Unknown Thrombopoietin CD111 [homophilic binding], CD112, CD113, CD155, HSV-1, HSV-2, PRV

CD103 (Integrin E)

175, integrin

CD104 (4 Integrin)

205, integrin

CD105 (Endoglin)

180, TGFR

CD106 (VCAM-1)

110, Ig

CD107a (LAMP-1) a a + + a + + + + + a a a

100-120, LAMP

a a a a

CD107b (LAMP-2)

100-120, LAMP

CD108

80, Ig

CD109

170

CD110

85-92, CR, Ig

CD111

75 [reduced], Ig

CD112

64 -72, Ig

+ w

Adhesion

CD111, CD112 [homophilic binding], CD113, CD155, CD226, HSV-1, PRV + Adhesion CD111, CD112, CD113 [homophilic binding], CD155

CD113

83, Ig

CD114 (G-CSF receptor)

130 [reduced], CR, Ig

Signal transduction, differentiation, survival + + s Signal transduction, differentiation, survival

G-CSF

Appendix A CD Molecules

CD115 (M-CSF receptor)

150, RTK, Ig

M-CSF

CD116 (GM-CSF receptor )

80-85, CR, Ig

Signal transduction, differentiation, survival

GM-CSF; associates with CD131 Continued

1673

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Neutrophil Eosinophil Basophil

Mast Cell

Monocyte

Dendritic Cell T Cell

B Cell

NK Cell Platelet

Erythrocyte

Thymocytes

Stem Cell/Precursor Endothelial Cell Epithelial Cell Known or Proposed Function Signal transduction, differentiation, survival Signal transduction SCF

CD Molecule (Common Name) w w/ + + +

Molecular Weight (kD, Unreduced), Family

Binding Partner(s)

Appendix A CD Molecules

CD117 (stem cell factor receptor, KIT) + + + +

145, RTK, Ig

CD118

190, CR

LIF, oncostatin M, IFN-a and -b; associates with CD130 IFN-g TNF-a, TNF-b TNF-a, TNF-b

CD119 (IFN-g receptor) + + + a + s s + + + + + + + + + + + + s a + + + + + + + + + + + + w + + + w + w + + + + + + + s s s s s + + + + + + s + + + + + s + + + + + + + + + + + + + + + + + +

90, CR, Ig

Signal transduction Signal transduction Signal transduction Signal transduction Decoy receptor Signal transduction Signal transduction Signal transduction Signal transduction Signal transduction Signal transduction Signal transduction Signal transduction

CD120a (TNF receptor 1)

55, TNFR

CD120b (TNF receptor 2)

75, TNFR

CD121a (IL-1 receptor, type 1)

75-85, Ig

IL-1 IL-1 IL-2, IL-15, associates with CD25, CD132 IL-3, associates with CD131 IL-4, IL-13, associates with CD132 IL-5, associates with CD131 IL-6, associates with CD130 IL-7, associates with CD132 IL-9, associates with CD132 IL-6, IL-11, oncostatin M, LIF; associates with CD126

CD121b (IL-1 receptor, type 2)

60-68, Ig

CD122 (IL-2 receptor, chain)

70-75, CR, Ig

CD123 (IL-3 receptor, chain)

70, CR, Ig

CD124 (IL-4 receptor, chain)

140, CR, Ig

CD125 (IL-5 receptor, chain)

60, CR, Ig

CD126 (IL-6 receptor, chain)

80, CR, Ig

CD127 (IL-7 receptor, chain)

80, CR, Ig

CD129 (IL-9 receptor, chain)

65-90, CR, Ig

CD130 (common chain of IL-6, IL-11 and LIF receptors) + + +

130-140, CR, Ig

CD131 (common chain of IL-3, IL-5 and GM-CSF receptors) + + +

120-140, CR, Ig

Signal transduction

IL-3, IL-5, GMCSF, associates with CD116, CD123, CD125 + + + + + Signal transduction IL2, IL4, IL7, IL9, IL15, associates with CD25, CD122, CD124, CD127, CD129

CD132 (common chain of IL-2, IL-4, IL-7, IL-9, IL-15 receptors)

65-70, CR, Ig

cursor l

ell

ll

Neutrophil Eosinophil Basophil

Mast Cell

Monocyte

Dendritic Ce T Cell

B Cell

NK Cell Platelet

Erythrocyte

Thymocytes

Stem Cell/Pr Endothelial

CD Molecule (Common Name) Binding Partner(s) s Unknown, mutation of gene responsible for retinal degeneration Activation/ costimulation, survival Differentiation + Migration, proliferation, differentiation Activation/ costimulation Adhesion, marker of plasma cells and Reed-Sternberg cells Unknown + + + a + + Signal transduction Signal transduction Hemostasis Hemostasis, possibly angiogenesis, tumor metastasis + + + + s + s Enzymatic activity Adhesion, angiogenesis Unknown Possibly adhesion, development, tumor metastasis + + + a/s w a/s + + + + + + + + + + + + Adhesion Signal transduction, immunoregulation Activation, signal transduction MSP FLT3 ligand CD252 Unknown + + +

Molecular Weight (kD, Unreduced), Family Known or Proposed Function

Epithelial C

CD133

120, TM5

CD134 (OX40)

35-50, TNFR

+ a

CD135 +

130, RTK

CD136

180, RTK

CD137 a s + +

83, TNFR

s a a

CD137L Collagen, bronectin, thrombospondin, basic broblast growth factor Unknown PDGF isoforms PDGF isoforms Thrombin, protein C Factor VII/ VIIa

CD138 (Syndecan-1)

70-92, glycosaminoglycan

CD139 s w a w s + + +

209-238 [reduced]

+ s

CD140a (PDGF receptor )

160-180, RTK, Ig

CD140b (PDGF receptor )

170-190, RTK, Ig

CD141 (BDCA-3, Thrombo-modulin)

105, lectin, BDCA-3

CD142 (Thromboplastin, tissue factor) a s a s

45-47, CR

CD143 (Angiotensinconverting enzyme)

90 or 170, peptidase

Angiotensins I and II, bradykinin, substance P CD144 [homotypic binding] Unknown Unknown

CD144 (VE-cadherin)

135, cadherin

CDw145

25,90,110

CD146

118, Ig

CD147 (Neurothelin) + w + + +

54, Ig

Possibly integrins; associates with CD98 Unknown CD150 (homotypic binding), measles virus (H), Gram-negative OmpC and OmpF

CD148

240-260, RPTP

CD150 (SLAM,SLAMF1)

65-85, Ig

CD151 + +

32, TM4

a a/s a

a(s) +

Adhesion, signal transduction Immunoregulation + Activation/ costimulation, immunoregulation

Integrins CD80, CD86 CD30

Appendix A CD Molecules

CD152 (CTLA-4)

50, Ig

CD153

40, TNF

1675
Continued

1676

Neutrophil Eosinophil Basophil

Mast Cell

Monocyte

Dendritic Cell T Cell

B Cell

NK Cell Platelet

Erythrocyte

Thymocytes

Stem Cell/Precursor Endothelial Cell Epithelial Cell Known or Proposed Function Activatin/ costimulation Adhesion CD40

CD Molecule (Common Name) + a + + + a/s + + + + + +

Molecular Weight (kD, Unreduced), Family

Binding Partner(s)

CD154 (CD40 ligand)

28-33, TNF

Appendix A CD Molecules

CD155 (poliovirus receptor)

60-90, Ig

Integrins, poliovirus, CMV, possibly CD56, CD111, CD112, CD226, vitronectin; associates with CD113 Unknown Membrane TNF and TGF

CD156a (ADAM8) + s + + a s + + + + + + + +

89, metalloproteinase

+ w

Adhesion, enzymatic activity Enzymatic activity Enzymatic activity Enzymatic activity, signal transduction, differentiation + + Immunoregulation Immunoregulation Immunoregulation Immunoregulation Activation Immunoregulation Immunoregulation Activation Activation

CD156b (TACE, TNF- converting enzyme)

130, metalloproteinase

CD156c

65, metalloproteinase

Membrane TNF and Ephrin A2 NAD, cyclic ADP-ribose

CD157

42-50, ADPribocyclase s + + + + + + + + + + s s + + + + + + + + s s + + + + + + + + + +

CD158a (KIR2DL1)

58, Ig

HLA-C HLA-C HLA-C HLA-C HLA-B HLA-B See CD158a See CD158a HLA-C (low afnity)

CD158b1

58, Ig

CD158b2

58, Ig

CD158c

58, Ig

CD158d (KIR2DL4)

41, Ig

CD158e1/e2

70, Ig

CD158f

58, Ig

CD158g

50, Ig

CD158h (KIR2DS1)

50, Ig

CD158i

50, Ig

+ + + + + s +

Activation Activation Immunoregulation Immunoregulation Immunoregulation s Activation/ costimulation NK cell activation, TH17 lymphocytes Adhesion Adhesion

HLA-C HLA-C HLA-A HLA-E; associates with CD94 HLA-E; associates with CD94 HLA-C LLT1 CD62E,L,P, CD169 CD62L

CD158j (KIR2DS1)

50, Ig

CD158k (KIR3DL2)

70, Ig

CD159a (NKG2A [CD94/ CD159a])

43, lectin

CD159c

36, lectin

CD160 (BY55)

80, Ig

CD161 (NKR-P1A)

80, lectin

CD162 (PSGL1)

160/250, sialomucin

CD162R

220-240, sialomucin

cursor

ell l

Neutrophil Eosinophil Basophil

Mast Cell

Monocyte

Dendritic Ce T Cell

B Cell

NK Cell Platelet

Erythrocyte

Thymocytes

Stem Cell/Pr Endothelial

CD Molecule (Common Name) Binding Partner(s) Endocytosis, possibly immunoregulation Adhesion, possibly development Adhesion, cell cycle, tumorogenesis Adhesion, differentiation/ development, costimulation Adhesion, signal transduction, possibly tumor metastasis Adhesion, signal transduction Adhesion, tumorogenesis Adhesion, differentiation of macrophages Immunoregulation, adhesion + s Adhesion, activation/ costimulation + Immunoregulation, cell death Activation + s + + + + + + a + + + + + + + + + + + Immunoregulation, cell death Adhesion Angiogenesis, hemostasis Unknown Possibly immunoregulation and tumor metastasis + w + + + s a + s + + s + + + + Tumor metastasis Unknown Apoptosis, immunoregulation Differentiation Hyaluronan CD6, CD166 [homophilic binding] Unknown, Plasmodium falciparum gametocytes CD62L a + s a + + + + a + + + s + + + + + +

Molecular Weight (kD, Unreduced), Family Known or Proposed Function

Epithelial Ce

CD163

110, SR

CD164

170-180, sialomucin

CD165

37

CD166 (ALCAM)

100-105, Ig

CD167a

125, RTK

Collagen type I-IV and VIII

CD167b a/s a s a + + + + +

130, RTK

Collagen type I-III and V Hyaluronan Sialylated glycans, CD43, CD206, CD227, Neisseria sp. Sialylated glycans CD171 (homophilic binding), CD9, CD24, CD56, laminin, integrins CD47, SP-A, SP-D Unknown CD47 Unknown Unknown Unknown CD22, CD33, CD170 and Siglec-6

CD168

80-88

CD169 (Siglec-1, sialoadhesin) + s s s + s + + + +

180, Ig

CD170 (Siglec-5)

140, Ig

CD171

200-230, Ig

CD172a + s + +

85-90, Ig, SIRP-

CD172b

110-120, Ig, SIRP-

CD172g

55, Ig

CD173

Carbohydrate

CD174 (Lewis Y)

Carbohydrate

CD175 (Tn)

Carbohydrate

CD175s (sialylTn)

Carbohydrate

CD176

Carbohydrate

Unknown Unknown CD95 Associates with CD179b, mIgM, CD79a/CD79b to form pre-BCR

CD177

49-55, Ly-6

CD178 (Fas ligand)

40 [monomer], TNF

Appendix A CD Molecules

CD179a

16-18, Ig

CD179b

22, Ig

Differentiation

1677

Associates with CD179a, mIgM, CD79a/CD79b to form pre-BCR Continued

1678

Neutrophil Eosinophil Basophil

Mast Cell

Monocyte

Dendritic Cell T Cell

B Cell

NK Cell Platelet

Erythrocyte

Thymocytes

Stem Cell/Precursor Endothelial Cell Epithelial Cell Known or Proposed Function Activation, signal transduction LPS CXCL6,8

CD Molecule (Common Name) + + s s + a + s + s + s + + + + a + + + + + + s s + + s + + + + s + + + s + + s s + + s s s s s + + s + s + + s + + s + s s w s s s + + + + + + + + s s + Signal transduction Signal transduction Signal transduction Signal transduction Signal transduction Signal transduction Signal transduction Signal transduction Signal transduction Signal transduction Signal transduction Signal transduction Signal transduction Signal transduction Immunoregulation Hemostasis Signal transduction + s + + s + + + s s s + + + + + + + a + + + + + + + + + + + + + + + +

Molecular Weight (kD, Unreduced), Family

Binding Partner(s)

Appendix A CD Molecules

CD180

95-105, TLR

CD181 (CXCR1)

39, TM7

CD182 (CXCR2, IL-8 receptor)

40, TM7

CXCL1-3,5,6, CXCL8 (IL-8) CXCL9-11 CXCL12, HIV-1 X4 CXCL13 CXCL16, strains of HIV and SIV CCL3,5,7,14 CCL2,7,8,13,16, HIV CCL5,7,8,11,13, HIV CCL17,22, HIV CCL3,4,5,11,14,16, HIV CCL20 CCL19,21 CCL1 CCL25 OX-2 receptor, Herpes virus Protein C, proteinase 3, unidentied phospholipid

CD183 (CXCR3)

40, TM7

CD184 (CXCR4)

45, TM7

CD185 (CXCR5)

42, TM7

CDw186 (CXCR6)

40, TM7

CD191 (CCR1)

42, TM7

CD192 (CCR2)

40, TM7

CD193 (CCR3)

45, TM7

CD194 (CCR4)

41, TM7

CD195 (CCR5)

62, TM7

CD196 (CCR6)

45, TM7

CD197 (CCR7)

45, TM7

CDw198 (CCR8)

41, TM7

CDw199 (CCR9)

43, TM7

CD200 (OX-2)

40-45, Ig

CD201

50 [reduced], Ig

CD202b

140, RTK

Angiogenesis, development, survival + Enzymatic activity s Endocytosis

Angiopoietins Ang-1, Ang-2, Ang-4 Extracellular nucleotides

CD203c

270, E-NNP

+ +

CD204

220, SR

Lipoproteins, LDL, collagen type IV, -amyloid, AGEs, apoptotic cells, LPS, LTA + + + s w + s s s Endocytosis Endocytosis Carbohydrates Mannosylated glycoproteins and antigens, CD45, CD169

CD205

205, lectin

CD206

162-175, lectin

cursor l

ell

ll

Neutrophil Eosinophil Basophil

Mast Cell

Monocyte

Dendritic Ce T Cell

B Cell

NK Cell Platelet

Erythrocyte

Thymocytes

Stem Cell/Pr Endothelial

CD Molecule (Common Name) Binding Partner(s) s Endocytosis Mannosylated glycoproteins, glycolipids and antigens, HIV Unknown CD50, CD102, mannosylated glycoproteins and antigens, HIV IL-10 IL-10, IL-22, IL-26, IL-28A,B, IL-29 IL-12 IL-13 IL-13 IL-15 IL-17 Signal transduction Signal transduction + + Signal transduction Signal transduction Endocytosis, signal transduction IL-18; associates with CD128b Associates with CD128a Insulin, IGF-II IGF-I (high afnity), IGF-II, Insulin Mannose-6 phosphate, IGF-II, TGF-b, LAP, LIF, proliferin, plasminogen, retinoic acid, HSV Immunoregulation, activation + a a + + + + + + + + + + + + w + + a a/s + + w s + + + s s + + + + Enzymatic activity Unknown Adhesion, activation Adhesion, signal transduction Metabolism, migration Adhesion, possibly immunoregulation Signal transduction Neuronal function Immunomodulation MHC class II molecules Glutathione Associates with CD81 CD112, CD155 CD54, CD169, CD62E,L,P Plasminogen and pro-UPA CD229 (homophilic binding) CD230 (homophilic binding) Unknown CD108, poxvirus semaphorin-like protein A39R + s Metabolism Associates with CD235a Continued

Molecular Weight (kD, Unreduced), Family Known or Proposed Function

Epithelial C

CD207 (Langerin)

40, lectin

CD208 (DC-LAMP) Adhesion, activation/ costimulation, endocytosis Signal transduction Signal transduction Signal transduction s + Signal transduction Signal transduction a + + + + + + + + + + + + + Signal transduction Signal transduction +

70-90, LAMP

s s Endocytosis

CD209 (DC-SIGN)

44, lectin

CDw210a + s s s a/s + + + + + + + + + + + + s + + + + + + s + + s + + + + + + + + + + + + + + + + + + + +

90-110, Ig

+ s

CDw210b

90-110, Ig

CD212 (IL-12R 1-chain)

110 [reduced], Ig

CD2131 (IL-13R 1-chain)

65, Ig

CD2132 (IL-13R 2-chain)

65, Ig

CD215 (IL15RA)

CD217 (IL-17 receptor)

130-158

CD218a (IL-18R)

70, Ig

CD218b (IL-18R)

70, Ig

CD220 (Insulin receptor)

400, RTK

CD221 (IGF1R, Insulinlike growth factor R)

90/135 [reduced], RTK

CD222

250, lectin

CD223 + a a + + + + + + +

70, Ig

a a

CD224 (-glutamyltransferase)

100, peptidase

CD225

17, IFITM

CD226

65, Ig, DNAM-1

CD227 (MUC.1)

220-700, mucin

CD228

97, transferrin

CD229 (Ly9, SLAMF3)

120, Ig

CD230

35, prion

CD231

150, TM4

Appendix A CD Molecules

CD232

200, plexin

CD233

95-110, anion exchanger

1679

1680

Neutrophil Eosinophil Basophil

Mast Cell

Monocyte

Dendritic Cell T Cell

B Cell

NK Cell Platelet

Erythrocyte

Thymocytes

Stem Cell/Precursor Endothelial Cell Epithelial Cell Known or Proposed Function Immunoregulation

CD Molecule (Common Name) s + + +

Molecular Weight (kD, Unreduced), Family

Binding Partner(s) CXCL1,5,8, CCL2,5,7, Plasmodium vivax and knowlesi CD170, inuenza virus, Plasmodium falciparum Unknown Plasmodium falciparum Plasmodium falciparum Big endothelin-3

Appendix A CD Molecules

CD234 (Duffy)

35-43, TM7

CD235a (Glycophorin A) s s s + s + s + + + + + + +

36 [reduced], glycophorin

Possibly prevention of cell aggregation Possibly prevention of cell aggregation Mechanical stability Mechanical stability Enzymatic activity Adhesion Red cell skeleton

CD235b (Glycophorin B)

20 [reduced], glycophorin

CD236 (Glycophorin C/D)

40, glycophorin

CD236R (Glycophorin C)

30, glycophorin

CD238 (Kell)

115-200, metalloproteinase

CD239 (B-CAM)

78-85 [reduced], Ig

Laminin Associates with CD47, CD235b, CD241, CD242 to form Rhesus antigen complex

CD240CE

30-32, TM12

CD240D + +

30, TM12

s s s

Red cell skeleton Red cell skeleton Mechanical stability

See CD240CE See CD240CE Part of the Rhesus antigen complex (see CD240CE)

CD240DCE

30, TM12

CD241

50, TM12

CD242 (ICAM-4)

42, Ig

Adhesion

Integrins, platelet brinogen receptor, endothelial cell vitronectin receptor; part of the Rhesus antigen complex (see CD240CE) + a/s + + + + Metabolism Costimulation, immunoregulation Certain drugs and toxins CD48

CD243 + + + + +

170, ABC

CD244 (2B4, SLAMF4)

70, Ig

CD245

220-250

w +

Costimulation Signal transduction

Unknown Possibly pleiotrophin, midkine

CD246

200, RTK + s

CD247 (CD3 chain)

16 [reduced]

Signal transduction

Associates with TCR / and /, and CD3g, d and e to form TCR-CD3 complex + Tumor angiogenesis Unknown

CD248 (Endosialin)

175, lectin

cursor l

ell

ll

Neutrophil Eosinophil Basophil

Mast Cell

Monocyte

Dendritic Ce T Cell

B Cell

NK Cell Platelet

Erythrocyte

Thymocytes

Stem Cell/Pr Endothelial

CD Molecule (Common Name) Binding Partner(s) Enzymatic activity, regulation of angiogenesis Activation/ costimulation, survival Apoptosis T cellB cell and dendritic cell interaction, lymph node development, differentiation, survival, bone remodelling + Activation/ costimulation, development/ differentiation, apoptosis Activation/ costimulation, development/ differentiation Activation/ costimulation, apoptosis Apoptosis Apoptosis Decoy receptor Decoy receptor + + s T cellB cell and dendritic cell interaction, lymph node development, differentiation, survival, bone remodelling + + + + + + s + a s + + + + + Apoptosis, signal transduction NGF, BDNF, neurotrophin-3, neurotrophin-4, -amyloid, CD230 Continued + Angiogenesis, inammation Immunoregulation Survival Survival CD134 (OX40) Angiotensin II + +

Molecular Weight (kD, Unreduced), Family Known or Proposed Function

Epithelial C

CD249 (aminopeptidase A) + a a + +

160, peptidase

CD252 (OX40 ligand)

34, TNF

CD253 (TRAIL) s s a

33-34, TNF

+ a a a a a

CD261, CD262, CD263, CD264 CD265, Osteoprotegerin

CD254 (TRANCE, RANKL)

35, TNF

CD256 (APRIL)

28, TNF

CD267, CD269

CD257 (BAFF, TNF13b)

45, TNF

CD267, CD268, CD269

CD258 (LIGHT)

29, TNF

CD270, LTbR

CD261 (TRAIL-R1) + w + + s s + + + + + + + + + + + + + + + + + + + + + +

57, TNFR

+ s s

CD253 CD253 CD253 CD253 CD254

CD262 (TRAIL-R2)

60, TNFR

CD263 (TRAIL-R3)

65, TNFR

CD264 (TRAIL-R4)

35, TNFR

CD265 (TRANCER)

97, TNFR

CD266 (TWEAK-R) s

14, TNFR

TWEAK CD256, CD257 CD257 CD256, CD257

CD267 (TACI)

32, TNFR

CD268 (BAFF-R)

25, TNFR

CD269

27, TNFR

CD270 (HVEM, TNFRSF14)

Appendix A CD Molecules

CD271 (NGFR, NGF receptor)

75, TNFR

1681

1682

Neutrophil Eosinophil Basophil

Mast Cell

Monocyte

Dendritic Cell T Cell

B Cell

NK Cell Platelet

Erythrocyte

Thymocytes

Stem Cell/Precursor Endothelial Cell Epithelial Cell Known or Proposed Function Immunoregulation

CD Molecule (Common Name) + s s + +

Molecular Weight (kD, Unreduced), Family

Binding Partner(s) CD272 (homotypic binding), CD258, CD270 CD279

CD272 (BTLA)

33, Ig

Appendix A CD Molecules

CD273

25, Ig

+ a Activation/ costimulation, immunoregulation + + a + s a + + + + + + Costimulation, immunoregulation Costimulation, immunoregulation Costimulation, immunoregulation Possibly activation/ costimulation Costimulation, differentiation/ development a s Immunoregulation

CD274 (B7-H1) s a + + + s a +

40, Ig

+ a

CD279 CD278 Unknown Unknown CD275

CD275 (ICOS-L; B7-H2)

60, Ig

CD276 (B7-H3)

40-45/110, Ig

CD277

56, Ig

CD278 (ICOS, inducible T-cell co-stimulator) a a

56, Ig

CD279 (PD1, programmed cell death 1) s +

55, Ig

CD273, CD274

CD280

180, lectin

Adhesion, extracellular matrix degradation Pathogen recognition, activation

Gelatin, collagen types I, II, IV, V; associates with uPA and CD87 M. leprae lipopeptide, Borrelia outer surface protein Pathogen recognition, activation Peptidoglycan, LTA, bacterial lipoprotein, Mycoplasma lipopeptide, zymosan, CMV, M. leprae, lipoarabinomannans

CD281 (TLR1)

90, TLR

CD282 (TLR2)

85, TLR

+ a/s

CD283 (TLR3)

100-120, TLR

Pathogen recognition, activation, apoptosis + + a/s w + Pathogen recognition, activation + + s s Pathogen recognition, activation

Double-stranded RNA

CD284 (TLR4)

85, TLR

Endotoxin (LPS), HSP60, -glucan, elastase, heparan sulfate Flagellin, diacyllipoproteins + + s Pathogen recognition, activation Single-stranded RNA

CD286 (TLR6)

85, TLR

CD288 (TLR8)

83, TLR

cursor l

ell

ll

Neutrophil Eosinophil Basophil

Mast Cell

Monocyte

Dendritic Ce T Cell

B Cell

NK Cell Platelet

Erythrocyte

Thymocytes

Stem Cell/Pr Endothelial

CD Molecule (Common Name) Binding Partner(s) + s + s + Endochondral bone formation, embryogenesis Endochondral bone formation, embryogenesis Activation + Regulation of fat metabolism, activation, survival Enzymatic activity, differentiation, inammation, immunoregulation Enzymatic activity Ion transport + s Pathogen recognition, adhesion + + + + + Bone morphogenetic proteins (BMPs) Bone morphogenetic proteins (BMPs) Prostaglandin D2 Leptin (LEP) Pathogen recognition, activation Unkown s + Pathogen recognition, activation Unmethylated CpG DNA + + + + +

Molecular Weight (kD, Unreduced), Family Known or Proposed Function

Epithelial C

CD289 (TLR9)

115-120, TLR

CD290 (TLR10)

91-100, TLR

CD292

50-58, RTK

CDw293

50-58, RTK

CD294 (CRTH2) + s + + + +

55-70, TM7

+ s

CD295 (leptin receptor)

130-150, Ig

CD296

37, ADPribosyltransferase

NAD, integrins, defensin-1

CD297 + s s + + + + + + + + +

38, ADPribosyltransferase

+ s

Possibly integrins Na, K Mannose bearing ligands, CD50, lentiviruses, CMV, hepatitis C virus, SARS coronavirus, Mycobacterium tuberculosis

CD298

32, Na/K-ATPase

CD299 (L-SIGN)

40, lectin

CD300a + + s s + + + +

60, Ig

Immunoregulation Immunoregulation Immunoregulation Adhesion, endocytosis

Unknown Unknown Unknown Galactose and N-acetylgalactosamine bearing ligands Endocytosis Unknown

CD300c

23, Ig

CD300e

Ig

CD301

38-42, lectin

CD302 s s s s

30, lectin

+ +

CD303 (BDCA-2)

38, lectin

Endocytosis, immunoregulation Angiogenesis, survival, tumor metastasis

Unknown VEGF, Semaphorin-3A

CD304 (BDCA-4, Neuropilin 1) + + + + +

140, neuropilin

CD305 (LAIR-1)

31, Ig

+ + + s + +

Immunoregulation Unknown Possibly immunoregulation Possibly immunoregulation Possibly immunoregulation Possibly immunoregulation

CD326, collagen CD326 Unknown Unknown Unknown Unknown Continued

CD306 (LAIR-2)

16, Ig

CD307a (FCRL1)

100, Ig

CD307b (FCRL2)

100, Ig

Appendix A CD Molecules

CD307c (FCRL3)

100, Ig

CD307d (FCRL4)

100, Ig

1683

1684

Neutrophil Eosinophil Basophil

Mast Cell

Monocyte

Dendritic Cell T Cell

B Cell

NK Cell Platelet

Erythrocyte

Thymocytes

Stem Cell/Precursor Endothelial Cell Epithelial Cell Known or Proposed Function Possibly immunoregulation Unknown VEGF Glycosaminoglycans, chondroitin sulphate, dermatan sulphate ULBP, MICA, MICB Associates with CD9, CD81 Associates with CD9, CD81 Possibly differentiation/ development s s Differentiation/ development Activation, adhesion Follicular dendritic cell-B-cell interaction Unknown

CD Molecule (Common Name) w + a s a a Adhesion, inammation + s Immune surveillance Cell polarity, motility + + + s Angiogenesis +

Molecular Weight (kD, Unreduced), Family

Binding Partner(s)

CD307d (FCRL5)

Appendix A CD Molecules

CD309

230, RTK

CD312

90, TM7

CD314 (NKG2D) a s

42, lectin

s s w

CD315 (prostaglandin F2 receptor negative regulator) + + s + + + + +

135, Ig

CD316

63, Ig

Cell polarity, motility

CD317

29-33

CD318 s s s a + +

140

Unknown CD319 [homophilic binding] Unknown

CD319 (SLAMF7/8, CRACC)

66, Ig

CD320

29, LDL-R

CD321 (JAM-1, junctional adhesion molecule) + s + s

32-35, Ig

Adhesion, embryogenesis + + Adhesion, embryogenesis + + + + + s + + Adhesion, embryogenesis Adhesion, embryogenesis Adhesion, development

CD321 (homophilic binding), CD11a, Reovirus CD322 [homophilic binding], JAM-3 CD103, catenins, PS1 CD325 [homophilic binding] CD326 [homophilic binding], CD306

CD322 (JAM-2, junctional adhesion molecule) s

45, Ig

CD324 (E-cadherin)

120, cadherin

CD325 (N-cadherin) + w s

140, cadherin

CD326 (Ep-CAM)

40

CDw327 (Siglec-6)

49, Ig

+ +

s s

+ s s

+ s

Immunoregulation Immunoregulation Immunoregulation, apoptosis, autophagy-like cell death

Sialylated glycans Sialylated glycans Sialylated glycans

CDw328 (Siglec-7)

75, Ig

CDw329 (Siglec-9)

50, Ig

ell ll

ecursor

ll

Neutrophil Eosinophil Basophil

Mast Cell

Monocyte

Dendritic C T Cell

B Cell

NK Cell Platelet

Erythrocyte

Thymocytes Stem Cell/P Endothelial

CD Molecule (Common Name) Binding Partner(s) s Embryogenesis, angiogenesis, tissue repair Embryogenesis, angiogenesis, tissue repair Embryogenesis Embryogenesis, tissue repair NK cell activation FGF Heparan sulfate proteoglycans, viral hemagglutinins, neuraminidase of the Sendai virus Viral hemagglutinins BAT-3, heparan sulfate proteoglycans, glycosaminoglycans Xenobiotics Hematopoiesis, differentiation/ development s Signal transduction, cancer marker S Tissue homeostasis, polarity, embryogenesis S Tissue homeostasis, polarity, embryogenesis Tissue homeostasis, polarity, embryogenesis + + w + + Alternative IgM and IgA receptor Positive regulation, Immunoglobulin SF (SLAM Family) + + + + s + s + + + s + + + + + + + Immunoglobulin SF (SLAM Family) Immunoglobulin SF Immunoglobulin SF TNF Receptor SF TNF Receptor SF Human IL-15R IL-15 Continued Notch 1,2,3 FGF FGF FGF + +

Molecular Weight (kD, Unreduced), Family Known or Proposed Function

Epithelial C

CD331 (FGFR1, FGF receptor 1) s s +

130, RTK

CD332 (FGFR2, FGF receptor 2) s s + s + + + + + +

115-135, RTK

CD333 (FGFR3, FGF receptor 3)

115-135, RTK

CD334 (FGFR4, FGF receptor 4)

110-140, RTK

CD335 (NKp46)

46, Ig

CD336 (NKp44) +

46, Ig

NK cell activation NK cell activation

CD337 (NKp30)

30, Ig

CD338 (ABCG2) s s +

72, ABC transporter

w s

Transport of xenobiotics

CD339 (Jagged1)

150, jagged ligands

CD340 (HER-2)

185, RTK

Associates with ERBB family members, plexin-B1 Wnt proteins, norrin

CD344 (Frizzled-4)

60 [unprocessed precursor], TM7

CD349 (Frizzled-9)

65 [unprocessed precursor], TM7

Wnt proteins

CD350 (Frizzled-10)

65 [unprocessed precursor], TM7 + + + + +

Wnt proteins

CD351 (Fc/ receptor)

IgM and IgA CD352 (homotypic binding) Unknown Unknown Unknown GITR-L

CD352 (SLAMF6; human: NTB-A; mouse: Ly108) +

CD353 (SLAMF8, NTBA)

CD354 (TREM1)

CD355 (CRTAM)

Appendix A CD Molecules

CD357 (GITR, TNFRSF18)

CD358 (TNFRSF21)

CD359 (IL15RA)

1685

1686

Neutrophil Eosinophil Basophil

Mast Cell

Monocyte

Dendritic Cell T Cell

B Cell

NK Cell Platelet

Erythrocyte

Thymocytes

Stem Cell/Precursor Endothelial Cell Epithelial Cell Known or Proposed Function Type I Cytokine Receptor syndecan proteoglycan family G protein-coupled receptor IL-21 Unknown Unknown Sphingosine 1 phosphate

CD Molecule (Common Name) + + + + + + + + + + + + + + + + + + +

Molecular Weight (kD, Unreduced), Family

Binding Partner(s)

CD360 (IL21R)

CD361 (EVI2B)

Appendix A CD Molecules

CD362 (SDC2)

CD363 (S1PR1)

Symbols: + present negative a activated c cytosolic s subset w weak List of abbreviations used: ABC ATP-binding cassette ADCC Antibody-dependent cellular cytotoxicity AGEs Advanced glycation end products BAT-3 HLA-B associated transcript 3 BCR B cell receptor BDNF Brain-derived neurotrophic factor CCP Complement control protein CD Cluster of differentiation CMV Cytomegalovirus CR Cytokine receptor ECM Extracellular matrix E-NNP Ectonucleotide pyrophosphatase/phosphodiesterase ESL E-selectin ligand FGF Fibroblast growth factor HIV Human immunodeciency virus HLA Human leukocyte antigen HSA Heat stable antigen HSV Herpes simplex virus HVEM Herpes virus entry mediator ICAM Intercellular adhesion molecule IFITM Interferon-induced transmembrane protein IFN Interferon Ig Immunoglobulin IGF Insulin-like growth factor IL Interleukin ITAM Immunoreceptor tyrosine-based activation motif ITIM Immunoreceptor tyrosine-based inhibition motif kD kiloDaltons LAMP Lysosomal associated membrane protein LAP Latency-associated peptide

LBP LPS binding protein LDL Low density lipoprotein LIF Leukemia inhibitory factor LFA Lymphocyte function associated antigen LLT1 Lectin-like transcript 1 LPAP Lymphocyte phosphatase-associated phosphoprotein LPS Lipopolysaccharide LTA Lipoteichoic acid Ly-6 Lymphocyte antigen 6 Mac Macrophage antigen MAdCAM Mucosal addressin cellular adhesion molecule MDR Multi-drug resistance MSP Macrophage-stimulating protein MHC Major histocompatibility complex MIC MHC class I polypeptide-related sequence NGF Nerve growth factor PTPase Protein tyrosine phosphatase PRV Pseudorabies virus RCA Regulators of complement activity RPTP Receptor-like protein tyrosine phosphatase RTK Receptor tyrosine kinase SECTM1 Secreted and transmembrane 1 SLAM(F) signaling lymphocyte activation molecule (family) SP Surfactant protein SR Scavenger receptor TCR T cell receptor TGFR Transforming growth factor TGFR Transforming growth factor receptor TLR Toll-like receptor TM4 Transmembrane 4 TM7 Transmembrane 7 TNF Tumor necrosis factor TNFR Tumor necrosis factor receptor ULBP UL16 binding protein uPA Urokinase type plasminogen activator uPAR Urokinase type plasminogen activator receptor VCAM Vascular cell adhesion molecule VLA Very late antigen References: Zola H, Swart, B, Nicholson I, Voss E. Leukocyte and Stromal Cell Molecules: The CD Markers. Wiley-Liss, 2007. ISBN-13:978-0-471-70132-3 OMIM: http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?db=OMIM Pubmed: http://www.ncbi.nlm.nih.gov/Entrez/ http://www.vetmed.wsu.edu/tkp/search.aspx http://hcdm.org/HLDA9Workshop/tabid/60/Default.aspx

Appendix A CD Molecules

1687