MEDICINAL CHEMISTRY

M.S. (Pharm.)

Course No.
Semester-I MC-510 MC-511 MC-520 !"-510 "C-5%0 "#-510 )*-510 )*-511 L)-510 Semester-II MC-,10 MC-,20 MC-, 0 MC-,50 "C-,10 "C-,11 )*-,11 LS-,10

Course Name
Basics of Drug Action Spectral Analysis Logic in Organic Synthesis-I Separation #echni$ues Che&otherapy of "arasitic an' Micro(ial Infections In'ustrial "rocess an' Scale-up #echni$ues Biostatistics Se&inar )eneral La( *+perience Total Credits Drug Design Logic In Organic Synthesis-II Structure an' -unction of Bio&olecules Stereoche&istry an' Drug Action Drug Meta(olis& "har&acological Screening an' Assays Se&inar )eneral La( *+perience in the area of Speciali.ation Total Credits

Credits
2 2 1 1 1 2 1 16 2 2 2 1 1 1 2 14

Semester-III "ro/ect 022 1ee2s3 #4-556 Synopsis #4-555 "resentation Total Credits Semester-IV #4-,56 #hesis #4-,55 Defence of #hesis Total Credits Grand Credits (I to IV Semesters)

5 8 5 12 50

1|P a g e

MEDICINAL CHEMISTRY
M.S. (Pharm.)

S ! ST " - I
!C-510 #asi$s o% &ru' ($tion (2 $redits)
1.

Inter- and intra-molecular interactions: 7ea2 interactions in 'rug &olecules8 Chirality an' 'rug action8 Co9alent: ion: ion-'ipole: hy'rogen (on'ing: C-4 hy'rogen (on'ing: 'ihy'rogen (on'ing: 9an 'er 1aals interactions an' theassociate' energies; *nergy concept an' its i&portance in 'rug action8 -irst: secon' an' thir' la1s of ther&o'yna&ics an' the principles 'eri9e' fro& these la1s 1hich are of significance to 'rug action8 -ree energy an' relationship (et1een ther&o'yna&ics an' statistics8 I&portance of che&ical potential in 'rug action8 #her&o'yna&ic cycle; Statistical ther&o'yna&ics in pre'icting the structure of (io&olecules an' their interaction 1ith 'rug &olecules8 Macro&olecular 9s; &icro&olecular correlation using ther&o'yna&ics an' statistical ther&o'yna&ics; Receptorology: Drug-receptor interactions: receptor theories an' 'rug action8 Occupancy theory: rate theory: in'uce' fit theory: &acro&olecular pertur(ation theory: acti9ation-aggregation theory; #opological an' stereoche&ical consi'eration; <inetics: en.y&e 2inetics in 'rug action; Do all &olecules of an en.y&e ha9e sa&e 2inetics= Mechanis&s of en.y&e catalysis8 *lectrostatic catalysis an' 'esol9ation8 Co9alent catalysis: aci'-(ase catalysis: strain > 'istortion in en.y&e catalysis8 Coen.y&e catalysis8 *+a&ple (ase' on he&oglo(in8 #heories of en.y&e inhi(ition an' inacti9ation8 *n.y&e acti9ation of 'rugs-pro'rugs; !ucleic aci's 0!A3 as targets for 'rug action8 !A-interacti9e agents8 Classes of 'rugs that interact 1ith nucleic aci's8 Intercalation: !A-al2ylation: !A-stran' (rea2ing an' their i&portance in 'rug action; Drug li2e &olecules an' theories associate' 1ith the recognition of 'rug li2e properties; "hysical organic che&istry of 'rug &eta(olis&: 'rug 'eacti9ation an' eli&ination8 "hase-I an' phase-II transfor&ations8 Concept of har' an' soft 'rugs8 Che&istry of ADM* an' to+icity properties of 'rugs;

2;

4.

5;

,;

?; 6;

!C-511 S)e$tral (nal*sis (2 $redits)

1; @ltra 9iolet an' 9isi(le spectroscopyA *nergy le9els an' selection rules: 7oo'1ar' -ieser: -ieser-<uhn an' !elson rules; Influence of su(stituent: ring si.e an' strain on spectral characteristics; Sol9ent effect; Stereoche&ical effect; !on-congugate' interactions; Spectral correlation 1ith structure; Infrare' spectroscopy 0IB3A Characteristics regions of the spectru&; Influence of
2|P a g e

2;

MEDICINAL CHEMISTRY
M.S. (Pharm.) su(stituents: ring si.e: hy'rogen (on'ing: 9i(rational coupling an' fiel' effect on fre$uency; Deter&ination of stereoche&istry; Spectral interpretation 1ith e+a&ples; ; !uclear &agnetic resonance spectro&etry 0!MB3A Magnetic nuclei: che&ical shift an' shiel'ing: rela+ation processes: che&ical an' &agnetic non e$ui9alence: local 'ia&agnetic shiel'ing an' &agnetic anisotropy: spin-spin splitting: "ascalCs triangle: coupling constant: &echanis& of coupling: $ua'rupole (roa'ening an' 'ecoupling: effect of confor&ations an' stereoche&istry on the spectru&: 'iastereo&eric protons: 9irtual coupling: long range coupling-epi: peri: (ay effects; Shift reagents-&echanis& of action: spin 'ecoupling an' 'ou(le resonance; Mass spectro&etry 0MS3A Molecular ion an' &etasta(le pea2: frag&entation patterns: nitrogen an' ring rules: McLafferty rearrange&ent: electron an' che&ical ioni.ation &o'es: applications;

%;

!C-520 +o'i$ in ,r'ani$ S*nt-esis-I

1.

(. $redits)

Organic reaction mechanismA Metho's of 'eter&ining reaction &echanis&s 02inetic an' non-2inetic &etho's38 *nergy profile 'iagra&s: reaction inter&e'iates: crosso9er e+peri&ents an' isotopic la(elling8 Or'er of reactions: re9ersi(le: consecuti9e an' parallel reactions: sol9ent: ionic strength an' salt effects8 Aci'(ase catalysis8 !ucleophilic su(stitution reactions8 @ni- an' (i&olecular reactions: attac2ing an' lea9ing groups: steric an' electronic effects8 !eigh(oring group participation8 -or&ation an' hy'rolysis of esters: a&i'es an' acyl hali'es8 Different &echanis&s *lectrophilic su(stitution reactions8 Aro&atic electrophilic su(stitutions inclu'ing -rie'el-Crafts reactions8 A''ition an' eli&ination reactions; Principles of synthetic planning : Logic-centere' &olecular synthesis8 Dislocation: synthetic tree: synthons: logical i&position of (oun'ary con'itions: 'irect associate' approach8 Structure-functionality relationships: functionality an' unsaturation le9els8 "olar reacti9ity analysis8 Control ele&ents: consonant an' 'issonant circuits8 "rotocol for synthetic 'esign; Alkylation: *nolates8 Begio- an' stereo-selecti9e enolate generation: DOD 9ersus DCDal2ylation: effects of sol9ent: counter cation an' electrophiles8 Sy&(iotic effect8 #her&o'yna&ically an' 2inetically controlle' enolate for&ations8 Earious transition-state &o'els to e+plain stereoselecti9e enolate for&ation8 *na&ines an' &etallo-ena&ines8 Begioselecti9ity in generation: applications in controlling the selecti9ity of al2ylation; Reaction of ylides: "hosphorous yli'es8 Structure an' reacti9ity: sta(ili.e' yli'es: effects of ligan's on reacti9ity: *>F-selecti9ity in for&ation of olefin 7ittig: 7ittig4orner an' 7a's1orth-*&&ons reactions - &echanistic reali.ations: *>Fselecti9ity in olefin for&ation of: Schlosser &o'ification8 "etersons olefin synthesis Sulphur Gli'es8 Sta(ili.e' an' non-sta(ili.e' yli'es8 #her&o'yna&ically an' 2inetically controlle' reactions 1ith car(onyl co&poun's: regio- an' stereoselecti9e reactions;

2;

%;

3|P a g e

MEDICINAL CHEMISTRY
M.S. (Pharm.) 5; Hydroboration : Control of che&o-: regio- an' stereo-selecti9ity: rearrange&ent of al2yl(oranes: Al2yl(oranes as organo&etallic reagents: e;g;: 5-BB!: the+yl(oranes: 'isia&yl(orane: chiral (oranes- Ipc2 B4 IpcB42 : etc

N/-510 Se)aration Te$-ni0ues (1 $redit)

1; 2; Chromatography: )eneral principles: classification of chro&atographic techni$ues: nor&al an' re9erse' phase: (on'e' phase: separation &echanis&s; Column chromatography: Merits an' 'e&erits: short-colu&n chro&atography an' flash chro&atography: 9acuu& li$ui' chro&atography 0ELC3: &e'iu& pressure li$ui' chro&atography: high pressure li$ui' chro&atography 04"LC3; #LC: 4"#LC: o9er chro&atography; pressure layer chro&atography 0O"LC3: centrifugal

; %; 5;

Counter-current chro&atography: 'roplet counter-current chro&atography; ione+change: affinity: si.e e+clusion an' ion-pair chro&atography; )as chro&atography: intro'uction to )C-MS an' LC-MS techni$ues;

/C-540 C-emot-era)* o% /arasiti$ and !i$ro1ial In%e$tions

1; 2; ; %; 5; ,; ?; 6; 5; Intro'uction to parasitic an' infectious 'iseases; Biology of tu(erculosis; Mechanis& of action of anti-tu(erculosis 'rugs; #argets for anti-tu(erculosis 'rug 'e9elop&ent; Mechanis& of 'rug-resistance in tu(erculosis; Biology of hu&an a&oe(iasis Mechanis& of action of anti-a&oe(ic 'rugs Biology of filarial infections Mechanis& of action of anti-filarial 'rugs

(1 $redit)

10; #argets of anti-filarial 'rug 'e9elop&ent; 11; Biology of 9iral infection; 12; Mechanis& of action of anti-4IE 'rugs 1 ; #argets for anti-4IE 'rug 'e9elop&ent; 1%; Biology of &alaria 15; Mechanis& of action of anti-&alarial 'rugs; 1,; #argets for anti-&alarial 'rug 'e9elop&ent 1?; Mechanis& of 'rug-resistance in &alaria; 16; Biology of leish&aniasis;

4|P a g e

MEDICINAL CHEMISTRY
M.S. (Pharm.)
15; Mechanis& of action of anti-leish&anial 'rugs 20; #argets for anti-leish&anial 'rug 'e9elop&ent; 21; Drug-resistance in leish&aniasis;

/T-510 Industrial /ro$ess and S$ale u) Te$-ni0ues (1 $redit)

1; 2; ; Status of phar&aceutical in'ustry 0(ul2 'rugs: natural pro'ucts an' for&ulations3 in In'ia 9is-a-9is in'ustriali.e' nations; Scale-up techni$ues for process opti&i.ation: &a+i&i.ation of pro'ucti9ity: in process control techni$ues 1ith e+a&ples; Che&ical technology of selecte' (ul2 'rugs8 Case stu'ies 1ith e&phasis on rationale for selection of routes: ra1 &aterials: process control &etho's: pollution control proce'ures etc; 0e+a&ples 'epicting no9el routes3: Data collection 'uring pilot plant trails: preparations of flo1 'iagra&s: &aterial (alance sheets an' technical 'ata sheets; Isolation techni$ues for natural pro'ucts fro& plants: ani&als: &arine an' &icro(ial sources; "rocess technologies for so&e selecte' natural pro'ucts of co&&ercial interest; Scale-up techni$ues for in'ustrial phar&acy: typical stan'ar' operating proce'ures for 'ifferent 'osage for&s8 In-process control proce'ures; "har&aceutical &anufacturing e$uip&ent in (ul2 'rugs an' for&ulations;

%; 5; ,; ?;

G -510 #iostatisti$s (2 $redits)

1.

Statistics: Intro'uction: its role an' uses; Collection8 Organi.ation8 )raphics an' pictorial representation of 'ata8 Measures of central ten'encies an' 'ispersion; Coefficient of 9ariation; Probability: Basic concepts8 Co&&on pro(a(ility 'istri(utions relate' to nor&al 'istri(ution; 'istri(utions an' pro(a(ility

2; ; %;

Sa&plingA Si&ple ran'o& an' other sa&pling proce'ures; Distri(ution of sa&ple &ean an' proportion; stimation and Hypothesis testing: "oint an' inter9al esti&ation inclu'ing fi'ucial li&its; Concepts of hypothesis testing an' types of errors; Stu'ent- t an' Chi s$uare tests; Sa&ple si.e an' po1er; !perimental design and analysis of "ariance: Co&pletely ran'o&i.e': ran'o&i.e' (loc2s; Latin s$uare an' factorial 'esigns; "ost- hoc proce'ures; Correlation and regression: )raphical presentation of t1o continuous 9aria(les8 "earsonCs pro'uct &o&ent correlation coefficient: its statistical significance; Multiple an' partial correlations; Linear regression8 Begression line: coefficient of 'eter&ination: inter9al esti&ation an' hypothesis testing for population slope; Intro'uction to &ultiple linear regression &o'el; "ro(it an' logit transfor&ations; #on-parametric tests: Sign8 Mann-7hitney @8 7ilco+on &atche' pair8 <rus2al 1allis an'

5; ,;

?;

5|P a g e

MEDICINAL CHEMISTRY
M.S. (Pharm.)
-rie'&an t1o 1ay ano9a tests; Spear&an ran2 correlation; 6; Statistical techni$ues in pharmaceutics: *+peri&ental 'esign in clinical trials8 "arallel an' crosso9er 'esigns; Statistical test for (ioe$ui9alence; Dose response stu'ies8 Statistical $uality control;

G -511 Seminar (1 $redit)

1; 2; ; %; 5; Intro'uction: infor&ation retrie9al syste&s; 7riting ter& papers an' reports; Organi.ation of scientific &aterial: thesis: 'issertation an' references; Bea'ing research papers; S2ill in oral presentation;

ach student has to present a seminar before end of the semester%

+G-510 General +a1orator* 2)erien$e -15 -ours 3 4ee5 (. $redits)

1.

Analytical techni$ues: 0?5 hours3 Spectral analysis 1or2shop 0%5 hours3 Separation #echni$ues 0 0 hours3 Computer and application in pharmaceutical sciences &'(( hours): Intro'uction to co&puters: (asic unit an' functions: 4>7 an' S>7: operating syste&s: 1or' processing: sprea' sheet: graphic progra&s: 'D(ase: 1in'o1s: statistical S>7 progra&s an' pac2ages; Steps in9ol9e' in S>7 'e9elop&ent: co&puter Ian guages 1ith e&phasis to -OB#BA! language an' progra&&ing: han's on e+perience in phar&aceutical soft1are syste&s @se of co&puters in infor&ation retrie9al syste&s; Speciali*ation &+, hours): #1o to three step synthesis in9ol9ing 1itting reaction an' glyci'ic estr con'ensation etc; "urification (y chro&atographic techni$ue an' i'entification (y IB: !MB: an' MS;

a3 (3
2;

6|P a g e

MEDICINAL CHEMISTRY
M.S. (Pharm.)

S ! ST " - II
!C-610 &ru' &esi'n (2 $redits)
1.

Structure acti"ity relationships in drug design Hualitati9e 9ersus $uantitati9e approaches: a'9antages an' 'isa'9antages: Ban'o& screening: nonran'o& screening: 'rug &eta(olis& stu'ies: clinical o(ser9ations: rational approaches to lea' 'isco9ery; 4o&ologation: chain (ranching: ring-chain transfor&ations: (ioisostens&: Insights into &olecular recognition pheno&enon: Structure-(ase' 'rug 'esign: ligan'-(ase' 'rug 'esign -olecular modeling ; *nergy &ini&i.ation: geo&etry opti&i.ation: confor&ational analysis: glo(al confor&ational &ini&a 'eter&ination8 Approaches an' pro(le&s: Bioacti9e 9s glo(al &ini&u& confor&ations8 Auto&ate' &etho's of confor&ational search: A'9antages an' li&itations of a9aila(le soft1are8 Molecular graphics: Co&putation &etho'ologies (ehin' &olecular &o'eling inclu'ing artificial intelligence &etho's .SAR *lectronic effects8 4a&&ett e$uation: Lipophilicity effects: 4ansch e$uation: Stenc *ffects: #aft *$uation: *+peri&ental an' theoretical approaches for the 'eter&ination of physico-che&ical para&eters: para&eter inter-'epen'ence: Case stu'ies: Begression analysis: e+trapolation 9ersus interpolation: linearity 9ersus non-lineanty: #he i&portance of (iological 'ata in the correct for&8 2D - HSAB8 D-HSAB-e+a&ples CoM-A an' CoMSIA -olecular docking and dynamics: Bigi' 'oc2ing: fle+i(le 'oc2ing: &anual 'oc2ing; A'9antages an' 'isa'9antages of fle+-I: fle+-S: auto'oc2 an' 'oc2 soft1are: 1ith successful e+a&ples; Monte Carlo si&ulations an' &olecular 'ytions an' &olecular 'yna&ics in perfor&ing confor&ational search: 'oc2ing: etc Pharmacophore Concept: phar&acophore &apping: &etho's of confor&ational search use' in phar&acophore &apping8 Co&parison (et1een the popular phar&acophore &etho's li2e catalyst>4ip4op: Disco#ech: )AS": etc; 1ith practical e+a&ples lectronic structure methods and $uantum chemical methods: Se&i-e&pirical an' a( initio &etho's; Confor&ational analysis: energy &ini&i.ation: co&parison (et1een glo(al &ini&u& confor&ation an' (ioacti9e confor&ation: "re'icting the &echanis& of organic reactions using electronic structure &etho's: Co&plete an' constraine' confor&ational search &etho's: their a'9antages an' 'isa'9antages: #heoretical a$ueous sol9ation calculations for the 'esign of ligan's Confor&ational inte-rcon9ersion: transition-state 'eter&ination an' their role in 'esigning rigi' analogs 0e no"o drug design techni$ues Informatics methods in drug design: Bio&for&atics: che&infor&atics: geno&ics: proteo&ics: che&ogeno&ics: phar&ainfor&atics: ADM* 'ata(ases: che&ical: (ioche&ical an' phar&aceutical 'ata(ases: Drug 'esign techni$ues using these 'ata(ases

2.

3.

4.

5.

6.

/%
8.

!C-620 +o'i$ in ,r'ani$ S*nt-esis-ll (. $redits)

1.

-etal1ammonia reduction Be'uction of &ono-: (i- an' tri-cyclic aro&atic syste&s an' 9arious functional groups: re'ucti9e al2ylation: regio- an' stereoselecti9ity: Be'uction of al2ynes8 Co&ple+ &etal hy'ri'es an' selectri'es

7|P a g e

MEDICINAL CHEMISTRY
M.S. (Pharm.)
2.

Reaction of electron-deficient intermediates Car(ene-nitrene an' free ra'ical-structure: sta(ility an' &o'es of generation; A''ition an' insertion reactions of car(enoi's an' nitrenoi's - regio- an' stereoselecti9ity: role of the &etal catalysts in the transition &etalcataly.e' reactions: other types of reaction of car(enoi's: e g : yli'e generation: 1: -'ipolar a''ition: rearrange&ent etc : Intra-&olecular ra'ical trapping process lea'ing to ring annulation - Bal'1inJs rule Organometallics Applications of organo-lithiu&: ca'&iu& an' ceriu& reagents: heteroato& 'irecte' lithiation8 O+y- an' a&i'o-&ercurations: )il&an reagent: &i+e' an' higher or'er cuprates: uses in nucleophilic su(stitution: clea9age of epo+i'es an' con/ugate a''ition reactions; Mechanis& of action: Spiro-annulation: 7ac2er o+i'ation: 7il2insonJs catalyst: car(onylation>hy'rofor&ylation reactions: 4ec2 arylation: Bole of &etal ligan's in controlling regio an' stereoselecti9ity: Catalytic an' stoichio&etric o+i'ation reactions; 4o&ogeneous an' heterogenous processes: Che&oselecti9e reactions: Bio-&i&icing processes 2mpolung and umpoled sythons Concept: acyl an' glycine cation>anion: ho&oenolate anion: 9icinyl 'icar(onian: car(onyl 'ication e$ui9alence: etc Asymmetric synthesis Chiral in'uction-factors controlling facial selecti9ity: Chiral reagents>catalysts: au+iliaries: en.y&es an' anti(o'ies: <inetic resolution: 'ou(le asy&K &etric in'uction: acyclic 'iastereoselection: asy&&etric a&plification: Asy&&etric synthesis of a&ino aci's an' (eta lacta&s Concerted reactions and photochemistry Molecular or(ital sy&&etry: frontier or(itals of 1: -(uta'iene; 1: :5- he+atnenes: allyl syste&: classification of pericyclic reactions: -MO approach: 7oo'1ar'-4off&an correlation 'iagra& &etho' an' "MO approach to pericyclic reactions: *lectrocyclic reactions conrotatory an' 'isrotatory &otions: L%nM: L%nN2M an' allyl syste&s: secon'ary or(ital interaction: Cycloa''ition- antarafacial an' the suprafacial ''itions: L%nM an' L%nN2M syte&s 1ith stereo-che&ical effects: 1: - 'ipolar cycloa''itions: chelotropic reactions: Sig&atropic re-arrange&ents-supra an' antarafacial shifts of 4; sig&atropic shifts of car(on &oiety: retention an' in9ersion of configuration: L : M-an' L :5M-sig&atropic rearrange&ents: flu+ional tauto&eris&: ene reactions8 -ranc2 Con'on principle: Oa(lons2i 'iagra&: singlet an' triplet states: photosensiti.ation: $uantu& effeciency: "hotoche&istry of car(onyl co&poun's: norrish type-l an' type-ll clea9ages: "ate&o-Buchi reaction: photore'uction; "hotoche&istry of enones an' para(en.o$uinones; Synthesis of comple! molecules: Earious approaches for the systhesis of #a+ol; -ors2olin: -<-50,: )i((erellines: "rostaglan'ins: Spatol: Aphi'icol& etc on the (asis of 'isconnection an' 'irect associati9e approaches;

3.

4. 5.

6.

7.

!C-6.0 Stru$ture and 6un$tion o% #iomole$ules (2 $redits)

1.

-ethods for the determination of structure of biomolecules Biological crystallographycrystallisation 'ata collection: refine&ent: i'entification of acti9e site: phase 'eter&ination hea9y ato& 'eri9ati9es: electron 'ensity &aps8 Differences in the s&all &olecule an' (io&olecules crystallography: Spectrofluori&etry- (asic principles of fluorescence: intensity of fluorescence: fluoresent group: sensiti9ity of fluorescence to en9iron&ent an' (iological applications: Optical acti9ity &easure&ents; OBD>CD applications to nucleic aci's an' proteins8 Differential scanning calori&etry 0DSC3 an' theor&ogra9i&etric analysis 0#)A3 of (io&olecules an' other ther&o'yna&ics (ase' instru&ental &etho's esti&ating the structural features of (io&olecules

8|P a g e

MEDICINAL CHEMISTRY
M.S. (Pharm.)
2; "roperties of a&&o aci's an' pepti'e (on': en' group 'eter&ination of pepti'es: se$uencing of pepti'es using 9arious che&ical an' analytical techni$ues: Aptechni$ues 1ith case stu'ies li2e L4B4 an' #B4 pepti'es "rotein structure (uil'ing (loc2 to $uaternary structure of proteins: Ba&achan'ran plots: "epti'o&i&etics; "rotein-ligan' interactions: Multiple (in'ing &o'es Structure of lipoproteins an' glycoproteins in relation to their function Structure of lipi's: polysacchari'es an' car(ohy'rates: Belationship (et1een their physico-che&ical properties an' (iological function Detaile' structure of nucleic aci's an' protein-nucleic aci' interactions: !ucleic aci' an' s&all &olecule interactions: D!A 'a&age an' repair Structure and function of biomolecules pertaining to different thearapeutic areas Cancertu(ulinerole in cell proliferation: 9arious (in'ing sites: the che&istry an' (iology of tu(ul&e inhi(itors: farnesyl transferase I-ray structure: ras protein an' its role: Infla&&ation-COI-1 an' COI-2 their structures an' physiological role: 4yperlipi'i&ia4M)-CoA its structure an' role in cholesterol &anipulation

; %; 5; ,;
7.

!C-650 Stereo$-emistr* and &ru' ($tion (2 $redits)

1.

-olecular isomerism Molecular &otion: ti&e scales an' energy: Confor&ation of open chain an' saturate' cyclic syste&s Chirality an' &olecular sy&&etry: !o&enclature an' representations: Macro&olecular stereoche&istry: Dyna&ic stereoche&istry Resolution procedures Biological an' che&ical8 Analytical chiral integrity 'eter&inations: "feiffer rule an' its 9iolations: Becent atte&pts to 'e9elop continuous scale for chirality8 Chiral ligan's as topo Beali.ation that stereoselecti9ity is a pre-re$uisite for e9olution8 Bole of chirality in selecti9e an' specific therapeutic agents; Case stu'ies: *nantioselecti9ity in 'rug a(sorption &eta(olis&: 'istri(ution an' eli&ination

2;
3.

%;

/C-610 &ru' !eta1olism (1 $redit)

1; 2; Biotransfor&ation of 'rugs: en.y&es responsi(le for (io-transfor&ations: &icroso&al an' non-&icroso&al &echanis&s -actors influencing en.y&e in'uction an' inhi(ition; *+cretion of 'rugs: (iliary an' fecal e+cretion: -actors effecting 'rug &eta(olis&: Drug &eta(olis& in fetus an' ne1 (orn8 Mo'els to stu'y 'rug &eta(olis&: Dose effect relationships; A'9erse 'rug reactions an' 'rug interactions: #o+ic reactions: allergic reactions: i'iosyncracy: acute poisoning an' its treat&ent;

9|P a g e

MEDICINAL CHEMISTRY
M.S. (Pharm.)

/C-611 /-arma$olo'i$al S$reenin' and (ssa*s (1 $redit)

1; 2; )eneral principles of screening: correlations (et1een 9arious ani&al &o'els an' hu&an situations: ani&al ethics; "har&acological screening &o'els for therapeutic areas such as hypertension:J cere(ral ischae&ia: pain: epilepsy: 'epression: "ar2insonJs 'isease: Al.hei&erJs 'isease: 'ia(etic: leish&ania etc; Correlation (et1een in-9itro an' in-9i9o screens8 Special e&phasis on cell- (ase' assay: (ioche&ical assay: ra'ioligan' (in'ing assay: high through put screening: high through put phar&aco2inetic analysis: specific use of reference 'rugs an' interpretation of results;

G -611 Seminar (1 Credit)

Stu'ents are re$uire' to su(&it 1ritten recor' an' present 'eta;ls of the pro/ect to (e pursue' in se&ester-Ill P IE #his shoul' inclu'e the purpose an' (asis of the pro/ect: stating ai&s: o(/ecti9es an' pro(a(le outco&es: (e a(le to supple&ent these 1ith necessary infor&ation: literature re9ie1 to1ar's it an' process for the pro/ect itself;

+S-610 General +a1orator* 2)erien$e 10 -ours34ee5 (2 $redits)

Synthesis of a co&ple+ 'rug inclu'es % to 5 steps: isolate each pro'uct: analy.e all the inter&e'iate an' final pro'ucts using spectral an' other analytical &etho's: report the yiel'; stu'y the theoretical organic che&istry using co&putation &etho's for the sa&e reaction an' learn the techni$ues of &olecular &o'eling;

10 | P a g e