Taibah University Aspirin Faculty of Science Chemistry Department Supervised by : Dr. Laila Shakir & Asst. Heba Alshareef Presented by: Zubaydah Abdullah Contents ! Some Background ! The Chemistry of Aspirin ! Physical properties ! Synthesis ! Mechanism ! IR and NMR Spectroscopy !Biological activity ! Brand names ! Conclusion ! 1897 In Germany, Bayer's Felix Ho!mann develops and patents a process for synthesising acetyl salicylic acid or aspirin. First clinical trials begin. Some Background [ 1 ][ 2 ] It would later be marketed as aspirin a for acetyl and spirin for Spirea, the genus name of the source plant for salicylic acid, the pain-relieving agent. Some Background [ 3 ] Contents ! Some Background ! The Chemistry of Aspirin ! Physical properties ! Synthesis ! Mechanism ! IR and NMR Spectroscopy ! Biological activity ! Brand names ! Conclusion Aspirin IUPAC Name: 2!acetyloxybenzoic acid
Molecular Formula: C 9 H 8 O 4
Molecular Weight: 180.15742 g/mol The chemical structure of aspirin: also known as acetylsalicylic acid The Chemistry of Aspirin [ 4 ] The Chemistry of Aspirin Stability and Reactivity : ! Stability: Stable in dry air. ! Hazardous Decomposition Products: Decomposes to acetic acid and salicylic acids in the presence of moist air. Carbon dioxide and carbon monoxide may form when heated to decomposition. ! Conditions to Avoid: Moisture. [ 5 ] Contents ! Some Background ! The Chemistry of Aspirin ! Physical properties ! Synthesis ! Mechanism ! IR and NMR Spectroscopy ! Biological activity ! Brand names ! Conclusion Physical properties [ 6 ] Contents ! Some Background ! The Chemistry of Aspirin ! Physical properties ! Synthesis ! Mechanism ! IR and NMR Spectroscopy ! Biological activity ! Brand names ! Conclusion According to the above reaction, Salicylic acid is treated with acetic anhydride causing the reaction that converts the hydroxyl group on salicylic acid into and ester functionality. The product of this reaction will be acetyl salicylic acid "aspirin# and acetic acid. Sulphuric acid or phosphoric acid will be used as a catalyst. Reaction : Synthesis [ 7 ][ 8 ] [ 9 ][ 10 ] The production of aspirin from raw materials can be divided into four separate reactions. These are shown: Synthesis [ 11 ] Contents ! Some Background ! The Chemistry of Aspirin ! Physical properties ! Synthesis ! Mechanism ! IR and NMR Spectroscopy ! Biological activity ! Brand names ! Conclusion Mechanism [ 12 ] Contents ! Some Background ! The Chemistry of Aspirin ! Physical properties ! Synthesis ! Mechanism ! IR and NMR Spectroscopy ! Biological activity ! Brand names ! Conclusion IR Spectroscopy [ 13 ] NMR Spectroscopy [ 14 ] Contents ! Some Background ! The Chemistry of Aspirin ! Physical properties ! Synthesis ! Mechanism ! IR and NMR Spectroscopy ! Biological activity ! Brand names ! Conclusion Aspirin works by reducing substances in the body that cause pain, fever, and inammation. Aspirin is used to : ! kill pain ! reduce fever or inammation ! treat or prevent heart attacks, strokes. Biological activity [ 15 ] Contents ! Some Background ! The Chemistry of Aspirin ! Physical properties ! Synthesis ! Mechanism ! IR and NMR Spectroscopy ! Biological activity ! Brand names ! Conclusion Brand names Contents ! Some Background ! The Chemistry of Aspirin ! Physical properties ! Synthesis ! Mechanism ! IR and NMR Spectroscopy ! Biological activity ! Brand names ! Conclusion Conclusion ! Aspirin is used for kill pain, reduce fever and prevent hearts attack. ! Preparation of aspirin by estercation of salicylic acid and acetic anhydride ! The structure of aspirin has been proved by Spectroscopic instruments as IR and NMR . ! The melting point = 135 ! References 1. aspirin!foundation.com/what/timeline.html 2. inventors.about.com/library/inventors/blaspirin.htm 3. mindhacks.com/2009/03/09/a!brief!history!of!aspirin 4. aspirin!foundation.com/what/chemistry.html 5. chem.uky.edu/courses/che554/0!SafetyIntro/AspirinMSDS.pdf 6. chemglue4u.com/lab!helper/organic!chem!lab!helpers/synthesis!of!acetylsalicylic!acid!aspirin/ 7. The Organic Chemistry of Biological Pathways by John McMurry and Tadhg Begley $Roberts and Company, 2005% 8. Organic Chemistry of Enzyme!Catalyzed Reactions by Richard Silverman $Academic Press, 2002%. 9. K. L. Williamson, Macroscale and Microscale Organic Experiments, 2nd Ed. 1994, Houghton Mi&in, Boston. p379; revised 10/18/06 10. Palleros, Daniel R. $2000%. Experimental Organic Chemistry. New York: John Wiley & Sons. p. 11. aspirin!foundation.com/what/reactions.html 12. Carstensen, J.T.; F Attarchi and XP Hou $1985%. "Decomposition of aspirin in the solid state in the presence of limited amounts of moisture". Journal of Pharmaceutical Sciences 77 13. stonybrook.edu 14. biosite.dk/leksikon/acetylsalicylsyre.htm 15. drugs.com/aspirin.html Thank you for your attention