Q.

1 Tick the main approach of peptic ulcer treatment: (a) Neutralization of gastric acid (b) Eradication of Helicobacter pylori (c) Inhibition of gastric acid secretion (d) All the above Q.2 Gastric acid secretion is under the control of the following agents EXCEPT: (a) Histamine (b) Acetylcholine (c) Serotonin (d) Gastrin Q. !ndicate the drug "elonging to proton pump inhi"itors: (a) irenzepine (b) !anitidine (c) "meprazole (d) #rimethaphan Q.# $ll of the following agents intensif% the secretion of gastric glands EXCEPT: (a) epsin (b) Gastrin (c) Histamine (d) $arbonate mineral %aters Q.& 'hich of the following drugs is an agent of su"stitution therap%( (a) Gastrin (b) Hydrochloric acid (c) Hystamine (d) $arbonate mineral %aters Q.) Choose the drug which is a *2+receptor antagonist: (a) "meprazole (b) irenzepine (c) $arbeno&olone (d) !anitidine Q., !ndicate the drug "elonging to -1+cholino"lockers: (a) $imetidine (b) !anitidine (c) irenzepin (d) "meprazole Q.. 'hich of the following drugs ma% cause re/ersi"le g%necomastia( (a) "meprazole (b) irenzepine (c) $imetidine (d) Sucralfate Q.0 Cimetidine has no effect on hepatic drug meta"olism. !t1s (a) #rue (b) 'alse (c)both (d) none Q.12 Tick the drug forming a ph%sical "arrier to *C3 and Pepsin: (a) !anitidine (b) Sucralfate (c) "meprazole (d) irenzepine Q.11 'hich drug is an analog of prostaglandin E1( (a) (isoprostole (b) )e*nol (c) Sucralfate (d) "meprazole Q.12 4elect the drug stimulating the protecti/e function of the mucous "arrier and the sta"ilit% of the mucous mem"rane against damaging factors: (a) )e*nol (b) Sucralfate (c) (isoprostol (d) "meprazole Q.1 $ntacids are weak "ases that react with gastric h%drochloric acid to form salt and water. !t1s (a) #rue (b) 'alse (c)both (d)none Q.1# -ost of drugs are antacids EXCEPT: (a) (isoprostol (b) (aalo& (c) (ylanta (d) Almagel Q.1& !ndicate the drug that cause meta"olic alkalosis: (a) Sodium bicarbonate (b) $imetidine (c) epto*+ismol (d) $arbeno&olone Q.1) $ll of the following drugs stimulate appetite EXCEPT: (a) ,itamins (b) +itters (c) 'epranone (d) Insulin

1.2.2 !ndicate an antiemetic agent which is related to neuroleptics: (a) (etoclopramide (b) Nabilone (c) #ropisetron (d) rochlorperazine Q.22 4elect the emetic agent ha/ing a refle5 action: (a) Ipecacuanha derivatives (b) Apomorphine hydroclorid (c) $hlorpromazine (d) (etoclopramide Q.2 $ll of the following drugs a re antiemetics EXCEPT: (a) (etoclopramide (b) "ndansetron (c) $hlorpromazine (d) Apomorphine hydrochloride Q.2# !ndicate the la5ati/e drug "elonging to osmotic la5ati/es: (a) )ocusate sodium (b) +isacodyl (c) henolphthalein (d) Sodium phosphate Q.*dopamine and 0*H#1*serotonin receptor bloc/ing effect (d) (*cholinobloc/ing effect Q.20 The !.22 Choose an emetic drug of central action: (a) Ipecacuanha derivatives (b) romethazine (c) #ropisetron (d) Apomorphine hydrochloride Q. 3 $" moiety (c) t%o /eto group (d) t%o nitrogen atoms Q.1.*receptor bloc/ing effect (b) (*cholinoreceptor stimulating effect (c) ). Chemicll%6 it is pol%meric condensation product of (a) Aluminium o&ide and aspirin (b) An acetyl salicylic ester of phenol (c) An acetyl salicylic ester of paracetamol (d) An acetyl salicylic ester of *naphthol Q.2& 'hich isomer of i"uprofen is more acti/e ( (a) (S) (*) isomer (b) (S) (2) isomer (c) (!) (2) isomer (d) (!) (*) isomer Q. 3 naphthyl) acetic acid (b) (S) 3 . :enor%late is a prodrug. !t is due to presence of (a) easily replacable hydrogen (b) 3 $" 3 $H. 3 ( 4 3 metho&y 3 . 3 ( 4* etho&y 3 .* naphthyl ) acetic acid .10 $ll of the following drugs intensif% gastrointestinal motilit% EXCEPT: (a) apaverine (b) (etoclopramide (c) )omperidone (d) $isapride Q. Phen%l"uta9one is acidic drut.P$C name for <apro5en is (a) (S) 3 . 4elect an anore5igenic agent affecting serotoninergic s%stem: (a) 'enfluramine (b) 'epranone (c) )esopimone (d) (asindole Q. !t1s: (a) #rue (b) 'alse (c) both SS (d) none Q.and H. Eth%l alcohol is an agent decreasing appetite.Q.2.2) !n the undermentioned list of prostaglandin s%nthetase inhi"otors6 which re7uire least dose8da%( (a) Indomethacin (b) Napro&en (c) iro&icam (d) 'enoprofen Q.21 Tick the mechanism of -etoclopramide antiemetic action: (a) H.

3 naphthyl) propionic acid (d) (S) 3 . 3 ( 4* etho&y 3 . (d) 9arfarin 6a 7 08Q.814 Ibuprofen is a < (a) .(c) (S) 3 . !t "elongs to the categor% of (a) Ethylenediamine (b) Amioal/yl ether (c) ropylamine derivatives (d) iperazine derivative . 3 (5*Isobutylphenyl) propionic acid (c) . 2 'hich of the following acids ha/e heighest degree of !onisation in an a7ueons solution( (a)Aspirin p 6a 7 180 (b) Indomethacin 6a 7 580(c) Ibuprofen p6a 7 08. 'hich is the to5ic meta"olite of $cetaminophen ( (a) N 3 acetylimido:uinone (b) p 3 aminophenol (c) p 3 nitrophenol (d) aniline Q. 3 (5* ropylphenyl) propionic acid (b) (. Terfenadine causes less sedation in comparison to other antihistamines "ecause (a) its duration of action is less (b) it does not penetrate the blood brain barrier (c) it is readily metabolised (d) None of the above Q. # 'hich of the following is < = $r%lanthranilic acid deri/ati/e (a) (efenamic Acid (b) #olmetin (c) Indomethacin (d) None of the above Q. . 1 4tarting material for !"uprofen is (a) Isopropoyl benzene (b) Isobutyl benezene (c) Isobutyl acetophenone (d) Isopropyl acetophenone Q. 2 Pro"enecid is a (a)5 3 (dipropyl sulphamoyl) benzoic acid (b) 5 3 (di isopropyl sulphamoyl) benzoic aicd (c) 5 3 (dipropyl sulphamoyl) cinnanic acid (d) 5 3 ( dipropyl sulpphamoyl) benzylic acid Q. 3 (5*Ethyl phenyl) propionic acid (d) . !t is an intermediate in the preparation of : (a) $hlorophenesin (b) henacetin (c) He&achlorohane (d) He&ylresorcinol Q. 0 Pheniramine maleate is an antihista+minic agaent "elonging to the class (a) Ethylenediamine (b) $yclic basic class analogs (c) Amino al/yl ehter analogs (d) None of the above Q. . Paracetamol is a # = acetamidophenol. 3 (4* metho&y * . 3 naphthyl) propionic acid Q. & 'hich of the following ring is present in 4ulindac. (a) Indole (b) indene (c) Iso&azole (d) None .#2 >iphenh%dramine6 is a antihistaminic drug. 3 (5*He&ylphenyl) propionic acid Q.

(a)It contain phenothiazine= substituted at position 3 -> (b) It is main ingredient of phenergan syrup (c) )e&tro is isomer is more active than levo isomer (d) It contain side chain of 3 $H.#2 ?egarding prometha9ine h%dro+chloride6 one of the statement is not true. 3 aminopiperidine (c) .#& The 2 = "en9%l p%ridiine and dimeth%l amino eth%l chloride are starting material for (a) heniramine (b) (ypramine (c) Novacaine (d) #ripelanamine Q.#2 !n the general formula ? = X+ C = C+ <6 X is either nitrogen or car"on6 ? B different groups.#1 26 6 #6 0 = Tetrah%dro = 2 = meth%l = 0 = phen%l = 1 * = indeno @ 26 1 = cA p%ridine is name for . This formula represent. >emenh%drinate is a com"ination of (a) ? * chlorotheophylline and . 3 Aminopyridine (d) .Q.#) The appropriate starting material for the s%nthesis of mep%ramine is (a) 5 3 Aminopyridine (b) . !dentif% it . 3 (diphenyl metho&y) N= N diethylamine Q. (a) Antitussive (b) Antipyretics (c) analgerics (d) Antihistamines Q.#.# 'hich one of the following antihistaminiic is a "asic ether( (a) heniramine (b) #riprolidine hydrochloride (c) )iphenhydramine H$l(d) romethazine Q. * $H 3 N ($H1).#. 3 (diphenyl metho&y) N= N diethylamine (c) ? 3 chlorotheobromine and . Q. :ranching6 shortening or lengthing of prop%lene "ridge in phenothia9ines causes (a) Increased activity (b) )ecreased activity (c) loss I the activity (d) None .## The most appropriate starting material for the s%nthesis of diphen%dramine is (a) +enzophenone and N= N 3 )imethyl aminoethanol (b) +enzhydrol and N= N 3 )imethyl aminoethanol (c) )ipheny ether and N= N* )imethyl aminoethanol (d) )iphenyl amine and . 3 (diphenyl metho&y) N= N diethylamine (d) ? 3 chlorocaffcine and . 3 chloro ethanol Q. (a) Azatadine (b)#erfenadine (c) henindamine (d) Antazoline Q. 3 (diphenyl metho&y) N= N dimethylamine (b) ?* chlorophylline and .Aminopiperazine Q.

#0 !n anthhistaminic drugs "% "ranching or e5tention of 2 = aminoeh%l side chain causes : (a) )ecreased activity (b) Increased activity (c) loos in activity (d) None Q.&1 'hich of the following ringis present in clemastine (a) pyrole (b) 'uron (c) Indole (d) None Q.&.&2'hich of the following ringis present in mep%ramine (a) piperidine (b) pyridine (c) pyrimidine (d) yradazine Q. (a) )ecline of the basal metabolic rate in the body (b) Increase in the rate and force of contraction of the heart (c) Increase in the blood cholestrol level (d) Increase in the heat production Q.Q.&2 'hich of the following ring is present in >o5%lamine (a) iperdine (b) yrimidine (c) yridine (d) yrazine Q.&. !ndicate the wrong statementCsD.&) !ndications of "romocriptine are following6 EXCEPT: (a) rolactin*secreting adenomas (b) Amenorrhea*Galactorrhea (c) rolactin deficiency (d) Acromegaly Q.&# *istidine is a heteroc%clic amino acid which on heating alone is decomposedproduce (a) Imidazole (b) Histamine (c) ropoinic acid (d) Ammonia Q.&0 *%pothalamic and pituitar% hormones Cand their s%nthetic analogsD ha/e pharmacologic applications in three areas6 EB$E # the follo%ing< (a) As replacement therapy for hormone deficiency states (b) As drug therapy for a variety of disorders using pharmacologic doses to elicit a hormonal effect that is not present at physiologic a blood levels (c) As a diagnostic tool for performing stimulation tests to diagnose hypo* or hyperfunctional endocrine states (d) As food supplements .&&'hich of the following organs is a target for prolactin( (a) @iver (b) Adrenal corte& (c) #hyroid (d) (ammary gland Q. Th%roid hormones produce /arious pharmacological effects. !ndications of th%roid hormones are following6 EXCEPT: (a) $retinism (b) (y&oedema (c) HashimotoAs disease (d) 'or treatment of simple obesity Q.& !n the general formula ? = X = C = C = < : X B <itrogen6 or Car"on6 ? B >ifferent groups8 #his formula represents < (a) Antitussive (b) Antipyretics (c) Analegesics (d) Antihistamines Q.

). !n purine "ios%nthesis ring closure in the molecule form%l gl%cinamide ri"os%l+&+ phosphate re7uires the cofactors: (A) A) (+) NA) ($) 'A) ()) A# and (g22 Q. These categories of histamine *1 antagonists are noted for the anticholinergic effect6 EXCEPT: (a) Al/ylamines (propylamines) (b) iperazines (c) Ethylenediamines (d) henothiazinesC Q.)2 'hich categor% of histamine *1 antagonists is noted for the "est antiemetic action( (a) Al/ylamines (propylamines) (b) Ethanolamines (c) iperazines (d) Ethylenediamines Q.)# 'hich categor% of histamine *1 antagonists is noted for the alpha+adrenoreceptor+ "locking effect( (a) Al/ylamines (propylamines) (b) Ethanolamines (aminoal/yl ethers)C (c) Ethylenediamines (d) henothiazines Q.) .Q.)2 The following statements concerning aspirin are true6 EXCEPT: (a) In contrast to most other NSAI)s= aspirin irreversibly inhibits $"B (b) Aspirin interferes %ith the chemical mediators of the /alli/rein system (c) Aspirin inhibits phospholipase A.2 P%rimidine "ios%nthesis "egins with the formation from glutamine6 $TP and CE26 of .)1 These categories of histamine *1 antagonists are noted for sedati/e effects6 EXCEPT: (a) iperidines (b) Ethanolamines (c) Ethylenediamines (d) henothiazine Q..)& 'hich categor% of histamine *1 antagonists is noted for the highest local anesthetic effect( (a) Al/ylamines (propylamines) (b) iperidines (c) Ethylenediamines (d) henothiazines Q.)0 P%rimidine and purine nucleoside "ios%nthesis share a common precursor: (A) ! (+) Glycine ($) 'umarate ()) Alanine Q. The ke% su"stance in the s%nthesis of purine6 phosphori"os%l p%rophosphate is formed "% (A) D*)*ribose 0*phosphate (+) 0*phospho E*)*ribosylamine ($) )*ribose ()) )eo&yribose Q. formation Q.)0 Purine "ios%nthesis is inhi"ited "% (A) Aminopterin (+) #etracyclin ($) (ethotre&ate ()) $hloramphenicol Q.)) 'hich categor% of histamine *1 antagonists is recogni9ed for as second+generation antihistamines( (a) Al/ylamines (propylamines) (b) iperidines (c) Ethylenediamines (d) henothiazinesC Q.). (d) Aspirin inhibits trombo&ane A.

..... !n "ios%nthesis of proteins the chain terminating codons are (A) UAA. $.& Termination of the s%nthesis of the ?<$ molecule is signaled "% a se7uence in the template strand of the ><$ molecule6 a signal that is recogni9ed "% a termination protein6 the (A) !ho (F) factor (+) G factor ($) H factor ()) I factor Q. UAG and UGA (+) JGG= JGJ and AGJ ($) AAJ= AAG and GAJ ()) G$G= G$A and G$J Q.G6 the onl% identified codon for methionine is important as (A) A releasing factor for peptide chains (+) A chain terminating codon ($) !ecognition site on #rna ()) A chain initiating codon Q.2 Genetic code is (A) $ollection of codon (+) $ollection of amino acids ($) $ollection of purine nucleotide ()) $ollection of pyrimidine nucleotide Q.... >egenerac% of genetic code implies that (A) $odons do not code for specific amino acid (+) (ultiple codons must decode the same amino acids ($) No anticodon on t!NA molecule ()) Specific codon decodes many amino acids Q.0 !nitiation of protein s%nthesis "egins with "inding of (A) 5>S ribosomal unit on m!NA (+) 4>S ribosomal unit ($) $harging of t!NA %ith specific amino acid ()) Attachment of aminoacyl t!NA on (rna Q..(A) $arbamoyl aspartate (+) "rotate ($) $arbamoyl phosphate ()) )ihydroorotate Q...2 The function of a repressor protein in an operon s%stem is to pre/ent s%nthesis "% "inding to (A) #he ribosome (+) A specific region of the operon preventing transcription of structural genes ($) #he !NA polymerase ()) A specific region of the m!NA preventing translation to protein .1 The two nitrogen of the p%rimidine ring are contri"uted "% (A) Ammonia and glycine (+) Asparate and carbamoyl phosphate ($) Glutamine and ammonia ()) Aspartate and ammonia Q.# Genetic code is (A) "verlapping (+) Non*overlapping ($) Not universal ()) Ambiguous Q.

1 Tetrac%lin pre/ents s%nthesis of pol%peptide "% (A) +loc/ing m!NA formation from )NA (+) !eleasing peptides from m!NA*t!NA comple& ($) $ompeting %ith m!NA for ribosomal binding sites (D) Preventing binding of aminoacyl tRNA .Q..

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