Human Genome project

Q. Mapping the human genome involves (a) Sequencing multiple variations of each gene (b) To study the entire DNA found in human cells (c) To study heterochromatic areas (d) All of these Q. Complete draft of human genome was announced in (a) 2003 (b) 1990 (c) 1998 (d) 2000 Q. Working draft of human genome was announced in (a) 2003 (b) 1990 (c) 1998 (d) 2000

Q. NIH stands for? (a) National Institutes of Health (b) National Human Genome Research Institute (c) National Institutes of Hospitality (d) None of these Q. HGP started in? (a) 1992 (b) 1990 (c) 1998

(d) 1953 Q. The aim of HGP is (a) To identify and map 20,000-25,000 genes of humans (b) To determine chemical base pairs of DNA of humans (c) Nucleotides contained in a human haploid reference genome (d) All of these

Q. HGP stands for (a) Human Genome Project (b) Heterogeneous Gene Project (c) Homogeneous Gene Project (d) None of these Q. IRGSP stands for (a) International rice genome sequencing project (b) Indian rice genome sequencing project (c) International rice genome sequenator project (d) International rice genome sequencing process

Q. Launching of rice genome project took place at (a) Japan (b) China (c) India (d)Singapore

Q. The variety of rice used for sequencing? (a) Japonica (b) Aizon (c) Peta

(d) Carolino Q. The size of rice genome is? (a) 430Mb (b) 500Mb (c) 590Mb (d) 523Mb Q. Which of the cereal crops has the smallest genome? (a) Wheat (b) Rice (c) Barley (d) Maize

Q. When does Rice genome project completed? (a) 1992 (b) 1900 (c) 1998 (d) 1953

Physical Mapping
Q. CpG Islands are (a) Areas in genome which are rich in C and G (b) Clusters of C with scattered G (c) Clusters of G with scattered C (d) All of these

Q. Which of the following sequences cannot be used as sequence tagged sites? (a) ESTs (b) Random genomic sequence (c) SSLPs (d) RFLPS Q. QTL stands for (a) Quantitative trait loci (b) Quality trait loci (c) Quanta trait loci (d) Noneof these Q. Which of the following genetic markers are present in highest number within human genome? (a) RFLPs (b) Minisatellites (c) Microsatellites (d) All of these Q. GISH stands for (a) Genomic in situ hybridization (b) Genetic in situ hybridization (c) Gene in situ hybridization (d) None of these Q. SNPs are formed as a result of (a) Point Mutation (b) Deletion (c) Duplication (d) All of these

Q. Which of the following is obtained via cDNA clones? (a)ESTs (b) SSLPs (c) STS (d) All of these Q. Which of the following is the most powerful physical technique is (a) STS (b) SNP (c) VNTRs (d) STRs Q. STS stands for (a) Sequence tagged sites (b) Simple tagged sites (c) Sequence tagged sequences (d) Similar tagged sequences

Q. The resolution of FISH can be improved by (a) Using interphase chromosomes (b) By Fiber FISH (c) Both (d) None of these Q. FLPter value refers to (a) Measure of fluorescent signal obtained by FISH relative ti its position to the end of short arm of chromosome (b) Measure of all signals of FISH (c) Measure of alternate signals of FISH (d) All of these

Q. FISH uses chromosomes of which stage of cell division? (a) Metaphase (b) Interphase (c) Telophase (d) Prometaphase Q. FISH stands for (a) Fluorescent in situ hybridization (b) Fluorescent intact hybridization (c) Fluorescent internal hybridization (d) None of these Q. Restriction mapping involves (a) Restriction digestion of total DNA of organism (b) Restriction digestion of single cell DNA (c) partial digestion of single cell DNA (d) None of these

Genetic mapping
Q. C- value refers to (a) Amount of DNA contained within a haploid nucleus (b) Amount of DNA contained within whole genome (c) Amount of DNA contained within the cell (d) None of these Q. Which of the following mechanism generate repetitive DNA? (a) Transposition (b) Deletion (c) Duplication

(d)(i) and (iii) both Q. Which of the following represents repetitive DNA? (a) SINEs (b) LINEs (c) VNTRs (d) All of these Q. Which of the following is an example of Developmentally controlled complex multigene family? (a) Histone family of Xenopus levis (b) Immunoglobin superfamily of humans (c) Hemoglobin family of humans (d) None of these Q. Which of the following multigene family expressed only during a particular state of development (a) Simple multigene family (b) Complex multigene family (c) Developmentally controlled complex multigene family (d) All of these Q. Multigene families are (a) Cluster of several similar genes (b) Formed by duplication of a single original gene (c) Generally with similar biochemical functions (d) All of these Q. Which of the following are the variants of SSLP (a) VNTRs (b) STRs (c) SNPs

(d) (i) and (ii) both Q. Which of the following is an example of markers used for genetic mapping? (a) RFLPs (b) SSLPs (c) SNPs (d) All of these Q. Molecular markers are (a) Genes that do not inherit (b) DNA sequences similar to genes but not genes (c) DNA sequences that are not genes but inheritable (d) None of these Q. The interspersed repeats are (a) Repeats whose individual repeat units are distributed in genome in random fashion (b) Repeats distributed alternately in genome (c) Are distributed evenly throughout the genome (d) All of these Q. Which of the following is an example of genome wide repeats? (a) LINEs (b) SINEs (c) LTR (d) All of these. Q. Which of the following is an example of X-linked recessive trait? (a) Duchenn muscular dystrophy (b) Testicular feminization syndrome (c) Hemophilia

(d) All of these Q. Which of the following is an example of autosomal recessive trait? (a) Albinism (b) Alzheimer (c) Color- blindness (d) Hemophilia Q. Proposita in pedigree is (a) Male, who was first in which the disease was identified (b) Female, who was first in which the disease was identified (c) Female, who carries the genes for disease (d) Male, who carries the genes for disease Q. If the trait is an X-linked recessive which of the following statements are true (a) children will not have the trait. (b) children might or might not have the trait. (c) all of the children will have the trait. (d) males will have the trait, but females will only have the trait if their father also has the trait.

Q. If a trait is autosomal recessive then (a) Both parents are affected; none of the children will be affected. (b) Both parents are affected; the children might or might not be affected. (c) Both parents are affected; all of the children will be affected. (d) None of these Q. If a trait is dominant then in pedigree chart (a) Will appear in every generation (b) Will appear in alternate generation

(c)Will appear in distant generations (d) Will not inherit further Q. Pedigree is (a) Diagram that represents family relationship (b) Represent diseases in family (c) Represent superhuman traits (d) Represent only dominant traits Q. Which of the following is a method for analyzing human genetics? (a) LOD score (b) Pedigree (c) Cross breeding (d) All of these

Structure of Prokaryotic
Q. Genes are said to be linked when (a) Their loci are located to each other (b) They inherit together for two or more generations (c) Their chromatids do not separate during chromosomal cross over (d) All of these

Q. For the analysis of linkage Neurospora is a good model as (a) It is easy to grow and has a haploid life cycle (b) Ordered arrangement of the products of meiosis in Neurospora ascospores (c) Its entire genome of seven chromosomes has been sequenced (d) All of these Q. Crossing over increases when

(a) Distance between genes increases (b) Distance between genes decreases (c) Distance between genes is equal (d) Is independent of distance Q. Linkage increases when (a) Distance between genes increases (b) Distance between genes decreases (c) Distance between genes is equal (d) Is independent of distance Q. Following are the features of satellite DNA (a) Consist of repetitive DNA (b) Form a separate band during centrifugation with density different from bulk DNA. (c) Consist of long Tandem repeats (d) All of these

Q. Truncated genes are (a) Genes that lack a segment or stretch from one end of complete gene (b) Genes that lack a segment or stretch from between of a complete gene (c) Genes that are short isolated regions of from within a gene (d) All of these. Q. Size of Human Genome is (a) 125 Mb (b) 3300 Mb (c) 3200 Mb (d) 120,000Mb Q. Gene density in eukaryotes is (a) Higher than prokaryotes

(b) Lower than prokaryotes (c) Equal to prokaryotes (d) None of these Q. Which of the following is a common feature of eukaryotic genome? (a) Presence of Introns (b) Presence of Transposons (c) Even distribution of genes (d) All of these Q. Which of the following histone protein attach with linker DNA (a) H1 (b) H2A and H2B (c) H3 (d) H4 Q. Core of Nucleosomes is consist of Histone proteins (a) H2A,H2B,H3 and H4 (b) H1, H2A,H2B and H3 (c) H2A,H2B and H3 (d) H1,H2A,H2B,H3 and H4 Q. Nucleosomes are composed of (a)Core DNA and Histones (b) Linker DNA and Histones (c) Linker DNA, Core DNA and Histones (d) None of these

Q. Histones consist of following amino acids (a) Arginine and Lysine

(b) Glutamine and Aspartate (c) Cystiene and Methionine (d) All of these Q. Histones are (a) Basic proteins (b) Acidic proteins (c) Neutral proteins (d) None of these Q. Histones are found in (a) Eukaryotes (b) Prokaryotes (c) Both (d) None of these Q. Which of the following protein is used in DNA packaging? (a) Histone (b) Albumin (c) Globin (d) Nuclease Q. Somatic cells are those cells that (a) Contain a haploid set of chromosomes. (b) Give rise to the gametes (c) Lack mitochondria (d) Contain a diploid set of chromosomes and make up majority of human cells. Q. Which of the following statements about an organism’s genome is false?

(a) The genome contains the genetic information to construct and maintain a living organism. (b) Genomes of cellular organism are composed of DNA. (c) The genome is able to express its own information without the activity of enzymes and proteins. (d) Eukaryotic genomes are composed of both nuclear and mitochondrial DNA. Q. Total no. of genes found in human genome (a) 20000-25000 (b) 50000-58000 (c) 100000 (d) 35000-40000 Q. Genome is (a) Haploid set of chromosomes (b) Diploid set of chromosomes (c) Polyploid set of chromosomes (d) None of these

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