Indestrux Report

By: Isiah Smith, Kevin Le, and Jennifer Tran

Mrs. Pam Hicks
Pharmacy Tech
11 April 2014














Company Name: Dermatuff, Inc.
Trade Name: Indestrux
Generic Name: Sheathrombin
Physical Description: A tube-like container that contains the required amount of drug
ready to be dispensed. It has a cover on the needle until it is ready to be used in any
given situation called an Epipen.
Primary Drug Classification: Platelet-Stimulating Agent
Intended Indications and Usage: To prevent prolonged bleeding and protect the skin
from deep injuries.
Contraindications: Hemophiliacs, people on the line of duty, and people with blood
thinners.
Dosage Standards: 0.3 mg for people who weigh at least 30 kilograms in adults.
Route of Administration: Epipen (Subcutaneous Injection)
Potential Drug/Food Interactions: Avoid taking any aspirin or NSAIDs since it may
cause damage or headache and dizziness to your body. Also, avoid any alcohol
since it may cause bleeding to worsen or not clot properly in your blood.
Potential Unwanted Side Effects: Abnormal bleeding, headache, dizziness, muscle
pain, stomach pain, or sleep problems.
Potential Effects on Laboratory Test: We tested our drug on hemophiliacs and about
20% of the individuals still bled as usual while the other 80% of the individuals had
their blood clotting increased speed which then they started to heal faster.
Potential Effects on Existing Medical Disorders: Do not take if you have any blood
cancers, kidney or liver disease, or high platelet levels since it may cause more
damage than it should be to your body.
Use During Pregnancy and in Children: It is not required to be used for pregnant
women considering they have increasing blood clotting factors due to their
hormones during pregnancy. When your children may get injured, you can use this
drug to help increase their blood to clot rapidly to help prevent major blood loss or
prevent further blood from coming out of their bodies.
Mechanism of Action: When injected into the bloodstream, our drug has Effector Cell
Protease Receptor-1 agonists (EPR-1) to bind with Factor Xa onto platelets or white
blood cells. The factor Xa will be produced in the intrinsic and extrinsic channels of
the coagulation cascade process that will increase or accelerate the production of
Factor Xa combined with Factor V to convert Prothrombin into Thrombin. Therefore,
Thrombin will help alleviate the pain or increase blood clotting when you have deep
cuts or burns. Factor Xa is where the intrinsic and extrinsic channels combine
together to help increase the reproduction of prothrombin in order to get thrombin to
increase blood clotting in the system of our bodies. The platelets would then be able
to increase in the construction of several blood clotting factors to prevent people
from bleeding out immediately.














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0.05
0.1
0.15
0.2
0.25
0.3
0.35
05
1
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1
5
2
0
2
5
3
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3
5
4
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Duration of Therapy (Minutes)
Indestrux (Sheathrombin)
Dose 1
Dose 2



Works Cited

Ambrosini, Grazia, and Dario C. Altieri. "Molecular Dissection of Effector Cell Protease
Receptor-1 Recognition of Factor Xa." Www.jbc.org. The American Society for
Biochemistry and Molecular Biology, Inc., 09 Nov. 1995. Web. 07 Apr. 2014.
<http://www.jbc.org/content/271/2/1243.abstract>.
Altieri, Dario C., and Susan J. Stamnes. "Protease-Dependent T Cell Activation:
Ligation of Effector Cell Protease Receptor-1 (EPR-1) Stimulates Lymphocyte
Proliferation." Www.sciencedirect.com. Elsevier B.V., 26 Apr. 2002. Web. 07 Apr.
2014. <http://www.sciencedirect.com/science/article/pii/S0008874984711300>.
"Blood Coagulation Factor Xa (FXa)." Www.enamine.net. Enamine, 1991-2014. Web.
07 Apr. 2014.
<http://www.enamine.net/index.php?option=com_content&task=view&id=52>.
"Coagulation Factor Xa." Www.haemtech.com. Haematologic Technologies, Inc., 2009.
Web. 07 Apr. 2014. <http://haemtech.com/Enzymes/Factor_Xa.htm>.
Schwartz, Robert A., Christopher J. Steen, and Pere Gascon. "Factor X ."
Www.emedicine.medscape.com. Ed. Paul Schick, Francisco Talavera, Ronald A.
Sacher, Rebecca J. Schmidt, and Emmanuel C. Besa. WebMD LLC, 01 Oct.
2013. Web. 07 Apr. 2014. <http://emedicine.medscape.com/article/209867-
overview>.
"The Coagulation Cascade." Www.thrombosisadviser.com. Bayer Pharma AG, 26 Feb.
2014. Web. 07 Apr. 2014. <http://www.thrombosisadviser.com/en/understanding-
thrombosis/the-coagulation-cascade/>.
Tracy, Nesheim, and Mann. "Platelet Factor Xa Receptor." Http://www.ncbi.nlm.nih.gov.
NLM, NIH, DHHS, Usa.gov, n.d. Web. 07 Apr. 2014.
<http://www.ncbi.nlm.nih.gov/pubmed/1331708>.