HVAC Systems Control Philosophy

Project: GMP Cell Therapy Facility

Customer: Tadmur Trading, oha, !atar
"#$ %&T'()CT%(&
The new GMP Cell Therapy Laboratory is to be constructed at first floor level in the
hospital. The laboratory comprises of Cleanrooms 1 & 2 which are !GMP Grade "
environments served by #$!%& Cleanroom ' which is an !GMP Grade " environment
served separately by #$!%#& the Processin( )oom and support rooms which are
!GMP Grade C environments served by #$!'.
This controls philosophy document details the control methodolo(y to achieve the
efficient operation of the mechanical services and the specified space conditions
re*uired.
$eatin( is provided by electric heaters either mounted in the #$! or as +one heaters in
the distribution ductwor,.
Coolin( is provided by chilled water ta,en from the chilled water circulation system
connected to an air cooled chiller at roof level.
$umidification is provided by electric self (eneratin( steam in-ection humidifiers in each
air handlin( unit.
"uildin( services are provided in accordance with the followin( documents.
/rawin( no 012'%34M21 $5#C 6chematic #$!'& % & %#
/rawin( no 012'%34M22 $5#C #$! /etails
/rawin( no 012'%34M2' #ir /istribution Layout
*#$ C(&T'(+ ',!)%',M,&TS
2.1 AH)- HVAC System
*#"#" Supply . ,/tract Fan (peration
6ystem to run continuously to maintain specified room pressures.
7ccupied periods. supply and e8tract at 1229 of desi(n duty.
!noccupied periods. supply and e8tract at 1229 of desi(n duty.
ach supply fan motor and e8tract fan motor to be fitted with inverter
drive speed controllers. 6upply fan speed to be controlled by differential
pressure si(nal measured across supply air silencer. The pressure set4
point value will be up to :2 Pa at 1229 but actual value to be measured
durin( commissionin( at the correct flow rates and the value obtained to
be used as set points for supply fan flowrate control. 8tract fan speed
to be controlled by differential pressure si(nal measured across e8tract
air silencer. The pressure set4point value will be up to :2 Pa at 1229 of
flow but actual value to be measured and confirmed durin(
commissionin( at the correct flow rates. the value obtained to be used as
set points for e8tract fan flowrate control.
Pa(e 1 of 3
HVAC Systems Control Philosophy
Project: GMP Cell Therapy Facility
Customer: Tadmur Trading, oha, !atar
#$!' supply fan is fitted with duty and standby motors and inverter
drives. Controls to automatically switch from duty to standby fan in the
event of Low ;low. Low ;low is tri((ered by a measured pressure
across the supply air silencer at <29 of the set4point value for 12
seconds. =n the event of low flow a latched 6upply #ir Low ;low lamp
shall be lit on the control panel and an alarm sent to the "M6 system.
#c,nowled(in( the alarm will re4set the auto chan(e over and e8tin(uish
the 6upply #ir Low ;low lamp.
/uplicate direct drive e8tract fans with inverter drives are fitted to the
(eneral e8tract system to provide run and standby operation. Motorised
dampers are fitted either side of each e8tract fan to allow isolation.
/ampers are to open and close automatically to isolate the fan that is not
runnin(. Controls are to automatically switch from duty to standby fan in
the event of Low ;low. Low ;low is tri((ered by a measured pressure
across the e8tract air silencer at <29 of the set4point value for 12
seconds. =n the event of low flow a latched 8tract #ir Low ;low lamp
shall be lit on the control panel and an alarm sent to the "M6 system.
#c,nowled(in( the alarm will re4set the auto chan(e over and e8tin(uish
the 8tract #ir Low ;low lamp.
*#"#* Heating
6in(le #$! mounted electric heater servin( controlled +one as follows>
?one '41 Process and ancillary rooms.
6pace temp in heatin( mode 2'@C A or 4 1@C room temperature tolerance
durin( occupied period. 1:@C unoccupied period set bac, room
temperature.
Minimum % sta(es each sta(e switched separately by output from +one
heatin(Bcoolin( P=/ control module. =nput to control module from space
avera(in( room temperature detector in individual +one return air
ductwor,.
*#"#- Cooling
6in(le air handlin( unit mounted chilled water coolin( coil.
Chilled water distribution from roof top mounted air cooled li*uid chiller.
Chilled water temperatures 1.<@C flow& 12.2@C return.
6pace temperature in coolin( mode 2'@C A or 4 1@C room temperature
tolerance durin( occupied period. Co room hi(h limit temperature control
durin( unoccupied period. Coolin( coil proportionally controlled by a
modulatin( ' port motorised control valve. 5alve motor to be controlled
by output from +one heatin(Bcoolin( control module.
Chilled water control valve to be selected to operate in mi8in( mode and
provide a minimum of 2.: valve authority.
6upply air temperature 1%@C to 22@C in coolin( mode.
Low limit control of supply duct air temperature at 1'@C.
Pa(e 2 of 3
HVAC Systems Control Philosophy
Project: GMP Cell Therapy Facility
Customer: Tadmur Trading, oha, !atar
2.1.% Humidi0ication
6pace humidity :29)$ A or D :9)$ room humidity tolerance durin(
occupied period. Co room low limit humidity control durin( unoccupied
period.
6in(le sta(e self (eneratin( direct in-ection humidifier to incorporate
proportional control of humidifier output by a si(nal from the humidity
control module. =nput to control module from space avera(in( sensor in
return air ductwor,. $i(h limit control of supply duct air humidity at E:9
)$ only active when humidifier is operatin(. de4humidification mode can
e8ceed E:9.
*#"#1 e2Humidi0ication
6pace humidity :29)$ A or D :9)$ room humidity tolerance durin(
occupied period. Co room hi(h limit humidity control durin( unoccupied
period.
/e4 humidification is controlled by the output from humidity control
module overridin( the coolin( si(nal to the chilled water coolin( coil
control valve. The #$! +one heater will provide re4heatin( as re*uired
to maintain room specified temperatures.
*#"#3 Ventilation
Minimum fresh air re*uired to suit occupancy of 1: persons at 12 lBs
each (ivin( a total of 1E2 lBs or 2.1E2 m'Bs. Ma8imum supply air (reater
than e8tract air volume by 2.2E m'Bs to maintain room pressure. flowrate
above this amount will re*uire additional sealin( of the buildin( fabric&
doors and services penetrations.
*#"#4 'oom Pressure Control
# room pressure of min A2:Pa is maintained in the Process )oom under
all flow conditions when doors are closed. )oom pressure is lost when
doors are opened. # full set of room pressures are shown on drawin( no
012'%34M21. )oom pressure is set up durin( commissionin( by
providin( supply and e8tract duct static pressure set points at 1229 flow
conditions.
)oom pressure is set up durin( commissionin( by providin( supply and
e8tract duct static pressure set points at 1229 flow conditions.
2.2 AH)5 . AH) 5A HVAC Systems
*#*#" Supply . ,/tract Fan (peration
6ystems to run continuously to maintain specified room pressures.
7ccupied periods. supply and e8tract at 1229 of desi(n duty.
!noccupied periods. supply and e8tract at 1229 of desi(n duty.
;umi(ation period. supply and e8tract switched off.
Post fumi(ation ventilation. supply and e8tract at :29 of desi(n duty.
Pa(e ' of 3
HVAC Systems Control Philosophy
Project: GMP Cell Therapy Facility
Customer: Tadmur Trading, oha, !atar
ach supply fan motor and e8tract fan motor to be fitted with inverter
drive speed controllers. 6upply fan speed to be controlled by differential
pressure si(nal measured across supply air silencer. The pressure set4
point value will be up to :2 Pa at 1229 of flow and up to 12.: Pa at :29
of flow FPost fumi(ation ventilationG but actual values to be measured
durin( commissionin( at the correct flow rates to be used as set points
for supply fan flowrate control. 8tract fan speed to be controlled by
differential pressure si(nal measured across e8tract air silencer. The
pressure set4point value will be up to :2 Pa at 1229 of flow and up to
12.: Pa at :29 of flow FPost fumi(ation ventilationG but to actual values
be measured durin( commissionin( at the correct flow rates to be used
as set points for e8tract fan flowrate control.
#$! supply fans are to be fitted with duty and standby motors and
inverter drives. Controls to automatically switch from duty to standby fan
in the event of Low ;low. Low ;low is tri((ered by a measured pressure
across the supply air silencer at <29 of the set4point value for 12
seconds. =n the event of low flow a latched 6upply #ir Low ;low lamp
shall be lit on the control panel and an alarm sent to the "M6 system.
#c,nowled(in( the alarm will re4set the auto chan(e over and e8tin(uish
the 6upply #ir Low ;low lamp.
/uplicate direct drive e8tract fans with inverter drives are fitted to the
(eneral e8tract systems to provide run and standby operation. Motorised
dampers are fitted either side of each e8tract fan to allow isolation.
/ampers are to open and close automatically to isolate the fan that is not
runnin(. Controls are to automatically switch from duty to standby fan in
the event of Low ;low. Low ;low is tri((ered by a measured pressure
across the e8tract air silencer at <29 of the set4point value for 12
seconds. =n the event of low flow a latched 8tract #ir Low ;low lamp
shall be lit on the control panel and an alarm sent to the "M6 system.
#c,nowled(in( the alarm will re4set the auto chan(e over and e8tin(uish
the 8tract #ir Low ;low lamp.

*#*#* Heating
lectric heater servin( each +one as follows>
AHU4
?one %41 ;inal Prep )oom
?one %42 Clean )oom 1
?one %4' Clean )oom 2
AHU4A
?one %#42 Clean )oom '
6pace temp in heatin( mode 2'@C A or 4 1@C room temperature tolerance
durin( occupied period. 1:@C unoccupied period set bac, room
temperature.
Pa(e % of 3
HVAC Systems Control Philosophy
Project: GMP Cell Therapy Facility
Customer: Tadmur Trading, oha, !atar
Minimum % sta(es each sta(e switched separately by output from
relevant +one heatin(Bcoolin( P=/ control module. =nput to control
module from space avera(in( room temperature detector in return air
ductwor,.
*#*#- Cooling
6in(le air handlin( unit mounted chilled water coolin( coil.
Chilled water distribution from roof top mounted air cooled li*uid chiller.
Chilled water temperatures 1.<@C flow& 12.2@C return.
6pace temperature in coolin( mode 2'@C A or 4 1@C room temperature
tolerance durin( occupied period. Co room hi(h limit temperature control
durin( unoccupied period. Coolin( coil proportionally controlled by a
modulatin( ' port mi8in( motorised control valve. ;or #$!% valve motor
controlled by output from ma8imum load module receivin( input from
three individual +one heatin(Bcoolin( control modules. Ma8imum load
module receives input from three +one P=/ control modules and uses
ma8imum load to control valve motor. ;or #$!%# valve motor to be
controlled by output from +one heatin(Bcoolin( control module.
Chilled water control valves to be selected to operate in mi8in( mode and
provide a minimum of 2.: valve authority.
6upply air temperature 1%@C to 22@C in coolin( mode.
Low limit control of supply duct air temperature at 1'@C.
2.2.% Humidi0ication
6pace humidity :29)$ A or D :9)$ room humidity tolerance durin(
occupied period. Co room low limit humidity control durin( unoccupied
period.
6in(le sta(e self (eneratin( direct in-ection humidifier in each air
handlin( unit havin( proportional control of humidifier output by a si(nal
from the humidity control module. =nput to control module from space
avera(in( sensor in return air ductwor,. $i(h limit control of supply duct
air humidity at E:9 )$ only active when humidifier is operatin(. de4
humidification mode can e8ceed E:9.
*#*#1 e2Humidi0ication
6pace humidity :29)$ A or D :9)$ room humidity tolerance durin(
occupied period. Co room hi(h limit humidity control durin( unoccupied
period.
/e4 humidification is controlled by the output from humidity control
module overridin( the coolin( si(nal to the chilled water coolin( coil
control valve. The individual +one heaters will provide re4heatin( as
re*uired to maintain room specified temperatures.
*#*#3 Ventilation
Minimum fresh air re*uired to suit occupancy of>

Pa(e : of 3
HVAC Systems Control Philosophy
Project: GMP Cell Therapy Facility
Customer: Tadmur Trading, oha, !atar
#$!% % persons at 12 lBs each (ivin( a total of %E lBs or 2.2%E m'Bs.
#$!%# ' persons at 12 lBs each (ivin( a total of '1 lBs or 2.2'1 m'Bs.
#$!% supply air (reater than e8tract air volume by 2.12 m'Bs.
#$!%# supply air (reater than e8tract air volume by 2.12 m'Bs.
8cess of supply air flowrate over e8tract are to maintain room pressure.
;lowrates above these amounts will re*uire additional sealin( of the
buildin( fabric& doors and services penetrations.
*#*#4 'oom Pressure Control
# room pressure of min A<2Pa is maintained in Clean )oom 1 and 2&
E2Pa in Cleanroom ' and A12Pa in the ;inal Preparation )oom under all
flow conditions when doors are closed. )oom pressure is lost when
doors are opened. # full set of room pressures are shown on drawin( no
012'%34M21. )oom pressure is set up durin( commissionin( by
providin( supply and e8tract duct static pressure set points at various
F1229 and :29G flow conditions.
*#*#6 Fumigation Control
Two fumi(ation control panels are to be provided to control the
fumi(ation process. Control panel to operate (as ti(ht dampers& plant
shutdown& operation of the fumi(ation process and post fumi(ation
ventilation. Panel 1 is dedicated to Cleanroom 1 and Cleanroom 2 which
are to be fumi(ated to(ether. panel 2 is dedicated to Cleanroom'. The
control panel is to be a recessed desi(n and mounted on the wall of the
Process )oom. # red flashin( fumi(ation beacon is to be mounted in the
ceilin( of the ;inal Preparation )oom over each clean room door. ach
door to be fitted with a prominent si(n statin( H/7 C7T CT) I$C
)/ L=G$T =6 ;L#6$=CGJ.
#ppendi8 # details the fumi(ation process and e*uipment re*uirements.
-#$ Condition Monitoring
'.1 'oom Conditions Monitoring and isplays
# visual pro(rammable display panel is to be mounted ad-acent the door of
Cleanroom 1& Cleanroom 2& Cleanroom ' and the Process )oom. ach panel
will indicate room temperature& humidity and pressure. =ndependent sensors
are to be provided to monitor space conditions as detailed below>
)oom temperature measured in each +one return air ductwor,.
)oom humidity measured in each +one return air ductwor,.
)oom pressure measured in each room. ach room pressure to be a
differential pressure measurement measured to an a(reed datum point in the
area ad-acent the GMP facility.
'.2 Filter Condition Monitoring
Pa(e 1 of 3
HVAC Systems Control Philosophy
Project: GMP Cell Therapy Facility
Customer: Tadmur Trading, oha, !atar
ach filter ban, to be fitted with differential pressure sensors to monitor the filter
condition. The pressure readin( obtained is to be used for front end monitorin(
and display in the "M6 system. These values are to be used to indicate
approachin( dirty and dirty filter alarms within the "M6 system as detailed
below>
AHU3 Approaching Dirty Dirty Sensor Range
Primary filter ;< 222Pa 222 Pa 2 to :22 Pa
Primary filter ;3 222Pa 222 Pa 2 to :22 Pa
Terminal $P# $1% ':2 Pa %22 Pa 2 to 1222 Pa
AHU4 Approaching Dirty Dirty Sensor Range
Primary filter ;< 222Pa 222 Pa 2 to :22 Pa
Primary filter ;3 222Pa 222 Pa 2 to :22 Pa
$P# $1% ':2 Pa %22 Pa 2 to 1222 Pa
Terminal $P# $1% ':2 Pa %22 Pa 2 to 1222 Pa
AHU4A Approaching Dirty Dirty Sensor Range
Primary filter ;< 222Pa 222 Pa 2 to :22 Pa
Primary filter ;3 222Pa 222 Pa 2 to :22 Pa
$P# $1% ':2 Pa %22 Pa 2 to 1222 Pa
Terminal $P# $1% ':2 Pa %22 Pa 2 to 1222 Pa
=n addition each filter ban, is to be fitted with a /wyer Ma(nehelic pressure
(au(e to provide indication of filter condition at plant room level. The monitored
pressures and (au(e ran(e are as follows.
AHU3 Dirty Magnehelic Gauge Range
Primary filter ;< 222 Pa 2 to :22 Pa
Primary filter ;3 222 Pa 2 to :22 Pa
Terminal $P# $1% %22 Pa 2 to 1222 Pa
AHU4 Dirty Magnehelic Gauge Range
Primary filter ;< 222 Pa 2 to :22 Pa
Primary filter ;3 222 Pa 2 to :22 Pa
$P# $1% %22 Pa 2 to 1222 Pa
Terminal $P# $1% %22 Pa 2 to 1222 Pa
AHU4A Dirty Magnehelic Gauge Range
Primary filter ;< 222 Pa 2 to :22 Pa
Primary filter ;3 222 Pa 2 to :22 Pa
$P# $1% %22 Pa 2 to 1222 Pa
Terminal $P# $1% %22 Pa 2 to 1222 Pa
ach #$! system to be provided with 2 no terminal $P# pressure
sensors and Ma(nehelic (au(es per system.
Pa(e < of 3
HVAC Systems Control Philosophy
Project: GMP Cell Therapy Facility
Customer: Tadmur Trading, oha, !atar
5#$ %SS),
3
th
/ecember 2211 ;irst =ssue P1
1#$ APP,&%7 A
:.1 Fumigation
Cleanrooms 1 and 2 has a dedicated fumi(ation panel and Cleanroom ' has a
dedicated fumi(ation panel. ach panel to include rotary selector switch& alarm
and operation li(hts. # separate red warnin( beacon is to be fitted into the
ceilin( above each cleanroom entrance.
;or Cleanrooms 1 and 2 fumi(ation is to ta,e place at the same time.
Cleanroom ' fumi(ation will ta,e place separately under the control of its own
fumi(ation control panel. Gas ti(ht isolation dampers& as shown on the
schematic& allow the room to be isolated for fumi(ation. The (as ti(ht dampers
are to be controlled by the fumi(ation control panel.
7n operation of the fumi(ation cycle the air handlin( unit is disabled& dampers
closed and fumi(ation soc,ets will be enabled for a pre set time Fad-ustableG.
#n input from the control panel 8normal90umigation: ,ey operated selector
switch enables the fumi(ation cycle.
Ihen the fumi(ation cycle is ener(ised& with 8Fumigation in Progress:
indication on the control panel& the supply and e8tract fans stop& fresh air and
e8haust air dampers move to their open position. The (as4ti(ht isolation
dampers and recirculation damper are driven to the closed position and end
switches illuminate 8ampers Closed: lampsK on the panel and allow the cycle
to proceed when all dampers are closed.
#fter an ad-ustable time period& the fumi(ation soc,ets are enabled for an
ad-ustable time period& with 8Fumigation Soc;ets ,na<led: indication on the
control panel.
7n completion of the (as cycle& fresh& e8haust and (as ti(ht isolation dampers
are driven fully open and recirculation damper closes. Ihen the (as ti(ht
dampers all reach the open position& as proved by their end switches& the
supply and e8tract fans are restarted and the de(as mode runs for an
ad-ustable time period li(htin( a 8egas: lamp on the control panel.
#t the end of this period the 8egas: lamp (oes out and the $5#C system
remains in this mode until the 8normal90umigation: ,ey operated selector
switch is returned to the normal position.
Pa(e E of 3
HVAC Systems Control Philosophy
Project: GMP Cell Therapy Facility
Customer: Tadmur Trading, oha, !atar
# second ,ey operated selector switch is provided on the control panel for
8&ormal9egas o=erride: which provides the ,ey holder with the followin(
additional function.
6hould it be deemed necessary at any time in the cycle to pur(e the
area of the (assin( a(ent& by operation of the switch into the override
position& the system is driven into the de(as mode.
Pa(e 3 of 3