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Journal Article


Clinical Impact of
Carcinoembryonic Antigen
Messenger Ribonucleic Acid
Expression in Tumor-Draining
Vein Blood on Postoperative
Liver Metastasis in Patients With
Colorectal Carcinoma
A Prospective, Cohort Study
Journal Diseases of the
Colon & Rectum
Publisher Springer New York
ISSN 0012-3706 (Print)
1530-0358
(Online)
Subject Medicine
Issue Volume 46,
Number 4 / April,
2003
DOI 10.1007/s10350-
004-6584-3
Pages 467-473
Online Date Thursday,
February 19, 2004
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Koki Sunouchi
1
,
Rikuo Machinami
1
,
Masaki Mori
1
,
Kazunobu Namiki
1
,
Shouichi Hattori
1
,
Yujiro Murata
1
,
Takeshi Tsuchiya
1
,
Hideaki Mizuno
1
and
Masao Tadokoro
1
(1) Departments of
Surgery,
Pathology, and
Internal Medicine,
Kawakita General
Hospital,
Suginami-ku,
Tokyo, Japan
Abstract PURPOSE:
This study was
designed to determine
the clinical impact of
carcinoembryonic
antigen messenger
ribonucleic acid
expression in tumor-
draining vein blood on
postoperative liver
metastasis in patients
English Go
... Go
SpringerLink - Journal Article
with colorectal
carcinoma. METHODS:
The study comprised
37 patients with
colorectal carcinoma
who underwent
laparotomy (Dukes A,
3; Dukes B, 16; Dukes
C, 15; and Dukes D,
3). Blood samples
were drawn from the
tumor-draining vein
and the tumor-feeding
artery. Total
ribonucleic acid was
extracted from the
blood and subjected to
reverse transcriptase-
polymerase chain
reaction to detect
carcinoembryonic
antigen messenger
ribonucleic acid. Tissue
sections of tumor were
stained with
hematoxylin and eosin
and were examined
immunohistochemically.
The duration of follow-
up ranged from two
years and three
months to three years
and six months.
RESULTS: Expression
of amplified
carcinoembryonic
antigen messenger
ribonucleic acid in
tumor-draining vein
blood was positive in
16 (43 percent) of the
37 patients, while that
in the feeding artery
blood was positive in 3
patients (8 percent).
There was no relation
between the protein
level of
carcinoembryonic
antigen and positive
expression of
carcinoembryonic
antigen messenger
ribonucleic acid.
Positive expression of
carcinoembryonic
antigen messenger
ribonucleic acid was
observed in two
patients with histologic
evidence of massive
venous invasion and in
Open: Entire document
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all three patients with
synchronous liver
metastasis.
Immunohistochemical
studies revealed that
all tumor specimens
with stromal type
(5/5) of
carcinoembryonic
antigen staining had
positive expression of
carcinoembryonic
antigen messenger
ribonucleic acid.
Postoperative liver
metastasis was
detected in four
patients, three of
whom (75 percent)
had positive
expression of
carcinoembryonic
antigen messenger
ribonucleic acid in
tumor-draining vein
blood. CONCLUSIONS:
Positive expression of
carcinoembryonic
antigen messenger
ribonucleic acid in
tumor-draining vein
blood differed by the
type of
immunohistochemical
staining with
carcinoembryonic
antigen. These data
suggest that patients
with positive
expression of
carcinoembryonic
antigen messenger
ribonucleic acid in
tumor-draining vein
blood may be at a high
risk for postoperative
liver metastasis.
Keywords Colorectal
carcinoma - Liver
metastasis - Tumor-
draining vein - CEA
mRNA - Polymerase
chain reaction
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