6/13/2014 Treatment of crusted scabies with albendazole: A case report [eScholarship]

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Dermatology Online Journal
UC Davis
Treatment of crusted scabies with albendazole: A case report
Thaer Douri MD, A Z Shawaf MD
Dermatology Online Journal 15 (10): 17
Ministry of Health, Syria-Hama. s-dori@scs-net.org
Abstract
Crusted scabies is a severe variant of scabies caused by the ectoparasite Sarcoptes scabiei. It is characterized by high mite burden,
extensive hyperkeratotic scaling, crusted lesions, variable pruritus, generalized lymphadenopathy, erythroderma, and eosinophilia, in some
cases. There is an increased incidence of crusted scabies, particularly among patients with HIV infection. We describe a 22-year-old Syrian
immunocompetent female who had hyperkeratotic psoriasiform plaques and hyperkeratosis without itching. She was treated with oral
albendazol and topical crotamiton with salicylic acid 5 percent.
Case report
Figure 1 Figure 2
A 22-year-old Syrian female had hyperkeratotic psoriasiform lesions of her axillae, anterior flexors, and the dorsum of her hands without
itching (Figs. 1-4); the lesions had started two years previously and they were treated as psoriasis plaques without benefit.
Figure 3 Figure 4
Her skin examination revealed large erythematous, hyperkeratotic, scaly plaques on the trunk, abdomen, and extremities, as well as
numerous small erythematous papules with scattered excoriations around the umbilicus. Her head, as well as her palmoplantar surfaces and
nails were free of any lesions.
Itching was absent. The patient had no history of significant medical problems and her general physical examination was normal. Laboratory
exams were normal and HIV negative.
The presence of itching in the patient's family members made us concerned about a possible diagnosis of scabies.
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Figure 7
Figure 5 Figure 6
A biopsy was made: The epidermis shows marked hyperkeratosis, acanthosis, and burrows in the
subcorneal layer containing female mites and feces (Figs. 5-7); the diagnosis of crusted scabies was
made.
She was successfully treated with 800 mg of albendazole with fatty meals for 3 consecutive days and an
application of a 5 percent salicylic acid in crotamiton twice daily for 1 week (Figs. 8 & 9). Her family was
treated with benzyl benzoate 25 percent.
Figure 8 Figure 9
Discussion
Crusted scabies is a severe variant of scabies caused by the ectoparasite Sarcoptes scabiei. The condition is characterized by high mite
burden, extensive hyperkeratotic scales, crusted lesions, variable pruritus, generalized lymphadenopathy, erythroderma, and eosinophilia, in
some cases. Crusted scabies may masquerade as hyperkeratotic eczema, psoriasis, Darier disease, and contact dermatitis [1].
In common scabies, there are few mites, probably because scratching destroys the burrows [1]. However, in crusted scabies there may be
thousands or even millions of mites. The diagnosis is confirmed by examination of scrapings and biopsies that are teeming with mites and
eggs [1].
Our patient, who apparently had not any underlying significant disease, lacked several features that are usually seen in crusted scabies. She
also did not have any palmoplantar or subungual lesions.
Itching, which is the hallmark of scabies, was minimal or absent in this patient. It is generally believed that patients with crusted scabies do
not itch. But, at least 50 percent of the patients have some degree of itching [2]. The itch, if present, diminishes with time. In our patient the
itching was absent.
Treatment of crusted scabies can be very challenging because of various factors including the host's compromised immunity, the widespread
nature of the eruption, the high mite burden, and the limited penetration of the topical agents into the hyperkeratotic lesions. Thus, the
treatment of crusted scabies doesn't only include scabicidals, but also keratolytic agents to remove the thick crusts, which are a nidus for the
mite. Removal of these crusts can be performed by employing a keratolytic agent such as 5-10 percent salicylic acid in petrolatumor 40
percent urea; soaking in a hot bath may also help. This may reduce the mite load and also enhances the efficacy of topical scabicidals [3].
Various topical agents and oral drugs used in the treatment of classical scabies are also used in treating crusted scabies [4] including topical
sulfur compounds, benzyl benzoate, crotamiton, lindane, malathion, permethrin, and ivermectin [5].
Oral ivermectin has been proven to be very effective and is now considered as the treatment of choice for crusted scabies [4] and other
resistant cases, but it is not available in Syria. Hence, we treat these patients with a daily dose of 800 mg of albendazole with fatty meals for
3 consecutive days and an application of 5 percent salicylic acid in crotamiton twice daily for 1 week.
Benzimidazoles (albendazole, fenbendazole, oxfenbendazole, mebendazole, and thiabendazole) are broad-spectrum antiparasitic agents
used against a wide range of nematodes and cestodes. By binding to free B-tubulin, benzimidazoles inhibit the polymerization of tubulin and
microtubule-dependant glucose uptake, leading to parasite death. These agents may additionally interfere with the synaptic transmission of
parasites through a probable cholinergic effect [6]. Effectiveness of oral and topical thiabendazole against scabies has been pointed out in
only a few reports since the 1960s [6, 7]; thiabendazole and the newer agent albendazole have been successfully used against pediculosis
capitis [8, 9]. Drs. N. Ayoub, M. Merhy, and R. Tomb treated 2 cases of scabies successfully with a daily dose of 1000 mg of albendazole
with fatty meals for 3 consecutive days and an application of a 5 percent salicylic acid ointment once daily for 1 week [10].
In conclusion, crusted scabies without involvement of palms, soles, and head is unusual. Our patient was also without subungual crusting,
but exhibited the usual lack of pruritus. Crusted scabies can occur in apparently healthy persons. This possibility should be kept in mind in
order to prevent misdiagnosis of this uncommon condition. Oral albendazol is safe and effective for treating scabies.
6/13/2014 Treatment of crusted scabies with albendazole: A case report [eScholarship]
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Acknowledgement: We thank reviewer Dr. Rasha Nabhan
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2009 Dermatology Online Journal