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Table 1.

Baseline Characteristics of the Study Participants, A


Characteristic
Age (yr)
Median
Interquartile range
Non-Hispanic white (%)
Family history of cancer (%)
Currently married (%)
College graduate (%)
Median body-mass index
Diabetes (%)
Current smoker (%)
>3 Alcoholic drinks/day (%)
Vigorous physical activity 5 times/wk
Poor or fair self-reported health (%)
Median total energy intake (kcal/day)
Median servings of food
Fruits (servings/day)
Vegetables (servings/day)
Red meat (g/day)
White meat (g/day)
Use of any vitamin supplement (%)
Previous or current use of
postmenopausal

Men (N = 229,119)
2 or 3 Cups

No Coffee

1 Cup

61.1
56.465.7
91.1
46.3
83
53
26.4
8.4
4.8
6.3
24.8
7.5
1869

63.5
58.667.2
91.1
46.3
85.5
46.7
26.5
8.6
6.5
10.4
21.3
7.5
1830

62.5
57.766.5
95.1
48.2
86.4
46.6
26.6
8
10.9
12.7
20.5
6.6
1882

1.5
1.9
33.1
25.8
59.6

1.4
1.9
34.6
26.1
58.2

1.2
1.9
36.5
26
58.1

Cause of Death
All
All causes
Participants
No. of deaths (%)
33,731
Age-adjusted hazard ratio (95% CI)
Multivariate-adjusted hazard ratio (95% CI)
Cancer
No. of deaths (%)
13,402
Age-adjusted hazard ratio (95% CI)
Multivariate-adjusted hazard ratio (95% CI)
Heart disease
No. of deaths (%)
8,127
Age-adjusted hazard ratio (95% CI)
Multivariate-adjusted hazard ratio (95% CI)
Respiratory disease
No. of deaths (%)
2,512
Age-adjusted hazard ratio (95% CI)
Multivariate-adjusted hazard ratio (95% CI)
Stroke
No. of deaths (%)
1,327
Age-adjusted hazard ratio (95% CI)
Multivariate-adjusted hazard ratio (95% CI)
Injuries and accidents

Table 2. Association of Daily Coffee Consumption with Total and C


No Coffee
<1 Cup
(N = 21,080)
(N = 34,710)
2766 (13.1)
4931 (14.2)
1
1.02 (0.981.07)
1
0.99 (0.951.04)
946 (4.5)
1
1

1729 (5.0)
1.06 (0.981.14)
1.01 (0.931.09)

712 (3.4)
1
1

1193 (3.4)
0.96 (0.871.05)
0.93 (0.851.02)

169 (0.8)
1
1

351 (1.0)
1.17 (0.971.40)
1.05 (0.871.27)

125 (0.6)
1
1

221 (0.6)
0.99 (0.801.24)
0.99 (0.791.24)

No. of deaths (%)


Age-adjusted hazard ratio (95% CI)
Multivariate-adjusted hazard ratio (95% CI)
Diabetes
No. of deaths (%)
Age-adjusted hazard ratio (95% CI)
Multivariate-adjusted hazard ratio (95% CI)
Infections
No. of deaths (%)
Age-adjusted hazard ratio (95% CI)
Multivariate-adjusted hazard ratio (95% CI)
Other causes
No. of deaths (%)
Age-adjusted hazard ratio (95% CI)
Multivariate-adjusted hazard ratio (95% CI)

1,211

113 (0.5)
1
1

186 (0.5)
0.96 (0.761.21)
0.98 (0.771.24)

850

87 (0.4)
1
1

165 (0.5)
1.10 (0.851.42)
1.07 (0.821.39)

685

68 (0.3)
1
1

112 (0.3)
0.95 (0.701.28)
0.95 (0.701.29)

5,617

546 (2.6)
1
1

974 (2.8)
1.02 (0.921.13)
1.02 (0.921.13)

Table 3. Association of Daily Coffee Consumption with Total and Cause-Specific Mortality a

Cause of Death
All
All causes
Participants
No. of deaths (%)
18,784
Age-adjusted hazard ratio (95% CI)
Multivariate-adjusted hazard ratio (95% CI)
Cancer
No. of deaths (%)
7,750
Age-adjusted hazard ratio (95% CI)
Multivariate-adjusted hazard ratio (95% CI)
Heart disease
No. of deaths (%)
3,701
Age-adjusted hazard ratio (95% CI)
Multivariate-adjusted hazard ratio (95% CI)
Respiratory disease
No. of deaths (%)
1,791
Age-adjusted hazard ratio (95% CI)
Multivariate-adjusted hazard ratio (95% CI)
Stroke
No. of deaths (%)
966
Age-adjusted hazard ratio (95% CI)
Multivariate-adjusted hazard ratio (95% CI)
Injuries and accidents
No. of deaths (%)
462
Age-adjusted hazard ratio (95% CI)
Multivariate-adjusted hazard ratio (95% CI)
Diabetes
No. of deaths (%)
446
Age-adjusted hazard ratio (95% CI)
Multivariate-adjusted hazard ratio (95% CI)
Infections
No. of deaths (%)
448

Table 2. Association of Daily Coffee Consumption with Total and C


No Coffee
<1 Cup
(N = 21,080)
(N = 34,710)
2161 (10.4)
3221 (10.7)
1
0.99 (0.941.05)
1
1.01 (0.961.07)
783 (3.8)
1
1

1153 (3.8)
0.99 (0.901.08)
0.99 (0.901.08)

461 (2.2)
1
1

673 (2.2)
0.96 (0.861.08)
1.00 (0.891.13)

187 (0.9)
1
1

315 (1.0)
1.11 (0.921.33)
1.09 (0.911.31)

115 (0.6)
1
1

191 (0.6)
1.09 (0.871.38)
1.15 (0.911.45)

57 (0.3)
1
1

91 (0.3)
1.07 (0.771.49)
1.11 (0.801.55)

71 (0.3)
1
1

95 (0.3)
0.90 (0.661.22)
1.00 (0.731.36)

65 (0.3)

77 (0.3)

Age-adjusted hazard ratio (95% CI)


Multivariate-adjusted hazard ratio (95% CI)
Other causes
No. of deaths (%)
Age-adjusted hazard ratio (95% CI)
Multivariate-adjusted hazard ratio (95% CI)

3,220

1
1

0.79 (0.571.10)
0.82 (0.591.15)

422 (2.0)
1
1

626 (2.1)
0.98 (0.871.11)
1.02 (0.901.16)

haracteristics of the Study Participants, According to Daily Coffee Consumption.*

(N = 229,119)

Women (N = 173,141)
1 Cup
2 or 3 Cups

4 or 5 Cups

6 Cups

No Coffee

61
56.665.5
96.9
48.6
85.2
44.9
26,7
8.1
20.3
13.1
19.7
7
2007

60.3
55.964.8
97.3
48.5
83.4
37.2
26.6
8
34.7
11.6
20.6
9.3
2175

60.9
56.165.6
89.8
51.3
45.4
33.9
25.9
7.4
8.1
1.8
18.2
12.2
1444

62.9
58.166.7
87.2
51.1
46.6
31.3
25.8
7
8.8
2.3
16.6
10.2
1432

62.2
57.566.3
93.9
52.2
46.1
31
25.5
5.2
15.9
3.1
16.1
8.2
1463

1.1
1.8
38.3
24.4
57.6

0.8
1.7
40.5
21.5
55.5

1.8
2.3
25.6
28.3
68.4
52.4

1.8
2.3
25.6
30.1
67
54.8

1.6
2.2
27.1
29.5
67.6
55.3

aily Coffee Consumption with Total and Cause-Specific Mortality among 229,119 Men.*
1 Cup
2 or 3 Cups
4 or 5 Cups
6 Cups
(N = 33,961)
(N = 97,144)
(N = 32,084)
(N = 10,139)
5049 (14.9)
14,115 (14.5)
4966 (15.5)
1904 (18.8)
0.99 (0.941.03)
1.03 (0.991.07)
1.21 (1.151.27)
1.60 (1.511.69)
0.94 (0.900.99)
0.90 (0.860.93)
0.88 (0.840.93)
0.90 (0.850.96)

P Value
for Trend
<0.001
<0.001

1824 (5.4)
1.06 (0.981.15)
0.96 (0.891.04)

5804 (6.0)
1.25 (1.171.34)
1.00 (0.931.07)

2219 (6.9)
1.57 (1.461.70)
1.04 (0.961.12)

880 (8.7)
2.13 (1.952.34)
1.08 (0.981.19)

<0.001
0.02

1243 (3.7)
0.94 (0.861.03)
0.92 (0.841.01)

3353 (3.5)
0.95 (0.871.03)
0.86 (0.790.94)

409 (1.3)
1.64 (1.371.96)
0.87 (0.790.96)

185 (1.8)
2.63 (2.133.24)
0.88 (0.781.00)

<0.001
0.03

352 (1.0)
1.07 (0.891.28)
0.93 (0.771.11)

1046 (1.1)
1.21 (1.031.43)
0.83 (0.700.98)

409 (1.3)
1.64 (1.371.96)
0.83 (0.691.00)

185 (1.8)
2.63 (2.133.24)
0.81 (0.651.00)

<0.001
0.004

222 (0.7)
0.91 (0.731.14)
0.92 (0.731.15)

555 (0.6)
0.87 (0.721.06)
0.84 (0.681.02)

141 (0.4)
0.76 (0.600.97)
0.65 (0.510.84)

63 (0.6)
1.21 (0.891.64)
0.83 (0.611.14)

0.57
0.003

202 (0.6)
1.01 (0.801.27)
1.02 (0.801.29)

492 (0.5)
0.90 (0.731.10)
0.88 (0.711.09)

168 (0.5)
1.00 (0.781.26)
0.87 (0.681.12)

50 (0.5)
1.00 (0.721.40)
0.72 (0.511.02)

0.93
0.02

154 (0.5)
0.98 (0.751.27)
1.00 (0.761.31)

310 (0.3)
0.73 (0.570.92)
0.75 (0.590.96)

107 (0.3)
0.83 (0.621.10)
0.80 (0.601.08)

27 (0.3)
0.71 (0.461.10)
0.60 (0.390.94)

0.001
<0.001

124 (0.4)
0.99 (0.741.34)
1.03 (0.761.40)

276 (0.3)
0.82 (0.631.07)
0.83 (0.631.10)

80 (0.2)
0.79 (0.571.09)
0.70 (0.500.98)

25 (0.2)
0.85 (0.541.35)
0.59 (0.370.95)

0.08
0.001

928 (2.7)
0.91 (0.811.01)
0.92 (0.821.02)

2279 (2.3)
0.84 (0.760.92)
0.81 (0.740.89)

658 (2.1)
0.81 (0.730.91)
0.71 (0.630.80)

232 (2.3)
1.00 (0.861.16)
0.72 (0.610.84)

0.002
<0.001

with Total and Cause-Specific Mortality among 173,141 Women.*

aily Coffee Consumption with Total and Cause-Specific Mortality among 229,119 Men.*
1 Cup
2 or 3 Cups
4 or 5 Cups
6 Cups
(N = 33,961)
(N = 97,144)
(N = 32,084)
(N = 10,139)
3388 (10.8)
7140 (10.5)
2099 (12.0)
775 (15.0)
0.93 (0.880.98)
0.93 (0.890.98)
1.13 (1.071.20)
1.51 (1.391.64)
0.95 (0.901.01)
0.87 (0.830.92)
0.84 (0.790.90)
0.85 (0.780.93)

P Value
for Trend
<0.001
<0.001

1313 (4.2)
1.02 (0.931.11)
1.01 (0.921.10)

3110 (4.6)
1.14 (1.051.23)
0.98 (0.901.06)

1016 (5.8)
1.52 (1.381.67)
1.01 (0.921.12)

375 (7.3)
2.00 (1.772.27)
1.03 (0.901.16)

<0.001
0.66

683 (2.2)
0.86 (0.760.96)
0.91 (0.811.03)

1379 (2.0)
0.83 (0.750.93)
0.85 (0.760.95)

378 (2.2)
0.95 (0.831.09)
0.78 (0.680.90)

127 (2.5)
1.16 (0.951.41)
0.72 (0.590.88)

0.67
<0.001

279 (0.9)
0.85 (0.711.03)
0.84 (0.691.01)

698 (1.0)
1.03 (0.881.22)
0.79 (0.670.93)

208 (1.2)
1.29 (1.061.57)
0.65 (0.530.79)

104 (2.0)
2.35 (1.852.99)
0.77 (0.610.99)

<0.001
<0.001

168 (0.5)
0.84 (0.661.06)
0.89 (0.701.13)

369 (0.5)
0.89 (0.721.10)
0.93 (0.751.15)

91 (0.5)
0.92 (0.701.21)
0.82 (0.621.09)

32 (0.6)
1.18 (0.791.74)
0.84 (0.561.25)

0.82
0.05

114 (0.4)
1.22 (0.881.67)
1.27 (0.921.76)

153 (0.2)
0.77 (0.571.05)
0.77 (0.561.06)

36 (0.2)
0.74 (0.491.12)
0.64 (0.420.98)

11 (0.2)
0.81 (0.421.54)
0.57 (0.291.10)

0.004
<0.001

93 (0.3)
0.79 (0.581.08)
0.91 (0.671.25)

140 (0.2)
0.56 (0.420.75)
0.77 (0.571.03)

38 (0.2)
0.63 (0.420.93)
0.82 (0.541.23)

9 (0.2)
0.53 (0.271.07)
0.57 (0.281.16)

<0.001
0.03

96 (0.3)

152 (0.2)

37 (0.2)

21 (0.4)

0.88 (0.641.20)
0.93 (0.681.29

0.66 (0.500.89)
0.69 (0.510.94)

0.66 (0.440.99)
0.60 (0.400.91)

1.36 (0.832.22)
0.97 (0.581.61)

0.63
0.13

642 (2.0)
0.89 (0.791.01)
0.94 (0.831.07)

1139 (1.7)
0.76 (0.680.85)
0.79 (0.710.89)

295 (1.7)
0.81 (0.700.94)
0.74 (0.640.87)

96 (1.9)
0.96 (0.771.20)
0.72 (0.570.90)

<0.001
<0.001

= 173,141)
4 or 5 Cups

6 Cups

61.6
57.065.8
96.5
52.7
43.5
28.7
25.1
4.5
31.1
3.3
16
8.2
1540

61
56.465.3
97.2
52.6
37.8
24.3
25
4.4
48.1
3
15.4
10
1642

1.4
2.2
28.4
27.3
66.1
51.2

1.2
2
29.6
23.9
62.4
45.1

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