384

CHIN J DEM VENEEOL

2014 4
28 4
Apr 2014Vol
28No
4

HIV / AIDS 53

HIV / AIDS

2010 1 2012 12

HIV / AIDS 53 T
53 24 29 37 8 10 4 11
13 HIV 1
AIDS
+
CD4 T

67 92% CD4 + T 200 / L 15 6 6 9 d

169 7 / L
HIV / AIDS
+
CD4 T

512 91 752 1

1001 7089 2014 04 0384 03

Clinical Analysis of 53 HIV / AIDS Cases Complicated with Genital Herpes

DU Jian-qunLU Si-hanLI YingHU ong-xinLAI Huan-xing
Department of DermatologyGuangzhou Eighth People's HospitalGuangzhou 510060China
Corresponding author LU Si-hanE-mail lusihan66@ 163 com
Abstract Objective

To explore the clinical feature of HIV / AIDS complicated with genital herpes Methods

Fifty-

three HIV / AIDS cases complicated with genital herpes in-patients and out-patients between 2010 and 2012
were retrospectively analyzed esults

Of the 53 patients
24 were male and 29 were femalethe average age

was 37 8 10 4 years old Genital herpesas the first symptom of HIV / AIDS at onset was observed in 11
cases Thirteen cases developed genital herpes within 1 month after the diagnosis of HIV / AIDS Anabrosis
and ulcer was the main lesionwhich was mainly distributed in penisbalanusgreater lip of pedendumlabium minus and crissumwhile less in croupscrotum and low back The average CD4 + lymphocyte counts was
169 7cells / L CD4 + counts were less than 200cells / L in 67 92% patients The average skin lesion healing time was 15 6 6 9 days Conclusion

The clinical manifestations of genital herpes in HIV / AIDS

are always seriouswhich mainly presented as a large area of anabrosis and ulcer Antiviral nucleosides and
foscarnet sodium treatment is effective but with a long healing time The incidence of genital herpes and the
healing time of skin lesion are closely related to CD4 + counts
Key words Genital herpes AIDS Clinical analysis
genital herpesGH

HSV

1 1

HSV-2

53

HIV / AIDS GH

24 29 0 83 1 23 75 37 8

2010 1 2012 12

10 4 20 40 37 69 81% 40 60 14

53 HIV / AIDS

26. 42% 60 2 3. 77% 44

83 02% 7 13 21% 2
3. 77% HIV HIV + 14 26 42%
26 49 06% + 4

2011B080702007

5 + 2

510060

13 21% + 1 +

E-mail lusihan66@ 163 com

 2014 4 28 4

1 2

Chin J Derm VenereolApr 2014Vol 28No 4

GH

385

1 2 9 /

37 69 81%
7

1 5

21 39 62% 2 32

15 6 6 9 d Spearman

60 38% 27 25

+
CD4 T r

4 23 12 7 12

= 0 253P = 0 034 0 05
95% CI 0. 496 0. 027 CD4 +

8 4 5 3

7d 35
8 15d 7
14 0 19 0 d

16 30d 6
30d 5 11 HIV / AIDS

HIV

1 1

GH

HIV +

2 HSV-2

HSV HIV

1 13 29 HIV
HIV +

GH

+ 2 5 14

HIV HIV HIV

26. 42% 6 4 3

1
9 10 HSV-2

HIV

HSV-

2 HSV-2
HIV-1 3 HSV-2
HIV
HIV AIDS
HSV HIV
HIV
HSV

AIDS
1

1 2

3
Fig 1

1 3

4-5

HSV

HIV / AIDS

Anabrosis and ulcers on a man's penisprepucecoronary sulcus and banaluscovered

HSV-2

by yellow necrotic tissue Fig 2

HSV-2

Anabrosis and ulcers on greater lip of pedendumla

-bium minuscrissum and buttockscovered by yellow necrotic tissue and granulation h

13. 3% 50% 6-7

-yperplasia at the bottom layer

HIV / AIDS

T
+

HSV-2-DNA CD3 T 892 9

+

708 3 / LCD8 T 696 5 571. 7

+
/ L CD4 T 169 7 217 8 / L

50 / L 21 39 62%
50 200 / L 15 28 30%

20 40

83 02%

200 350 / L 9 16 98% 350 / L 8 15 09%

GH

CD4 + / CD8 + 1 0 23 0 24 HSV-

DNA 1 69 5 9 10 9 / mL 42

HIV GH

10 / mL 27

GH

50 94% 1

HIV / AIDS

1 4

HIV /

3%

AIDS HSV-DNA

53 HSV-

 2014 4 28 4

386

Chin J Derm VenereolApr 2014Vol 28No 4

DNA-PC 11 HIV / AIDS

FDA CDC

1 11

HIV

26 42%

GH HIV / AIDS CD4

13

HIV / AIDS GH

67 92% 200
39 62% 50 / L

+
/L CD4 T GH

+
CD4 T

CD4 T
9-10

+
+
+
CD3 CD4 T CD4 /
+

CD8 CD8 T
+
T CD4 T

HSV
CD8 + T
HSV HIV / AIDS
+
CD4 T

HSV CD4 + T
+
CD4 T

Th1 / Th2 Th1

Th2 HSV
Th2 HSV
HIV / AIDS HSV
HSV / HIV
3
11-12

HIV GH

HSV-2
2 3 5

1 M 3 2001
547
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positive patients in CoventryUnited KingdomJ Sex Transm Infect

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/ d
500mg 1g

2004
80 1 77

3 / d 10d12

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