13-01-16 5:09 PM Positive Effect of an Autologous Platelet Concentrate in Lateral Epicondylitis in a Double-Blind Randomized Controlled Trial

Page 1 of 3 http://ajs.sagepub.com/content/38/2/255
++
The American Journal of Sports Medicine The American Journal of Sports Medicine
ajs.sagepub.com
doi: doi: 10.1177/0363546509355445 10.1177/0363546509355445
Am J Sports Med February 2010 February 2010 vol. 38 no. 2 255-262 255-262
Positive Effect of an Autologous Platelet Concentrate in Lateral Epicondylitis in a
Double-Blind Randomized Controlled Trial
Platelet-Rich Plasma Versus Corticosteroid Injection With a 1-Year Follow-up
Joost C. Peerbooms Joost C. Peerbooms, MD , MD
*
, , Jordi Sluimer Jordi Sluimer, MD , MD

, , Danil J. Bruijn Danil J. Bruijn, PhD , PhD

*
and and Taco Gosens Taco Gosens, PhD , PhD

Author Affiliations

Address correspondence to Taco Gosens, PhD, St Elisabeth Hospital, Hilvarenbeekseweg 60, Tilburg, 5022 GC, Netherlands (e-mail:
t.gosens@elisabeth.nl).
Abstract
Background Background Platelet-rich plasma (PRP) has shown to be a general stimulation for repair.
Purpose Purpose To determine the effectiveness of PRP compared with corticosteroid injections in patients with chronic lateral epicondylitis.
Study Design Study Design Randomized controlled trial; Level of evidence, 1.
Patients Patients The trial was conducted in 2 teaching hospitals in the Netherlands. One hundred patients with chronic lateral epicondylitis were randomly
assigned in the PRP group (n = 51) or the corticosteroid group (n = 49). A central computer system carried out randomization and allocation to the trial
group. Patients were randomized to receive either a corticosteroid injection or an autologous platelet concentrate injection through a peppering
technique. The primary analysis included visual analog scores and DASH Outcome Measure scores (DASH: Disabilities of the Arm, Shoulder, and Hand).
Results Results Successful treatment was defined as more than a 25% reduction in visual analog score or DASH score without a reintervention after 1 year. The
results showed that, according to the visual analog scores, 24 of the 49 patients (49%) in the corticosteroid group and 37 of the 51 patients (73%) in the
PRP group were successful, which was significantly different (P <.001). Furthermore, according to the DASH scores, 25 of the 49 patients (51%) in the
corticosteroid group and 37 of the 51 patients (73%) in the PRP group were successful, which was also significantly different (P = .005). The corticosteroid
group was better initially and then declined, whereas the PRP group progressively improved.
Conclusion Conclusion Treatment of patients with chronic lateral epicondylitis with PRP reduces pain and significantly increases function, exceeding the effect of
corticosteroid injection. Future decisions for application of the PRP for lateral epicondylitis should be confirmed by further follow-up from this trial and
should take into account possible costs and harms as well as benefits.
Keywords:
l ateral epi condyl i ti s l ateral epi condyl i ti s pl atel et ri ch pl asma pl atel et ri ch pl asma corti costeroi ds corti costeroi ds pai n pai n functi on functi on
Footnotes
No potential conflicts of interest declared.
Articles citing this article
The Systemic Effects of Platelet-Rich Plasma Injection The Systemic Effects of Platelet-Rich Plasma Injection
Am J Sports Med January 1, 2013 41 186-193
Abstract Abstract Full Text Full Text Full Text (PDF) Full Text (PDF)
Current Concepts in Examination and Treatment of Elbow Tendon Injury Current Concepts in Examination and Treatment of Elbow Tendon Injury
Sports Health: A Multidisciplinary Approach November 19, 2012 0 1941738112464761v1-1941738112464761
Abstract Abstract Full Text Full Text Full Text (PDF) Full Text (PDF)
Plantar fasciitis Plantar fasciitis
BMJ October 11, 2012 345 e6603
Full Text Full Text Full Text (PDF) Full Text (PDF)
Quantifying Clinically Significant Change: A Brief Review of Methods and Presentation of a Hybrid Approach Quantifying Clinically Significant Change: A Brief Review of Methods and Presentation of a Hybrid Approach
Am J Sports Med October 1, 2012 40 2385-2393
Abstract Abstract Full Text Full Text Full Text (PDF) Full Text (PDF)
13-01-16 5:09 PM Positive Effect of an Autologous Platelet Concentrate in Lateral Epicondylitis in a Double-Blind Randomized Controlled Trial
Page 2 of 3 http://ajs.sagepub.com/content/38/2/255
Comparative Effectiveness of Injection Therapies in Lateral Epicondylitis: A Systematic Review and Network Meta-analysis Comparative Effectiveness of Injection Therapies in Lateral Epicondylitis: A Systematic Review and Network Meta-analysis
of Randomized Controlled Trials of Randomized Controlled Trials
Am J Sports Med September 12, 2012 0 0363546512458237v1-363546512458237
Abstract Abstract Full Text Full Text Full Text (PDF) Full Text (PDF)
Evaluation and Management of Elbow Tendinopathy Evaluation and Management of Elbow Tendinopathy
Sports Health: A Multidisciplinary Approach September 1, 2012 4 384-393
Abstract Abstract Full Text Full Text Full Text (PDF) Full Text (PDF)
Injuries of the Elbow and the Current Treatment of Tendon Disease Injuries of the Elbow and the Current Treatment of Tendon Disease
Am. J. Roentgenol. September 1, 2012 199 546-557
Abstract Abstract Full Text Full Text Full Text (PDF) Full Text (PDF)
The Biomechanical and Histologic Effects of Platelet-Rich Plasma on Rat Rotator Cuff Repairs The Biomechanical and Histologic Effects of Platelet-Rich Plasma on Rat Rotator Cuff Repairs
Am J Sports Med September 1, 2012 40 2037-2044
Abstract Abstract Full Text Full Text Full Text (PDF) Full Text (PDF)
The Effect of Platelet-Rich Fibrin Matrix on Rotator Cuff Tendon Healing: A Prospective, Randomized Clinical Study The Effect of Platelet-Rich Fibrin Matrix on Rotator Cuff Tendon Healing: A Prospective, Randomized Clinical Study
Am J Sports Med June 1, 2012 40 1234-1241
Abstract Abstract Full Text Full Text Full Text (PDF) Full Text (PDF)
Ultrasound-guided platelet-rich plasma injections for the treatment of osteoarthritis of the hip Ultrasound-guided platelet-rich plasma injections for the treatment of osteoarthritis of the hip
Rheumatology (Oxford) January 1, 2012 51 144-150
Abstract Abstract Full Text Full Text Full Text (PDF) Full Text (PDF)
The management of tennis elbow The management of tennis elbow
BMJ November 2, 2011 342 d2687
Full Text Full Text Full Text (PDF) Full Text (PDF)
Clinical and Ultrasonographic Results of Ultrasonographically Guided Percutaneous Radiofrequency Lesioning in the Clinical and Ultrasonographic Results of Ultrasonographically Guided Percutaneous Radiofrequency Lesioning in the
Treatment of Recalcitrant Lateral Epicondylitis Treatment of Recalcitrant Lateral Epicondylitis
Am J Sports Med November 1, 2011 39 2429-2435
Abstract Abstract Full Text Full Text Full Text (PDF) Full Text (PDF)
Platelet-Rich Plasma Versus Autologous Whole Blood for the Treatment of Chronic Lateral Elbow Epicondylitis: A Platelet-Rich Plasma Versus Autologous Whole Blood for the Treatment of Chronic Lateral Elbow Epicondylitis: A
Randomized Controlled Clinical Trial Randomized Controlled Clinical Trial
Am J Sports Med October 1, 2011 39 2130-2134
Abstract Abstract Full Text Full Text Full Text (PDF) Full Text (PDF)
Growth factor-based therapies provide additional benefit beyond physical therapy in resistant elbow tendinopathy: a Growth factor-based therapies provide additional benefit beyond physical therapy in resistant elbow tendinopathy: a
prospective, single-blind, randomised trial of autologous blood injections versus platelet-rich plasma injections prospective, single-blind, randomised trial of autologous blood injections versus platelet-rich plasma injections
Br. J. Sports. Med. September 1, 2011 45 966-971
Abstract Abstract Full Text Full Text Full Text (PDF) Full Text (PDF)
One-Year Follow-up of Platelet-Rich Plasma Treatment in Chronic Achilles Tendinopathy: A Double-Blind Randomized One-Year Follow-up of Platelet-Rich Plasma Treatment in Chronic Achilles Tendinopathy: A Double-Blind Randomized
Placebo-Controlled Trial Placebo-Controlled Trial
Am J Sports Med August 1, 2011 39 1623-1629
Abstract Abstract Full Text Full Text Full Text (PDF) Full Text (PDF)
Tissue engineered biological augmentation for tendon healing: a systematic review Tissue engineered biological augmentation for tendon healing: a systematic review
Br Med Bull June 1, 2011 98 31-59
Abstract Abstract Full Text Full Text Full Text (PDF) Full Text (PDF)
Ongoing Positive Effect of Platelet-Rich Plasma Versus Corticosteroid Injection in Lateral Epicondylitis: A Double-Blind Ongoing Positive Effect of Platelet-Rich Plasma Versus Corticosteroid Injection in Lateral Epicondylitis: A Double-Blind
Randomized Controlled Trial With 2-year Follow-up Randomized Controlled Trial With 2-year Follow-up
Am J Sports Med June 1, 2011 39 1200-1208
Abstract Abstract Full Text Full Text Full Text (PDF) Full Text (PDF)
SportsMedUpdate SportsMedUpdate
13-01-16 5:09 PM Positive Effect of an Autologous Platelet Concentrate in Lateral Epicondylitis in a Double-Blind Randomized Controlled Trial
Page 3 of 3 http://ajs.sagepub.com/content/38/2/255
Br. J. Sports. Med. May 1, 2011 45 527-529
Full Text Full Text Full Text (PDF) Full Text (PDF)
Platelet Activation by Collagen Provides Sustained Release of Anabolic Cytokines Platelet Activation by Collagen Provides Sustained Release of Anabolic Cytokines
Am J Sports Med April 1, 2011 39 729-734
Abstract Abstract Full Text Full Text Full Text (PDF) Full Text (PDF)
Musculoskeletal Applications of Platelet-Rich Plasma: Fad or Future? Musculoskeletal Applications of Platelet-Rich Plasma: Fad or Future?
Am. J. Roentgenol. March 1, 2011 196 628-636
Abstract Abstract Full Text Full Text Full Text (PDF) Full Text (PDF)
Platelet-Rich Plasma Augmentation for Arthroscopic Rotator Cuff Repair: A Randomized Controlled Trial Platelet-Rich Plasma Augmentation for Arthroscopic Rotator Cuff Repair: A Randomized Controlled Trial
Am J Sports Med February 1, 2011 39 258-265
Abstract Abstract Full Text Full Text Full Text (PDF) Full Text (PDF)
IOC consensus paper on the use of platelet-rich plasma in sports medicine IOC consensus paper on the use of platelet-rich plasma in sports medicine
Br. J. Sports. Med. December 1, 2010 44 1072-1081
Full Text Full Text Full Text (PDF) Full Text (PDF)