FC Path(SA) Chem

THE COLLEGES OF MEDICINE OF SOUTH AFRICA

Incorporated Association not for gain
Reg No 1955/000003/08

Examination for the Fellowship of the
College of Pathologists of South Africa - Chemical

19 March 2012

Paper 1 Laboratory Management and Practice (3 hours)

All questions are to be answered. Each question to be answered in a separate book (or books if more than
one is required for the one answer)

1 Describe a quality assurance approach to detect and manage sources of errors in
Point of Care Testing (POCT). [100]

2 The National Health Laboratory Services and the Department of Health have tasked
you with compiling a proposal for the biochemical support to the transplant unit for a
new tertiary hospital. Critically discuss your rationale. [100]

3 Discuss the applicability of the concept of Uncertainty in Measurement in Clinical
Chemistry. [100]

4 Write short notes on the following
a) Auto verification.
b) Capability index.
c) Aptamers.
d) 17 hydroxyprogesterone analysis. [100]





















FC Path(SA) Chem

THE COLLEGES OF MEDICINE OF SOUTH AFRICA

Incorporated Association not for gain
Reg No 1955/000003/08

Examination for the Fellowship of the
College of Pathologists of South Africa - Chemical

20 March 2012

Paper 2 Applied Clinical Biochemistry (3 hours)

All questions are to be answered. Each question to be answered in a separate book (or books if more than
one is required for the one answer)

1 Discuss conformational disorders, their clinical significance and the role of the
chemical pathology laboratory in the diagnosis of these disorders. [100]

2 Briefly discuss each of the following
a) Serum apolipoprotein B.
b) The use of hair as a testing medium.
c) Leptin-adiponectin ratio. [100]

3 Critically discuss the validity of serum Prostate Specific Antigen (PSA) as a
population screening tool for prostate cancer. [100]

4 Discuss the magnitude, patterns and impact of biological rhythms (if any) on the
interpretation of the following hormones and enzymes and discuss approaches to
enable standardised interpretations in view of such possible changes
a) Aldosterone.
b) Serum testosterone in males
c) Thyroid Stimulating Hormone
d) Gamma Glutamyl Transferase
e) Alkaline Phosphatase [100]