1.

The following are body mass index (BMI) scores measured in 12 patients who are free of diabetes and participating in a
study of risk factors for obesity Body mass index is measured as the ratio of weight in kilograms to height in meters
s!uared
2" 2# $1 $$ 2% 2& $& '1 2' $2 $" '(
)alculate the mean BMI (show answer to two decimal places) (*oints + 1)

Answer: 31.67
,uestion 2 2. -hat is the standard de.iation of the mean BMI in !uestion /10 )alculate
to two decimal places (*oints + 1)

Answer: 5.88
,uestion $ 3. 1enerate a 2"3 confidence inter.al estimate of the true BMI )alculate to
two decimal places and use the form 4(////5 ////)4 (*oints + 1)

Answer: (27.93, 35.40)
,uestion ' 4. )onsider the data in *roblem /1 6ow many sub7ects would be needed to
ensure that a 2"3 confidence inter.al estimate of BMI had a margin of error not
exceeding 2 units0 (*oints + 1)

N = 34
,uestion " 5. The mean BMI in patients free of diabetes was reported as 2&2 The
in.estigator conducting the study described in *roblem /1 hypothesi8es that the BMI in
patients free of diabetes is higher -hat are the null and alternati.e hypotheses0
(*oints + 1)
6o+ mean1 9 mean2: 61+ mean1 ; mean2
6o+ p1 9 p2: 61+ p1 ; p2
Ho: mean = 28.2; H1: mean > 28.2
6o+ mean 9 2&2: 61+ mean ; 2&2
,uestion % 6. <or /"5 what test statistic will you use0 (*oints + 1)
1=sample 8 test
1-sam!e " "es"
chi=s!uare goodness of fit test
Matched t=test
Independent samples t=test
,uestion # 7. -hat is the decision rule0 (*oints + 1)
#e$e%" H0 &' " > 1.796
>e7ect 6( if 8 ? 12%
>e7ect 6( if t ? 22(1 or if t@=22(1
>e7ect 6( if chi=s!uare ? 12%&
,uestion & 8. )ompute the test statistic for /"5 and carry your result to two decimal
places (*oints + 1)
t9 2.04
,uestion 2 9. Atate your conclusion for /" (*oints + 1)

#e$e%" H0
,uestion 1( 10. Bn in.estigator conducts a study to in.estigate whether mean peak expiratory flow
(*C<) is lower in children with chronic bronchitis as compared to those without Data on *C< are
collected and summari8ed below Based on the data5 is there statistical e.idence of a lower mean *C< in
children with chronic bronchitis as compared to those without0 >un the appropriate test at a9(("

1roup Eumber of )hildren Mean *C< Atd De. *C<
)hronic Bronchitis 2" 2&1 %&
Eo )hronic Bronchitis 2" $12 #'
()a" are ")e n*!! an+ a!"erna"&,e )-o")eses. (*oints + 1)
6o+ F1 9 F2 .s 61+ F1 ; F2
Ho: /1 = /2 ,s. H1: /1 0 /2
6o+ Fd 9 ( .s 61+ Fd ; (
6o+ p9(" .s 61+ p?("
,uestion 11 11. -hat is the appropriate test statistic for /1(0 (*oints + 1)
matched 8=test
independent samples 8=test
matched t=test
&n+een+en" sam!es "-"es"
chi=s!uare test of independence
,uestion 12 12. )alculate the test statistic for /1( 1i.e only the number5 and calculate to two decimal places
(*oints + 2)
t-value = -1.89
,uestion 1$ 13. Atate the conclusion for /1( (*oints + 1)
#e$e%" N*!! H-o")es&s
,uestion 1' 14. Gsing the data in /1(5 construct a 2"3 confidence inter.al for the mean
*C< in children without chronic bronchitis (*oints + 2)
(288.5, 349.5)
,uestion 1" 15. 6ow many children would be re!uired to ensure that the margin of error
in /1' does not exceed 1( units0 (*oints + 1)

N=211
,uestion 1% 16. B clinical trial is run to in.estigate the effecti.eness of an experimental drug in
reducing preterm deli.ery to a drug considered standard care and to placebo *regnant women are
enrolled and randomly assigned to recei.e either the experimental drug5 the standard drug or placebo
-omen are followed through deli.ery and classified as deli.ering preterm (H $# weeks) or not The data
are shown below
*reterm Deli.ery Cxperimental Drug Atandard Drug *lacebo
Ies 1# 2$ $"
Eo &$ ## %"
()a" are ")e n*!! an+ a!"erna"&,e )-o")eses. (*oints + 1)
6o+ F1 9 F2 9 F$
61+ means are not all e!ual
6o+ F1 9 F2 9 F$
61+ F1 ? F2 ? F$
H0: 1rea"men" an+ re"erm +e!&,er- are &n+een+en"
H1: 1rea"men" an+ re"erm +e!&,er- are no" &n+een+en"
6o+ JH12%
61+ J?12%
,uestion 1# 17. <or /1%5 what is the appropriate test statistic0 (*oints + 1)
Mann=-hitney G
-ilcoxon >ank Aum Test
Bnalysis of Kariance
2)&-s3*are "es" o' &n+een+en%e
Lruskal=-allis test
,uestion 1& 18. -hat is the critical .alue to re7ect the null hypothesis0 (ie5 what is the decision rule0)
Mnly state the number to two decimal places (*oints + 1)
2)&-s3*are > 5.99
,uestion 12 19. )ompute the test statistic Display your answer to two decimal places
(*oints + 2)
2)&-s3*are = 8.96
,uestion 2( 20. Gsing the data in problem /1%5 generate a 2"3 confidence inter.al for
the difference in proportions of women deli.ering preterm in the experimental and
standard drug treatment groups (*oints + 1)
954 25 = (-0.1706, 0.0506)
,uestion 21 21. B study is run comparing 6DN cholesterol le.els between men who
exercise regularly and those who do not The data are shown below
>egular Cxercise E Mean Atd De.
Ies $" '&" 12"
Eo 12( "%2 112
1enerate a 2"3 confidence inter.al for the difference in mean 6DN le.els between men
who exercise regularly and those who do not (*oints + 2)
954 25 = (-13.17, -3.63)
,uestion 22 22.
B clinical trial is run to assess the effects of different forms of regular exercise
on 6DN le.els in persons between the ages of 1& and 22 *articipants in the
study are randomly assigned to one of three exercise groups = -eight training5
Berobic exercise or AtretchingOIoga P and instructed to follow the program for &
weeks Their 6DN le.els are measured after & weeks and are summari8ed below
Cxercise 1roup E Mean
-eight Training 2( '2#
Berobic Cxercise 2( '$1
AtretchingOIoga 2( "#(
1o"a! 60 49.9

-e want to test the null hypothesis that the mean 6DN le.els in each of the exercise
groups are e!ual5 .s the alternati.e hypothesis that the means are not all e!ual5 at alpha
9 ((" -hat is the appropriate test statistic0 (*oints + 1)
Lruskal=-allis test
AN67A
)hi=s!uare test of independence
)hi=s!uare goodness of fit test
Independent samples t=test
,uestion 2$ 23. <or the pre.ious !uestion5 what is the critical .alue to re7ect the null hypothesis0 (*oints + 1)
3.16
,uestion 2' 24. )ompute the test statistic for /22
6int+ the AA(within) 9 215&%( (*oints + 2)

8 = 0.378
,uestion 2" 25. Atate the conclusion for /22 (*oints + 1)
A%%e" N*!! H-o")es&s.
,uestion 2% 26. The table below summari8es baseline characteristics on patients
participating in a clinical trial
)haracteristic *lacebo (n912") Cxperimental (n912") *
Mean (Q AD) Bge "' Q '" "$ Q '2 (#&"%
3 <emale $23 "23 ((2&2
3 Ness than 6igh Achool Cducation 2'3 223 ((2&%
3 )ompleting 6igh Achool $#3 $%3
3 )ompleting Aome )ollege $23 '23
Mean (Q AD) Aystolic Blood *ressure 1$% Q 1$& 1$' Q 12' ('#$%
Mean (Q AD) Total )holesterol 21' Q 2'2 21( Q 2$1 (&2"'
3 )urrent Amokers 1#3 1"3 ("#'1
3 with Diabetes &3 $3 (('$&
Bre there any statistically significant differences in baseline characteristics between
treatment groups0 Rustify your answer (*oints + 2)

1)ere &s s&9n&'&%an" +&''eren%e &n ")e roor"&on o' 'ema!es &n "wo 9ro*s. ( 0 0.05)
A!so ")ere &s a s&9n&'&%an" +&''eren%e &n ")e roor"&on o' a"&en"s w&") +&a:e"es. (0
0.05)
(&") rese%" "o o")er %)ara%"er&s"&%s, ")ere &s no s&9n&'&%an" +&''eren%e ( > 0.05)
,uestion 2# 27. Based on the table in /2%5 match each of the following study !uestions
to the appropriate null and alternati.e hypotheses+
(*oints + $)
*otential Matches+
1 + 6(+ )ategories are independent of treatment le.el
61+ )ategories are not independent of treatment le.el
2 + 6(+ p1 9 p2
61+ p1 ; p2
$ + 6(+ F1 9 F2 61+ F1 ; F2
Bnswer
: "o %omare a9es :e"ween 9ro*s => ;3
: "o %omare 4 'ema!es :e"ween 9ro*s=> ; 2
: "o %omare e+*%a"&ona! !e,e!s :e"ween 9ro*s => ; 1
,uestion 2& 28. The margin of error is always greater than or e!ual to the standard
error (*oints + 1)
1r*e
<alse
,uestion 22 29. If a test is run and p9(($"%5 then we can re7ect 6( at a9((1 (*oints +
1)
True
8a!se
,uestion $( 30. If a 2"3 )I for the difference in two independent means is (21 to '")5
there is no significant difference in means (*oints + 1)
True
8a!se
,uestion $1 31. In the standard normal distribution5 the mean 9 the median (*oints + 1)
1r*e
<alse
,uestion $2 32. B logistic regression model returns a coefficient for .ariable B of 212
-hat is the odds ratio for .ariable B0 )alculate to two decimal places (*oints + 1)

6++s ra"&o = 8.33