Lecture Plan for Bachelor of Pharmacy Subject: Pharmaceutical Organic chemistry Sem: 3 rd Batch:2 nd Teacher :Ganesh Parajuli Lecture Hour unit Unit Topic Objective/Learning outcomes Assignment seven 1 Nucleophilic aromatic substitution Introduce about Nucleophilic substitution in aromatic compound. Compare the Nucleophilic substitution in aromatic substrate and aromatic substrate Explain about the Mechanism of aromatic substitution * SNAr mechanism ,reactivity and its orientation and evidences * Benzyne Mechanism and its evidences
Four hours 2 Unsaturated Carbonyl Compounds Give concept about the unsaturated carbonyl compounds Explain about the preparation of unsaturated carbonyl compounds by different methods *Aldol Condensation *Perkin Condensation *From -halo acids Electrophilic addition reaction Nucleophilic addition reaction Michael Reaction Diels Alder reaction
Ten hours 3 Conservation of Orbital Symmetry Give concept about the molecular orbital with respect to organic molecules like benzene and methane Concept about the conservation of molecular orbital symmetry Introduce about the pericyclic reaction and its types Electrocyclic reaction Frontier Orbital theory Cycloaddition reaction Sigmatropic Reaction
3 hours 4 Neighboring group effect Effect of neighboring group in Nucleophilic Substitution Stereochemistry of product Explain about the anchimeric assistance
Two hours 5 Catalysis By transition Metal Complexes Importance of role of transition metal complex in Organic reaction Role of Wilkinson Catalyst IN hydrogenation of alkene and its stereochemistry Role of octacarbonyl Dicobalt in oxoprocess
Two hours 6 Stereoselective and stereospecific reaction Give knowledge about the Stereoselective and stereospecific reaction with suitable examples
Twelve hours 7 Heterocyclic Compounds Introduce about the heterocyclic compounds Preparation and properties of Pyrrole,Furan andThiophane. Preparation and properties of Pyridine Preparation and properties of Indole, Quinoline and Isoquinoline
Eight hours 8 Carbohydrates Definition of carbohydrate Classification of carbohydrate Glucose chain structure and ring chain form structure Mutarotion and epimers Discuss about the classification,sources,and structure of Fructose ,Sucrose Maltose and starch, Amylose ,Amylopectin ,Cellulose Chain lengthening of aldose- Killani Fisher Synthesis Shortening of carbon chain of aldose-Ruff degradation and formation of osazone
Four hours 9 Lipids Occurrence and composition of fats Saponification of fats Detergents Hydrogenation of oils Phosphoglyceride and phospholipids
Five hours 10 Proteins and nucleic acids Structure of amino acids Amino acid as a dipolar ions Isoelectric point of amino acid Peptide linkage Protein and classification Structure of protein
Denaturation of protein Nucleic acid Structure of DNA and RNA Watson and Crick Model
Three hours 11 Uses and preparation of some new reagents used in drug synthesis Salicylic acid Cinamic acid Quinoline Ethylacetoacetate Acetic anhydride Pyridine Benzaldehyde Acetophenone Dimethylaniline Tosyl chloride Diphenyl Succinic anhydride