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V Vol. 22, No.

5 May 2000

CE Refereed Peer Review

Evaluating and
FOCAL POINT Stabilizing the
★Ferrets have a number of
diseases that require prompt
recognition; familiarity with
Critical Ferret:
specific diagnostic and
therapeutic techniques is
Basic Diagnostic and
necessary to ensure adequate
critical care.
Therapeutic Techniques*
University of California, Davis Indianapolis Zoo, Indianapolis, Indiana
KEY FACTS Keith G. Benson, DVM Jan C. Ramer, DVM
■ Ferret phlebotomy is most easily University of Wisconsin
achieved using the jugular vein Joanne Paul-Murphy, DVM
or cranial vena cava.

■ Thoracic radiography is a crucial ABSTRACT: Understanding the differences and similarities between ferrets and other domestic
diagnostic tool for evaluating carnivores facilitates rapid acquisition of diagnostics as well as administration of life-saving
ferrets that are weak, coughing, measures. Restraint, phlebotomy, and tracheal wash techniques vary from those traditionally
lethargic, and/or dyspneic. used in small animal medicine. Interpretation of radiographs and diagnostic ultrasonography
requires familiarity with normal ferret anatomy. Furthermore, intravenous and intraosseous
■ The urethral opening of male catheterization, urethral catheterization, fluid therapy, and nutritional support all have ferret-
ferrets is located on the ventral specific caveats; appreciation of these differences can ensure that ferrets receive high-quality
care in a timely fashion.
aspect of the penis several
millimeters proximal to the
glans.

D
omestic ferrets represent a healthy portion of small animal patient loads.
■ When placing intravenous
Therefore, veterinarians must not only provide ferret owners with pre-
catheters, prepuncturing the
ventive care for their pets but also be able to deliver quality emergency
skin is often recommended.
care. This article describes some common diagnostic and therapeutic techniques
used in emergency medicine, with focus on how the methodologies are adapted
■ Intraosseous catheters in the
to the specific requirements of domestic ferrets.
tibia or femur are useful in
ferrets, particularly small animals
RESTRAINT
where intravenous access may
Most ferrets are amenable to simple, gentle, manual restraint. However, ferrets
be difficult to achieve.
that are highly mobile or fractious or are in pain may require special handling to
successfully restrain them. One technique involves grasping the ferret’s skin on
the scruff of its neck and lifting all four limbs off the table; most ferrets immedi-
*A companion article entitled “Evaluating and Stabilizing the Critical Ferret: Initial As-
sessment, Differential Diagnosis, and Diagnostic Plan” appeared in the March 2000 issue
(Vol. 22, No. 3) of Compendium.
Compendium May 2000 Small Animal/Exotics

TABLE I
Chemical Restraint Agents for Domestic Ferrets
Protocol Dose and Route of Administration
29
Acepromazine 0.1–0.3 mg/kg IM
Isoflurane 2% to 3% in O2 1 L/min, 3% to 3.5% in O2 induction, 0.5% to 2.5% in O2
maintenance
Ketamine 10–20 mg /kg8 IM, short duration; 30–60 mg/kg8 IM
Xylazine 1 mg/kg8 SC, IM
Ketamine–diazepam 10–20 mg/kg ketamine,1–2 mg/kg diazepam7 IM; 25–35 mg/kg ketamine, 2–3 mg/kg
diazepam30 IM
Ketamine–midazolam 20–30 mg/kg ketamine, 0.2 mg/kg midazolam IM
Ketamine–acepromazine 10–30 mg/kg ketamine, 0.05–0.3 mg/kg acepromazine29 SC, IM
Ketamine–xylazine 25 mg/kg ketamine, 2 mg/kg xylazine31 IM; 30 mg/kg ketamine, 0.3 mg/kg
xylazine31 IM
Ketamine–medetomidine 5 mg/kg ketamine, 0.08 mg/kg medetomidine32 IM
Tiletamine–zolazepam 12–22 mg/kg each33 IM

Reversal Agents
Yohimbine 0.5 mg/kg8 IM
Atipamazole 0.4 mg/kg32 IM
Naloxone 0.04–0.1 mg/kg8 SC, IM, IC

IC = intracardiac; IM = intramuscularly; O2 = oxygen; SC = subcutaneously.

ately cease struggling when held in this position. An- mean arterial pressure of ferrets is less than 60 mm Hg.
other approach is to place the ferret in dorsal recum- Thus the degree of hypotension is dose related.4
bency, using one hand to hold the scruff of its neck and
the other hand to hold its pelvic limbs and pelvis and DIAGNOSTICS
then straightening the ferret’s body. In addition to Phlebotomy
physically restraining fractious ferrets, offering them a Because ferrets have small superficial vessels and
small amount of preferred pet food (Prescription Diet® tough skin, phlebotomy becomes more challenging
a/d; Hill’s Pet Nutrition, Topeka, KS), Nutrical® (Evsco than it is in other companion animals. In ferrets, phle-
Pharmaceuticals, Buena Vista, NJ), or chicken baby botomy sites include the cephalic vein, lateral saphe-
food on a tongue depressor (held rostral to the nose) nous vein, femoral vein, jugular vein, cranial vena cava,
often distracts the animal during certain procedures, and ventral tail artery.5–7 Small (0.1- to 0.3-ml) samples
such as jugular or cranial vena caval venipuncture. of blood can be withdrawn from the cephalic or lateral
Various chemical restraint protocols (Table I) can saphenous vein similar to the same procedure used in
also be used for domestic ferrets. Isoflurane and a ket- dogs and cats. Small needles (25 to 30 gauge) and sy-
amine–benzodiazepine combination are the most com- ringes (0.5 to 1.0 ml) are recommended for these sites.
mon anesthetics used. Advantages of using sedation Because withdrawing samples from the cephalic vein
must be weighed against the potential complications likely precludes subsequent catheterization of the vessel,
that can occur in compromised patients. The rapid in- veterinarians should consider whether the cephalic vein
duction, recovery, and controlled depth of anesthesia may be needed to administer fluids or medication.
make isoflurane an excellent choice for many critically Withdrawing blood from the jugular vein is more com-
ill ferrets. Inhalation anesthetics should be administered mon for larger sample volumes. The jugular vein has a
to ferrets using a nonrebreathing system. Because narrow diameter and is superficial. This vein can be
isoflurane reduces the number of circulating erythro- easily traversed when inserting a needle; thus bending it
cytes via splenic sequestration in ferrets, this agent at an angle of 20˚ to 30˚ can facilitate venipuncture.
should be used with caution in severely anemic ani- Blood can also be collected from the cranial vena
mals.1–3 Isoflurane administration to domestic ferrets is cava; fractious ferrets may require general anesthesia. A
associated with substantial decreases in arterial blood 1-inch, 22-gauge needle on a 3- or 5-ml syringe should
pressure. At 1.0 minimum alveolar concentration, the be used to collect blood from this vessel. The ferret

CHEMICAL RESTRAINT ■ ISOFLURANE ■ BLOOD COLLECTION


Small Animal/Exotics Compendium May 2000

pulmonary edema,
pulmonary infil-
trates, and soft tis-
sue masses can be
determined from
standard radiograph-
ic views of the tho-
rax. The status, size,
and shape of the
heart, however, can
Figure 1B be difficult to evalu-
Figure 1—(A) Lateral and ate. The cardiac silhouette of ferrets is naturally globoid
(B) ventrodorsal radio- (Figure 1) and thus cannot be scrutinized with the
graphs showing the normal same criteria used to judge canine and feline hearts.9 A
ferret thorax. contrast esophagram may be helpful to confirm a diag-
nosis of megaesophagus.10
should be restrained in Abdominal radiography can identify accumulations
dorsal recumbency with of fluid, organomegaly, space-occupying masses, and
its neck extended. The gastrointestinal foreign bodies. The intestine of normal
notch between the man- ferrets should not contain intraluminal gas. Spleno-
ubrium and first rib should megaly is a common, nonspecific finding in older fer-
be palpated—this is the rets because the splenic size gradually increases with
site of entry for the nee- age. The causes of splenomegaly include neoplasia, ane-
Figure 1A dle. The needle should mia, sepsis, chronic illness, and extramedullary hemato-
be angled approximately poiesis.11 Whereas 5% of ferrets with splenomegaly
10˚ from the horizontal plane and directed toward the have splenic disease, most have extramedullary hemato-
contralateral coxofemoral joint. Slight negative pressure poiesis and/or congestion.12 Plain radiography and con-
should be applied to the syringe and the needle ad- trast studies of the urinary tract can help veterinarians
vanced slowly until blood begins to flow. After the sam- evaluate markedly enlarged prostates, cystic and ure-
ple has been withdrawn, some veterinarians opt to ap- thral calculi, cystic kidneys, and bladder cysts.13
ply direct pressure at the notch of the manubrium and
first rib. Ultrasonography
Cardiac
Tracheal Wash Ferrets in cardiac failure require minimal restraint for
Because ferrets have a small-diameter trachea, the echocardiography. However, ferrets that are not in car-
transglottal approach should be used for tracheal wash- diac failure may be too fractious for thorough evalua-
es. Ferrets should be anesthetized and intubated using a tion without anesthesia; isoflurane administered in oxy-
sterile 2.5- to 4-mm diameter endotracheal tube.8 A gen via facemask is a safe and effective restraint method.
sterile 3.5-Fr red rubber or polypropylene catheter Two-dimensional echocardiography should be used to
should be advanced through the endotracheal tube to measure chamber size, wall thickness, and shortening
the level of the third to sixth intercostal space. From 2 fraction and assess valvular function. Pleural effusions
to 3 ml of sterile 0.9% sodium chloride or lactated and masses in the cranial mediastinum are best evaluat-
Ringer’s solution should be injected into the catheter ed using thoracic ultrasound imaging. Echocardio-
and the fluid immediately withdrawn while the thorax graphic values for ferrets have been reported.12
is coupaged. The sample should be submitted for cyto-
logic and microbiologic evaluations. If practitioners Abdominal
suspect systemic mycosis, fungal cultures should be Ferrets are excellent subjects for abdominal ultrasonog-
specifically requested. raphy because they usually can be manually restrained
for the procedure. Linear-array probes are ideal, and a
Radiography frequency of 7.5 MHz is recommended. The abdominal
Thoracic radiography is a crucial diagnostic tool for cavity can be evaluated for effusion, size, and architecture
evaluating ferrets that are weak, coughing, lethargic, of the liver, spleen, adrenal glands, intestinal tract, re-
and/or dyspneic. The presence of thoracic effusions, gional lymph nodes, reproductive tract (prostate in male

TRANSGLOTTAL APPROACH ■ CONTRAST STUDIES ■ ECHOCARDIOGRAPHY


Compendium May 2000 Small Animal/Exotics

ferrets; ovaries, ovarian remnants, obtained, they may be han-


uterus in intact jills), and pan- dled and analyzed as they are
creas. The normal adrenal size in dogs and cats.
in ferrets is 2 to 3 mm wide × Veterinarians are cautioned
8 to 10 mm long.13 Color flow to avoid overzealous flushing
Doppler technology can be of IV or IO catheters with
used to detect impingement of heparinized saline. Studies in
an enlarged adrenal gland on humans have demonstrated
the vena cava by measuring an little benefit in flushing cathe-
increased velocity of blood ters with heparinized saline,
flow at that point. The normal and the potential for heparin
mesenteric lymph node mea- overdose in ferrets is substan-
sures 10 to 15.2 mm × 5.6 to Figure 2—Illustration depicting the correct placement of tial.20 We prefer to reserve hep-
9.6 mm.15 Ultrasonography- an intraosseous catheter in the femur of a ferret. arinized saline flushes for in-
guided biopsy or fine-needle stances where catheters are being
aspiration of the lymph nodes maintained without material
can be performed with the flowing through them for 6
same techniques as those used hours or more. If heparinized
in dogs and cats. saline is required for a hep-
arin lock, only the volume
THERAPEUTICS needed to fill the catheter it-
Intravenous self should be used. To avoid
Catheterization injecting heparin into the ani-
Because the skin of ferrets mal, this material should be
is tough, prepuncturing it us- withdrawn before anything is
ing a 20-gauge needle before administered by catheter.
the catheter is placed can pre- © 2000 R. Peterson
vent the catheter from be- Urethral Catheterization
coming crimped along the Figure 3—Illustration depicting urethral catheterization of of Male Ferrets
a male ferret.
stylet. All rubber connections Catheterization of male fer-
and injection ports should be rets has been described in the
covered with bandage material to prevent ferrets from literature.21 The distal aspect of the os penis should be
chewing and ingesting any rubber. hooked with the flexure curving dorsally. Because the ure-
Cephalic and saphenous catheters are well tolerated thral opening is proximal to the hooked end and laying on
by ferrets. Jugular catheters are not well tolerated by the ventral surface of the glans, it can be difficult to visual-
alert ferrets but have been used with success in de- ize (Figure 3). The use of magnifying loupes can thus be
pressed patients.1,8,16 If intravenous (IV) catheterization helpful during the procedure. The small size of the ure-
is difficult or impractical (e.g., in ferrets with hypoten- thral opening makes catheterization challenging, and a
sion, small ferrets), intraosseous (IO) catheterization of well-lubricated 22- or 24-gauge IVcatheter may be needed
the femur is a rapid, effective alternative.17 At the head to initially flush the urethra. Some male ferrets are large
of the femur, an area measuring 2 × 2 inches should be enough to allow passage of a 3.5-Fr red rubber catheter.
clipped and aseptically prepared. We prefer using a lo- The use of an IV catheter guide wire or sterile guitar string
cal anesthetic at the site and within the periosteum to within the lumen of the catheter facilitates passage around
minimize discomfort; however, general anesthesia may the ischial arch.16 Because the urethra of male ferrets is
be required. A small incision should be made using a long and acutely curved at the ischial arch, tomcat
No. 15 blade or 20-gauge needle. A 1.5-inch, 22-gauge catheters are not appropriate because the stiffness of the
spinal needle should then be advanced medial to the material may lead to mucosal damage. A soft, 3.0-Fr uri-
greater trochanter, in the trochanteric fossa, through nary catheter designed specifically for use in ferrets is also
the cortex, and into the medullary space (Figure 2). available (Cook Veterinary Products, Bloomington, IA).
Care must be taken not to pass through the greater Male ferrets with severe dehydration or hyperkalemia
trochanter and into the periosteal space along the distal require minimal restraint; generally, most ferrets must be
femur. This technique can be used to obtain bone mar- sedated or anesthetized to safely manipulate genital tissue.
row samples for analysis.18,19 After samples have been With the ferret in dorsal recumbency, the penis should be

TYPES OF CATHETERS ■ HEPARINIZED SALINE ■ MAGNIFYING LOUPES


Small Animal/Exotics Compendium May 2000

TABLE II Fluid Composition


Analgesic Drugs for Ferrets Isotonic crystalloid so-
lutions are the most
Drug Dose and Route of Administration common fluids adminis-
Aspirin 0.5–22 mg/kg30 PO tered to ferrets. Lactated
Buprenorphine 0.01–0.03 mg/kg1 SC, IM, IV; 0.01 mg/kg8 SC, IM Ringer’s solution and
Butorphanol 0.1–0.25 mg/kg34 SC, IM, IV; 0.05–0.1 mg/kg8 SC, IM 0.9% sodium chloride
Carprofen 2.2 mg/kg every 12 hours PO are acceptable choices for
Fentanyl citrate 0.2 ml/kg8 IM volume expansion. Fer-
Phenylbutazone 100 mg/kg8 PO rets with hypoalbumine-
IM = intramuscularly; IV = intravenously; PO = orally; SC = subcutaneously. mia (serum albumin less
than 2.0) may benefit
from administration of
gently exposed by pushing against the base of the os penis colloid solutions (e.g., hetastarch, dextrans). There are no
while retracting the prepuce. In male ferrets with urinary published guidelines for administering colloids to ferrets;
calculi or urethrospasm, open-ended catheters are often we recommend following guidelines developed for colloid
easier to pass than are catheters with side ports. The open administration in cats. Hypoglycemic ferrets can benefit
end allows retrograde flushing and distention of the ure- from the addition of dextrose to these solutions, and
thra. Administration of IV diazepam or addition of dilute potassium supplementation in ferrets with hypokalemia
lidocaine to the flush may help relax the urethra. The can be administered according to feline protocols.22
catheter should be advanced into the bladder. At this
point, practitioners can (1) collect a urine sample, (2) Nutritional Support
flush the bladder with sterile isotonic fluid (e.g., lactated Critically ill ferrets are frequently anorectic. In most
Ringer’s solution, 0.9% sodium chloride), or (3) instill a ferrets, forced alimentation is possible with simple sy-
radiopaque contrast medium as part of a diagnostic ringe feedings. Pureed ferret food, poultry baby foods, or
study.21 The catheter can be affixed by adding “tape Prescription Diet® a/d (50 ml/kg/day23) are acceptable
wings” to the catheter and suturing these to the abdomi- and palatable to ferrets. Prescription Diet® a/d is soft
nal skin just cranial to the prepuce. Closed drainage sys- enough to be administered through a syringe. Percuta-
tems are preferred, but ferrets can easily tangle lines. neous gastrostomy tubes can be used in ferrets as in other
carnivores.24 Ferrets may resist abdominal wraps; we have
Fluid Therapy found that using minimal bandaging material can lower
Subcutaneous the animal’s distress level. Ferrets have a particular affini-
Subcutaneous fluid administration is commonly used ty for chewing rubber items, including pezzer-type
and quite helpful. An effective method that can be ac- catheters; thus care must be taken to protect the tube at
complished by one staff member is to scruff the skin be- all times. We use a small circumferential wrap that is ap-
tween the shoulder blades and deposit fluid using a but- proximately 3 inches wide and find this approach superi-
terfly catheter. Subcutaneous fluids are not indicated in or to applying a stockinet jacket or full abdominal wrap.
ferrets with severe dehydration or in shock and should be
reserved for ferrets with mild dehydration or for mainte- Analgesia
nance after the hydration status has been normalized. Several analgesics, including butorphanol and bu-
prenorphine (Table II), are appropriate for use in fer-
Intravenous and Intraosseous rets. The degree of sedation is lower with buprenor-
The rate of fluid administration in ferrets is higher phine than with butorphanol. As with other species,
than that administered to larger companion animals; veterinarians should be careful with NSAID adminis-
precise rates for ferrets have not been determined, but tration in dehydrated patients and patients with preex-
75 to 100 ml/kg/day is commonly administered.16 Flu- isting gastric mucosal disease (e.g., helicobacteriosis),
id deficits should be corrected within 24 to 36 hours. coagulation disorders, or renal disease.
Serum electrolyte levels should be monitored in pa-
tients receiving large volumes of fluids throughout the Thoracocentesis
course of therapy. Postobstructive diuresis should be In addition to being a diagnostic tool, thoracocente-
anticipated in male ferrets being treated for urethral ob- sis can be a useful therapeutic procedure. By reducing
struction. Careful monitoring of body weight, skin tur- the volume of pleural effusion, patients can ventilate a
gor, urine output, and serum electrolytes is imperative. larger portion of their lungs and thus improve ventila-

FLUID DEFICITS ■ COLLOID ADMINISTRATION ■ PERCUTANEOUS GASTROSTOMY


Compendium May 2000 Small Animal/Exotics

tion–perfusion matching and oxygenation of


venous blood. Fluid removed during thoraco- Protocol for Collecting Blood from Ferret Donors
centesis should be submitted for cytologic and
chemical evaluation, and cultures should be ■ Assemble materials: clippers, cotton balls soaked in
submitted if there is evidence of sepsis. The povidone–iodine solution and cotton balls soaked in
caudal placement of the heart in ferrets (be- alcohol; 22-gauge, 6-inch butterfly catheter; 12- or 20-ml
tween the sixth and eighth rib) must be con- syringe with 1 ml of acid citrate dextrose for every 6 ml
sidered when attempting this procedure. Fer-
of blood to be harvested.
rets should be lightly sedated or anesthetized
with isoflurane. The lateral thorax should be ■ Examine, weigh, and obtain a rectal temperature of the
clipped and aseptically prepared; a 21-gauge, donor, recording values on the donor record sheet.
1-inch butterfly catheter and 20-ml syringe ■ Sedate the donor with either 2% to 3% isoflurane in oxygen
with a three-way stopcock should be used. or 20 to 35 mg/kg intramuscular ketamine combined with
The catheter should be passed approximately 0.2 mg/kg intramuscular midazolam.
one third up the lateral thoracic wall from the
■ With the onset of sedation or anesthesia, apply sterile
sternum between the fourth and fifth or ninth
and tenth ribs. The procedure requires two lubricant to the donor’s eyes.
veterinary staff: one to direct the needle while ■ Clip and aseptically prepare the area around the donor’s
another manipulates the syringe and stopcock. manubrium and the ventral cervical area.
■ Place the butterfly catheter into the jugular vein or cranial
Blood Transfusions vein cava and slowly draw 5 to 7 ml/kg body weight into
Blood transfusions in ferrets have been de-
the syringe containing the acid citrate dextrose.
scribed in the literature.25 Transfusion should
be considered when a patient’s hematocrit has ■ Remove the catheter, apply 2 minutes of direct pressure
dropped precipitously to 15% or gradually to onto the site, and observe the donor’s recovery from
12%.16 Veterinarians may choose to transfuse a sedation/anesthesia.
ferret before the hematocrit reaches these lev- ■ Do not harvest whole blood from healthy ferrets more
els, depending on the patient’s clinical signs. often than every 21 days.
Ferrets that are dyspneic or weak may benefit
from additional erythrocytes, particularly if
blood loss has been acute and there has been insuffi- the PCV of ferrets.3 Blood should be administered by
cient time to compensate for reduced oxygen-carrying very slow bolus or using a syringe pump shortly after
capacity. Ferrets with coagulation disorders, jills with the blood has been harvested from the donor. Whole
hyperestrogenemia and secondary aplastic anemia, and blood should be passed through a filter to avoid inad-
ferrets with substantial intraoperative hemorrhage are vertently delivering thrombi to the patient. Although
examples of candidates for whole blood transfusion. transfusion reactions have not been reported in ferrets,
Ferrets lack distinct blood groups, thereby simplifying they should be monitored for hypotension, fever, ur-
selection of blood donors.26 Ferrets can safely donate ticaria, hemolysis, and emesis.22
5% to 7% of their blood volume (equivalent of 5 to 7
ml/kg body weight).25 Although there is no standard Endotracheal Intubation
recommendation for the volume of whole blood to be The small oral cavity and caudal placement of the glot-
delivered to ferrets, most authors suggest using canine tis in ferrets (Figure 4) make endotracheal intubation
or feline parameters.25,27 We recommend the following challenging. It is important for veterinarians to use a
formula (PCV = packed cell volume)22: small-blade laryngoscope, such as a 2.5- to 4-mm endo-
tracheal tube with stylet. The tongue should be manually
Blood Volume Donor (ml) = Blood Volume Recipient (ml) retracted in a rostral direction and ventrally deflected, us-
ing the laryngoscope to reveal the glottis. Because the os-
× Post PCV – Pre PCV tium generally cannot be visualized, the epiglottis should
Donor PCV be depressed using the tube to allow airway visualization.
If this approach is not possible, practitioners can occa-
Efficiency is important when collecting blood from sionally deflect the tube off the caudal aspect of the soft
ferret donors (see Protocol for Collecting Blood from palate, thereby positioning the tube down into the airway.
Ferret Donors) because isoflurane anesthesia can reduce To minimize laryngospasm, topical anesthetic agents can

BLOOD COLLECTION PROTOCOL ■ DONOR SELECTION ■ TRANSFUSION REACTIONS


Small Animal/Exotics Compendium May 2000

anesthesia in ferrets. Am J Vet Res 58:781–785, 1997.


3. Marini RP, Jackson LR, Esteves MI, et al: Effect of isoflu-
rane on hematologic variable in ferrets. Am J Veterinary Res 55:
1479–1483, 1994.
4. Imai A, Steffey EP, Farver TB, Ilkiw JE: Assessment of iso-
flurane anesthesia in ferrets and rats. Am J Vet Res 60:1579–
1585, 1999.
5. Brown SA: Basic anatomy, physiology and husbandry, in
Hillyer EV, Quesenberry KE (eds): Ferrets, Rabbits, and Ro-
dents: Clinical Medicine and Surgery. Philadelphia, WB Saun-
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6. Bleakly SP: Simple technique for bleeding ferrets (Mustela
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Figure 4—The normal ferret glottis. nine ferrets. JAVMA 205:444–447, 1994.
11. Erdman SE, Li X, Fox JG: Hematopoietic diseases, in Fox JG
(ed): Biology and Diseases of the Ferret. Baltimore, Williams
be applied by swabbing the area using a cotton-tipped ap- & Wilkins, 1998, pp 231–246.
plicator saturated with 1% lidocaine solution or using 12. Stamoulis ME, Miller MS, Hillyer EV: Cardiovascular dis-
sterile lidocaine gel.1 Application of benzocaine-contain- eases, Hillyer EV, Quesenberry KE (eds): Ferrets, Rabbits, and
Rodents: Clinical Medicine and Surgery. Philadelphia, WB
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in ferrets and thus is not recommended.28 13. Fox JG, Pearson RC, Bell JA: Diseases of the genitourinary
system, in Fox JG (ed): Biology and Diseases of the Ferret. Bal-
Bandaging timore, Williams & Wilkins, 1998 pp 247–272.
14. O’Brien RT, Paul-Murphy J, Dubielzig RR: Ultrasonogra-
Ferrets have short, flexible limbs that decrease in diam- phy of adrenal glands in normal ferrets. Vet Radiol Ultra-
eter distally and offer few bony projections on which to sound 37:445–448, 1996.
anchor bandaging. The use of stirrups and Elastikon® 15. Paul-Murphy J, O’Brien RT, Spaeth A, et al: Ultrasonogra-
(Johnson & Johnson, Arlington, TX), a highly adhesive phy and fine needle aspirate cytology of the mesenteric
material, can be helpful. Elastikon® can be gently warmed lymph node in normal domestic ferrets (Mustela putorius
furo). Vet Radiol Ultrasound 40:308–310, 1999.
in a microwave to improve adhesive properties, making it 16. Quesenberry K: Basic approach to veterinary care, in Hillyer
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17. Anderson NL: Intraosseous fluid therapy in small exotic mam-
ally, it may become necessary to lightly sedate a ferret to mals, in Bonagura JD (ed): Kirk’s Currrent Veterinary Therapy
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SUMMARY for femoral bone marrow collection in the ferret. Lab Anim
Sci 40:654–655, 1990.
Critically ill ferrets present veterinarians with some 19. Morrisey JK, Ramer JC: Ferrets: Clinical pathology and
unique challenges because of their small body size and sample collection. Vet Clin North Am Exotic Anim Pract
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specific recommendations and requirements, veterinari- 20. Stevens LC, Haire WD, Tarantolo S, et al: Normal saline
ans can effectively treat ferrets requiring emergency versus heparin slush for maintaining central venous pressure
catheter patency during apheresis collection of peripheral
medicine. blood stem cells. Transfusion Sci 18:187–193, 1997.
21. Marini RP, Esteves MI, Fox JG: A technique for catheteriza-
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BENZOCAINE-CONTAINING SPRAYS ■ ANCHORING BANDAGES


Compendium May 2000 Small Animal/Exotics

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methemoglobinemia attributed to topical application of the About the Authors
anesthetic in several laboratory animal species. Am J Vet Res Dr. Benson is a resident in Zoological Medicine, School of
54:1322–1326, 1993. Veterinary Medicine, University of California, Davis, Cali-
29. Mason DE: Anesthesia, analgesia and sedation for small mam-
fornia. Dr. Ramer is a staff veterinarian at the Indianapolis
mals, in Hillyer EV, Quesenberry KE (eds): Ferrets, Rabbits,
and Rodents: Clinical Medicine and Surgery. Philadelphia, Zoo, Indianapolis, Indiana. Dr. Paul-Murphy is the chief of
WB Saunders Co, 1997, pp 378–391. service of the Special Species Health Service at the
30. Brown SA: Ferrets, in A Practitioner’s Guide to Rabbits and School of Veterinary Medicine, University of Wisconsin,
Ferrets. Lakewood, CO, American Animal Hospital Associa- Madison, Wisconsin.
tion, 1993, pp 43–111.

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