Therapeutic Algorithm for Hypotension and/or Shock
Circulation Airway Breathing
Shock and/or MAP < 60 mm Hg* Intubation and mechanical ventilation Respiratory distress, hypoxemia, PCO2 mental status Intubation and mechanical ventilation Hypovolemic shock Septic shock Obstructive shock Right ventricular MI See Acute myocardial infarction 2 (14-16 g) IVs or cordis/central line Elevate legs 2-3 liters NS over 10-20 min PRBC if bleeding 2-3 liters NS over 10-30 min Persistent shock? Maintenance fluids 200 500 ml NS over 10-20 min Persistent shock? Specific Rx: PE- thrombolysis if not contraindicated Pneumothorax chest tube Tamponade pericardial tap Constriction pericardial stripping No No Yes Yes No Yes Maintenance fluids Consider RHC to optimize CO with fluids** Dobutamine What is the systolic BP? If persistent shock, consider IABP and cardiac catheterization < 70 70-100 >100 (nl DBP) Levo Dopa + Dobut Dobut + NTG or NTP Consider RHC to guide therapy 1-2 liters NS / 20 min Persistent shock? Dopa to MAP > 60 Levo if refractory ADH if refractory to Levo and consider stress-dose steroids even if ACTH stim is normal Continue fluid boluses until: - shock resolves or - CVP, S3, rales, and PO2, then insert RHC Continue NS/PRBC until shock resolves Surgical consult if bleeding Maintenance fluids Cardiogenic shock IV, arterial access, Foley catheter, EKG, + NG tube Stratify based on Diagnostic Algorithm for Hypotension If no CHF present: 100-500 ml NS/10 min **How to do a fluid challenge to maximize cardiac output PCWP Volume of NS to infuse over 5-10 min < 12 500 ml 12-16 250 ml > 16 100 ml Observe the in PCWP and SV PCWP < 3-5 mm Hg PCWP > 5-7 mm Hg SV > 15% PCWP > 5-7 mm Hg SV < 15% STOP fluid challenges If PCWP > 20, consider diuresis Repeat w/250-500 ml bolus Shock resolved? No further CO? PCWP > 18-20? No Yes Dopa dopamine 2-20 mcg/kg/min; Dobut dobutamine 5-15 mcg/kg/min; Levo levophed 2-30 mcg/min; NTG nitroglycerine 25-600 mcg/min NTP nitroprusside -0.1-5 mcg/kg/min; ADH- vasopressin 0.04-0.12 u/min. (*MAP goal is 75% of baseline value) MAP mean arterial pressure. DBP diastolic blood pressure. RHC right heart catheterization. SV stroke volume (cardiac output/heart rate). NS normal saline. PRBC packed red blood cells. MI myocardial infarction. IABP intra-aortic balloon pump. CO cardiac output.
Hall JB et al. Principles of Critical Care 2 nd ed., McGraw Hill, New York, 1998 Guidelines for cardiopulmonary resuscitation and emergency cardiac care. JAMA 268: 2171, 1992 Malay MB et al. Low-dose vasopressin in the treatment of vasodilatory septic shock. J Trauma 47(4):699-703, 1999