Biology 220, Fall 2014 (Changes in future iterations of this syllabus will appear in Red)

When and Where? Gross Hall, Room 103, 8:30 AM to 9:45 AM

Instructors: Dave Sherwood, Professor of Biology, 4216 FFSC, 613 8192, david.sherwood@duke.edu
Meng Chen, Professor of Biology, 3103 FFSC, 684-8442, meng.chen@duke.edu
TAs: Melissa Keenan (Tu 12:00-12:50 p.m. (Bio Sci 144) & 1:40-2:30 p.m. (Bio Sci 144)
Emily (Jie-Ning) Yang (W 1:40-2:30p.m. (Bio Sci 063))
Emily (Jie-Ning) Yang (M 12:00-12:50 p.m. (LSRC D243)

Text: Hardin, et al. Beckers World of the Cell. Eight Edition
Gilbert Developmental Biology 10th Edition
A mature draft (and a fairly reasonable facsimile) of the power point used for the lecture will be posted the day before each class.
Final Grade:25% Test 1 (in class, 2 sides of an 8.5 x 11 crib sheet allowed, must be hand written and turned in)
25% Test 2 (in class, 2 sides of an 8.5 x 11 crib sheet allowed, must be hand written and turned in)
50% Final, 2 sides of an 8.5 x 11 crib sheet allowed, must be hand written and turned in.
Extra Credit: from problem sets given out at discussion groups
Make up exams for excused absences will be given at Professor Chen and Sherwoods Discretion.
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Discussion Groups will be organized around problems sets that are given out each week. Questions that may arise from the lectures will
also be addressed. There will be a homework problem set each week that will be given out in the discussion section. These will be turned in
the following week and count for 1.5 points of extra-credit. A reasonable attempt to answer the question will be given full credit. Importantly,
to receive full credit, you must attend the discussion section to pick up the homework and return it at the following discussion section. There
will be 10 problem homework sets, so a possible 15 points in extra credit.
The curve, which typically ranges from D to A+, will be based on the grades for each exam. Thus, you can earn an A+ without doing any of
the extra credit work. After the curve is determined, extra credit points will be added and can potentially shift students from one grade to a
higher grade.
Date Mon. Topic Reading Discussion
Tues 26 Aug. Introduction, Cells, Model Systems,
Microscopy (DRS)
World of the Cell
Chapter 1
Chapter 4: 75-81
Appendix: A1-A15
No Discussion meeting
in the frst week
Thur 28 Aug. Microscopy, Chemical Bonds & membranes
(DRS)
World of the Cell
Chapter 2: 34-35
Chapter 3: 44-46
Chapter 7: 156-180
Tues 2 Sept. Compartments & Nuclear Transport (DRS) World of the Cell
Chapter 4: 82-99 (overview of cell)
Problem Set#1 (DRS)
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Chapter 18: 536-543
Chapter 11: 298-99
Appendix: A18-22, A28-29
Thur 4 Sept. The ER and Protein Delivery (DRS) World of the Cell
Chapter 12: 324-364
Chapter 22:695-702
Tues 9 Sept. Membrane synthesis, fippases and vesicle
trafcking (DRS)
World of the Cell
Chapter 12
Chapter 3: 65-72
Problem Set #2 (DRS)
Thur 11 Sept. ER to Golgi (DRS) Chapter 12
Tues 16 Sept.
Exocytosis (DRS)
Chapter 12 Problem Set #3 (DRS)
Thur 18 Sept. Endocytosis Chapter 12
Mon 22 Sept. Whole Class Review Session (DRS)
Place/Time TBD
Tues 23 Sept. Mitochondria and electron transport chain (MC)World of the Cell
Chapter 5
Chapter 10: 252-257; 267-284
TA led Exam Review
Thur 25 Sept. Exam 1
Tues 30 Sept. Plastid and protein import (MC) World of the Cell
Chapter 11: 293-308
Chapter 22: 7-2-703
Problem Set #4(DRS)
Homework #4
Mitochondria (MC)
Thur 2 Oct. Cytoskeleton I (MC) World of the Cell
Chapter 15: 422-423;
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Chapter 16: 433-441; 459-474
Tues 7 Oct. Cytoskeleton II (MC) World of the Cell
Chapter 15: 424-433
Chapter 16: 450-453;
Chapter 19: 570-579
Problem Set #5 Energy
and Cytoskeleton I;
Homework #5 Plastids
and Cytoskeleton I
(MC)
Homework #6
Cytoskeleton II and
Membrane Transport
Thur 9 Oct Membrane transport pumps and carriers (MC)World of the Cell
Tues 14 Oct. NO CLASS-Fall Break NO Discussion
Sections
Thur 16 Oct. Ion Channels (MC) World of the Cell
Chapter 8
Tues 21 Oct. Nerves and electrical conduction (MC) World of the Cell
Chapter 13: 365-391
Problem Set #6
Cytoskeleton II and
Membrane Transport;
(MC)
Homework #7
Ion Channels and
Nerves
Thur 23 Oct. Cell Junctions, adhesion, the extracellular
matrix and integrins (MC)
World of the Cell
Chapter 17: 477-497
Tues 28 Oct. Stem cells and cell lineage (MC) A: 1131-1204 Problem Set #7
Electrical conduction
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and Cell Junctions
(MC)
Homework #8
Cell Junctions and Cell
Lineage
Thurs 30 Oct. Whole Class Review Session (MC)
N.b.! End of Material for 2
nd
Exam
Tues 4 Nov Signal transduction - G proteins (DRS) World of the Cell
Chapter 14: 392-405, 414-417
Review for Exam-no
problem sets
Thurs 6 Nov. Exam 2
Tues 11 Nov. Signal transduction RTK, Notch, Hh, Wnt
(DRS)
World of the Cell
Chapter 14: 405-414
Problem Set #8 (DRS)
Thurs 13 Nov. AP axis: organization (DRS) Developmental Biology Gilberts:
Chapter 6: 185-211
Chapter 9: 309-314
Tues 18 Nov. Limbs building a three dimensional structure
(DRS)
Developmental Biology Gilberts:
Chapter 14: 489-510
Problem Set #9 (DRS)
Thurs 20 Nov. Vertebrate gastrulation & Cell Movement (DRS)Gilberts: TBD
Tues 25 Nov. Plant development (MC) Gilbert: 627-654 No Discussion
Sections
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Thurs 27 Nov. THANKSGIVING-NO CLASS
Tues 2 Dec. Plant development (MC) Gilbert: 627-654 Problem Set #10 Plant
Development and
Signaling (MC)
Thurs 4 Dec. Plant Signaling (MC) Gilbert: 627-654
Dec. Whole Class Review Session (MC and DRS) TBD
Tues 9 Dec. 9 a.m. 12 p.m.
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